EXPUNGED | Aug 17, 2023 | PAPER | BOARD |
Termination Decision: TERMINATION Due to Settlement After Institution of Trial 35 U.S.C. § 317, 37 C.F.R. § 42.74 | Aug 17, 2023 | PAPER | BOARD |
Joint Motion To Terminate Proceedings | Aug 15, 2023 | PAPER | PETITIONER |
Joint Request To Treat Settlement Agreement As Business Confidential Information And To Keep Separate | Aug 15, 2023 | PAPER | PETITIONER |
Confidential Settlement Agreement Filed Under Seal | Aug 15, 2023 | EXHIBIT | PETITIONER |
Exhibit 3003 | Jul 28, 2023 | EXHIBIT | BOARD |
Petitioner's Supplemental Brief on Collateral Estoppel | Jul 26, 2023 | PAPER | PETITIONER |
ORDER Setting Oral Argument | Jul 20, 2023 | PAPER | BOARD |
Exhibit 3002 | Jul 17, 2023 | EXHIBIT | BOARD |
Petitioner's Request for Oral Argument | Jul 6, 2023 | PAPER | PETITIONER |
Patent Owner's Surreply | Jun 22, 2023 | PAPER | PATENT OWNER |
Bausch Reply to Patent Owner Response | May 11, 2023 | PAPER | PETITIONER |
133 Patent Application Data Sheet | May 11, 2023 | EXHIBIT | PETITIONER |
Pending 955 Application Data Sheet | May 11, 2023 | EXHIBIT | PETITIONER |
Pending 825 Application Data Sheet | May 11, 2023 | EXHIBIT | PETITIONER |
133 Patent Filing Receipt | May 11, 2023 | EXHIBIT | PETITIONER |
Pending 955 Filing Receipt | May 11, 2023 | EXHIBIT | PETITIONER |
Pending 825 Filing Receipt | May 11, 2023 | EXHIBIT | PETITIONER |
384 Patent | May 11, 2023 | EXHIBIT | PETITIONER |
Deposition Transcript of Dr. C. Kathleen Dorey, October 4, 2022 | May 11, 2023 | EXHIBIT | PETITIONER |
Deposition Transcript of Dr. C. Kathleen Dorey, April 18, 2023 | May 11, 2023 | EXHIBIT | PETITIONER |
Dorey Exhibit 1 from Cross-Examination of Dr. C. Kathleen Dorey, April 18, 2023 | May 11, 2023 | EXHIBIT | PETITIONER |
Dorey Exhibit 2 from Cross-Examination of Dr. C. Kathleen Dorey, April 18, 2023 | May 11, 2023 | EXHIBIT | PETITIONER |
ORDER Granting Patent Owner’s Motion for Admission Pro Hac Vice of Paul J. Tahan 37 C.F.R. § 42.10 | Apr 17, 2023 | PAPER | BOARD |
From: Simon, Anthony G. To: Trials Cc: [email protected]; [email protected]; Chou, Monica; [email protected]; IPTeam Subject: RE: IPR2022-01029 Date: Friday, April 14, 2023 4:30:36 PM | Apr 17, 2023 | EXHIBIT | BOARD |
Order Granting Petitioner's Motion for Admission Pro Hac Vice of Steven C. Kline and Monica Chou | Apr 12, 2023 | PAPER | BOARD |
Bausch's Notice of Deposition of Dr. Gierhart | Apr 10, 2023 | PAPER | PETITIONER |
PHV Motion | Apr 5, 2023 | PAPER | PATENT OWNER |
Declaration of Paul J. Tahan in Support of Motion for Admission Pro Hac Vice | Apr 5, 2023 | EXHIBIT | PATENT OWNER |
Patent Owner's Updated Exhibit List | Apr 5, 2023 | PAPER | PATENT OWNER |
PHV Motion for S. Kline | Apr 4, 2023 | PAPER | PETITIONER |
Declaration of S Kline | Apr 4, 2023 | EXHIBIT | PETITIONER |
PHV Motion for M Chou | Apr 4, 2023 | PAPER | PETITIONER |
Declaration of M Chou | Apr 4, 2023 | EXHIBIT | PETITIONER |
Petitioner's Updated Mandatory Notice | Apr 4, 2023 | PAPER | PETITIONER |
Petitioner's Updated Exhibit List | Apr 4, 2023 | PAPER | PETITIONER |
Bausch's Notice of Deposition of Dr. Dorey | Apr 4, 2023 | PAPER | PETITIONER |
Joint Notice of Stipulation to Change Due Dates | Apr 4, 2023 | PAPER | PETITIONER |
