Quest Diagnostics Incorporated vs UNM Rainforest Innovations

Notice of Refund

Petitioner Quest Diagnostics Incorporated's Request for Refund of Inter Partes Review Post-Institution Fees Pursuant to 37 C.F.R. Section 42.15(b)

Termination Decision Document

Petitioner and Patent Owner's Joint Motion to Terminate Inter Partes Review Proceedings Pursuant to 35 U.S.C. Section 317(A)

Petitioner and Patent Owner's Joint Request to File Settlement and License Agreement as Business Confidential Information Pursuant to 35 U.S.C. Section 317

Exhibit 1029: Settlement and License Agreement

Motion to Admit C. Key Pro Hac Vice

Declaration of C. Key Regarding Pro Hac Vice Admission

Patent Owner's Power of Attorney

Patent Owner's Mandatory Notice

Notice of Accord Filing Date

Exhibit 1001: U.S. Patent No. 7,314,760 to Cole, et al.

Exhibit 1004: Bahado-Singh, R., et al., Elevated maternal urine level of B-core fragment of human chorionic gonadotropin versus serum triple test in the second-trimester detection of Down syndrome, American Journal of Obstetrics and Gynecology (1999)

Exhibit 1009: Brasher, M., et al., Isoelectric Focusing, Encyclopedia of Immunology, Second Edition, Academic Press, 1510-1514 (1998)

Exhibit 1006: Abushoufa, R., et al., The development of a sialic acid specific lectin-immunoassay for the measurement of human chorionic gonadotrophin glycoforms in serum ..., Clinical Endocrinology 52, 499-508 (2000)

Exhibit 1002: File History of U.S. Patent No. 7,314,760

Exhibit 1003: Berger, P., et al., Variants of Human Chorionic Gonadotropin from Pregnant Women and Tumor Patients recognized by Monoclonal Antibodies, Journal of Clinical Endocrinology and Metabolism 77(2), 347-351 (1993)

Exhibit 1005: Yoshimura, M., et al., Thyrotropic Activity of Basic Isoelectric Forms of Human Chorionic Gonadotropin Extracted from Hydatidiform Mole Tissues, Journal of Clinical Endocrinology and Metabolism, 78 (4) 862-866 (1994)

Exhibit 1007: Marquart, N. (Ed.), Obstetrics and Gynecology, Fourth Edition, Chapter 43, Lippincott Williams & Wilkins, 524-532 (2002)

Exhibit 1008: Cuckle, H.S., et al., Detection of hydatidiform mole in maternal serum screening programmes for Down's syndrome, British Journal of Obstetrics and Gynaecology, 99, 495-497 (June 1992)

Exhibit 1010: Cole, L.A., et al., The Heterogeneity of Human Chorionic Gonadotropin (hCG). III. The Occurrence and Biological and Immunological Activities of Nicked hCG, Endocrinology, 129 (3), 1559-1567 (September 1991)

Exhibit 1011: Cole, L.A., et al., Urinary Screening Tests for Fetal Down Syndrome: I. Fresh B-core Fragment, Prenatal Diagnosis, 19 (4), 350-350 (1999)

Exhibit 1013: Curriculum Vitae of Dr. Kurt Thomas Barnhart, M.D., M.S.C.E.

Exhibit 1015: Pages from SCImago, (n.d.). SJR - SCImago Journal & Country Rank [Portal]. Retrieved 8/19/2020, from http://www.scimagojr.comScimago Journal & Country Rankings

Exhibit 1017: Eldar-Geva, T., et al., High maternal serum chorionic gonadotropin level in Downs' syndrome pregnancies is caused by elevation of both subunits messenger ribonucleic acid level..., J. Clin. Endocrinol. Metab., 80, 3528-3531 (1995)

Exhibit 1018: Spencer, K., Evaluation of an assay of the free beta-subunit of choriogonadotropin and its potential value in screening for Down's syndrome, Clin. Chem., 37, 809-814 (1991)

Exhibit 1019: Spencer, K., et al., Free beta-hCG as first-trimester marker for fetal trisomy, Lancet, 339, 1480 (1992)

Exhibit 1021: Muller, F., et al., Maternal serum human chorionic gonadotropin level at fifteen weeks is a predictor for preeclampsia, Am. J. Obstet. Gynecol., 175, 37-40 (1996)

Exhibit 1022: Berkowitz, R.S., et al., Natural history of partial molar pregnancy, Obstet. Gynecol., 66, 677- 81 (1985)

Exhibit 1014: Stenman, U., et al., The classification, functions and clinical use of different isoforms of HCG, Human Reproduction Update, 12(6), 769-87 (2006)

Exhibit 1016: Hay, D.L., Discordant and variable production of human chorionic gonadotropin and its free a- and b-subunits in early pregnancy, J. Clin. Endocrinol. Metab., 61 (6), 1195-1200 (1985)

Exhibit 1020: Bahado-Singh, R.O., et al, The role of hyperglycosylated hCG in trophoblast invasion and the prediction of subsequent pre-eclampsia, Prenat. Diagn., 22, 478-481 (2002)

Exhibit 1023: Bishop, J.C., et al., All MoMs are not eqal: some statistical properties associated with reporting results in the form of multiples of the median, Am. J. Hum. Genet., 52(2), 425-430 (1993)

Exhibit 1024: McChesney, R., et al., Intact HCG, free HCG b subunit and HCG b core fragment: longitudinal patterns in urine during early pregnancy, Human Reproduction, 20(4), 928-935 (2005)

Exhibit 1025: Fishel, S.B., et al., Human chorionic gonadotropin secreted by pre-implantation embryos cultured in vitro, Science 223, 816-818 (1984) ("Fishel")

Exhibit 1027: Cole, L.A., et al., Immunoassay of human chorionic gonadotropin, its free subunits, and metabolites, Clin. Chem., 43, 2233-2243 (1997) ("Cole")

Petitioner's Power of Attorney

Petition for Inter Partes Review of U.S. Patent 7,314,760

Exhibit 1026: Parry, S., et al., Placental Protein Hormones, in DeGroot LJ, Jameson JL (ed): Endocrinology, 4th ed, Ch. 178, p. 2379, WB Saunders (2001) ("Parry")

Exhibit 1028: Ozturk, M., et al., Physiological studies of human chorionic gonadotropin (hCG),ahCG and BhCG as measured by specific monoclonal immunoradiometric assays, Endocrinology, 120 (2), 549-558 (1987) ("Ozturk")

Exhibit 1012: Declaration of Dr. Kurt Thomas Barnhart, M.D., M.S.C.E.