The detailed information for PTAB case with proceeding number IPR2022-00855 filed by Miltenyi Biomedicine GmbH et al. against The Trustees of the University of Pennsylvania et al. on Apr 12, 2022. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Case Details

Proceeding Number
IPR2022-00855
Filing Date
Apr 12, 2022
Petitioner
Miltenyi Biomedicine GmbH et al.
Respondent
The Trustees of the University of Pennsylvania et al.
Status
Terminated-Settled
Respondent Application Number
14997136
Respondent Tech Center
1600
Respondent Patent Number
9540445
Institution Decision Date
Oct 11, 2022
Termination Date
May 23, 2023

Proceeding Documents

The table below shows documents filed in the case, listing each document name, filing date, document type, and filing party. Tracking these filings indicates the activity of the parties involved in the case, and the types of documents filed can provide insights into the legal strategies being employed.


Document NameFiling DateCategoryFiling Party

Alert me when new update on this case

Due to Settlement After Institution of Trial and Granting-in-part and Denying-in-part Joint Motion to Keep Settlement Agreement Separate and Confidential 35 U.S.C. 317; 37 C.F.R. 42.72, 42.74

May 23, 2023PAPERBOARD

Ex. 3003

May 22, 2023EXHIBITBOARD

2023-05-16 Motion to Terminate

May 16, 2023PAPERPATENT OWNER

Motion to Keep Separate and Confidential

May 16, 2023PAPERPATENT OWNER

EX2083

May 16, 2023EXHIBITPATENT OWNER

Petitioner's Amended Notice of Deposition of Robert Negrin

Apr 28, 2023PAPERPETITIONER

Petitioner's Notice of Deposition of Adam Bagg

Apr 28, 2023PAPERPETITIONER

Petitioners' Notice of Deposition of Dr. Robert Negrin

Apr 17, 2023PAPERPETITIONER

ORDER Granting Petitioners Motion for Additional Discovery 37 C.F.R. sec 42.51 b 2

