Order | Jun 23, 2025 | PAPER | BOARD |
Final Written Decision: JUDGMENT Final Written Decision Determining No Challenged Claims Unpatentable 35 U.S.C. § 318(a) Dismissing Petitioner’s Motion to Exclude Evidence as Moot 37 C.F.R. § 42.64 | Jun 23, 2025 | PAPER | BOARD |
Other: Hearing transcript | Apr 23, 2025 | PAPER | BOARD |
Panel Change Order | Apr 16, 2025 | PAPER | BOARD |
Petitioner's Demonstratives (Confidential) | Mar 25, 2025 | EXHIBIT | PETITIONER |
Petitioner's Demonstratives (Public) | Mar 25, 2025 | EXHIBIT | PETITIONER |
Patent Owner's Updated Exhibit List | Mar 25, 2025 | PAPER | PATENT OWNER |
Patent Owner Demonstratives | Mar 25, 2025 | EXHIBIT | PATENT OWNER |
Petitioner's Updated Exhibit List | Mar 25, 2025 | PAPER | PETITIONER |
Ex. 3005 | Mar 24, 2025 | EXHIBIT | BOARD |
Petitioner's Reply in Support of Motion to Exclude | Mar 18, 2025 | PAPER | PETITIONER |
ORDER Setting Oral Argument 37 C.F.R. § 42.70 | Mar 11, 2025 | PAPER | BOARD |
Patent Owner's Opposition to Petitioner's Motion to Exclude | Mar 11, 2025 | PAPER | PATENT OWNER |
ScholarWorks Website | Mar 11, 2025 | EXHIBIT | PATENT OWNER |
Hussain 2018 | Mar 11, 2025 | EXHIBIT | PATENT OWNER |
Shauna Wiest Declaration | Mar 11, 2025 | EXHIBIT | PATENT OWNER |
Mowery 1979 | Mar 11, 2025 | EXHIBIT | PATENT OWNER |
PO Updated Exhibit List Served with Supp Evidence | Mar 11, 2025 | EXHIBIT | PATENT OWNER |
Patent Owner's Updated Exhibit List | Mar 11, 2025 | PAPER | PATENT OWNER |
Petitioner's Motion to Exclude | Mar 4, 2025 | PAPER | PETITIONER |
Patent Owner's Reply to Petitioner's Opposition to Patent Owner's Motion to Seal | Feb 28, 2025 | PAPER | PATENT OWNER |
Patent Owner's Request for Oral Argument | Feb 11, 2025 | PAPER | PATENT OWNER |
Petitioner's Request for Oral Argument | Feb 11, 2025 | PAPER | PETITIONER |
Patent Owner's Updated Mandatory Notices | Feb 6, 2025 | PAPER | PATENT OWNER |
Patent Owner's Updated Power of Attorney | Feb 6, 2025 | PAPER | PATENT OWNER |
Petitioner's Opposition to Patent Owner's Motion to Seal | Feb 3, 2025 | PAPER | PETITIONER |
Patent Owner's Sur-Reply | Feb 3, 2025 | PAPER | PATENT OWNER |
Patent Owner's Updated Exhibit List | Feb 3, 2025 | PAPER | PATENT OWNER |
Guengerich Depo Transcript (2025-01-24) | Feb 3, 2025 | EXHIBIT | PATENT OWNER |
E-mail granting authorization to file motion for withdrawal of Counsel | Jan 31, 2025 | EXHIBIT | BOARD |
Patent Owner's Notice of Deposition of Dr. F. Peter Guengerich | Jan 16, 2025 | PAPER | PATENT OWNER |
Patent Owner's Motion to Seal and for Entry of Protective Order | Jan 3, 2025 | PAPER | PATENT OWNER |
Patent Owner's Objections to Evidence Submitted with Petitioner's Reply | Dec 31, 2024 | PAPER | PATENT OWNER |
REDACTED PUBLIC VERSION Petitioner's Reply | Dec 23, 2024 | PAPER | PETITIONER |
CONFIDENTIAL Petitioner's Reply | Dec 23, 2024 | PAPER | PETITIONER |
Centrum Silver Adults Label (200 Tablets) Multivitamin | Dec 23, 2024 | EXHIBIT | PETITIONER |
Glenn J. Jaffee, et al., “C5 Inhibitor Avacincaptad Pegol for Geographic Atrophy Due to Age-Related Macular Degeneration, Ophthalmology” | Dec 23, 2024 | EXHIBIT | PETITIONER |
Heier, Jeffrey S. et al. - Pegcetacoplan for the Treatment of Geographic Atrophy, (2023) | Dec 23, 2024 | EXHIBIT | PETITIONER |
Shen, Liangbo L. et al. - American Academy of Ophthalmology – Natural History of Autosomal Recessive Stargardt Disease, (2019) | Dec 23, 2024 | EXHIBIT | PETITIONER |
Deposition Transcript of Del Priore, Lucian | Dec 23, 2024 | EXHIBIT | PETITIONER |
Deposition Transcript of Prestwich, Ph.D., Glenn D | Dec 23, 2024 | EXHIBIT | PETITIONER |
Alkeuspharma.com - Home Page Website | Dec 23, 2024 | EXHIBIT | PETITIONER |
Bain Capital - Current and former portfolio companies | Dec 23, 2024 | EXHIBIT | PETITIONER |
Alkeus Pharma Web Page - Director's Profiles | Dec 23, 2024 | EXHIBIT | PETITIONER |
Michael Song Linked In Profile | Dec 23, 2024 | EXHIBIT | PETITIONER |
Monica Hennessey Linked In Profile | Dec 23, 2024 | EXHIBIT | PETITIONER |
Christine Xu Linked In Profile | Dec 23, 2024 | EXHIBIT | PETITIONER |
Cyriac Joyce Linked In Profile | Dec 23, 2024 | EXHIBIT | PETITIONER |
RunyaoT. Linked In Profile | Dec 23, 2024 | EXHIBIT | PETITIONER |
CONFIDENTIAL - Transcript of Leonide Saad Ph.D. Deposition | Dec 23, 2024 | EXHIBIT | PETITIONER |
Public Redacted Version - Transcript of Leonide Saad Ph.D. Deposition | Dec 23, 2024 | EXHIBIT | PETITIONER |
Rebuttal Declaration of Dr. F. Peter Guengerich | Dec 23, 2024 | EXHIBIT | PETITIONER |
