Embody, Inc. et al. v. LifeNet Health - IPR2025-00249

Patent Owner's Response

Declaration of Dr. Antonios G. Mikos, Ph.D. in Support of Patent Owner’s Response

Curriculum Vitae of Dr. Antonios G. Mikos, Ph.D.

Transcript of October 7, 2025 Deposition of Dr. David Simpson

Woodruff et al., The return of a forgotten polymer- Polycaprolactone in the 21st century, 35 Progress in Polymer Science 1217-1256 (2010)

Zeugolis et al., Electro-spinning of pure collagen nano-fibres — Just an expensive way to make gelatin?, 29 Biomaterials 2293- 2305 (2008)

Barnes et al., Cross-Linking Electrospun Type II Collagen Tissue Engineering Scaffolds with Carbodiimide in Ethanol, Tissue Engineering (Vol. 13) 1593-1605 (2007)

Rothamel et al., Biodegradation of differently crosslinked collagen membranes: an experimental study in the rat, 16 Clin. Oral Impl. Res. 369-378 (2005)

U.S. Patent No. 9,572,909 to Simpson, et al.

Sikavitsas, et al., Formation of three-dimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor, J. Biomed. Mater. Res., 62, 136- 148 (2002)

Engler, et al., Matrix elasticity directs stem cell lineage specification, Cell 126, 677-689 (2006)

Gennison, et al., Human muscle hardness assessment during incremental isometric contraction using transient elastography, 38 J. Biomechanics, 1543-1550 (2005)

Johnson, et al., Tensile and Viscoelastic Properties of Human Patellar Tendon, J. of Orthopaedic Research, 796-803 (1994)

Hashemi, et al., The mechanical properties of human patellar tendon are correlated to its mass density and are independent of sex, 20 Chemical Biomechanics, 645-652 (2005)

Butler, et al., Comparison of Material Properties in Fascicle-Bone Unites from Human Patellar Tendon and Knee Ligaments, 19 J. Biomechanics, 425-432 (1986)

Butler, et al., Location-Dependent Variations in the Material Properties of the Anterior Cruciate Ligament, 25 J. Biomechanics, 511-518 (1992)

Ma, et al., In vitro and in vivo mechanical properties of human ulnar and median nerves, J Biomed Mater Res Part A 2013:101A:2718–2725

Ni Annaidh, et al., Characterization of the anisotropic mechanical properties of excised human skin, J. Mech. Behavior of Biomedical Materials, 139-148 (2012)

Attorney’s Illustrated Medical Dictionary (1997) – “sheet”

Dorland’s Illustrated Medical Dictionary (29th ed. 2000) – “sheet”

Crisan, et al., A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs, Cell Stem Cell 3, 301-313 (2008)

Lustig, et al., Solute Diffusion in Swollen Membranes, IX. Scaling Laws for Solute Diffusion in Gels, 36 J. Applied Polymer Science, 735-747 (1988)

General Order: Related Matters Updates

ORDER Granting-in-Part and Denying-in-Part Patent Owner’s Motion for Additional Discovery 37 C.F.R. § 42.51(b)(2)

Patent Owner's Notice of Deposition

Patent Owner's Updated Mandatory Notices

Patent Owner's Power of Attorney

Petitioners' Opposition to Patent Owner's Request for Additional Discovery

EX1100 Answer and Affirmative Defenses - 23-cv-479 (E.D. Va.)

EX1101 Zimmer Biomet Patent Marking

Patent Owner's Motion for Additional Discovery

First Amended Complaint

Exhibit N to the First Amended Complaint

Exhibit O to the First Amended Complaint

Patent Owner’s Proposed Discovery Requests

Webpage, Tapestry® Biointegrative Implant

Webpage, Tapestry® RC Biointegrative Implant System

Webpage, ActivBraid® Collagen Co-Braid

Presentation by Jeff Conroy, CEO, Embody, LSI USA '22 Emerging Medtech Summit

Press Release dated January 5, 2023, "Zimmer Biomet to Acquire Embody, Inc."

Webpage, Wayback Machine, Our Technology - Embody

Order: Conduct of the Proceeding - Authorizing Motion for Additional Discovery - 37 CFR 42.5, 42.51(b)(2)

Ex. 3103

Institution Decision: DECISION Granting Institution of Inter Partes Review 35 U.S.C. § 314, 37 C.F.R. § 42.4

Order: SCHEDULING ORDER

Director Discretionary Decision: Refer

Sur-Reply to Patent Owner’s Request for Discretionary Denial

Patent Owner's Discretionary Denial Reply

Email Correspondence

Email Correspondence

Opposition to Patent Owner's Request for Discretionary Denial

Patent Owner's Preliminary Response

Ex. 2003 - Dorland’s Illustrated Medical Dictionary (29th ed. 2000) – "progenitor"

Ex. 2004 - Dorland’s Illustrated Medical Dictionary (29th ed. 2000) – "stem c[ell]"

PO Discretionary Denial Brief

Ex. 2001, Simpson

Ex. 2002, Patel

Notice: Extending Deadline for Discretion Briefing

Notice: Notice filing date accorded

Notice: Mandatory Notice

Notice: Power of Attorney

EX1002 - ’227 Patent Prosecution History (Part 1 of 2)

EX1002 - ’227 Patent Prosecution History (Part 2 of 2)

EX1005 - Huang2

EX1004 - CV of David G. Simpson, Ph.D.

EX1006 - Kumbar

EX1007 - '223 Patent Prosecution History (Part 1 of 2)

EX1007 - '223 Patent Prosecution History (Part 2 of 2)

EX1008 - Huang1

EX1009 - U.S. Patent App. Pub. No. 2004/0037813

EX1010 - Ayres 2008

EX1011 - Lee, U.S. Patent Application No. US 2010/0331980 A1

EX1013 - Ayres 2006

EX1015 - Jose

EX1016 - Fu

EX1018 - U.S. Patent Application No. US 2011/0293685 A1

EX1019 - Beachley

EX1020 - Declaration of Emma Xu

EX1021 - U.S. Provisional Patent App. No. 61/0255,35

EX1022 - McClure

EX1023 - Meinel

EX1024 - Vidal Memo

EX1001 - U.S. Patent No. 11,318,227

EX1003 - Declaration of David G. Simpson, Ph.D.

Notice : Power of Attorney

Petition : as filed