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U.S. Patent No. 10,793,916 | Aug 15, 2025 | EXHIBIT | PETITIONER |
Prosecution history for the ’916 patent (1 of 3) | Aug 15, 2025 | EXHIBIT | PETITIONER |
Prosecution history for the ’916 patent (2 of 3) | Aug 15, 2025 | EXHIBIT | PETITIONER |
Prosecution history for the ’916 patent (3 of 3) | Aug 15, 2025 | EXHIBIT | PETITIONER |
Declaration of Michael Metzker, Ph.D. | Aug 15, 2025 | EXHIBIT | PETITIONER |
Curriculum Vitae of Michael Metzker, Ph.D. | Aug 15, 2025 | EXHIBIT | PETITIONER |
U.S. Patent No. 9,752,188 (“Schmitt”) | Aug 15, 2025 | EXHIBIT | PETITIONER |
PCT Publication No. WO 2012142213 A2 (“Vogelstein”) | Aug 15, 2025 | EXHIBIT | PETITIONER |
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PCT Publication No. WO 2012/099832 A2 (“Hendricks”) | Aug 15, 2025 | EXHIBIT | PETITIONER |
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U.S. Patent Publication No. 2012/0316074 A1 (“Saxonov”) | Aug 15, 2025 | EXHIBIT | PETITIONER |
Schwarzenbach et al., Cell-free nucleic acids as biomarkers in cancer patie | Aug 15, 2025 | EXHIBIT | PETITIONER |
Human genome variation, fact sheet, National Human Genome Research Institut | Aug 15, 2025 | EXHIBIT | PETITIONER |
Guardant Health, Inc. v. Foundation Medicine, IPR2017-01448, Paper 2 – Peti | Aug 15, 2025 | EXHIBIT | PETITIONER |
Metzker, Sequencing technologies — the next generation, NATURE REVIEWS GENE | Aug 15, 2025 | EXHIBIT | PETITIONER |
Guardant Health, Inc. v. University of Washington, IPR2022-00816, Paper 3 – | Aug 15, 2025 | EXHIBIT | PETITIONER |
Metzker & Caskey, Polymerase Chain Reaction, In ENCYCLOPEDIA OF MEDICAL DEV | Aug 15, 2025 | EXHIBIT | PETITIONER |
Mamanova et al., Target-enrichment strategies for next-generation sequencin | Aug 15, 2025 | EXHIBIT | PETITIONER |
Guardant Health, Inc. v. University of Washington, IPR2022-00450, Paper 3 – | Aug 15, 2025 | EXHIBIT | PETITIONER |
Guardant Health, Inc. v. University of Washington, IPR2022-01388, Paper 2 – | Aug 15, 2025 | EXHIBIT | PETITIONER |
Guardant Health, Inc. v. University of Washington, IPR2022-00935, Paper 2 – | Aug 15, 2025 | EXHIBIT | PETITIONER |
U.S. Provisional Patent Application No. 61/600535 (“Diehn Provisional”) | Aug 15, 2025 | EXHIBIT | PETITIONER |
Twinstrand Biosciences, Inc. v. Guardant Health, Inc., IPR2022-01400, Paper | Aug 15, 2025 | EXHIBIT | PETITIONER |
Twinstrand Biosciences, Inc. v. Guardant Health, Inc., IPR2022-01400, Paper | Aug 15, 2025 | EXHIBIT | PETITIONER |
Twinstrand Biosciences, Inc. v. Guardant Health, Inc., IPR2022-01400, Paper | Aug 15, 2025 | EXHIBIT | PETITIONER |
Li et al., Structure-independent and quantitative ligation of single-strand | Aug 15, 2025 | EXHIBIT | PETITIONER |
U.S. Patent No. 9,085,798 (“Chee”) | Aug 15, 2025 | EXHIBIT | PETITIONER |
Thomas et al., Sensitive mutation detection in heterogeneous cancer specime | Aug 15, 2025 | EXHIBIT | PETITIONER |