PATENT OWNER’S RESPONSE TO PETITION PURSUANT TO 37 C.F.R. § 42 | Feb 9, 2023 | PAPER | PATENT OWNER |
Declaration of Dr. C. Kathleen Dorey, Ph. D. | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Effect of Zeaxanthin and Antioxidant Supplementation on Vascular Endothelial Growth Factor (VEGF) Expression in Apolipoprotein-E Deficient Mice, Fernández-Robredo et al | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Declaration of Dr. Dennis Gierhart | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Deposition of Dennis Gierhart, Ph.D., dated October 18, 2022, from Case No. IPR2022-00089 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds (2000) Vitamin E In Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. National Academies Press (US); Washington DC | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Office of Dietary Supplements, Vitamin E. Fact sheet for health professionals, National Institutes of Health, https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/, March 26, 2021,Accessed 1/22/2023 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Jiang Q, Christen S, Shigenaga MK, Ames BN (2001) gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 74, 714-722 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Di Mambro VM, Azzolini AE, Valim YM, Fonseca MJ (2003) Comparison of antioxidant activities of tocopherols alone and in pharmaceutical formulations. Int J Pharm 262, 93-99 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Forman HJ, Zhang H (2021) Targeting oxidative stress in disease: promise and limitations of antioxidant therapy. Nat Rev Drug Discov 20, 689-709 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Sharifi-Rad M, Anil Kumar NV, Zucca P, Varoni EM, Dini L, Panzarini E, Rajkovic J, et al. (2020) Lifestyle, oxidative stress, and antioxidants: Back and forth in the pathophysiology of chronic diseases Front Physiol 11, 694 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Crabtree DV, Adler AJ, Snodderly DM (1996) Radial distribution of tocopherols in rhesus monkey retina and retinal pigment epithelium-choroid. Invest Ophthalmol Vis Sci 37, 61-76 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Yeum KJ, Taylor A, Tang G, Russell RM (1995) Measurement of carotenoids, retinoids, and tocopherols in human lenses. Invest Ophthalmol Vis Sci 36, 2756-2761 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Bieri JG, Evarts RP (1974) Gamma tocopherol: metabolism, biological activity and significance in human vitamin E nutrition. Am J Clin Nutr 27, 980-986 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Giovannucci E (2000) Gamma-tocopherol: a new player in prostate cancer prevention? J Natl Cancer Inst 92, 1966-1967 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Helzlsouer KJ, Huang HY, Alberg AJ, Hoffman S, Burke A, Norkus EP, Morris JS, Comstock GW (2000) Association between alpha-tocopherol, gamma-tocopherol, selenium, and subsequent prostate cancer. J Natl Cancer Inst 92, 2018-2023 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Age-Related Eye Disease Study Research G (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9. Arch Ophthalmol 119, 1439-1452 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Rozanowska M, Edge R, Land