Ben Fidler, “An unconventional drug startup lures Vertex founder Josh Boger back to biotech,” BioPharmaDive (Jun. 5, 2023) | Dec 23, 2024 | EXHIBIT | PETITIONER |
Jonathan Saltzman, “Cambridge biotech raises $150 million and rehires founder of Vertex,” Boston Globe (Jun. 5, 2023) | Dec 23, 2024 | EXHIBIT | PETITIONER |
Ilyas Washington, PubMed Publication Entries, 2001-2007 | Dec 23, 2024 | EXHIBIT | PETITIONER |
Rowan Walrath, “Vertex founder Josh Boger is back in biotech. Here’s why he ‘unretired.” Boston Business Journal (Jun. 11, 2023) | Dec 23, 2024 | EXHIBIT | PETITIONER |
Timmer Report Alkeus, a Bootstrap Success Story | Dec 23, 2024 | EXHIBIT | PETITIONER |
Luke Timmerman, “Alkeus, A Bootstrap Success Story, Grows Up With $150M Series B”, Timmerman Report (Jun. 2023) | Dec 23, 2024 | EXHIBIT | PETITIONER |
Gildeuretinol Slows Progression of Stargardt Disease (10-24) | Dec 23, 2024 | EXHIBIT | PETITIONER |
Ex. 3003 | Dec 13, 2024 | EXHIBIT | BOARD |
Patent Owner's Updated Exhibit List | Dec 13, 2024 | PAPER | PATENT OWNER |
Boyer 2024 | Dec 13, 2024 | EXHIBIT | PATENT OWNER |
Notice of Deposition of Leonide Saad | Nov 8, 2024 | PAPER | PETITIONER |
Notice of Deposition of Glenn Prestwhich | Nov 1, 2024 | PAPER | PETITIONER |
Petitioner's Notice of Deposition of Dr. Del Priore | Oct 29, 2024 | PAPER | PETITIONER |
Petitioner's Opposition to Patent Owner's Motion to Seal | Oct 23, 2024 | PAPER | PETITIONER |
Ex. 3002 | Sep 30, 2024 | EXHIBIT | BOARD |
Petitioner's Objections to Evidence | Sep 30, 2024 | PAPER | PETITIONER |
Anslyn 2006 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Ben-Shabat 2002 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Prestwich Declaration | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Prestwich CV | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Guengerich 2016 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Guengerich Email to IW (09.21.2010) | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Guengerich Email to IW (09.24.2010) | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Kim 2004 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Rando 2001 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Saari 1998 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Ma 2011 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Rózanowska 2005 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Gollapalli 2004 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Maeda 2006 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Maiti 2006 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Greene 1968 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Ben-Shabat 2001 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Travis 2007 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Andrew F. Calman MD PhD Contact this Expert Witness | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Oxford Dictionary 2006 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Lamb 2004 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Rattner 2006 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Pirali 2019 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Fisher 2006 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Mowery 1979 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Verdegem 1997 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Sakai 1996 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Bok 1993 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Weng 1999 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Krauser 2005 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Westheimer 1961 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Nelson 2003 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Scholl 2016 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Scholl 2019 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Scholl 2022 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Kay 2022 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Scholl 2024 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Gorin 2024 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
2024.07.18 Alkeus Press Release | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
2024.01.10 Alkeus Press Release | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
[SEALED] Boyer 2024 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
2024.09.17 Alkeus Press Release | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
2021.07.14 Alkeus Press Release | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