Buckingham, Chromosomal structure and chromosomal mutations, In MOLECULAR D | Aug 15, 2025 | EXHIBIT | PETITIONER |
Gemayel et al., Variable tandem repeats accelerate evolution of coding and | Aug 15, 2025 | EXHIBIT | PETITIONER |
Tóth et al., Microsatellites in different eukaryotic genomes: Survey and an | Aug 15, 2025 | EXHIBIT | PETITIONER |
Laghi et al., Differences and evolution of the methods for the assessment o | Aug 15, 2025 | EXHIBIT | PETITIONER |
Richard & Pâques, Mini- and microsatellite expansions: the recombination co | Aug 15, 2025 | EXHIBIT | PETITIONER |
Hastings et al., Mechanisms of change in gene copy number, NATURE REVIEWS G | Aug 15, 2025 | EXHIBIT | PETITIONER |
Hiatt et al., Single molecule molecular inversion probes for targeted, high | Aug 15, 2025 | EXHIBIT | PETITIONER |
Somatic & germline mutations, https://my.clevelandclinic.org/health/body/23 | Aug 15, 2025 | EXHIBIT | PETITIONER |
Gene changes and cancer, https://www.cancer.org/cancer/understanding-cancer | Aug 15, 2025 | EXHIBIT | PETITIONER |
International Human Genome Sequencing Consortium, Initial sequencing and an | Aug 15, 2025 | EXHIBIT | PETITIONER |
International Human Genome Sequencing Consortium, Finishing the euchromatic | Aug 15, 2025 | EXHIBIT | PETITIONER |
Forbes, et al., COSMIC: mining complete cancer genomes in the Catalogue of | Aug 15, 2025 | EXHIBIT | PETITIONER |
Genomic Data Commons Data Portal, https://portal.gdc.cancer.gov/ ((last vis | Aug 15, 2025 | EXHIBIT | PETITIONER |
Metzker, Emerging technologies in DNA sequencing, GENOME RESEARCH 15:1767–1 | Aug 15, 2025 | EXHIBIT | PETITIONER |
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Kinde et al., Detection and quantification of rare mutations with massively | Aug 15, 2025 | EXHIBIT | PETITIONER |
Turner et al., Methods for genomic partitioning, ANNUAL REVIEW OF GENOMICS | Aug 15, 2025 | EXHIBIT | PETITIONER |
Edwards & Gibbs, Multiplex PCR: Advantages, development, and applications, | Aug 15, 2025 | EXHIBIT | PETITIONER |
Sharma et al., (TG/CA)n repeats in human gene families: abundance and selec | Aug 15, 2025 | EXHIBIT | PETITIONER |
Gnirke et al., Solution hybrid selection with ultra-long oligonucleotides f | Aug 15, 2025 | EXHIBIT | PETITIONER |
Meyerson et al., Advances in understanding cancer genomes through second-ge | Aug 15, 2025 | EXHIBIT | PETITIONER |
Preston et al., Innovation at Illumina: The road to the $600 human genome, | Aug 15, 2025 | EXHIBIT | PETITIONER |
Bentley et al., Accurate whole human genome sequencing using reversible ter | Aug 15, 2025 | EXHIBIT | PETITIONER |
Kircher et al., Double indexing overcomes inaccuracies in multiplex sequenc | Aug 15, 2025 | EXHIBIT | PETITIONER |
Pierce et al., A unique and universal molecular barcode array, NATURE METHO | Aug 15, 2025 | EXHIBIT | PETITIONER |
Schmitt et al., Detection of ultra-rare mutations by next-generation sequen | Aug 15, 2025 | EXHIBIT | PETITIONER |
Glenn, Field guide to next-generation DNA sequencers, MOLECULAR ECOLOGY RES | Aug 15, 2025 | EXHIBIT | PETITIONER |