EJ, Navaratnam S, Sarna T, Truscott TG (2019) Scavenging of retinoid cation radicals by urate, Trolox, and alpha-, beta-, gamma-, and delta-tocopherols. Int J Mol Sci 20 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Thomson LR, Toyoda Y, Delori FC, Garnett KM, Wong ZY, Nichols CR, Cheng KM, Craft NE, Dorey CK (2002) Long term dietary supplementation with zeaxanthin reduces photoreceptor death in light-damaged Japanese quail. Exp Eye Res 75, 529-542 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Thomson LR, Toyoda Y, Delori FC, Garnett KM, Wong ZY, Nichols CR, Cheng KM, Craft NE, Dorey CK (2002) Long term dietary supplementation with zeaxanthin reduces photoreceptor death in light-damaged Japanese quail. Exp Eye Res 75, 529-542 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Trevithick-Sutton CC, Foote CS, Collins M, Trevithick JR (2006) The retinal carotenoids zeaxanthin and lutein scavenge superoxide and hydroxyl radicals: a chemiluminescence and ESR study. Mol Vis 12, 1127-1135 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Aonuma H, Koide K, Masuda K, Watanabe I (1997) Retinal light damage: protective effect of alpha-tocopherol. Jpn J Ophthalmol 41, 160-167 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Christen S, Woodall AA, Shigenaga MK, Southwell-Keely PT, Duncan MW, Ames BN (1997) gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications. Proc Natl Acad Sci U S A 94, 3217-3222 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Liu M, Wallin R, Wallmon A, Saldeen T (2002) Mixed tocopherols have a stronger inhibitory effect on lipid peroxidation than alpha-tocopherol alone. J Cardiovasc Pharmacol 39, 714-721 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Huang HY, Appel LJ (2003) Supplementation of diets with alpha-tocopherol reduces serum concentrations of gamma- and delta-tocopherol in humans. J Nutr 133, 3137-3140 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Handelman GJ, Machlin LJ, Fitch K, Weiter JJ, Dratz EA (1985) Oral alpha-tocopherol supplements decrease plasma gamma-tocopherol levels in humans. J Nutr 115, 807-813 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Morton LW, Ward NC, Croft KD, Puddey IB (2002) Evidence for the nitration of gamma-tocopherol in vivo: 5-nitro-gamma-tocopherol is elevated in the plasma of subjects with coronary heart disease. Biochem J 364, 625-628 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Bone RA, Landrum JT, Friedes LM, Gomez CM, Kilburn MD, Menendez E, Vidal I, Wang W (1997) Distribution of lutein and zeaxanthin stereoisomers in the human retina. Exp Eye Res 64, 211-218 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Shyam R, Gorusupudi A, Nelson K, Horvath MP, Bernstein PS (2017) RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye. Proc Natl Acad Sci U S A 114, 10882-10887 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Arunkumar R, Gorusupudi A, Bernstein PS (2020) The macular carotenoids: A biochemical overview. Biochim Biophys Acta Mol Cell Biol Lipids 1865, 158617 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Bone RA, Landrum JT, Hime GW, Cains A, Zamor J (1993) Stereochemistry of the human macular carotenoids. Invest Ophthalmol Vis Sci 34, 2033-2040 