BTC Corporation vs TG Biotech Co., Ltd.

Determining No Challenged Claims Unpatentable 35 U.S.C. § 318(a) Granting Patent Owner’s Motion to Strike 37 C.F.R. 42.64

Other: Hearing transcript

Petitioners' Notice of Submission of Demonstrative Exhibits for Oral Hearing.pdf

Patent Owner's Notice of Submission of Demonstrative Exhibits for Oral Hearing

LEAP Practitioner Request and Verification Form (Petitioner)

LEAP Practitioner Request and Verification Form (Patent Owner)

Order: ORDER Conduct of Proceeding 37 C.F.R. § 42.70

Order: Setting Oral Argument 37 C.F.R. sec. 42.70

Exhibit 3004

Patent Owner's Motion to Strike

Patent Owner's Request for Oral Argument

Granting Patent Owner’s Motion for Pro Hac Vice Admission of Joo Mee Kim 37 C.F.R. § 42.10

Patent Owner's Sur-Reply

Exhibit 2017

Patent Owner's Exhibit List

Exhibit 3003

Patent Owner's Notice of Remote Deposition of Neal Davies

EXPUNGED

PETITIONERS’ EXHIBIT LIST

Updated Mandatory Notices of Patent Owner

Patent Owner's Objections to Evidence Pursuant to 37 C.F.R. Section 42.64

Patent Owner's Motion for Admission Pro Hac Vice of Joo Mee Kim

Patent Owner's Exhibit List

Declaration of Joo Mee Kim In Support of Motion for Pro Hac Vice Admission

PETITIONER’S REPLY BRIEF

Second Declaration of Neal Davies, Ph.D.

Transcript of April 14, 2023 Deposition of Dr. Valentina Naumovski

Teng et al., “High-performance liquid chromatographic analysis of mometasone furoate and its degradation products Application to in vitro degradation studies,” Journal of Pharmaceutical and Biomedical Analysis, 26 (2001)

Power of Attorney for Petitioner

UPDATED MANDATORY NOTICES OF PETITIONERS

PETITIONERS’ NOTICE OF REMOTE DEPOSITION OF DR. NAUMOVSKI

Part 1 - Higher resolution data from Excel spreadsheet utilized in Exhibit 1013

Part 2 - Higher resolution data from Excel spreadsheet utilized in Exhibit 1013

Neal Davies Deposition Transcript

Seung-Su Lee Deposition Transcript

Meyer (2019)

Damulin B Standard CymitQuimica

Damulin B Standard Biopurify Phytochemicals

Evidentiary Declaration of Valentina Naumovski, Ph.D.

Stokvis 6.1 (2004)

George (1965)

Damulin B Certificate of Analysis

Expert Declaration of Valentina Naumovski, Ph.D.

Patent Owner's Response

Patent Owner's Exhibit List

Higher resolution data for Exhibit 1013 from Excel spreadsheet

Higher resolution data for Exhibit 1016 from Excel spreadsheet

Power of Attorney for Petitioner

UPDATED MANDATORY NOTICES OF PETITIONERS

Exhibit 3002

Patent Owner's Notice of Remote Deposition of Seung-Su Lee

Patent Owner's Notice of Remote Deposition of Neal Davies

Notice of Stipulation to Extend Due Date 1 and a Portion of Due Dates 2 and 3

Patent Owner's Notice of Submission of December 21, 2022 Conference Call Transcript

Patent Owner's Exhibit List

Exhibit 2004

Exhibit 3001

Updated Mandatory Notices of Patent Owner

EXPUNGED

Korean Pub. No. 10-2007-0109282 to Baek et al.

Declaration of translation of Exhibit 1027

Korean Pub. No. 10-2006-0063041 to Kang et al.

