The detailed information for PTAB case with proceeding number IPR2022-00963 filed by Eyenovia, Inc. against Sydnexis, Inc. on May 3, 2022. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Case Details

Proceeding Number
IPR2022-00963
Filing Date
May 3, 2022
Petitioner
Eyenovia, Inc.
Respondent
Sydnexis, Inc.
Status
Institution Denied
Respondent Application Number
14726139
Respondent Tech Center
1600
Respondent Patent Number
9421199
Institution Decision Date
Nov 8, 2022
Termination Date
Nov 8, 2022

Proceeding Documents

The table below shows documents filed in the case, listing each document name, filing date, document type, and filing party. Tracking these filings indicates the activity of the parties involved in the case, and the types of documents filed can provide insights into the legal strategies being employed.


Document NameFiling DateCategoryFiling Party

Alert me when new update on this case

Petitioner's Request for Refund of Post-Institution Fees

Nov 22, 2022PAPERPETITIONER

Institution Decision

Nov 8, 2022PAPERBOARD

Patent Owner's Preliminary Response

Aug 11, 2022PAPERPATENT OWNER

EX2001 - US 9,421,199 File History

Aug 11, 2022EXHIBITPATENT OWNER

EX2002 - Lund et al

Aug 11, 2022EXHIBITPATENT OWNER

EX2003 - US 9,770,447 File History

Aug 11, 2022EXHIBITPATENT OWNER

EX2005 - US 10,251,875 File History

Aug 11, 2022EXHIBITPATENT OWNER

EX2006 - IPR2022-00384 EX1002 - Byrn Declaration

Aug 11, 2022EXHIBITPATENT OWNER

Patent Owner's Mandatory Notices

May 17, 2022PAPERPATENT OWNER

Patent Owner's Power of Attorney

May 17, 2022PAPERPATENT OWNER

Notice: Notice filing date accorded

May 11, 2022PAPERBOARD

Petition for Inter Partes Review of U.S. Patent No. 9,421,199

May 3, 2022PAPERPETITIONER

Petitioner's Power of Attorney

May 3, 2022PAPERPETITIONER

U.S. Patent No. 9,421,199 to Ostrow et al.

May 3, 2022EXHIBITPETITIONER

Declaration of Dr. Stephen Byrn, Ph. D.

May 3, 2022EXHIBITPETITIONER

Chia et al.

May 3, 2022EXHIBITPETITIONER

Albert A. Kondritzer & Peter Zvirblis, Stability of Atropine in Aqueous Solution, J. AM. PHARM. ASS���N 46(9):531���535 (1957)

May 3, 2022EXHIBITPETITIONER

John D. Mullins & Gerald Hecht, Pharmaceutical Necessities and Ophthalmic Preparations, in REMINGTON: THE SCIENCE AND PRACTICE OF PHARMACY, VOLUME II 1380���1416, 1563���1576 (Alfonso R. Gennaro ed., 19th ed. 1995)

May 3, 2022EXHIBITPETITIONER

Siegel et al., Stability of Procaine in Deuterium Oxide, J. PHARM. SCIS. 53(8):978���979 (1964)

May 3, 2022EXHIBITPETITIONER

McBrien et al., Point-Counterpoint. How does atropine exert its anti-myopia effects?, OPHTHALMIC & PHYSIOL OPT. 33:373���378 (2013)

May 3, 2022EXHIBITPETITIONER

Chua et al., Atropine for the Treatment of Childhood Myopia, OPHTHALMOLOGY 113(12):2285���2291 (2006)

May 3, 2022EXHIBITPETITIONER

Shih et al., An intervention trial on efficacy of atropine and multi-focal glasses in controlling myopic progression, ACTA OPHTHALMOLOGICA SCANDINAVICA 79:233���236 (2001)

May 3, 2022EXHIBITPETITIONER

U.S. Patent Publication No. 2007/0254914 to Wu et al.