Apr 11, 2023PAPERBOARD

Ex. 3002

Apr 7, 2023EXHIBITBOARD

Patent Owners Opposition to Petitioners Motion for Additional Discovery

Apr 4, 2023PAPERPATENT OWNER

EX 2082

Apr 4, 2023EXHIBITPATENT OWNER

Petitioner's Motion for Additional Discovery

Mar 21, 2023PAPERPETITIONER

Petitioner's Objections to Evidence Submitted with Patent Owner's Response

Feb 21, 2023PAPERPETITIONER

EX 2047

Feb 13, 2023EXHIBITPATENT OWNER

EX 2048

Feb 13, 2023EXHIBITPATENT OWNER

EX 2049

Feb 13, 2023EXHIBITPATENT OWNER

EX 2050

Feb 13, 2023EXHIBITPATENT OWNER

EX 2051

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EX 2052

Feb 13, 2023EXHIBITPATENT OWNER

EX 2053

Feb 13, 2023EXHIBITPATENT OWNER

EX 2054

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EX 2055

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EX 2056

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EX 2057

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EX 2058

Feb 13, 2023EXHIBITPATENT OWNER

EX 2059

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EX 2060

Feb 13, 2023EXHIBITPATENT OWNER

EX 2061

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EX 2062

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EX 2063

Feb 13, 2023EXHIBITPATENT OWNER

EX 2064

Feb 13, 2023EXHIBITPATENT OWNER

EX 2065

Feb 13, 2023EXHIBITPATENT OWNER

EX 2066

Feb 13, 2023EXHIBITPATENT OWNER

EX 2067

Feb 13, 2023EXHIBITPATENT OWNER

EX 2068

Feb 13, 2023EXHIBITPATENT OWNER

EX 2069

Feb 13, 2023EXHIBITPATENT OWNER

EX 2070

Feb 13, 2023EXHIBITPATENT OWNER

EX 2071

Feb 13, 2023EXHIBITPATENT OWNER

EX 2072

Feb 13, 2023EXHIBITPATENT OWNER

EX 2073

Feb 13, 2023EXHIBITPATENT OWNER

EX 2074

Feb 13, 2023EXHIBITPATENT OWNER

EX 2075

Feb 13, 2023EXHIBITPATENT OWNER

EX 2076

Feb 13, 2023EXHIBITPATENT OWNER

EX 2077

Feb 13, 2023EXHIBITPATENT OWNER

EX 2078

Feb 13, 2023EXHIBITPATENT OWNER

EX 2079

Feb 13, 2023EXHIBITPATENT OWNER

EX 2080

Feb 13, 2023EXHIBITPATENT OWNER

EX 2081

Feb 13, 2023EXHIBITPATENT OWNER

Patent Owner's Exhibit List

Feb 13, 2023PAPERPATENT OWNER

2023-02-13 Patent Owner Response

Feb 13, 2023PAPERPATENT OWNER

Second Joint Stipulation to Modify Due Dates 1-3

Jan 26, 2023PAPERPATENT OWNER

2022-12-28 Notice of Deposition - Junghans

Dec 28, 2022PAPERPATENT OWNER

Petitioners' Updated Mandatory Notices

Nov 28, 2022PAPERPETITIONER

Petitioners' Power of Attorney

Nov 28, 2022PAPERPETITIONER

Joint Stipulation to Modify Scheduling Order

Nov 11, 2022PAPERPETITIONER

Patent Owner's Objections to Evidence

Oct 25, 2022PAPERPATENT OWNER

Petitioner's Objections to Evidence

Oct 25, 2022PAPERPETITIONER

Institution Decision: Granting Institution of Inter Partes Review 35 U.S.C. sec. 314

Oct 11, 2022PAPERBOARD

Order: SCHEDULING ORDER

Oct 11, 2022PAPERBOARD

Ex. 3001

Aug 22, 2022EXHIBITBOARD

Sur-Reply of Patent Owner and Real Party in Interest

Aug 19, 2022PAPERPATENT OWNER

POPR Reply

Aug 12, 2022PAPERPETITIONER

PRELIMINARY RESPONSE OF PATENT OWNER TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA AND REAL PARTY IN INTEREST NOVARTIS PHARMA AG

Jul 19, 2022PAPERPATENT OWNER

Jason Fagone, Has Carl June Found a Key to Fighting Cancer?, PHILA. MAG. (Aug. 1, 2013).

Jul 19, 2022EXHIBITPATENT OWNER

Denise Grady, An Immune System Trained to Kill Cancer, N.Y. TIMES (Sept. 12, 2011), https://www.nytimes.com/2011/09/13/health/13gene.html.

Jul 19, 2022EXHIBITPATENT OWNER

Jasone Fagone, Walt Keller, Leukemia Survivor, Has Passed, PHILA. MAG. (Feb. 20, 2014), https://www.phillymag.com/news/2014/02/20/walt-keller-leukemia-survivor-obituary-1953-2014/.

Jul 19, 2022EXHIBITPATENT OWNER

Gina Kolata, A Cancer Treatment Makes Leukemia Vanish, but Creates More Mysteries, N.Y. TIMES (Feb. 2, 2022), https://www.nytimes.com/2022/02/02/health/leukemia-car-t-immunotherapy.html.

Jul 19, 2022EXHIBITPATENT OWNER

Denise Grady, In Girl���s Last Hope, Altered Immune Cells Beat Leukemia, N.Y. TIMES (Dec. 9, 2012), https://www.nytimes.com/2012/12/10/health/a-breakthrough-against-leukemia-using-altered-t-cells.html.

Jul 19, 2022EXHIBITPATENT OWNER

Denise Grady, F.D.A. Approves First Gene-Altering Leukemia Treatment, Costing $475,000, N.Y. TIMES (Aug. 30, 2017), https://www.nytimes.com/2017/08/30/health/gene-therapy-cancer.html.

Jul 19, 2022EXHIBITPATENT OWNER

FOOD AND DRUG ADMIN., FDA APPROVAL BRINGS FIRST GENE THERAPY TO THE UNITED STATES (Aug. 30, 2017), https://www.fda.gov/news-events/press-announcements/fda-approval-brings-first-gene-therapy-united-states.

Jul 19, 2022EXHIBITPATENT OWNER

FOOD AND DRUG ADMIN., BREAKTHROUGH THERAPY (Jan. 4, 2018), https://www.fda.gov/patients/fast-track-breakthrough-therapy-accelerated-approval-priority-review/breakthrough-therapy.

Jul 19, 2022EXHIBITPATENT OWNER

FOOD AND DRUG ADMIN., PRIORITY REVIEW (Jan. 4, 2018), https://www.fda.gov/patients/fast-track-breakthrough-therapy-accelerated-approval-priority-review/priority-review.