Cock et al., The Sanger FASTQ file format for sequences with quality scores | Aug 15, 2025 | EXHIBIT | PETITIONER |
CASAVA 1.8: enhanced variant calling in whole-genome resequencing data (201 | Aug 15, 2025 | EXHIBIT | PETITIONER |
Li et al., Mapping short DNA sequencing reads and calling variants using ma | Aug 15, 2025 | EXHIBIT | PETITIONER |
Li & Durbin, Fast and accurate short read alignment with Burrows–Wheeler tr | Aug 15, 2025 | EXHIBIT | PETITIONER |
Li & Durbin, Fast and accurate long-read alignment with Burrows–Wheeler tra | Aug 15, 2025 | EXHIBIT | PETITIONER |
Langmead et al., Ultrafast and memory-efficient alignment of short DNA sequ | Aug 15, 2025 | EXHIBIT | PETITIONER |
Li et al., The sequence alignment/map format and SAMtools, BIOINFORMATICS 2 | Aug 15, 2025 | EXHIBIT | PETITIONER |
DePristo et al., A framework for variation discovery and genotyping using n | Aug 15, 2025 | EXHIBIT | PETITIONER |
McKenna et al., The Genome Analysis Toolkit: A MapReduce framework for anal | Aug 15, 2025 | EXHIBIT | PETITIONER |
https://github.com/broadinstitute/gatk/releases (last visited Aug 11, 2025) | Aug 15, 2025 | EXHIBIT | PETITIONER |
Koboldt et al., VarScan: variant detection in massively parallel sequencing | Aug 15, 2025 | EXHIBIT | PETITIONER |
Koboldt et al., VarScan 2: Somatic mutation and copy number alteration disc | Aug 15, 2025 | EXHIBIT | PETITIONER |
Cibulskis et al., Sensitive detection of somatic point mutations in impure | Aug 15, 2025 | EXHIBIT | PETITIONER |
U.S. Patent No. 9,840,743 | Aug 15, 2025 | EXHIBIT | PETITIONER |
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U.S. Patent Publication No. 2010/0264331 (“Sacko”) | Aug 15, 2025 | EXHIBIT | PETITIONER |
M. van Lier, et al., A review on the molecular diagnostics of Lynch syndrom | Aug 15, 2025 | EXHIBIT | PETITIONER |
C. Boland and A. Goel, Microsatellite Instability in Colorectal Cancer, GAS | Aug 15, 2025 | EXHIBIT | PETITIONER |
C. Boland, et al., A National Cancer Institute Workshop on Microsatellite I | Aug 15, 2025 | EXHIBIT | PETITIONER |
F. Sinicrope and D. Sargent, Clinical implications of microsatellite instab | Aug 15, 2025 | EXHIBIT | PETITIONER |
G. Li, Mechanisms and functions of DNA mismatch repair, CELL RESEARCH 18 (2 | Aug 15, 2025 | EXHIBIT | PETITIONER |
U.S. Provisional Application 61/613,413 (“Schmitt '413 provisional”) | Aug 15, 2025 | EXHIBIT | PETITIONER |
Foundation Medicine, Inc. v. Guardant Health, Inc., IPR2019-00652, Paper 47 | Aug 15, 2025 | EXHIBIT | PETITIONER |
Foundation Medicine, Inc. v. Guardant Health, Inc., IPR2019-00652, Paper 54 | Aug 15, 2025 | EXHIBIT | PETITIONER |
Foundation Medicine, Inc. v. Guardant Health, Inc., IPR2019-00652, Paper 12 | Aug 15, 2025 | EXHIBIT | PETITIONER |
Hall-Ellis Declaration | Aug 15, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application Publication No. 2014/0296081 (“Diehn”) | Aug 15, 2025 | EXHIBIT | PETITIONER |
Petition: as filed | Aug 15, 2025 | PAPER | PETITIONER |