Declaration of translation of Exhibit 1029

Jang et al., "Hypoglycemic and Hypolipidemic Effects of Crude Saponin Fractions from Panax ginseng and Gynostemma pentaphyllum," Journal of Pharmaceutical Sciences (Yakhak Hoeji), 45:5 (2001), 545-556 [Original]

Declaration of translation of Exhibit 1031

Patent Owner's Objections to Evidence Pursuant to 37 C.F.R. Section 42.64

Order: Panel Change Order

Institution Decision: Grant

Order: Scheduling Order

Patent Owner Preliminary Response

Liu, F., Ren, D., Guo, D. A., Pan, Y., Zhang, H., & Hu, P. (2008).

Plunkett, G. M., Soltis, D. E., & Soltis, P. S. (1996)

Ji, David, Roman, M., Zhou, J., & Hildreth, J. (2007)

Mandatory Notices of Patent Owner

Patent Owner's Power of Attorney

Notice: NOTICE OF FILING DATE ACCORDED TO PETITION AND TIME FOR FILING PATENT OWNER PRELIMINARY RESPONSE

U.S. Patent No. 8,357,786

File History of ���786 patent

Declaration of Neal Davies, Ph.D.

Curriculum Vitae of Neal Davies, Ph.D.

U.S. Patent No. 5,776,460 to Kim et al.

PCT Publication No. WO 2008/140178

Razmovski-Naumovski et al., "Chemistry and pharmacology of Gynostemma pentaphyllum," Phytochemistry Reviews 4: (2005) 197-219

Translation of Korean Pub. No. 10-2007-0109282 to Baek et al.

Certification of translation for Exhibit 1008

Translation of Korean Pub. No. 10-2006-0063041 to Kang et al.

Certification of translation for Exhibit 1010

Wu et al., "Determination by UPLC-MS of four dammarane-type saponins from heat-processed Gynostemma pentaphyllum," Bioscience, Biotechnology, and Biochemistry, 78:2 (2014) 311-316

Experimental Report: Analytical Determination of Gypenoside L, Gypenoside LI, Ginsenoside Rg3, Damulin A and Damulin B contents in Extracts of Gynostemma pentaphyllum leaves

Declaration of Seung-Su Lee, Ph.D in support of Ex. 1013

Curriculum Vitae of Seung-Su Lee, Ph.D.

Experimental Report: Analytical determination of Damulin A contents in extract of Gynostemma pentaphyllum leaves of U.S. Pub. 2006/0246263

Declaration of Seung-Su Lee, Ph.D in support of Ex. 1016

Jang et al., "Hypoglycemic and Hypolipidemic Effects of Crude Saponin Fractions from Panax ginseng and Gynostemma pentaphyllum," Journal of Pharmaceutical Sciences (Yakhak Hoeji), 45:5 (2001), 545-556

Kim W.Y. et al., "Steaming of ginseng at high temperature enhances biological activity, " J. Nat. Prod. 63: (2000), 1702���1704

U.S. Publication No. 2006/0246163 to Huh et al.

Wang et al., Carbohydrate Polymers 68 (2007) 54-58

Razmovski-Naumovski et al., ���Gynostemma pentaphyllum cultivation in Sydney, Australia and its comparison with products from China,��� J. Applied Horticulture, 7(2) (July-December 2005), 99-104

Megalli et al., ���Phytopreventative antihyperlipidemic effects of gynostemma pentaphyllum in rats,��� J. Pharm Pharm Sci. 8: (2005), 507-515

Megalli et al., ���Anti-Hyperlipidemic and Hypoglycemic Effects of Gynostemma pentaphyllum in the Zucker Rat,��� Journal of Pharmacy and Pharmaceutical Sciences, 9(2): (2006), 282-296

Kao, T.H. et al., ���Determination of flavonoids and saponins in Gynostemma pentaphyllum (Thunb.) Makino by liquid chromatography���mass spectrometry,��� Analytica chimica acta 626 (2008), 200���211

Certification of translation for Exhibit 1018

Power of Attorney for Petitioner BTC Corporation

PETITION FOR INTER PARTES REVIEW OF U.S. PATENT NO. 8,357,786 UNDER 37 C.F.R. �� 42