May 3, 2022EXHIBITPETITIONER

Lee et al., Prevention of Myopia Progression with 0.05% Atropine Solution, J OCUL PHARMACOL THER. 22(1):41���46 (2006)

May 3, 2022EXHIBITPETITIONER

Fang et al., Prevention of Myopia Onset with 0.025% Atropine in Premyopic Children, J OCUL PHARMACOL THER. 26(4):341���345 (2010)

May 3, 2022EXHIBITPETITIONER

Shih et al., Effects of Different Concentrations of Atropine on Controlling Myopia in Myopic Children, J OCUL PHARMACOL THER. 15(1):85���90 (1999)

May 3, 2022EXHIBITPETITIONER

Wu et al., The Long-Term Results of Using Low-Concentration Atropine Eye Drops for Controlling Myopia Progression in Schoolchildren, J OCUL PHARMACOL THER. 27(5):461���466 (2011)

May 3, 2022EXHIBITPETITIONER

Chia et al., Atropine for the Treatment of Childhood Myopia: Changes after Stopping Atropine 0.01%, 0.1% and 0.5%, AM. J. OPHTHALMOLOGY 157(2):451���457.e1 (2014)

May 3, 2022EXHIBITPETITIONER

International Publication No. WO 2012/161655 to Donald Tan and Wei Han Chua

May 3, 2022EXHIBITPETITIONER

Zvirblis et al., The Kinetics of the Hydrolysis of Atropine, J. AM. PHARM. ASS���N 45(7): 450���454 (1956)

May 3, 2022EXHIBITPETITIONER

Schier et al., Preparing for Chemical Terrorism: Stability of Injectable Atropine Sulfate, ACAD. EMERG. MED. 11(4):329���334 (2004)

May 3, 2022EXHIBITPETITIONER

Kushner et al., Pharmacological uses and perspectives of heavy water and deuterated compounds, CAN. J. PHYSIOL. PHARMACOL. 77:79���88 (1999) - Part 1

May 3, 2022EXHIBITPETITIONER

Kushner et al., Pharmacological uses and perspectives of heavy water and deuterated compounds, CAN. J. PHYSIOL. PHARMACOL. 77:79���88 (1999) - Part 2

May 3, 2022EXHIBITPETITIONER

Blake et al., Studies with Deuterated Drugs, J. PHARM. SCIS. 64(3):367���391 (1975)

May 3, 2022EXHIBITPETITIONER

Thomas G. Gant, Using Deuterium in Drug Discovery: Leaving the Label in the Drug, J. MED. CHEM. 57(9):3595���3611 (2014)

May 3, 2022EXHIBITPETITIONER

Allan B. Foster, Deuterium Isotope Effects in the Metabolism of Drugs and Xenobiotics: Implications for Drug Design, ADVANCES IN DRUG RESEARCH 14:1���40 (1985)

May 3, 2022EXHIBITPETITIONER

Katherine B. J. Schowen, Solvent Hydrogen Isotope Effects, TRANSITION STATES OF BIOCHEM. PROCESSES 225���283 (Richard D. Gandour & Richard L. Schowen eds., 1978)

May 3, 2022EXHIBITPETITIONER

Paul K. Glasoe & F. A. Long, Use Of Glass Electrodes To Measure Acidities In Deuterium Oxide, J. PHYS. CHEM. 64(1):188���190 (1960)

May 3, 2022EXHIBITPETITIONER

Sen et al., Role of heavy water in biological sciences with an emphasis on thermostabilization of vaccines, EXPERT REV. VACCINES 8(11): 1587���1602 (2009) - Part 1

May 3, 2022EXHIBITPETITIONER

Sen et al., Role of heavy water in biological sciences with an emphasis on thermostabilization of vaccines, EXPERT REV. VACCINES 8(11): 1587���1602 (2009) - Part 2

May 3, 2022EXHIBITPETITIONER

Sen et al., Role of heavy water in biological sciences with an emphasis on thermostabilization of vaccines, EXPERT REV. VACCINES 8(11): 1587���1602 (2009) - Part 3

May 3, 2022EXHIBITPETITIONER

Sen et al., Role of heavy water in biological sciences with an emphasis on thermostabilization of vaccines, EXPERT REV. VACCINES 8(11): 1587���1602 (2009) - Part 4