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Mares J (2016) Lutein and Zeaxanthin Isomers in Eye Health and Disease. Annu Rev Nutr 36, 571-602 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Rasmussen HM, Muzhingi T, Eggert EMR, Johnson EJ (2012) Lutein, zeaxanthin, meso-zeaxanthin content in egg yolk and their absence in fish and seafood. J Food Composition Analysis 27, 139-144 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Nolan JM, Beatty S, Meagher KA, Howard AN, Kelly D, Thurnham DI (2014) Verification of Meso-Zeaxanthin in Fish. J Food Process Technol 5, 335 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Everts S (2013) Mirror molecules. Sci Am 308, 78-81 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Avetisov V, Goldanskii V (1996) Mirror symmetry breaking at the molecular level. Proc Natl Acad Sci U S A 93, 11435-11442 | Feb 9, 2023 | EXHIBIT | PATENT OWNER |
Institution Decision: DECISION Granting Institution of Inter Partes Review 35 U.S.C. § 314 | Nov 17, 2022 | PAPER | BOARD |
Order: SCHEDULING ORDER | Nov 17, 2022 | PAPER | BOARD |
Patent Owner's Mandatory Notice | Jun 3, 2022 | PAPER | PATENT OWNER |
Patent Owner's Power of Attorney | Jun 3, 2022 | PAPER | PATENT OWNER |
Notice: NOTICE OF FILING DATE ACCORDED TO PETITION AND TIME FOR FILING PATENT OWNER PRELIMINARY RESPONSE | May 24, 2022 | PAPER | BOARD |
Bausch's Power of Attorney | May 17, 2022 | PAPER | PETITIONER |
U.S. Patent No. 11,045,431 | May 17, 2022 | EXHIBIT | PETITIONER |
File History for U.S. Patent No. 11,045,431 | May 17, 2022 | EXHIBIT | PETITIONER |
File History for Provisional Application No. 60/435,522 | May 17, 2022 | EXHIBIT | PETITIONER |
Transaction History for Provisional Application No. 60/435,522 | May 17, 2022 | EXHIBIT | PETITIONER |
Status of Provisional Application No. 60/435,522 | May 17, 2022 | EXHIBIT | PETITIONER |
Excerpt of File History for U.S. Patent No. 9,192,586 | May 17, 2022 | EXHIBIT | PETITIONER |
FAO, Tocopherol Concentrate, Mixed, U.N. (1986) | May 17, 2022 | EXHIBIT | PETITIONER |
WO 2001/019383 (Lang) | May 17, 2022 | EXHIBIT | PETITIONER |
U.S. Patent No. 6,582,721 | May 17, 2022 | EXHIBIT | PETITIONER |
WO 2003/063848 (Barker) | May 17, 2022 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,747,544 (Garnett) | May 17, 2022 | EXHIBIT | PETITIONER |
WO 2002/047493 | May 17, 2022 | EXHIBIT | PETITIONER |
Nicholas A. Phelps Brown et al., Nutrition supplements and the eye, 12 EYE 127 (1998) (Brown) | May 17, 2022 | EXHIBIT | PETITIONER |
D. Max Snodderly, Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins, 62(suppl) AM. J. CLIN. NUTR. 1448S (1995) | May 17, 2022 | EXHIBIT | PETITIONER |
Takashi Maoka et al., The First Isolation of Enantiomeric and Meso-Zeaxanthin in Nature, 83B COMP. BIOCHEM. PHYSIOL. 121 (1986) | May 17, 2022 | EXHIBIT | PETITIONER |
Jeff C. Evans et al., Optimal Tocopherol Concentrations to Inhibit Soybean Oil Oxidation, 79 J. OF THE AM. OIL CHEMISTS��� SOC���Y 47 (2002) | May 17, 2022 | EXHIBIT | PETITIONER |
Michael McGuffin & Anthony L. Young, Premarket Notifications of New Dietary Ingredients���A Ten-Year Review, 59 FOOD & DRUG L.J. 229 (2004) | May 17, 2022 | EXHIBIT | PETITIONER |