Jul 19, 2022EXHIBITPATENT OWNER

Barbara Savoldo et al., CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients, 121 J. CLINICAL INVESTIGATION 1822 (2011).

Jul 19, 2022EXHIBITPATENT OWNER

Brian G. Till et al., Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells, 112 BLOOD 2261 (2008).

Jul 19, 2022EXHIBITPATENT OWNER

Renier J. Brentjens et al., Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias, 118 BLOOD 4817 (2011).

Jul 19, 2022EXHIBITPATENT OWNER

Renier Brentjens et al., Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event in a phase I clinical trial, 18 MOLECULAR THERAPY 666 (2010).

Jul 19, 2022EXHIBITPATENT OWNER

Renier J. Brentjens et al., A Phase I Trial for the Treatment of Chemo refractory Chronic Lymphocytic Leukemia with CD19-Targeted Autologous T Cells, 16 MOLECULAR THERAPY S15 (2008).

Jul 19, 2022EXHIBITPATENT OWNER

Jennifer Couzin-Frankel, The dizzying journey to a new cancer arsenal, 340 SCI. 1514 (2013).

Jul 19, 2022EXHIBITPATENT OWNER

Jennifer Couzin-Frankel, Breakthrough of the Year 2013: Cancer Immunotherapy, 342 SCI. 1432 (2013).

Jul 19, 2022EXHIBITPATENT OWNER

David L. Porter et al., Chimeric Antigen Receptor Modified T Cells Directed Against CD 19 (CTL0l 9 cells) Have Long-Term Persistence And Induce Durable Responses In Relapsed, Refractory CLL, 122 BLOOD 4162 (2013).

Jul 19, 2022EXHIBITPATENT OWNER

David L. Porter et al., Randomized, Phase II Dose Optimization Study Of Chimeric Antigen Receptor Modified T Cells Directed Against CD 19 (CTL019) In Patients With Relapsed Refractory CLL, 122 BLOOD 873 (2013).

Jul 19, 2022EXHIBITPATENT OWNER

Stephan A. Grupp et al., T Cells Engineered With A Chimeric Antigen Receptor (CAR) Targeting CD 19 (CTL0l 9) Produce Significant In Vivo Proliferation, Complete Responses... 122 BLOOD 67 (2013).

Jul 19, 2022EXHIBITPATENT OWNER

James N. Kochenderfer et al., B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD 19 chimeric-antigen-receptor transduced T cells, 119 BLOOD 2709 (2012).

Jul 19, 2022EXHIBITPATENT OWNER

Carl June Named One of Time���s 100 Most Influential People in the World, PENN MEDICINE (Apr. 26, 2018), https://pathology.med.upenn.edu/news/carl-june-named-one-times-100-most-influential-people-world.

Jul 19, 2022EXHIBITPATENT OWNER

Holly Auer, Penn Medicine Immunotherapy Pioneer Carl June, MD, Awarded 2015 Paul Ehrlich and Ludwig Darmstaedter Prize, PENN TODAY (Mar. 11, 2015)

Jul 19, 2022EXHIBITPATENT OWNER

Andrew Pollock, Setting the Body���s ���Serial Killers��� Loose on Cancer, N.Y. TIMES (Aug. 1, 2016), https://www.nytimes.com/2016/08/02/health/cancer-cell-therapy-immune-system.html.

Jul 19, 2022EXHIBITPATENT OWNER

2015 Watanabe Award Winner Carl H. June, IND. CLINICAL AND TRANSLATIONAL SCIS. INST., https://indianactsi.org/awards/watanabe-award-winners/2015-watanabe-award-winner-carl-h-june/ (last visited July 12, 2022).

Jul 19, 2022EXHIBITPATENT OWNER

Agilent Presents Thought Leader Award to Drs. Carl H. June and Michael Milone, AGILENT TECHS. INC. (Nov. 17, 2020), https://www.agilent.com/about/newsroom/presrel/2020/17nov-ca20030.html.

Jul 19, 2022EXHIBITPATENT OWNER

Information Disclosure Statement Initialed by Examiner (Apr. 18, 2016), U.S. Patent Application No. 14,997,136.

Jul 19, 2022EXHIBITPATENT OWNER

Supplemental Information Disclosure Statement Initialed by Examiner (Apr. 18, 2016), U.S. Patent Application No. 14,997,136.