May 3, 2022EXHIBITPETITIONER

U.S. Patent Publication No. 2011/0076331 to Bayerl

May 3, 2022EXHIBITPETITIONER

Kho Kiat Nee, The Use Of Deuterium Oxide To Stabilize Pharmaceuticals Against Chemical Degradation, Slide Serve - Theophilus Stavros (2014)

May 3, 2022EXHIBITPETITIONER

Peter Krumbiegel, Large deuterium isotope effects and their use: a historical review, ISOTOPES IN ENVTL. & HEALTH STUDIES 47(1):1���17 (2011)

May 3, 2022EXHIBITPETITIONER

Amanda Yarnell, Heavy-Hydrogen Drugs Turn Heads, Again, CHEMICAL & ENG���G NEWS 87(25):36���39 (2009)

May 3, 2022EXHIBITPETITIONER

Graham S. Timmins, Deuterated drugs; where are we now?, EXPERT OPIN. THER. PAT. 24(10):1067���1075 (2014)

May 3, 2022EXHIBITPETITIONER

Anschel et al., Parenteral Formulation VI: Hydrolytic Degradation of Esters in Parenteral Solutions, BULLETIN OF THE PARENTERAL DRUG ASS���N 26(6):271���289 (1972)

May 3, 2022EXHIBITPETITIONER

Filed Application of U.S. Patent No. 9,421,199, May 29, 2015

May 3, 2022EXHIBITPETITIONER

U.S. Patent No. 9,421,199, Non-Final Rejection, March 7, 2016

May 3, 2022EXHIBITPETITIONER

U.S. Patent No. 5,716,952 to WoldeMussie et al.

May 3, 2022EXHIBITPETITIONER

U.S. Patent Publication No. 2012/0015035 to Wildsoet et al.

May 3, 2022EXHIBITPETITIONER

U.S. Patent Publication No. 2012/0203161 to Herekar

May 3, 2022EXHIBITPETITIONER

U.S. Patent No. 9,421,199, Response to Non-Final Rejection, April 5, 2016

May 3, 2022EXHIBITPETITIONER

U.S. Patent No. 9,421,199, Interview Summary, April 13, 2016

May 3, 2022EXHIBITPETITIONER

U.S. Patent No. 9,421,199, Notice of Allowance, June 13, 2016

May 3, 2022EXHIBITPETITIONER

U.S. Patent No. 9,770,447, Advisory Action, April 13, 2017

May 3, 2022EXHIBITPETITIONER

Provisional Patent Application No. 60/016,502

May 3, 2022EXHIBITPETITIONER

Provisional Patent Application No. 62/096,433

May 3, 2022EXHIBITPETITIONER

Certified English Translation of CN 101049287A to Wu Peichang et al.

May 3, 2022EXHIBITPETITIONER

Chowhan et al., Ophthalmic Preparations, in REMINGTON: THE SCIENCE AND PRACTICE OF PHARMACY 907929 (22nd ed. 2013)

May 3, 2022EXHIBITPETITIONER

Lallemand et al., Successfully Improving Ocular Drug Delivery Using the Cationic Nanoemulsion, Novasorb, J. DRUG DELIVERY 2012:1���16 (2012)

May 3, 2022EXHIBITPETITIONER

Rajpal et al., Bromfenac ophthalmic solution for the treatment of postoperative ocular pain and inflammation: safety, efficacy, and patient adherence, PATIENT PREFER ADHERENCE 8:925���31 (2014)

May 3, 2022EXHIBITPETITIONER

Kirchhoff et al., Analysis of atropine, its degradation products and related substances of natural origin by means of reversed-phase high-performance liquid chromatography, J. CHROMATOGRAPHY A 1046:115���120 (2004)

May 3, 2022EXHIBITPETITIONER

Garcia-Valldecabres et al., pH Stability of ophthalmic solutions, OPTOMETRY 75(3):161���168 (2004)

May 3, 2022EXHIBITPETITIONER

PB Patel et al., Ophthalmic Drug Delivery System: Challenges and Approaches, SYSTEMATIC REVIEWS IN PHARMACY 1(2):113���120 (2010)

