Gene Company Pty Ltd vs The Trustees of Columbia University in the City of New York et al.

Adverse judgment: post-institution

Ex. 3001

Notice of Stipulation to Modify Trial Due Dates 1-3

Patent Owner's Notice of Deposition of Dr. F. Peter Guengerich

Patent Owner's Notice of Deposition of Dr. Andrew Calman

Patent Owner's Objections to Evidence

Decision Granting Institution of Inter Partes Review

Scheduling Order

Patent Owner's Updated Mandatory Notices

PO's Updated Mandatory Notices

PO's Updated Power of Attorney

Notice : Mandatory Notice

Notice : Power of Attorney

Petitioner's Updated Mandatory Notices

Notice: Notice filing date accorded

Declaration of Dr. F. Peter Guengerich, Ph.D.

Robert Bergen, H., Furr, H. C., & Olson, J. A., Synthesis of Tri‐, Tetra‐,

Furr, H. C., Amedee-Manesme, O., Clifford, A. J., Bergen 3rd, H. R., Jones,

DE202006014588U1 (English Translation) (“Ortho Pharma”)

WO 2006/007314 to Widder et al. (“Widder”)

Mata, N. L. et al., Biosynthesis of a major lipofuscin fluorophore in mice

Fishkin et al., Isolation and Characterization of a Retinal Pigment Epithel

Haskins, N. J., The Application of Stable Isotopes in Biomedical Research,

Baillie, T. A., The Use of Stable Isotopes in Pharmacological Research, Pha

Van Langenhove, A., Isotope Effects: Definitions and Consequences for Pharm

Roth and König, Kinetic Isotope Effect of the 1.5-Hydrogen Displacement in

Itou et al., Quantum Treatment of Hydrogen Nuclei in Primary Kinetic Isotop

Remington: The Science and Practice of Pharmacy, 19th ed. (1995) (chs. 80 &

Parish et al., Isolation and One-step Preparation of A2E and Iso-A2E, Gluor

Furr et al. Stable Isotope Dilution Techniques for Assessing Vitamin A Stat

Shaban & Richter, A2E and Blue Light in the Retina: The Paradigm of Age-rel

Shaban et al., Phosphatidylglycerol Potently Protects Human Retinal Pigment

Age-Related Eye Disease Study Research Group, A Randomized, Placebo-control

First Declaration of Irinia Hinrichs

Second Declaration of Irinia Hinrichs

McCullough FS, Northrop-Clewes CA, Thurnham DI. The Effect of Vitamin A on

J. A. Olson, The Biosynthesis and Metabolism of Carotenoids and Retinol (Vi

Del Priore LV, Kuo YH, Tezel TH. Age-related Changes in Human RPE Cell Dens

Wolf, G., A History of Vitamin A and Retinoids. The FASEB Journal, 10: 1102

Sommer, A., Effects of Vitamin A Deficiency on the Ocular Surface, Ophthalm

Radu, Roxana A. et al., Reductions in Serum Vitamin A Arrest Accumulation o

File History of U.S. Patent Application No. 12/733,631

File History of U.s. Patent Application No. 14/510,975

Sparrow JR, Fishkin N, Zhou J, Cai B, Jang YP, Krane S, Itagaki Y, Nakanish

Wolf G., Lipofuscin and Macular Degeneration., Nutr Rev. 61(10):342-6 (2003

Fishkin N, Jang YP, Itagaki Y, Sparrow JR, Nakanishi K. A2-Rhodopsin: A New

Law WC & Rando RR, The Molecular Basis of Retinoic Acid Induced Night Blind

Sieving PA, Chaudhry P, Kondo M, Provenzano M, Wu D, Carlson TJ, Bush RA, T

Chopdar A, Chakravarthy U, Verma D, Age Related Macular Degeneration. BMJ (

Berson EL, Rosner B, Sandberg MA, Hayes KC, Nicholson BW, Weigel-DiFranco C

Jacobson SG, Cideciyan AV, Regunath G, Rodriguez FJ, Vandenburgh K, Sheffie

Alberts D et al., Safety and Efficacy of Dose-intensive Oral Vitamin A in S

Ross DA, Recommendations for Vitamin A Supplementation. J Nutr. 132(9 Suppl

Haskell MJ et al., Use of the Deuterated-retinol-dilution Technique to Asse

Haskell MJ, et al., Assessment of Vitamin A Status by the Deuterated-retino

Kushner DJ, Baker A, Dunstall TG, Pharmacological Uses and Perspectives of

Blake MI, Crespi HL, Katz JJ, Studies with Deuterated Drugs, J Pharm Sci. 6

McCarty LP, Malek RS, Larsen ER. The Effects of Deuteration on the Metaboli

Bull E. What is Nutraceutical? Pharm J. 265:57-58 (2000) (“Bull”)

Kuksa V, Imanishi Y, Batten M, Palczewski K, Moise AR. Retinoid Cycle in th

Switching’ in Cytochrome P450‐catalyzed Reactions, BioEssays, 7(5), 215-219

WO 95/04018 to Marcus F. Boehm (“Boehm”)

Ribaya-Mercado et al., “Dietary vitamin A intakes of Filipino elders with a

Kemp, C. Visual Function and Rhodopsin Levels in Humans with Vitamin A Defi

Rosenfeld, P.J. et al. Ranibizumab for Neovascular Age-Related Macular Dege

Sommer, A. Oral Versus Intramuscular Vitamin A in the Treatment of Xerophth

Duszka, et al., Rat Intestinal β-Carotene Dioxygenase Activity Is Located P

Petitioner Gene Company Pty Ltd Power of Attorney

U.S. Patent No. 9,486,432 to Washington et al.

Curriculum Vitae of Dr. Guengerich.

Declaration of Dr. Andrew Calman, M.D., Ph.D.

Curriculum Vitae of Dr. Calman.

Radu, Roxana A. et al. “Treatment with Isotretinoin Inhibits Lipofuscin Acc

Petition : as filed