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U.S. Patent No. 11,058,757 (“the ’757 Patent”)

Declaration of Dr. Dennis Kasper

Curriculum Vitae of Dr. Dennis Kasper

Prosecution History of the ’757 Patent (Part 1 of 3)

Prosecution History of the ’757 Patent (Part 2 of 3)

Prosecution History of the ’757 Patent (Part 3 of 3)

International Publication No. WO 2014/118201 (“Porro”)

International Publication No. WO 2017/011338 (“Mekalanos”)

U.S. Patent No. 8,808,707 (“Siber”)

International Publication No. WO 2016/149771 (“Babb”)

International Publication No. WO 2016/207905 (“Matur”)

International Publication No. WO 2015/121783 (“Gu”)

Plotkin, Vaccines (6th ed. 2013)

Nahm, Pneumococcal Capsules, 28 Clin. Microbiol. Rev. 871 (2015)

Mekalanos Provisional Application No. 62/191,028

Mekalanos Redline with Provisional

Prosecution History of U.S. Application No. 17/347,435 (Part 1 of 4)

Prosecution History of U.S. Application No. 17/347,435 (Part 2 of 4)

Prosecution History of U.S. Application No. 17/347,435 (Part 3 of 4)

Prosecution History of U.S. Application No. 17/347,435 (Part 4 of 4)

PDR 2011 Prevnar 13, Physicians' Desk Reference (65th ed. 2011)

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International Publication No. WO 2006/065137 (“Nierop”)

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Payton, Lyophilized Vaccine Development, Practical Aspects (2022)

Lesinski, Novel Vaccine Strategies, 47 J. Microbiol. Methods (2001)

Mekalanos Claim Comparison with Provisional

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PDR 1990 Pneumovax 23, Physicians' Desk Reference (44th ed. 1990)

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