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Declaration of Dr. Adam Dicker, M.D., Ph.D. in Support of Petition for Inter Partes Review of U.S. Patent No. 7,744,913

File History of U.S. Patent No.: 8,257,723

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U.S. Patent No.: 7,744,913, W.R. Noyes, Issued: June 29, 2010

U.S. Patent No.: 8,257,723, W.R. Noyes, Issued: September 4, 2012

Curriculum Vitae of Dr. Adam Dicker

File History of U.S. Patent No.: 7,744,913

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S.S. Yoon et al., ¿¿¿Surgical treatment and other regional treatments for colorectal cancer liver metastases,¿¿¿ The Oncologist 4(3):197-208 (1999)

L.F. Fajardo, ¿¿¿Morphology of radiation effects on normal tissues,¿¿¿ in PRINCIPLES AND PRACTICE OF RADIATION ONCOLOGY, Chapter 4 (eds. C.A. Perez and L.W. Brady) (Lippincott Company, Philadelphia) (3rd ed. 1998)

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J.P. Hoffman et al., ¿¿¿Use of saline-filled tissue expanders to protect the small bowel from radiation,¿¿¿ Oncology (Williston Park) 12(1):51-54 (January 1998) (¿¿¿Hoffman II¿¿¿)

B.D. Minsky et al., ¿¿¿Carcinoma of the esophagus. Part 1: Primary therapy,¿¿¿ Oncology (Williston Park) 13(9):1225-1236 (September 1999)

D.C. Damin and A.R. Lazzaron, ¿¿¿Evolving treatment strategies for colorectal cancer: a critical review of current therapeutic options,¿¿¿ World Journal of Gastroenterology 20(4): 877-887 (January 28, 2014)

E.K. Reddy and C.M. Mansfield, ¿¿¿Carcinoma of the prostate,¿¿¿ in THERAPEUTIC RADIOLOGY: NEW DIRECTIONS IN THERAPY, Chapter 11 (Medical Examination Publishing Company, New Hyde Park, New York) (1983)

P. Wust et al., ¿¿¿Hyperthermia in combined treatment of cancer,¿¿¿ Lancet Oncology 3(8):487-497 (August 2002)

F.W. George et al., ¿¿¿Cobalt-60 telecurietherapy in the definitive treatment of carcinoma of the prostate: a preliminary report,¿¿¿ Journal of Urology 93:102-109 (January 1965)

J.A. Del Regato, ¿¿¿Radiotherapy in the conservative treatment of operable and locally inoperable carcinoma of the prostate,¿¿¿ Radiology 88:761-766 (1967)

M.A. Bagshaw et al., ¿¿¿External beam radiation therapy of primary carcinoma of the prostate,¿¿¿ Cancer 36:723-728 (1975)

S.E.M. Langley and R. Laing, ¿¿¿Prostate brachytherapy has come of age: a review of the technique and results,¿¿¿ BJU International 89:241-249 (2002)

A. Dicker et al., ¿¿¿Introduction,¿¿¿ in BASIC AND ADVANCED TECHNIQUES IN PROSTATE BRACHYTHERAPY, Chapter 1 (eds. A. Dicker et al.) (CRC Press, Taylor & Francis, London and New York) (2005)

W.U. Shipley et al., ¿¿¿Advanced prostate cancer: the results of a randomized comparative trial of high dose irradiation boosting with conformal...,¿¿¿ International Journal of Radiation Oncology: Biology Physics 32(1):3-12 (April 1995)

W.R. Lee et al., ¿¿¿Lateral rectal shielding reduces late rectal morbidity following high dose three-dimensional conformal ...,¿¿¿ International Journal of Radiation Oncology: Biology Physics 35(2):251-257 (May 1996) (¿¿¿Lee I¿¿¿)

D. Kuban et al., ¿¿¿Hazards of dose escalation in prostate cancer radiotherapy,¿¿¿ International Journal of Radiation Oncology: Biology Physics 57(5):1260-1268 (December 2003)

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Cherr et al., ¿¿¿Rectourethral fistula and massive rectal bleeding from iodine-125 prostate brachytherapy: a case report,¿¿¿ The American Surgeon 67(2):131-134 (February 2001)

B.E. Waddell et al., ¿¿¿Absorbable mesh sling prevents radiation-induced bowel injury during ¿¿¿sandwich¿¿¿ chemoradiation for rectal cancer,¿¿¿ Archives of Surgery 135(10):1212-1217 (October 2000) (¿¿¿Waddell I¿¿¿)

U.S. Patent No.: 6,206,930, K.J.L. Burg et al., Issued: March 27, 2001

M.A. Moerland et al., ¿¿¿Evaluation of permanent I-125 prostate implants using radiography and magnetic resonance imaging,¿¿¿ International Journal of Radiation Oncology: Biology Physics 37:927-933 (1997)

K.B. Clough et al., ¿¿¿Laparoscopic unilateral ovarian transposition prior to irradiation: prospective study of 20 cases,¿¿¿ Cancer 77:2638-2645 (1996)

S. M. Tadavarthy et al., ¿¿¿Polyvinyl alcohol (Ivalon)--a new embolic material,¿¿¿ American Journal of Roentgenology 125:609-616 (1975)

S. K¿¿nemann et al., ¿¿¿Fractionated perioperative high dose rate brachytherapy using a tissue equivalent bendy applicator,¿¿¿ British Journal of Radiology 75:453-459 (2002)

U.S. Patent No.: 6,210,314, M. Ein-Gal, Issued: April 3, 2001

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B.E. Waddell et al., ¿¿¿Prevention of chronic radiation enteritis,¿¿¿ Journal of the American College of Surgeons 189:611-624 (1999) (¿¿¿Waddell II¿¿¿)

C. Kettle and R.B. Johanson, ¿¿¿Absorbable synthetic versus catgut suture material for perineal repair,¿¿¿ Cochrane Database of Systematic Reviews 2: CD000006 (2000)

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Petition for Inter Partes Review

Petitioner¿¿¿s Explanation of Multiple Petitions Challenging Patent No. 7,744,913 and Ranking of Petitions