Parse Biosciences vs 10x Genomics, Inc.

Petitioner Parse Biosciences, Inc.'s Supplemental Power of Attorney for Concord Cheung

Petitioner Parse Biosciences, Inc.'s Supplemental Mandatory Notice Adding Backup Counsel Under 37 C.F.R. Section 42.8(a)(3)

Patent Owner's Notice of Appeal

Final Written Decision: original

Other: Hearing transcript

Patent Owner's Submission of Unresolved Objections to Petitioner's Demonstratives

Petitioner's Objections to Patent Owner's Demonstratives

Patent Owner 10x Genomics, Inc.’s Demonstrative Slides

Petitioner Parse Biosciences, Inc.'s Oral Argument Demonstrative

Patent Owner's Reply in Support of its Motion to Exclude

Petitioner's Reply to Patent Owner's Opposition to Motion to Exclude

Patent Owner's Supplemental Paper Regarding Quakenbush Report Excerpt

Petitioner’s Opposition to Patent Owner’s Motion to Exclude

EX1068

Patent Owner's Opposition to Petitioner's Motion to Exclude

Petitioner's Supplemental Paper In Support Of Submission Of Dr. Quackenbush Report Excerpt

EX1067

Petitioner's Motion to Exclude

Patent Owner's Motion to Exclude

ORDER Conduct of the Proceeding 37 C.F.R. § 42.5

Setting Oral Argument 37 C.F.R. § 42.70

Patent Owner's Request for Oral Hearing

Petitioner’s Supplemental Paper Regarding Why Petitioner’s Arguments Are Not New Or Improper

EX1066

Petitioner’s Objections To Evidence Under 37 C.F.R. § 42.64

Petitioner’s Request For Oral Argument Pursuant To 37 C.F.R. § 42.70(a)

Patent Owner's Objections to Evidence

Patent Owner’s Authorized Supplemental Paper Identifying Exemplary New and Improper Arguments and Theories in Petitioner’s Reply and Related Papers

EX2020 - May 2, 2024 Deposition Transcript of Gregory Cooper, Ph.D.

EX2021 - Parse Biosciences, Inc. v. 10x, Genomics Inc., IPR2023-00955, Pap.1 (May 25, 2023)

Patent Owner's Sur-Reply

EX2023 - Parse Biosciences, Inc. v. 10x Genomics, Inc. IPR2023-00955, EX1002 (Apr. 20, 2023) (Declaration of Gregory Cooper, Ph.D.)

EX2101 - S. Guan, A. Blanchard, P. Zhang, & Z. Zhu, Alteration of Sequence Specificity of the Type IIS Restriction Endonuclease BtsI, (July 26, 2010) (marked as EX2101 in Dr. Cooper’s May 2, 2024 deposition (EX2020))

EX2102 - C. Wansgasnuwat et al, Efficient and cost-effective bacterial mRNA sequencing from low input samples through ribosomal RNA depletion, BMC Genomics (2020) 21:717 (marked as EX2102 in Dr. Cooper’s May 2, 2024 deposition (EX2020))

EX2103 - V. Llorens-Rico et al, Single-cell approaches in human microbiome research, Cell (2022) 185:2725 (marked as EX2103 in Dr. Cooper’s May 2, 2024 deposition (EX2020))

EX2104 - N. Sarkar, Polyadenylation of mRNA in Prokaryotes, Annu. Rev. Biochem (1997) 66:173-97 (marked as EX1067 in Dr. Cooper’s May 2, 2024 deposition (EX2020))

EX2105 - S. Slomovic et al., RNA Polyadenylation in Prokaryotes and Organelles; Different Tails Tell Different Tales, Critical Revs. In Plant Scis. (2006) 25:65-77 (marked as EX1068 in Dr. Cooper’s May 2, 2024 deposition (EX2020))

Deposition Notice of Gregory Cooper, Ph.D.

Patent Owner's Objections to Evidence

Petitioner's Reply to Patent Owner's Response

EX1057

EX1058

EX1059

EX1060

EX1061

EX1062

EX1063

EX1064

EX1065

ORDER Granting Petitioner’s Motions for Pro Hac Vice Admission of Edward R. Reines 37 C.F.R. § 42.10

PETITIONER PARSE BIOSCIENCES, INC.’S NOTICE OF DEPOSITION OF JOHN QUUACKENBUSH

Petitioner Parse Biosciences, Inc.'s Supplemental Mandatory Notice Adding Backup Counsel Under 37 C.F.R. Section 42.8(a)(3)

Petitioner Parse Biosciences, Inc.'s Supplemental Power of Attorney for Edward R. Reines

Petitioner Parse Biosciences, Inc.'s Motion for Admission Pro Hac Vice of Edward R. Reines Pursuant to 37 C.F.R. Section 42.10

Petitioner Parse Biosciences, Inc.'s Updated Exhibit List

Exhibit 1054 - Declaration of Edward R. Reines in support of pro hac vice motion

Exhibit 1055 - In re Reines Federal Circuit decision, 14-MA0004

Exhibit 1056 - Personal Statement of Edward R. Reines, Fed. Cir. 14-MA004

EXPUNGED

Panel Change Order

EX2013 - Declaration of John Quackenbush, Ph.D. (Corrected)

