QIAGEN Sciences, LLC v. Tecan Group AG - IPR2025-00029

Patent Owner's Notice of Deposition of Michael L. Metzker, Ph.D.

Patent Owner's Objections to Petitioner's Evidence Submitted with Petitioner's Reply

Patent Owner's Unopposed Notice of Intent to Designate Provisionally Recognized PTAB Attorney Timothy J. Beavers as Back-Up Counsel Under 37 C.F.R. § 42.10

Exhibit 2200 - Declaration of Timothy J. Beavers in Support of Notice of Intent to Designate Provisionally Recognized PTAB Attorney as Back-Up Counsel Under 37 C.F.R. § 42.10

Petitioner's Reply

Ex.1101 - Siebert

Ex.1102 - Green 2010

Ex.1112 - Fradkov

Ex.1116 - Briggs 2009

Ex.1120 - Bustamante Deposition Transcript (10/7)

Ex.1121 - Metzker Declaration ISO Reply

General Order: Related Matters Updates

Notice of Deposition of Carlos Bustamante

Petitioner's Objections to Patent Owner's Supplemental Evidence

Petitioner's Objections to Patent Owner's Evidence

Exhibit 2040- Mullis 1986

Exhibit 2041 - Kanagawa 2003

Exhibit 2042 - Aird 2011

Exhbit 2043 - Chenchik 1996

Exhibit 2044 - Devon 1995

Exhibit 2045 - Padegimas 1998

Exhibit 2046- Arnold 1991

Exhibit 2047- Miura 2005

Exhibit 2048-Tsoktouridis 2005

Exhibit 2049-Bower 2010

Exhibit 2050-Sohn 2011

Exhibit 2051-Almomani 201

Exhibit 2052-Myllykangas 2011

Exhibit 2053-Quail 2008

Exhibit 2054-Kozarewa 2009

Exhibit 2056-Grunenwald 2010

Exhibit 2057-Glenn 2011

Exhibit 2060-Niedringhaus 2011

Exhibit 2063-Irwin 2011

Exhibit 2064-Lange 2010

Exhibit 2065-Barchi 2019

Exhibit 2066-Gnirke 2009

Exhibit 2067-Smith 2021

Exhibit 2068-Scaglione 2019

Exhibit 2069-Benjamino 2021

Exhibit 2071-Quail 2011

Exhibit 2075-Bielas 2013

Exhibit 2082-Nugen Nature

Exhibit 2083-Scolnick 2015

Exhibit 2084-Nugen BioSpace

Exhibit 2085-Allegro V2

Exhibit 2108-Metzker Deposition Day 1

Exhibit 2109-Metzker Deposition Day 2

Exhibit 2110-Glaszmann 2010

Exhibit 2111-Wright 2005

Exhibit 2112-Generational Challenge Program

Exhibit 2113-Park 2009

Exhibit 2114-Kaufmann 2009

Exhibit 2115-Kaufmann 2010

Exhibit 2116-CBOL 2009

Exhibit 2117-Han 2009

Exhibit 2118-Meyer 2009

Exhibit 2119-Barker 2005

Exhibit 2120-Nygaard 2006

Exhibit 2121-Matsuzaki 2004

Exhibit 2122 - Affymetrix Data Sheet 2009

Exhibit 2123 - Jiang 2008

Exhibit 2124 - Dalma-Weiszhausz 2006

Exhibit 2125 - Affymetrix Data Sheet 2007

Exhibit 2126 - Dahl 2005

Exhibit 2127-Benjamin 2005

Exhibit 2128-Zhou 2005

Exhibit 2129-Ronaghi 2005

Exhibit 2130-Howell 2006

Exhibit 2131-Li 2006

Exhibit 2132-Wang 2006

Exhibit 2133-Wang 2006b

Exhibit 2134-Loakes 2007

Exhibit 2135-Morin 2007

Exhibit 2136-Strömqvist Meuzelaar 2007

Exhibit 2137-Zakharova 2008

Exhibit 2138-Bui 2009

Exhibit 2139-Palka-Santini 2009

Exhibit 2140-Jin 2011

Exhibit 2141-Liu 2012

Exhibit 2142-Liu 2024

Exhibit 2143-QIAseq Targeted DNA Panel

Exhibit 2144-QIAseq Targeted RNAscan Panel

Exhibit 2147 - QIAGEN 2018

Exhibit 2148-QIAseq SPE 2018

Exhibit 2149 - QIAGEN NGS 2018

Exhibit 2050-Sohn 2011

Exhibit 2151 - Applied Biosystems 2005

Exhibit 2152-Ammiraju 2008

Exhibit 2153-Porreca 2007

Exhibit 2155-Bronner

Exhibit 2165-Wright Supplemental 2005

Exhibit 2166-Willenbrock 2009

Exhibit 2167-Matsuzaki Supp 2004

Exhibit 2168-Boutrand 2001

Exhibit 2169-Moorthie 2011

Exhibit 2170-DI11 Qiagen Answer

Exhibit 2171 - ’628 Application

Exhibit 2172 - QIAseq Targeted DNA Panels Wayback

Exhibit 2173-Wolfgruber 2009

Exhibit 2174 - Lu Supplement 2008

Exhibit 2175-Bui 2009b

Exhibit 2176-Callow 2004

Exhibit 2177 - Stenberg

Exhibit 2178-Kaur 2018

Exhibit 2179-Kelley

Exhibit 2180 - Shapero References

Exhibit 2107-Declaration of Carlos Bustamante

Exhibit 2146 - QIAGEN 2016

Patent Owner's Response

Patent Owner’s Notice of Deposition of Michael L. Metzker, Ph.D.