May 3, 2022EXHIBITPETITIONER

European Patent Publication No. 0332826 to Zev Tashma

May 3, 2022EXHIBITPETITIONER

PHYSIOCHEMICAL PRINCIPLES OF PHARMACY 56���92 (4th ed. 2006)

May 3, 2022EXHIBITPETITIONER

Stephen S. Minor & Richard L. Schowen, One-Proton Solvation Bridge in Intramolecular Carboxylate Catalysis of Ester Hydrolysis, J. AM. CHEM. SOC. 95(7):2279���2281 (1973)

May 3, 2022EXHIBITPETITIONER

DRUG REPOSITIONING BRINING NEW LIFE TO SHELVED ASSETS AND EXISTING DRUGS 53���64, 291���343 (Michael J. Barratt & Donald E. Frail eds., 2012)

May 3, 2022EXHIBITPETITIONER

Cath O���Driscoll, Heavyweight drugs, CHEM. & INDUS. 24���26 (2009)

May 3, 2022EXHIBITPETITIONER

UK Patent Application GB 2293100 to Ian George Stephen Furminger & Philip James Sizer

May 3, 2022EXHIBITPETITIONER

U.S. Patent No. 7,691,099 to Berry

May 3, 2022EXHIBITPETITIONER

U.S. Patent Publication No. 2012/0135084 to Bayerl

May 3, 2022EXHIBITPETITIONER

June G. Winter and J. M. W. Scott, Studies in Solvolysis. Part IV. Substituent and Solvent Isotope Effects in the Solvolysis of a Series of Benzyl Trifluroacetates, CAN. J. CHEM. 50:1886���90 (1972)

May 3, 2022EXHIBITPETITIONER

William P. Jencks & Joan Carriuolo, General Base Catalysis of Ester Hydrolysis, J. AM. CHEM. SOC. 83(7):1743���50 (1961)

May 3, 2022EXHIBITPETITIONER

Bender et al., Deuterium Oxide Solvent Isotope Effects in the Nucleophilic Reactions of Phenyl Esters, J. AM. CHEM. SOC. 84(4):595���599 (1962)

May 3, 2022EXHIBITPETITIONER

June G. Winter & J. M. W. Scott, Studies in solvolysis. Part I. The neutral hydrolysis of some alkyl trifluoroacetates in water and deuterium oxide, CANADIAN J. CHEM. 46:2887���2894 (1968)

May 3, 2022EXHIBITPETITIONER

Bradley A. Hanson et al., A Mechanistic and Kinetic Study of the E-Ring Hydrolysis and Lactonization of a Novel Phosphoryloxymethyl Prodrug of Camptothecin, PHARM. RESEARCH 20(7):1031���1038 (2003)

May 3, 2022EXHIBITPETITIONER

English Translation of Jinshen Li, Preparation and Quality Control of 0.04% Atropine Sulfate Eye Drops, CHINA PHARMACY 17(2):111���113 (2006)

May 3, 2022EXHIBITPETITIONER

Atropine Sulfate Ophthalmic Solution, Highlights of Prescribing Information, Revised July 2014

May 3, 2022EXHIBITPETITIONER

Certified English Translation of Yuanda Wen, Preparation and Clinical Curative Effects of 0.05% Atropine Sulfate Eye Drops, CHINA PHARMACIST 11(2):194���196 (2008)

May 3, 2022EXHIBITPETITIONER

Ronald F. Donnelly & C��line Corman, Physical Compatibility and Chemical Stability of a Concentrated Solution of Atropine Sulfate (2 mg/mL) for Use as an Antidote in Nerve Agent Casualties, INT���L J. PHARM. COMPOUNDING 12(6):550���552 (2008)

May 3, 2022EXHIBITPETITIONER

M. R. W. Brown & D. A. Norton, The Preservation of Ophthalmic Preparations, J. SOC. COSMETIC CHEMISTS 16:369���393 (1965)

May 3, 2022EXHIBITPETITIONER

A. J. Kresge, Solvent Isotope Effect in H2O-D2O Mixtures, PURE APPL. CHEM. 8(3-4):243���258 (1964)

May 3, 2022EXHIBITPETITIONER

Driver et al., The Stability of Atropine Sulfate Solutions Stored in Plastic Syringes in the Operating Room, ANESTH. ANALG. 89:1056���1058 (1999)