2023.06.05 Alkeus Press Release | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
NCT02402660 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
NCT03845582 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Strauss 2019 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Sears 2017 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Cocce 2018 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Guengerich Depo Transcript | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Calman Depo Transcript | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
NCT02230228 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
NCT04239625 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
FDA Breakthrough Therapy | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Alkeus Website | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Harper’s Biochemistry | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Koenekoop 2003 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Howes 2006 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Robison 1980 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Robison 1982 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Katz 1986 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Katz 1987 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Katz 1992 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Radu 2008 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Owsley 2000 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Owsley 2001 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Baehr 2003 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Dragnev 2000 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Freemantle 2003 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Soriatan (Wayback 2008.06.16) | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Targretin (Wayback 2008.06.15) | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Accutane (Wayback 2008.09.02) | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Hong 1994 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Gudas 1994_Part 1 of 2 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Gudas 1994_Part 2 of 2 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Nason-Burchenal 1999 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Camerini 2001 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Villablanca 1995 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Isotretinoin (Wayback 2008.06.03) | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Puduvalli 2004 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Voo 2004 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
NEI Stargardt Disease 2024 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
UCSF Stargardt Disease 2024 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Karan 2005 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Brody 2001 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Rovner 2002 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Guymer 2006 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
van Leeuwen 2005 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Tan 2008 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Seddon 1994 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Johnson 2002 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Chong 2007 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
AREDS2 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Michaelides 2003 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Goldstein 2005 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Miedziak 2000 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
FDA Stargardt Disease 2022 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Penniston 2006 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Glenn 1994 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Li 2005 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Mamor and Gamel 1993 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Massof 1993 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Cartmel 1999 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Kennedy 1995 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Hodge 2023 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Hamel 2006 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
