SynAffix B.V. vs HANGZHOU DAC BIOTECH CO., LTD.

Other: Hearing transcript

EXPUNGED

Petitioner Demonstratives

Petitioner Updated Exhibit List

Patent Owner's Current Exhibit List

Patent Owner's Demonstratives

Notice: Petitioner's LEAP request GRANTED (Jolene S. Fernandes)

Patent Owner's Reply ISO Motion to Exclude

Petitioner's Opposition To Patent Owner's Motion To Exclude

Patent Owner's Motion to Exclude Evidence

Petitioner's Sur-Sur-Reply To Patent Owner's Sur-Reply

Petitioner's Updated Exhibit List

Ex. 1089 - Axup, Synthesis of site-specific antibody-drug

Ex. 1090 - WO 2019-191728

Ex. 1091 - Deposition Transcript of Lawrence Nathan Tumey

E-mail authorizing modification of due dates

Petitioner's Second Notice of Deposition of Lawrence Nathan Tumey, Ph.D.

Order: Setting Oral Argument

Sheila Baker PhD. 4-9-2025 Deposition Transcript

Petitioner Updated Exhibit List

EPO Boards of Appeal Final Decision re European Counterpart to 682 Patent

E-mail authorizing entry of EPO decision and deposition transcript

Deposition of Ravi Chari

Declaration of Dr. Lawrence Nathan Tumey in Support of Patent Owner’s Sur-Reply

Patent Owner’s Sur-Reply to Petition for Inter Partes Review of U.S. Patent No. 10,131,682

Patent Owner's Updated Mandatory Notices

Patent Owner's Power of Attorney

Petitioner And Patent Owner Joint Request for Oral Argument

Order: ORDER Conduct of the Proceeding Authorizing Filng of Additional Evidence and Briefing Declaration

Patent Owner's Notice of Deposition of Dr. Sheila Baker

Patent Owner's Second Notice of Deposition of Dr. Ravi Chari

Patent Owner’s Second Notice of Objections to Evidence

Decision Granting Rehearing in IPR2022-01531

Diagram of Chemical Structure

Diagram of Chemical Structure

Diagram of Chemical Structure

Lawrence Nathan Tumey, PhD. 2-25-2025 Deposition Transcript

Dondoni et al. A New Ligation Strategy for Peptide and Protein Glycosylation Photoinduced Thiol–Ene Coupling

Wang et al. Binding of Serum Albumin on Tumor Cells and Characterization of the Albumin Binding Protein

Nakamura et al. Water-soluble Taxol Conjugates with Dextran and Targets Tumor Cells by Folic Acid Immobilization

Lamarque et al. Copper catalyzed 1,3-dipolar cycloaddition reaction of azides with N-(2-trifluoroacetylaryl)propargylamines A mild entry to novel 1,4-disubstituted-[1,2,3]-triazole derivatives

Wang et al. Rapid Assembly of Matrix Metalloprotease Inhibitors Using Click Chemistry

Nairn et al., Development of Copper-Catalyzed Azide−Alkyne Cycloaddition for Increased in Vivo Efficacy of Interferon β‑1b by Site-Specific PEGylation

Meldal et al. Cu-Catalyzed Azide-Alkyne Cycloaddition Chem

Ponchon et al. Encapsidation and transfer of phage DNA into host cells From in vivo to single particles studies

Wang et al., Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition

International Publication No. WO 02/087497 A2 (LI, Chun)

Jamur et al. Cell Fixatives for Immunostaining Chapter 8

Declaration Of Dr. Sheila Baker

European Patent Specification EP 2 922 818 B1 patent

EPO Board Decision

Auxiliary Request 6 - clean

Auxiliary Request 6 - redline

Appeal minutes

Yu et al. Synthesis and Biological Activities of a 3'-Azido Analogue of Doxorubicin Against Drug-Resistant Cancer Cells

Huang et al. Copper-free click conjugation of methotrexate to a PAMAM dendrimer platform

George et al. Taxol Photoaffinity Labels 2. Synthesis and Biological Evaluation

Reply Declaration of Dr. Ravi Chari

Petitioner's Updated Exhibit List

Petitioner Reply to Patent Owner Response

EXPUNGED

Petitioner’s Revised Notice of Deposition of Lawrence Nathan Tumey, Ph.D.

