Sarepta Therapeutics, Inc et al. vs The Trustees of the University of Pennsylvania et al.

Exclusive Licensee’s Updated Mandatory Notices

May 22, 2025 Patent Owners' Demonstratives Slides

Patent Owners' Updated Exhibit List

2025-05-22 Petitioner's Demonstrative Slides

IPR2024-00580 Petitioner's Updated Exhibit List

ORDER Granting Joint Request to Modify Dates 37 C.F.R. § 42.70

Petitioner's and Patent Owners' Joint Request to Modify Dates

E-mail excusing Patent Owner's lead counsel from hearing

ORDER Setting Oral Argument 37 C.F.R. § 42.70

Patent Owners' Sur-Reply

Errata Sheet to Transcript of Dr. Jude Samulski’s Deposition, taken on March 6, 2025 (EX1063)

Panel Change Order

Petitioner and Patent Owners' Joint Request for Oral Argument

Patent Owner's Objections to Evidence

Petitioner's Reply to PO Response

Haberman

Wu 2006

809 Patent

Bowles

Samulski Deposition Transcript

Schaffer Deposition Transcript with Errata

224 Patent

922 Publication

552 PCT

Kern

111 Provisional

Maersch

Wang

Schaffer Reply Declaration

Lu

126 Provisional

Petitioner's Notice of Deposition of Dr. Richard Jude Samulski

EX2023 Bartel

EX2024 Jang

EX2025 Schaffer

EX2026 Ojala

EX2027 Samulski Declaration

EX2028 Richard Jude Samulski CV

EX2029 Li

EX2030 Desposition Transcript Schaffer

EX2031 Essential Amino Acids

EX2032 Sequence Alignments

EX2033 Lochrie

EX2034 Opie

EX2035 Zhou

EX2036 Jiang

EX2037 Jagadisan

EX2038 Larrey

EX2039 Conroy

EX2040 Hoffman

EX2041 Gao

EX2042 Jiang

EX2043 A Gene Therapy

Patent Owners Response

ORDER Granting Patent Owner’s Motions for Admission Pro Hac Vice of Dr. Casey M. Kraning and Deanna J. Reichel 37 C.F.R. § 42.10

Joint Stipulation to Modify Due Dates 1-3

Motion for Pro Hac Vice Casey Kraning

Declaration of Casey Kraning

Motion for PHV Deanna Reichel

Declaration of Deanna Reichel

PO Notice of Deposition of Dr. David Schaffer

PATENT OWNER’S OBJECTION TO EVIDENCE

Petitioner Objection to Evidence

Order: Scheduling Order

Granting Institution of Inter Partes Review 35 U.S.C. § 314

Notice : Power of Attorney

Notice : Mandatory Notice

Patent Owner's Preliminary Response

EX2002 Flotte-Gene therapy The first two

EX2003 Gao 2004-Clades of Adeno-Associated Viruses

EX2007 Minskaia 2023

EX2010 Ogden 2019

EX2013 Chao 2000

EX2015 Gao US7198951

EX2016 Xie Figures

EX2017 Cohen 2002

EX2018 Uchino et al

EX2019 Mietzsch-Comparative Analysis

EX2001 Gardlik 2005

EX2004 Gao-Novel adeno-associated

EX2005 Leonard and Berns

EX2006 Grieger and Samulski

EX2008 Arbetman-Novel Caprine Adeno

EX2009 Bowles and Samulski

EX2011 Blake-et-al-2002

EX2012 Grieger_2005

EX2014 Gao US7282199

EX2020 Alignments

Notice : Mandatory Notice

Notice : Power of Attorney

NOTICE OF FILING DATE ACCORDED TO PETITION AND TIME FOR FILING PATENT OWNER PRELIMINARY RESPONSE

U.S. Patent No. 11,680,274 (“the ’274 patent”)

Prosecution history of the ’274 Patent (“the ’274 Prosecution History”)

U.S. Provisional Patent Application No. 60/669,083 (“the ’083 Provisional”)

U.S. Provisional Patent Application No. 60/733,497 (“the ’497 Provisional”)