EX2011 - Parse Biosciences, Inc. v. 10x, Genomics Inc., IPR2023-00958, EX1002 (May 25, 2023) (Declaration of Gregory Cooper, Ph.D)

EX2012 - Parse Biosciences, Inc. v. 10x, Genomics Inc., IPR2023-00958, EX1054 (May 25, 2023) (Georgi K. Marinov et al., From single-cell to cell-pool transcriptomes: Stochasticaly in gene expression and RNA splicing, 24.3 Genome Research 496-510 (2014) (“Marinov”))

EXPUNGED

EX2014 - Bruce Alberts, et al., Molecular Biology of the Cell, Garland Science (4th ed. 2002)

EX2015 - Declaration of Sayem Osman

EX2016 - Piovesan et al., On the length, weight, and GT content of the human genome, BMC Res. Notes 12:106 (2019) (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391780/#:~:text=Considering%20a%20mean%20weight%20in,units%2Fcarat.htm)

EX2017 - T. Chauhan, T4 DNA Ligase: Introduction, Functions, Applications, and Protocol, (available at https://geneticeducation.co.in/t4-dna-ligase/)

EX2018 - Deposition Transcript of Gregory Cooper, Ph.D.

EX2019 - Li et al., Amplification and analysis of DNA sequences in single human sperm and diploid cells, Nature 335(6189):414-417 (1998)

Patent Owner's Response

Notice of Deposition of Gregory Cooper, Ph.D.

Patent Owner's Objections to Evidence

EXPUNGED

ERRATA

Institution Decision: Grant

Order: Scheduling Order

EX2001 - U.S. Patent Pub. No. 2007/0020640 A1

EX2002 - File History of U.S. App. No. 13/859,450

EX2003 - Dictionary of Microbiology and Molecular Biology (2d ed. 1987)

EX2004 - File History of U.S. App. No. 14/792,094

EX2005 - File History of U.S. App. No. 13/387,343

EX2006 - U.S. Patent Pub. No. 2007/0238113

EX2007 - Laird et al., Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules, 101 PNAS 204-09 (Dec. 12, 2003)

EX2008 - Parse Biosciences, Inc. v. 10x, Genomics Inc., IPR2023-00958, Pap.1, (May 25, 2023)

EX2009 - File History of U.S. App. No. 14/172,694

EX2010 - Declaration of Sayem Osman

Patent Owner's Preliminary Response

Patent Owner's Mandatory Notices

Patent Owner's Power of Attorney and Designation of Lead & Back-up Counsel

Notice: Notice filing date accorded

Petition : as filed

U.S. Patent No. 10,155,981

Declaration of Gregory Cooper, Ph.D.

PCT Patent Publication No. WO 2010/117620 (Linnarsson)

Encoding PCR Products with Batch-Stamps and Barcodes (McCloskey)

U.S. Patent No. 10,155,981 FH

Gene expression in individual cells (Brail)

Measurement of Number of Molecules (Hug)

Twenty-five years of quantitative PCR (VanGuilder)

Polymerase Chain Reaction (Schochetman)

PCR-Induced Sequence Artifacts and Bias (Acinas)

A genome-wide study of preferential (Yang)

Amplification biases: possible difference (Degrelle)

Molecular barcodes detect redundancy (Miner)

U.S. Patent No. 8,298,767

U.S. Patent Provisional Application No. 61/164,759 (Linnarsson Provisional)

10X Genomic’s Opening Br ISO Mtn to Dismiss

10X Genomic’s Reply Br ISO Mtn to Dismiss

Scheduling Order

Federal Judicial Caseload Statistics (2022)

Gregory Cooper CV

The Use of Coded PCR Primers (Binladen)

Effects of primer-template mismatches (Kwok)

Motion Success for Stay Pending IPR In Delaware District

High-Efficiency Cloning of Full-Length (Okayma)

Chapter 6 How Cells read the Genome

Assignment Record for U.S. Patent 8,298,767

10x Genomics Legal Notice

Declaration of Sylvia D. Hall-Ellis, Ph.D.

US Patent No. 8,835,358

Translation: DNA to mRNA to Protein (Clancy)

Defining cell types and states (Trapnell)

Representative in Vitro cDNA Amplification (Brady)

Analysis of gene expression (Eberwine)

Normalization and Subtraction (Bonaldo)

In vitro cloning of complex mixtures (Brenner)

Polymerase Chain Reaction (Persing)

An improved single-cell cDNA amplification (Kurimoto)

Method for single-cell microarray analysis (Esumi)

Cloning Full-length, Cap-Trapper-Selected (Shibata)

U.S. Patent Application 2004/0166499

An Overview of Next-Generation Sequencing (Gkazi)

Relocalization of elF4E by its binding partners

DNA sequencing: bench to bedside and beyond

Keeping Uracil Out of DNA (Vertessy)

Next-Generation DNA Sequencing Methods (Mardis)

Next-Generation DNA Sequencing (Shendure)

The impact of next-generation sequencing (Mardis 2)

The new paradigm of flow cell (Holt)

National Human Genome Research Institute, Nucleotide

National Human Genome Research Institute, Polymerase Chain

Becton, Dickinson and Company and Cellular Research, Inc.’s First Amended

Exhibits 26 and 27

US 9,708,659

Notice : Parse Biosciences, Inc.'s Power of Attorney