Ex. 2035

Ex. 2036

Ex. 2037

Ex. 2038

Ex. 2039

Ex. 2041

Ex. 2042

Ex. 2043

Ex. 2044

Ex. 2045

Ex. 2040 part 1 of 3

Ex. 2040 part 2 of 3

Ex. 2040 part 3 of 3

Patent Owner’s Response to Petition for Inter Partes Review

Patent Owner’s Current Exhibit List

Notice of Stipulation to Extend Deadlines for Due Dates 1-3

Patent Owner's Notice of Deposition of Dr. Ravi Chari

Petitioner’s Objections to Evidence

Patent Owner's Objections to Evidence

Institution Decision: granting institution on request for rehearing

Scheduling Order

ORDER Conduct of the Proceeding

Order: DECISION Granting Rehearing; Decision on Rehearing

PO Response to Petitioner Request for Director Review

Ex. 3004

Ex. 3003

Order: Providing for Briefing on Review

DRP Delegation Order

Order: DRP Identification Order

Ex. 3100 Director Review Request

Petitioner’s Request For Director Review

Institution Decision: DECISION Denying Institution of Inter Partes Review 35 U.S.C. § 314, 37 C.F.R. § 42.4

Patent Owner's Pre-Institution Response to Petitioner's Brief

Petitioner Brief in Response to Patent Owner's Preliminary Sur-Reply

Patent Owner's Pre-Institution Surreply

Petitioner's Updated Mandatory Notices

Petitioner's Updated Exhibit List

Condensed Transcript of Teleconference with Board on July 3, 2023

Petitioner’s Preliminary Reply To Patent Owner’s Preliminary Response

E-mail requesting reply

Order: Other

Patent Owner Preliminary Response

Declaration of L. Nathan Tumey, Ph.D.

CV of Lawrence Nathan Tumey, Ph.D.

Maeda, H., et al., Polymeric drugs for efficient tumor-targeted drug delivery

Adair, J.R., et al., Antibody–drug conjugates

Kovtun, Y.V., et al., Antibody-Maytansinoid Conjugates

Goldmacher, V., et al., Antibody–Drug Conjugates: Using Monoclonal Antibodies

Ducry, L., et al., Antibody-Drug Conjugates: Linking Cytotoxic Payloads

Carter P.J., et al., Antibody-Drug Conjugates for Cancer Therapy

Daugherty, A.L., et al., Formulation and Delivery Issues

Pappanaicken, R.K., et al., Evaluation of Ketone-Oxime Method

Jeffrey, S.C., et al., Expanded Utility of the β-Glucuronide Linker

Mather, B., et al., Michael addition

Lopez-Jaramillo, F., et al., Vinyl Sulfone

Acchione, M., et al., Impact of linker and conjugation chemistry

Hamblett, K., et al., Effects of Drug Loading

Junutula, J., et al., Site-specific conjugation

Casi, G., Antibody-Drug Conjugates: Basic Concepts, Examples, and Future Perspectives

Li, L., et al., Vinyl Sulfone Bifunctional Derivatives

Ballini, R., et al., Conjugate Additions

Gallagher, S., et al., Immunoblotting and Immunodetection

Springer Nature, Citation Details

682 Patent FH, NFOA dated August 15, 2017

U.S. Patent No. 5,094,848 (Brixner)

682 Patent FH, Applicant Remarks to NFOA dated August 15, 2017

682 Patent FH, NFOA dated March 8, 2018

WO199741897 (Lees)

682 Patent FH, Applicant Remarks to NFOA dated March 8, 2018

682 Patent FH, FOA dated July 10, 2018

WO2012145112 (Fishkin)