U.S. Patent Application Publication 2003/0138772 (“the ’772 Publication”)

Xie et al., Proc. Nat’l Acad. Sci., 2002, pp. 10405-10410 (“Xie”)

Snowdy, A dissertation submitted to the faculty of UNC (2003) ("Snowdy")

Fabb et al., Hum. Mol. Gen., 2002, Vol. 11, No. 7, pp. 733-741 (“Fabb")

Opening Expert Report of Paola Leone (Public Excerpts)

Rebuttal Expert Report of Paola Leone (Public Excerpts)

Rebuttal Expert Report of Michael Metzker (Excerpts)

U.S. Patent No. 10,526,617 (“the ’617 patent”)

Declaration of Thomas Hyatt under 37 C.F.R. § 1.68 (“Hyatt Decl.”)

Declaration of Christopher DuBose under 37 C.F.R. § 1.68 (“DuBose Decl.”)

Jans and Jans, Oncogene, 1994, Vol. 9, No. 10, 2961-2968 (“Jans & Jans”)

AAVrh.10/AAVrh.46 Alignment

AAVrh.10/AAV8 Alignment

AAV2/AAVrh.10/AAV8 Alignment

AAVrh.10/AAV8 Phosphorylation Sites

Table Showing Xie Surface Amino Acids (“Xie Surface Table”)

Penn-I Complaint

Penn-II Complaint

Initial Claim Chart

U.S. Patent 9,434,928 (“the ’928 patent”)

Scheduling Order

Kwon and Schaffer, Pharm. Research, 2008, Vol. 25, No. 3, 489-499 (“Kwon")

Kotterman and Schaffer, Nat. Rev., Genetics, 2014, 15, 445-51 ("Kotterman")

Grimm and Kay, Curr. Gene Therapy, 2003, Vol. 3, pp. 281-304 (“Grimm”)

Wu et al., J. Virol., 2000, Vol. 74, No. 18, pp. 8635-8647 (“Wu”)

Blom et al., J. Mol. Biol., 1999, Vol. 294, pp. 1351-1362 (“Blom”)

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Chen et al., Genes & Dev., 1995, Vol. 9, pp. 1586-1597 (“Chen”)

Lange et al., PNAS, 2000, Vol. 97, pp. 1032-1037 (“Lange”)

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Penrose and McBride, J. Virol., 2000, Vol. 74, No. 13, 6031-38 (“Penrose")

Whiteside, Mol. and Cell. Biol., 1995, Vol. 15, 5339-45 (“Whiteside")

Alberts, MOLECULAR BIOLOGY OF THE CELL, 3rd Ed. (Alberts II)

DNA Fact Sheet

Genomic Variation

Central Dogma

Genetic Code

PCR Fact Sheet

Vectors 101

Mandal et al., Faraday Discussions, 2018, Vol. 207, pp. 115-135 (“Mandal”)

Ponnazhagan et al., Cancer Res., 2001, Vol. 61, 6313-21 (“Ponnazhagan”)

Chiorini et al., J. Virol., 1999, Vol. 73, No. 2, 1309-1319 (“Chiorini")

Mori et al., Virology, 2004, Vol. 330, pp. 375-383 (“Mori”)

Hauck and Xiao, J. Virol., 2003, Vol. 77, pp. 2768-2774 (“Hauck”)

Matsushita et al., Gene Therapy, 1998, Vol. 5, pp. 938-945 (“Matsushita”)

Kim et al., J. Biol. Chem., 1999, Vol. 274, pp. 37538–37543 (“Kim”)

U.S. Patent 8,999,678 File History Excerpts

Notice : Power of Attorney

NetPhos/AAVrh.10 Phosphorylation Sites (“NetPhos-AAVrh.10”)

Gene Therapy

Schaffer CV

Alberts, MOLECULAR BIOLOGY OF THE CELL, 3rd Ed. (Alberts I)

Declaration of Dr. David V. Schaffer, 37 C.F.R. § 1.68 (“Schaffer Decl")

Petition : as filed