PreOmics GmbH et al. vs The Brigham and Women’s Hospital, Inc.

Petitioners' Objections to Evidence

Summary of EX1007 (Zaccaria) SBF1 Entry

Summary of EX1007 (Zaccaria) PIK3R4 Entry

Summary of EX1009 (Bryk) SBF1 and PIK3R4 Entries

Alexey I. Nesvizhskii, A Survey of Computational Methods and Error Rate Estimation Procedures for Peptide and Protein

Summary of EX1008 (Hu) LTBP Entry

Summary of EX1007 (Zaccaria) “Other ACs” as alternative to O95248

Summary of EX1007 (Zaccaria) “Other ACs” as alternative to A0JP11

Shidbas Banerjee & Shyamalava Mazumdar, Electrospray Ionization Mass Spectrometry: A Technique to Access the Information Beyond the Molecular Weight of the Analyte, 2012 INT’L J. ANALYTICAL CHEMISTRY, Article ID 282574 1-40 (2012).

Vinzenz Lange et al., Selective reaction monitoring for quantitative proteomics: a tutorial, 4(222) MOLECULAR SYSTEMS BIOLOGY 1-14 (2008)

Dietrich A. Volmer & Lori Lee Jessome, Ion Suppression: A Major Concern in Mass Spectrometry, 24(5) LCGC NORTH AM. 498-510, available at https://www.chromatographyonline.com/view/ion-suppression-major-concern-mass-spectrometry

Jianru Stahl-Zeng et al., High Sensitivity Detection of Plasma Proteins by Multiple Reaction Monitoring of N-Glycosites, 6(10) MOLECULAR & CELLULAR PROTEOMICS 1809-1817 (2007)

Hasmik Keshishian et al., Quantitative, Multiplexed Assays for Low Abundance Proteins in Plasma by Targeted Mass Spectrometry and Stable Isotope Dilution, 6(12) MOLECULAR & CELLULAR PROTEOMICS 2212-2229 (2007)

Gert Lubec & Leila Afjehi-Sadat, Limitations and Pitfalls in Protein Identification by Mass Spectrometry, 107 CHEMICAL REVIEWS 3568-3584 (2007)

Deposition Transcript of Dr. J. Vargas

Declaration of Dr. M. Cima

Curriculum Vitae of Dr. M. Cima

DONALD VOET, JUDITH G. VOET & CHARLOTTE W. PRATT, FUNDAMENTALS OF BIOCHEMISTRY: LIFE AT THE MOLECULAR LEVEL Section 6-4 (2nd ed. 2006)

Henry H. Heng, HeLa Genome Versus Donor’s Genome, 501 NATURE 167 (2013)

Q14766-4, PEPTIDEATLAS, https://db.systemsbiology.net/sbeams/cgi/PeptideAtlas/GetProtein?atlas_build_id=559&protein_name=Q14766-4&action=QUERY (last visited September 21, 2025)

DONALD VOET, JUDITH G. VOET & CHARLOTTE W. PRATT, FUNDAMENTALS OF BIOCHEMISTRY: LIFE AT THE MOLECULAR LEVEL Section 19-1 (2nd ed. 2006)

CRC HANDBOOK OF CHEMISTRY AND PHYSICS: A READY-REFERENCE BOOK OF CHEMICAL AND PHYSICAL DATA, 7-1 (David R. Lide ed., 72nd ed. 1991)

Patent Owner Response

Updated Notice of Deposition of Jessica Vargas, PHD.

Notice of Joint Stipulation to Modify the Scheduling Order

Notice of Deposition of Jessica Vargas, PH.D.

Petitioner's Updated Exhibit List

Patent Owner's Objections to the Institution Decision

Institution Decision: Granting Institution of Inter Partes Review 35 U.S.C. sec. 314

Order: SCHEDULING ORDER

Patent Owner's Updated Mandatory Notices

Patent Owner's Preliminary Response

Marilena Hadjidemetriou et al. - In Vivo Biomolecule Corona around Blood-Circulating

John E. Blume et al., - Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona

Bonislawski 2020 - Seer Closes $55M Funding Round

O Farokhzad LinkedIn

Morteza Mahmoudi, LINKEDIN

Claudia Corbo, LINKEDIN

Unopposed Motion to Withdraw Gina Cremona as Back-Up Counsel

Petitioners Updated Mandatory Notices

Notice : Mandatory Notice

Notice : Power of Attorney

Notice: Notice filing date accorded

Petition : as filed

Notice : Power of Attorney (PREOMICS)

Notice : Power of Attorney (BIOGNOSYS)

U.S. Patent No. 11,435,360

File History of U.S. Patent No. 11,435,360 - Part 1 of 6

File History of U.S. Patent No. 11,435,360 - Part 2 of 6

File History of U.S. Patent No. 11,435,360 - Part 3 of 6

File History of U.S. Patent No. 11,435,360 - Part 4 of 6

File History of U.S. Patent No. 11,435,360 - Part 5 of 6

File History of U.S. Patent No. 11,435,360 - Part 6 of 6

Declaration of Dr. Jessica Vargas

Curriculum Vitae of Dr. Jessica Vargas

Cai (2013)

Walkey (2014)

Zaccaria (2015)

Hu (2014)

Bryk

Hajipour

U.S. Patent No. 10,866,242 to Farokhzad

Declaration of Nancy Adams

Curriculum Vitae of Nancy Adams

Nanjappa (2014)

Ahmed (2009)

Cao (2015)

U.S. Provisional Patent Application No. 62/435,409

Ishihama (2005)

U.S. Patent No. 8,796,184 to Chilkoti

Plasma Proteome Database Website FAQs (Feb 19 2015)

Dean (2005)

Norouzi

NCBI.NLM.NIH Website (Mar. 20, 2014)

Graves (2002)

Berg (2007)

McDonald (2002)

Aebersold (2003)

Yates (2009)

Feist (2015)

Szabo (2015)

Bantscheff (2007)

Harris (2007)