FFB 2023 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Comander 2023 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Petrukhin 2013 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Kim 2007 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Mukherjee 2014 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Tsui 2007 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Sherman 2013 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Issa 2015 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Han 2024 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
NCT00307398 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
NCT00429936 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
NCT00485394 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Del Priore 2024 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Orphanet 2003 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Anderson 1995 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Jurgensmeier 2007 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
NCT00346853 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Parodi 2015 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Caruso 2008 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
NCT00060749 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Shapiro 2015 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Piotter 2021 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Mihai 2013 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Charters 2024 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
FDA Patient Listening Sessions 2024 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Aleman 2007 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Mata 2013 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Sternberg 2010 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Stokkermans 2009 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
2017.10.06 FDA News Release | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
2018.09.24 FDA News Release | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Belite Bio - Company Presentation | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Saad Declaration | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Del Priore Declaration | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Del Priore CV | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Patent Owner's Motion to Seal and Enter Default Protective Order | Sep 23, 2024 | PAPER | PATENT OWNER |
Patent Owner Response | Sep 23, 2024 | PAPER | PATENT OWNER |
Patent Owner's Updated Exhibit List | Sep 23, 2024 | PAPER | PATENT OWNER |
Wiest Declaration Part 1 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Wiest Declaration Part 2 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Wiest Declaration Part 3 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Greenhill Declaration Part 1 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Greenhill Declaration Part 2 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Greenhill Declaration Part 3 | Sep 23, 2024 | EXHIBIT | PATENT OWNER |
Notice of Stipulation to Modify Trial Due Dates 1-3 | Sep 5, 2024 | PAPER | PATENT OWNER |
Rehearing: DECISION Denying Patent Owner’s Request for Rehearing of Decision on Institution 35 U.S.C. § 42.71(d) | Aug 7, 2024 | PAPER | BOARD |
Patent Owner's Notice of Deposition of Dr. F. Peter Guengerich | Jul 29, 2024 | PAPER | PATENT OWNER |
Patent Owner's Notice of Deposition of Dr. Andrew Calman | Jul 29, 2024 | PAPER | PATENT OWNER |
Patent Owner's Objections to Evidence | Jul 9, 2024 | PAPER | PATENT OWNER |
Petitioner's Objections to Evidence Supporting POPR | Jul 9, 2024 | PAPER | PETITIONER |
Patent Owner's Request for Rehearing of the Institution Decision | Jul 8, 2024 | PAPER | PATENT OWNER |
Decision Granting Institution of Inter Partes Review | Jun 24, 2024 | PAPER | BOARD |
Scheduling Order | Jun 24, 2024 | PAPER | BOARD |
Patent Owner Pre-Institution Sur-Reply | Apr 26, 2024 | PAPER | PATENT OWNER |
PETITIONER GENE CO.s PRE-INSTITUTION REPLY | Apr 19, 2024 | PAPER | PETITIONER |
Exhibit 3001 | Apr 12, 2024 | EXHIBIT | BOARD |
Patent Owner Preliminary Response | Mar 29, 2024 | PAPER | PATENT OWNER |
Patent Owner's Exhibit List | Mar 29, 2024 | PAPER | PATENT OWNER |