May 3, 2022EXHIBITPETITIONER

Food Drug Administration Center for Drugs Evaluation Research GUIDANCE FOR INDUSTRY: DRUG STABILITY GUIDELINES (DECEMBER 9, 2008)

May 3, 2022EXHIBITPETITIONER

DICTIONARY OF CHEMISTRY (2nd ed. 2003)

May 3, 2022EXHIBITPETITIONER

Sodium phosphate monobasic Safety Data Sheet, Version 1.1, G-BIOSCIS. (Jan. 9, 2012)

May 3, 2022EXHIBITPETITIONER

Sodium Phosphate Dibasic, Anhydrous Material Safety Data Sheet, SCHOLAR CHEM. (Jan. 23, 2009)

May 3, 2022EXHIBITPETITIONER

Pfannkoch, The Preparation of Buffers and Other Solutions: A Chemist���s Perspective, MOLECULAR BIOLOGY PROBLEM SOLVER: A LABORATORY GUIDE Ch. 3:31���47 (Alan S. Gerstein ed., 2001)

May 3, 2022EXHIBITPETITIONER

HANDBOOK OF PHARMACEUTICAL EXCIPIENTS 5���7, 193���196, 281���284, 351���352, 741���742, 984���989 (Raymond C. Rowe et al. eds., 7th ed. 2012) - Part 1

May 3, 2022EXHIBITPETITIONER

HANDBOOK OF PHARMACEUTICAL EXCIPIENTS 5���7, 193���196, 281���284, 351���352, 741���742, 984���989 (Raymond C. Rowe et al. eds., 7th ed. 2012) - Part 2

May 3, 2022EXHIBITPETITIONER

International Patent Publication No. WO 2013/167865 to Purandare

May 3, 2022EXHIBITPETITIONER

U.S. Patent Publication No. 2008/0300316 to Gant et al.

May 3, 2022EXHIBITPETITIONER

Waterman et al., Hydrolysis in Pharmaceutical Formulations, PHARM. DEV. & TECH. 7(2):113���146 (2002)

May 3, 2022EXHIBITPETITIONER

Lin et al., Formulation and stability of an extemporaneous 0.02% chlorhexidine digluconate ophthalmic solution, J. FORMOSAN MED. ASS���N 114:1162���1169 (2015)

May 3, 2022EXHIBITPETITIONER

Susina et al., Effect of Deuterium Oxide on Local Anesthetic Activity of Procaine, J. PHARM. SCIS. 51(12):1166���1169 (1962)

May 3, 2022EXHIBITPETITIONER

Dimitrios Stefanidis & William P. Jencks, General Base Catalysis of Ester Hydrolysis, J. AM. CHEM. SOC. 115:6045���6050 (1993)

May 3, 2022EXHIBITPETITIONER

Berton et al., Stability of Ophthalmic Atropine Solutions for Child Myopia Control, PHARMACEUTICS 12(8):781 (2020)

May 3, 2022EXHIBITPETITIONER

John D. Mullins & Gerald Hecht, Tonicity, Osmoticity, Osmolality and Osmolarity and Stability of Pharmaceutical Products, in REMINGTON: THE SCIENCE AND PRACTICE OF PHARMACY, VOLUME I 613���627, 639���647 (Alfonso R. Gennaro ed., 19th ed. 1995)

May 3, 2022EXHIBITPETITIONER

Atropine Sulfate Ophthalmic Solution, Highlights of Prescribing Information, Revised July 2014, Wayback Machine and Affidavit

May 3, 2022EXHIBITPETITIONER

Badar�� et al., Retinal Biocompatibility of Brilliant Blue G with Deuterated Water for Chromovitrectomy, J. OPHTHALMIC & VISION RESEARCH 9(2):204���209 (2014)

May 3, 2022EXHIBITPETITIONER

International Publication No. WO 94/21298 to Karl Simpson & Radu Crainic

May 3, 2022EXHIBITPETITIONER

U.S. Application No. 16/805,612, Information Disclosure Statement, March 2, 2020

May 3, 2022EXHIBITPETITIONER