Hall Affidavit, with Authenticated U.S. FDA 95S-0316 75-Day Premarket Notification for New Dietary Ingredient for Zeaxanthin (Report 96) and Web Access Links Attached | May 17, 2022 | EXHIBIT | PETITIONER |
Excerpt (Exh. B) of Exh. 1019 - Authenticated U.S. FDA 95S-0316 75-Day Premarket Notification for New Drug Ingredient for Zeaxanthin (Report 96) | May 17, 2022 | EXHIBIT | PETITIONER |
Joachim Paust, Technical Syntheses, in 2 CAROTENOIDS 259 (George Britton et al. eds., 1996) | May 17, 2022 | EXHIBIT | PETITIONER |
THE MERCK INDEX: AN ENCYCLOPEDIA OF CHEMICALS, DRUGS, AND BIOLOGICALS (Maryadele J. O'Neil et al. eds., 13th ed. 2001) (Excerpt) | May 17, 2022 | EXHIBIT | PETITIONER |
FAO, Zeaxanthin: Chemical and Technical Assessment (CTA), U.N. (2004) | May 17, 2022 | EXHIBIT | PETITIONER |
Declaration of Elizabeth J. Johnson, Ph.D. with CV | May 17, 2022 | EXHIBIT | PETITIONER |
Third Amended Complaint (D.I. 192), ZeaVision, LLC v. Roche Vitamins, Inc., C.A. No. 4:03-CV-00212-DJS (E.D. Mo. Mar. 23, 2004) | May 17, 2022 | EXHIBIT | PETITIONER |
Roche Vitamins launched Zeaxanthin as an ingredient to support eye health, NAT. PRODUCTS INSIDER, Aug. 20, 2001 | May 17, 2022 | EXHIBIT | PETITIONER |
Anita M. Van der Hagen, et al., Free Radicals and Antioxidant Supplementation: A Review of Their Roles in Age-Related Macular Degeneration, 64 J. AM. OPTOMETRIC ASS'N 871 (1993) | May 17, 2022 | EXHIBIT | PETITIONER |
Johanna M. Seddon, et al., Dietary Carotenoids, Vitamins A, C, and E, and Advanced Age-Related Macular Degeneration, 272 J. OF AM. MED. ASS'N 1413 (1994) | May 17, 2022 | EXHIBIT | PETITIONER |
Norman I. Krinsky, et al., Biologic Mechanisms of the Protective Role of Lutein and Zeaxanthin in the Eye, 23 ANN. REV. NUTR. 171 (2003) | May 17, 2022 | EXHIBIT | PETITIONER |
Thomas G. Guilliams, ed., Free Radicals, Antioxidants and Eye Diseases, 2 THE STANDARD (1999) | May 17, 2022 | EXHIBIT | PETITIONER |
WEBSTER'S NINTH NEW COLLEGIATE DICTIONARY (9th ed. 1991) (Excerpt) | May 17, 2022 | EXHIBIT | PETITIONER |
AREDS Report No. 8, 119 ARCH OPHTHALMOLOGY 1417 (2001) | May 17, 2022 | EXHIBIT | PETITIONER |
AREDS Report No. 9, 119 ARCH OPHTHALMOLOGY 1439 (2001) | May 17, 2022 | EXHIBIT | PETITIONER |
Elizabeth J. Johnson, et al., Nutritional Manipulation of Primate Retinas, III: Effects of Lutein or Zeaxanthin Supplementation on Adipose Tissue and Retina of Xanthophyll-Free Monkeys, 46 INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCI. 692 (2005) | May 17, 2022 | EXHIBIT | PETITIONER |
ZeaVision, LLC v. Bausch & Lomb Inc., No. 4:21-cv-00739 (E.D. Mo.), D.I. 7 (First Amended Complaint) | May 17, 2022 | EXHIBIT | PETITIONER |
Maggie B. Covington, Omega-3 Fatty Acids, 70 AMERICAN FAMILY PHYSICIAN 133 (2004) | May 17, 2022 | EXHIBIT | PETITIONER |
Hadi Moini, et al., Antioxidant and Prooxidant Activities of ��-Lipoic Acid and Dihydrolipoic Acid, 182 TOXICOLOGY AND APPLIED PHARMACOLOGY 84 (2002) | May 17, 2022 | EXHIBIT | PETITIONER |
Fish Oil Monograph, 5 ALTERNATIVE MED. REVIEW 576 (2000) | May 17, 2022 | EXHIBIT | PETITIONER |
REMINGTON���S PHARMACEUTICAL SCIENCES (Alfonso R. Gennaro ed., 18th ed.) (1990) (excerpt) | May 17, 2022 | EXHIBIT | PETITIONER |
Petition for Inter Partes Review of U.S. Patent No. 11,045,431 | May 17, 2022 | PAPER | PETITIONER |