Jul 19, 2022EXHIBITPATENT OWNER

World Intell. Prop. Org. Patent Application No. WO 02/077029 A2.

Jul 19, 2022EXHIBITPATENT OWNER

Pilot Study for Patients with Chemotherapy Resistant or Refractory CD19 Leukemia and Lymphoma (CART-19), CLINICALTRIALS.GOV (April 29, 2009), [http://web.archive.org/web/20090903002304/http://clinicaltrials.gov/ct2/show/NCT00891215].

Jul 19, 2022EXHIBITPATENT OWNER

Amendments to the Claims (Nov. 13, 2018), U.S. Patent Application No. 15,353,899.

Jul 19, 2022EXHIBITPATENT OWNER

Steven A. Rosenberg et al., Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma, 319 NEW ENG. J. MED. 1676 (1988).

Jul 19, 2022EXHIBITPATENT OWNER

Michael C. Jensen et al., Antitransgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Redirected T Cells in Humans, 16 BIOLOGY BLOOD AND MARROW TRANSPLANTATION 1245 (2010).

Jul 19, 2022EXHIBITPATENT OWNER

Richard A. Morgan et al., Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2, 18 MOLECULAR THERAPY 843 (2010).

Jul 19, 2022EXHIBITPATENT OWNER

David L. Porter et al., A phase 1 trial of donor lymphocyte infusions expanded and activated ex vivo via CD3/CD28 costimulation, 107 BLOOD 1325 (2006).

Jul 19, 2022EXHIBITPATENT OWNER

Grazyna Lipowska-Bhalla, Targeted immunotherapy of cancer with CAR T cells: achievements and challenges, 61 CANCER IMMUNOLOGY, IMMUNOTHERAPY 953 (2012).

Jul 19, 2022EXHIBITPATENT OWNER

Latest paper from the father of CAR-T: CAR-T really completely cured cancer, MEDICALTREND.ORG, https://medicaltrend.org/2022/02/03/latest-paper-from-the-father-of-car-t-car-t-really-completely-cured-cancer/ (last visited July 13, 2022).

Jul 19, 2022EXHIBITPATENT OWNER

Bipulendu Jena et al., Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor, 116 BLOOD 1035 (2010).

Jul 19, 2022EXHIBITPATENT OWNER

Michael H. Kershaw et al., A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer, 12 CLINICAL CANCER RSCH. 6106 (2006).

Jul 19, 2022EXHIBITPATENT OWNER

Cor H.J. Lamers et al., Treatment of Metastatic Renal Cell Carcinoma With Autologous T-Lymphocytes Genetically Retargeted Against Carbonic Anhydrase IX: First Clinical Experience, 24 J. CLINICAL ONCOLOGY e20 (2006).

Jul 19, 2022EXHIBITPATENT OWNER

ASH honors Bruce R. Blazar, M.D., and Carl H. June, M.D., with 2012 Ernest Beutler Lecture and Prize, SCIENCEX (Aug. 27, 2012), https://sciencex.com/wire-news/107531358/ash-honors-bruce-r-blazar-md-and-carl-h-june-md-with-2012-ernest.html.

Jul 19, 2022EXHIBITPATENT OWNER

Renier J. Brentjens et al., Genetically Targeted T Cells Eradicate Systemic Acute Lymphoblastic Leukemia Xenografts, 13 CLINICAL CANCER RSCH. 5426 (2007).

Jul 19, 2022EXHIBITPATENT OWNER

U.S. Patent No. 7,402,431.

Jul 19, 2022EXHIBITPATENT OWNER

Cancer treatment myths: Any truth to these common beliefs?, MAYO CLINIC (March 22, 2022), https://www.mayoclinic.org/diseases-conditions/cancer/in-depth/cancer/art-20046762.

Jul 19, 2022EXHIBITPATENT OWNER

Adam Bagg Aff., July 19, 2022.

Jul 19, 2022EXHIBITPATENT OWNER

SITC Smalley Award 2013 Recipient, SOC���Y FOR IMMUNOTHERAPY OF CANCER, https://www.sitcancer.org/funding/named-funds-and-awards2/smalley/2013 (last visited July 19, 2022).