Joint Stipulation to Change Due Dates 1, 2, and 3

Order Denying Director Review of Institution Decision

Updated Mandatory Notice

Authorized Response to Director Review Request

Email, Subject_IPR2025-00028 and IPR2025-00029 Director Review Requests

Patent Owner's Objections to Petitioner's Evidence

Petitioner's Objections to Patent Owner's Evidence

Patent Owner's Request for Director Review

Institution Decision: Grant

Order: Scheduling Order

Patent Owner's Preliminary Response

Exhibit 2001 - Affymetrix SNP Array 6.0

Exhibit 2002 - Introduction to Affymetrix Microarrays

Exhibit 2003 - Microarray Affymetrix Chips

Exhibit 2004 - Dalma-Weiszhausz 2006

Exhibit 2005 - Evans 2009

Exhibit 2006 - NHGRI 2021

Exhibit 2007 - Goodwin 2016

Exhibit 2008 - Mardis 2017

Exhibit 2009 - Ernani 2009

Exhibit 2010 - Milbury 2009

Exhibit 2011 - Mamanova 2011

Exhibit 2012 - Treangen 2012

Exhibit 2013 - Shokralla 2012

Exhibit 2014 - QIAGEN 2010

Exhibit 2015 - Han 2006

Exhibit 2016 - Matz 1999

Exhibit 2017 - Bru 2008

Exhibit 2018 - Bustin 2005

Exhibit 2019 - Duncavage 2011

Exhibit 2020 - Brownie 1997

Exhibit 2021 - Mertes 2011

Exhibit 2022 - Shen 2010

Exhibit 2023 - Deutsche 2011

Exhibit 2024 - Tewhey 2009

Exhibit 2025 - ’768 Prosecution History

Exhibit 2026 - ’785 Prosecution History

Exhibit 2027 - ’340 Prosecution History

Exhibit 2028 - Declaration of Carlos D. Bustamente, Ph.D.

Exhibit 2029 - Garber 2008

Exhibit 2030 - Illumina 2014

Exhibit 2031 - Matsuzaki 2004

Exhibit 2032 - Risen 2021

Exhibit 2033 - Affymetrix Assay Kit

Exhibit 2034 - Nature 2007

Exhibit 2035 - Kennedy 2003

Notice: Notice filing date accorded

Notice : Mandatory Notice

Notice : Power of Attorney

Notice : Power of Attorney

U.S. Patent No. 10,876,108

Curriculum vitae of Dr. Michael Metzker, Ph.D.

Expert Declaration of Sylvia Hall-Ellis, Ph.D.

Shapero (2004)

Delseny (2010)

U.S. Patent No. 10,036,012 (the “’012 patent”)

U.S. Patent No. 9,650,628 (the “’628 patent”)

U.S. Patent Publication No. 2005/0142577 (“Jones”)

Syvänen (2001)

Tucker (2009)

Metzker (2005)

Metzker (2006)

Sanger (1977)

Ju (1995)

Mardis (1999)

Smith (1986)

Prober (1987)

Gibbs (1990)

Bentley (2008)

Rothberg (2011)

Technology Spotlight: Illumina Sequencing, Illumina, Inc. (2010)

Metzker (2010)

Saiki (1985)

Saiki (1988)

Gibbs (1989)

Newton (1989)

Chamberlain (1988)

Grompe (1993)

Jain (2015)

Hamady (2009)

Asserted Patents and Claim Charts from Related Litigation

TruSeq RNA and DNA Sample Preparation Kits, Illumina, Inc. (2010)

Illumina (2008)

Ion Torrent Amplicon Sequencing, Life Technologies, Corp. (2011)

Mamanova (2010)

Turner (2009)

Edwards (1994)

Ewing (1998a)

Ewing (1998b)

European Patent Application No. 0 356 021

Siebert (1995)

U.S. Patent No. 5,565,340

Albert (2007)

Hodges (2007)

Gnirke (2009)

Porreca (2007)

Krishnakumar (2008)

Tewhey (2009)

U.S. Patent No. 7,741,463 ("Gormley")

Turner (2009b)

Prosecution History of U.S. Patent No. 10,876,108 (Part 1/8)

Prosecution History of U.S. Patent No. 10,876,108 (Part 2/8)

Prosecution History of U.S. Patent No. 10,876,108 (Part 3/8)

Prosecution History of U.S. Patent No. 10,876,108 (Part 4/8)

Prosecution History of U.S. Patent No. 10,876,108 (Part 5/8)

Prosecution History of U.S. Patent No. 10,876,108 (Part 6/8)

Prosecution History of U.S. Patent No. 10,876,108 (Part 7/8)

Prosecution History of U.S. Patent No. 10,876,108 (Part 8/8)

Quail (2009)

Rozen (2000)

Petition : as filed

Declaration of Michael L. Metzker, Ph.D.