Tang 1998 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Pardoen 1986 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Travis 2007 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Lang 2005 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Widder 2007 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Kaufman 2011 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Foster 1985 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Guengerich Declaration IPR2017-01256_EX1002 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Guengerich Depo Tr IPR2017-01256_EX2047 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Guengerich Depo Tr IPR2021-00347_EX2041 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Widder 2006 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Mata 2011 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Widder 2012 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Huang 2022 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Hussain 2018 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Zernant 2019 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Ciulla 2019 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Morrison 1973 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Kim 2007 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Saettel 2000 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Black 1998 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Connors 1990 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
O'Ferrall 1975 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Doering 2006 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Vitamin D - Fact Sheet | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
DeBoer 2022 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Griffith News | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Taiwan News | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Parliament Report 2 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Parliament Report | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Belite SEC Form F1 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
March Pages From Textbook | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
J. Haung LinkedIn | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
WS PR | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Sessler Declaration | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Sessler CV | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Anslyn 2006 | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
LinkedIn Article | Mar 29, 2024 | EXHIBIT | PATENT OWNER |
Patent Owner's Updated Mandatory Notices | Mar 22, 2024 | PAPER | PATENT OWNER |
PO's Updated Mandatory Notices | Mar 12, 2024 | PAPER | PATENT OWNER |
PO's Updated Power of Attorney | Mar 12, 2024 | PAPER | PATENT OWNER |
Notice : Mandatory Notice | Jan 9, 2024 | PAPER | PATENT OWNER |
Notice : Power of Attorney | Jan 9, 2024 | PAPER | PATENT OWNER |
Notice: Notice filing date accorded | Dec 29, 2023 | PAPER | BOARD |
Declaration of Dr. F. Peter Guengerich, Ph.D. | Dec 20, 2023 | EXHIBIT | PETITIONER |
Robert Bergen, H., Furr, H. C., & Olson, J. A., Synthesis of Tri‐, Tetra‐, | Dec 20, 2023 | EXHIBIT | PETITIONER |
Furr, H. C., Amedee-Manesme, O., Clifford, A. J., Bergen 3rd, H. R., Jones, | Dec 20, 2023 | EXHIBIT | PETITIONER |
DE202006014588U1 (English Translation) (“Ortho Pharma”) | Dec 20, 2023 | EXHIBIT | PETITIONER |
WO 2006/007314 to Widder et al. (“Widder”) | Dec 20, 2023 | EXHIBIT | PETITIONER |
Mata, N. L. et al., Biosynthesis of a major lipofuscin fluorophore in mice | Dec 20, 2023 | EXHIBIT | PETITIONER |
Fishkin et al., Isolation and Characterization of a Retinal Pigment Epithel | Dec 20, 2023 | EXHIBIT | PETITIONER |
Haskins, N. J., The Application of Stable Isotopes in Biomedical Research, | Dec 20, 2023 | EXHIBIT | PETITIONER |
Baillie, T. A., The Use of Stable Isotopes in Pharmacological Research, Pha | Dec 20, 2023 | EXHIBIT | PETITIONER |
Van Langenhove, A., Isotope Effects: Definitions and Consequences for Pharm | Dec 20, 2023 | EXHIBIT | PETITIONER |
Roth and König, Kinetic Isotope Effect of the 1.5-Hydrogen Displacement in | Dec 20, 2023 | EXHIBIT | PETITIONER |
Itou et al., Quantum Treatment of Hydrogen Nuclei in Primary Kinetic Isotop | Dec 20, 2023 | EXHIBIT | PETITIONER |
Remington: The Science and Practice of Pharmacy, 19th ed. (1995) (chs. 80 & | Dec 20, 2023 | EXHIBIT | PETITIONER |
Parish et al., Isolation and One-step Preparation of A2E and Iso-A2E, Gluor | Dec 20, 2023 | EXHIBIT | PETITIONER |
Furr et al. Stable Isotope Dilution Techniques for Assessing Vitamin A Stat | Dec 20, 2023 | EXHIBIT | PETITIONER |
Shaban & Richter, A2E and Blue Light in the Retina: The Paradigm of Age-rel | Dec 20, 2023 | EXHIBIT | PETITIONER |
Shaban et al., Phosphatidylglycerol Potently Protects Human Retinal Pigment | Dec 20, 2023 | EXHIBIT | PETITIONER |
Age-Related Eye Disease Study Research Group, A Randomized, Placebo-control | Dec 20, 2023 | EXHIBIT | PETITIONER |