Widdison, W.C., et al., Semisynthetic Maytansine Analogues

682 Patent FH, Applicant Remarks to FOA dated July 10, 2018

682 Patent FH, Notice of Allowance

682 Patent FH Reexamination, IDS Form Signed September 10, 2020

WO2009134976 (Singh ’976)

Patent Owner's Power of Attorney

Patent Owner's Updated Mandatory Notices

Order

Patent Owner's Unopposed Motion to Withdraw Counsel and Substitute New Counsel

NOTICE OF FILING DATE ACCORDED TO PETITION AND TIME FOR FILING PATENT OWNER PRELIMINARY RESPONSE

Notice : Mandatory Notice

U.S. Patent No. 10,131,682 (the 682 Patent)

Ex Parte Reexamination Certificate for the U.S. Patent No. 10,131,682

Unusual Binding Sites for Horseradish Peroxidase

International Publication No. WO 1995/013312 (Harris)

U.S. Patent Publication No. 2010/0129314 (Singh)

U.S. Patent No. 5,208,020 (Chari)

U.S. Patent No. US 5,414,135 (Snow)

U.S. Patent Application Publication No. 2011/0301334 (Bhakta)

Application of Strain-Promoted Azide-Alkyne Cycloaddition

Sulfones and Sulfoxides, Ullmann's Encyclopaedia of Industrial Chemistry

Synthesis and Evaluation of Hydrophilic Linkers for Antibody_Maytansinoid

U.S. Patent No. 6,214,345 (Firestone)

Prosecution History excerpts for US 10,131,682

Excerpts for File Wrapper of Ex Parte Reexamination No. 90/014,390

Scan of Morales-Sanfrutos from Linda Hall Library

WorldCat entry for Morales-Sanfrutos

Download of Morales-Sanfrutos from Linda Hall Library OPAC

WTS Scan of Strauss from Linda Hall Library

Download of Strauss from Purdue University Libraries

WorldCat entry for Strauss

Download of Linda Hall Library OPAC record for Strauss

WTS Scan of Thomas from Linda Hall Library

WorldCat entry for Thomas

Download of Linda Hall Library OPAC record for Thomas

Scan of Roy from Linda Hall Library

Screenshot of link to Roy via Purdue University Libraries

Download of Roy from Purdue University Libraries

WorldCat entry for Roy

Monographic record for Roy at Linda Hall Library

Scan of Zhao from National Library of Medicine

Download of WorldCat entry for Zhao

Download of National Library of Medicine OPAC record for Zhao

Certified translation of priority French Application No. FR 10/52589

International Publication No. WO2011124571

U.S. Patent No. 5,122,614 (Zalipsky)

Boja & Fales, Anal. Chem. 2001 (Boja)

Lewis Phillips et al., Cancer Res (2008) 68 (22)

Pietersz et al., Advances in Immunology Vol. 56: 301-387 (1994)

Trail & Bianchi, Current Opinion in Immunology 11:584–588 (1999)

Ghose et al., Journal of the National Cancer Institute, 657–676 (Ghose)

Panousis & Pietersz, Drugs & Aging 15 (1): 1-13 (1999)

Alley et al., Bioconjug Chem. 2008 Mar;19(3):759-65

SGEN Doronina Nat biotech

Screencapture Wayback Machine Bioconjugate Chemistry

Curriculum Vitae of Dr. James Mullins

Vinyl sulfone bifunctional tag reagents for single-point modification

Download of Morales-Sanfrutos from Purdue U. Libraries

Download of Thomas from Purdue University Libraries

Thomas ACS Digital Publication record

Declaration of Dr. James Mullins

Download of Zhao from Purdue University Libraries

Zhao ACS Digital Publication record - Screen capture

US Patent No. 8,236,319 (Chari-2)

Morales-Sanfrutos Digital Publication record

Roy Digital Publication Record

Petitioner's Power of Attorney

CV of RAVI V. J. CHARI

Petition For Inter Parties Review

Declaration of Dr. Ravi Chari