Jul 19, 2022EXHIBITPATENT OWNER

AAI-Steinman Award for Human Immunology Research Past Recipients, AM. ASS���N OF IMMUNOLOGISTS, https://www.aai.org/Awards/Career-Awards/AAI-Steinman-Award-for-Human-Immunology-Research/Past-Recipients.aspx (last visited July 19, 2022).

Jul 19, 2022EXHIBITPATENT OWNER

IPR2022-00855 Mandatory Notices by Patent Owner

May 2, 2022PAPERPATENT OWNER

Power of Attorney

May 2, 2022PAPERPATENT OWNER

Notice: Notice filing date accorded

Apr 19, 2022PAPERBOARD

Arnold Declaration

Apr 19, 2022EXHIBITPETITIONER

445 Petition

Apr 12, 2022PAPERPETITIONER

445 Petition - POA

Apr 12, 2022PAPERPETITIONER

Exhibit List

Apr 12, 2022PAPERPETITIONER

9,540,445 Patent

Apr 12, 2022EXHIBITPETITIONER

Junghans Decl

Apr 12, 2022EXHIBITPETITIONER

Campana

Apr 12, 2022EXHIBITPETITIONER

Nicholson

Apr 12, 2022EXHIBITPETITIONER

Honsik

Apr 12, 2022EXHIBITPETITIONER

CART-19 ClinicalTrials.gov - Internet Archive Decl and Exhibit

Apr 12, 2022EXHIBITPETITIONER

Jensen

Apr 12, 2022EXHIBITPETITIONER

Milone

Apr 12, 2022EXHIBITPETITIONER

Littman

Apr 12, 2022EXHIBITPETITIONER

Sadelain

Apr 12, 2022EXHIBITPETITIONER

Riddell

Apr 12, 2022EXHIBITPETITIONER

Porter

Apr 12, 2022EXHIBITPETITIONER

Porter Protocol

Apr 12, 2022EXHIBITPETITIONER

PCT/US2011/064191 File History Excerpts

Apr 12, 2022EXHIBITPETITIONER

U.S. Provisional Application 61/502,649 File History

Apr 12, 2022EXHIBITPETITIONER

U.S. Provisional Application 61/421,470 File History

Apr 12, 2022EXHIBITPETITIONER

445 Patent File History excerpts

Apr 12, 2022EXHIBITPETITIONER

Imai

Apr 12, 2022EXHIBITPETITIONER

Ng

Apr 12, 2022EXHIBITPETITIONER

SIFT webpage - Internet Archive Decl and Exhibit

Apr 12, 2022EXHIBITPETITIONER

Turco

Apr 12, 2022EXHIBITPETITIONER

Dudrick

Apr 12, 2022EXHIBITPETITIONER

Porter Correction

Apr 12, 2022EXHIBITPETITIONER

U.S. Patent Application No. 15/353,899 File History Excerpts

Apr 12, 2022EXHIBITPETITIONER

Immunobiology

Apr 12, 2022EXHIBITPETITIONER

Molecular Biology

Apr 12, 2022EXHIBITPETITIONER

Jena

Apr 12, 2022EXHIBITPETITIONER

Klebanoff

Apr 12, 2022EXHIBITPETITIONER

Huston

Apr 12, 2022EXHIBITPETITIONER

Mosteller

Apr 12, 2022EXHIBITPETITIONER

McDowell

Apr 12, 2022EXHIBITPETITIONER

Boursier

Apr 12, 2022EXHIBITPETITIONER

Sukhatme

Apr 12, 2022EXHIBITPETITIONER

NCT01029366 webpage

Apr 12, 2022EXHIBITPETITIONER

Porter Protocol - Sept 24 2011

Apr 12, 2022EXHIBITPETITIONER

Porter Protocol - April 22 2012

Apr 12, 2022EXHIBITPETITIONER

Schneider

Apr 12, 2022EXHIBITPETITIONER

U.S. Patent No. 8,911,993 File History Excerpts

Apr 12, 2022EXHIBITPETITIONER

Zhao

Apr 12, 2022EXHIBITPETITIONER

Kochenderfer 2010

Apr 12, 2022EXHIBITPETITIONER

Brentjens

Apr 12, 2022EXHIBITPETITIONER

Davila

Apr 12, 2022EXHIBITPETITIONER

Kochenderfer 2009

Apr 12, 2022EXHIBITPETITIONER

Mead

Apr 12, 2022EXHIBITPETITIONER

Arnold Declaration

Apr 12, 2022EXHIBITPETITIONER