First Declaration of Irinia Hinrichs | Dec 20, 2023 | EXHIBIT | PETITIONER |
Second Declaration of Irinia Hinrichs | Dec 20, 2023 | EXHIBIT | PETITIONER |
McCullough FS, Northrop-Clewes CA, Thurnham DI. The Effect of Vitamin A on | Dec 20, 2023 | EXHIBIT | PETITIONER |
J. A. Olson, The Biosynthesis and Metabolism of Carotenoids and Retinol (Vi | Dec 20, 2023 | EXHIBIT | PETITIONER |
Del Priore LV, Kuo YH, Tezel TH. Age-related Changes in Human RPE Cell Dens | Dec 20, 2023 | EXHIBIT | PETITIONER |
Wolf, G., A History of Vitamin A and Retinoids. The FASEB Journal, 10: 1102 | Dec 20, 2023 | EXHIBIT | PETITIONER |
Sommer, A., Effects of Vitamin A Deficiency on the Ocular Surface, Ophthalm | Dec 20, 2023 | EXHIBIT | PETITIONER |
Radu, Roxana A. et al., Reductions in Serum Vitamin A Arrest Accumulation o | Dec 20, 2023 | EXHIBIT | PETITIONER |
File History of U.S. Patent Application No. 12/733,631 | Dec 20, 2023 | EXHIBIT | PETITIONER |
File History of U.S. Patent Application No. 14/510,975 | Dec 20, 2023 | EXHIBIT | PETITIONER |
Sparrow JR, Fishkin N, Zhou J, Cai B, Jang YP, Krane S, Itagaki Y, Nakanish | Dec 20, 2023 | EXHIBIT | PETITIONER |
Wolf G., Lipofuscin and Macular Degeneration., Nutr Rev. 61(10):342-6 (2003 | Dec 20, 2023 | EXHIBIT | PETITIONER |
Fishkin N, Jang YP, Itagaki Y, Sparrow JR, Nakanishi K. A2-Rhodopsin: A New | Dec 20, 2023 | EXHIBIT | PETITIONER |
Law WC & Rando RR, The Molecular Basis of Retinoic Acid Induced Night Blind | Dec 20, 2023 | EXHIBIT | PETITIONER |
Sieving PA, Chaudhry P, Kondo M, Provenzano M, Wu D, Carlson TJ, Bush RA, T | Dec 20, 2023 | EXHIBIT | PETITIONER |
Chopdar A, Chakravarthy U, Verma D, Age Related Macular Degeneration. BMJ ( | Dec 20, 2023 | EXHIBIT | PETITIONER |
Jacobson SG, Cideciyan AV, Regunath G, Rodriguez FJ, Vandenburgh K, Sheffie | Dec 20, 2023 | EXHIBIT | PETITIONER |
Alberts D et al., Safety and Efficacy of Dose-intensive Oral Vitamin A in S | Dec 20, 2023 | EXHIBIT | PETITIONER |
Ross DA, Recommendations for Vitamin A Supplementation. J Nutr. 132(9 Suppl | Dec 20, 2023 | EXHIBIT | PETITIONER |
Haskell MJ et al., Use of the Deuterated-retinol-dilution Technique to Asse | Dec 20, 2023 | EXHIBIT | PETITIONER |
Haskell MJ, et al., Assessment of Vitamin A Status by the Deuterated-retino | Dec 20, 2023 | EXHIBIT | PETITIONER |
Kushner DJ, Baker A, Dunstall TG, Pharmacological Uses and Perspectives of | Dec 20, 2023 | EXHIBIT | PETITIONER |
Blake MI, Crespi HL, Katz JJ, Studies with Deuterated Drugs, J Pharm Sci. 6 | Dec 20, 2023 | EXHIBIT | PETITIONER |
McCarty LP, Malek RS, Larsen ER. The Effects of Deuteration on the Metaboli | Dec 20, 2023 | EXHIBIT | PETITIONER |
Bull E. What is Nutraceutical? Pharm J. 265:57-58 (2000) (“Bull”) | Dec 20, 2023 | EXHIBIT | PETITIONER |
Kuksa V, Imanishi Y, Batten M, Palczewski K, Moise AR. Retinoid Cycle in th | Dec 20, 2023 | EXHIBIT | PETITIONER |
Berson EL, Rosner B, Sandberg MA, Hayes KC, Nicholson BW, Weigel-DiFranco C | Dec 20, 2023 | EXHIBIT | PETITIONER |
Miwa, GT & Lu, AY, Kinetic Isotope Effects and ‘Metabolic Switching’ in Cyt | Dec 20, 2023 | EXHIBIT | PETITIONER |
WO 95/04018 to Marcus F. Boehm (“Boehm”) | Dec 20, 2023 | EXHIBIT | PETITIONER |
Ribaya-Mercado et al., “Dietary vitamin A intakes of Filipino elders with a | Dec 20, 2023 | EXHIBIT | PETITIONER |
Kemp, C. Visual Function and Rhodopsin Levels in Humans with Vitamin A Defi | Dec 20, 2023 | EXHIBIT | PETITIONER |
Rosenfeld, P.J. et al. Ranibizumab for Neovascular Age-Related Macular Dege | Dec 20, 2023 | EXHIBIT | PETITIONER |
Sommer, A. Oral Versus Intramuscular Vitamin A in the Treatment of Xerophth | Dec 20, 2023 | EXHIBIT | PETITIONER |
File History resulting in U.S. Reissue Patent No. RE47,045 | Dec 20, 2023 | EXHIBIT | PETITIONER |
Duszka, et al., Rat Intestinal β-Carotene Dioxygenase Activity Is Located P | Dec 20, 2023 | EXHIBIT | PETITIONER |
American Optometric Association, “Care of the Patient with Age-Related Macu | Dec 20, 2023 | EXHIBIT | PETITIONER |
Petitioner Gene Company Pty Ltd Power of Attorney | Dec 20, 2023 | PAPER | PETITIONER |
U.S. Patent No. RE47,045 to Washington et al. | Dec 20, 2023 | EXHIBIT | PETITIONER |
Curriculum Vitae of Dr. Guengerich. | Dec 20, 2023 | EXHIBIT | PETITIONER |
Declaration of Dr. Andrew Calman, M.D., Ph.D. | Dec 20, 2023 | EXHIBIT | PETITIONER |
Curriculum Vitae of Dr. Calman | Dec 20, 2023 | EXHIBIT | PETITIONER |
Radu, Roxana A. et al. “Treatment with Isotretinoin Inhibits Lipofuscin Acc | Dec 20, 2023 | EXHIBIT | PETITIONER |
Petition : as filed | Dec 20, 2023 | PAPER | PETITIONER |