Judgment Final Written Decision
Determining All Challenged Claims Unpatentable | Apr 14, 2020 | PAPER | BOARD |
Ex. 2079 Board email authorizing corrected transcript | Mar 26, 2020 | EXHIBIT | PATENT OWNER |
Corrected Hearing Transcript | Mar 26, 2020 | PAPER | PATENT OWNER |
Patent Owner Third Updated Exhibit List | Mar 26, 2020 | PAPER | PATENT OWNER |
Hearing Transcript | Mar 11, 2020 | PAPER | BOARD |
Petitioner Objections to PO's Demonstratives | Jan 13, 2020 | PAPER | PETITIONER |
Patent Owner's Reply in support of Motion to Exclude Evidence | Jan 10, 2020 | PAPER | PATENT OWNER |
Denying Patent Owner's Request on Rehearing of Decision Granting Institution
37 C.F.R. 42.71(d) | Jan 9, 2020 | PAPER | BOARD |
Petitioner's Opposition to Patent Owner's Motion to Exclude | Jan 3, 2020 | PAPER | PETITIONER |
Ex. 1060 - Gillis Declaration | Jan 3, 2020 | EXHIBIT | PETITIONER |
Ex. 1061 - EMSO | Jan 3, 2020 | EXHIBIT | PETITIONER |
Order - Oral Hearing - 37 CFR 42.70 | Dec 27, 2019 | PAPER | BOARD |
Patent Owner's Motion to Exclude Evidence | Dec 24, 2019 | PAPER | PATENT OWNER |
Patent Owner Sur-Reply | Dec 17, 2019 | PAPER | PATENT OWNER |
Patent Owner Second Updated Exhibit List | Dec 17, 2019 | PAPER | PATENT OWNER |
Ex. 2078 Transcript of Second Deposition of Jonathan Braun M.D., Ph.D. | Dec 17, 2019 | EXHIBIT | PATENT OWNER |
Patent Owner's Request for Oral Argument | Dec 3, 2019 | PAPER | PATENT OWNER |
Petitioner Request for Oral Hearing | Dec 3, 2019 | PAPER | PETITIONER |
PANEL CHANGE ORDER
Conduct of the Proceedings
37 C.F.R. ¿¿ 42.5 | Nov 25, 2019 | PAPER | BOARD |
Patent Owner's Objections to Reply Evidence | Nov 18, 2019 | PAPER | PATENT OWNER |
Exhibit 1050 - Uccello | Nov 12, 2019 | EXHIBIT | PETITIONER |
Exhibit 1052 - Boopathy | Nov 12, 2019 | EXHIBIT | PETITIONER |
Exhibit 1054 - Yin | Nov 12, 2019 | EXHIBIT | PETITIONER |
Exhibit 1055 - Jain | Nov 12, 2019 | EXHIBIT | PETITIONER |
Exhibit 1056 - Brook | Nov 12, 2019 | EXHIBIT | PETITIONER |
Exhibit 1057 - Weber | Nov 12, 2019 | EXHIBIT | PETITIONER |
Exhibit 1058 - Cheroutre | Nov 12, 2019 | EXHIBIT | PETITIONER |
Exhibit 1059 - Schultz Declaration | Nov 12, 2019 | EXHIBIT | PETITIONER |
Exhibit 1051 - Zhang | Nov 12, 2019 | EXHIBIT | PETITIONER |
Exhibit 1053 - Bouhnik | Nov 12, 2019 | EXHIBIT | PETITIONER |
Patent Owner's Notice of 2nd Deposition of Jonathan Braun, M.D., Ph.D | Nov 12, 2019 | PAPER | PATENT OWNER |
Petitioner's Power of Attorney | Nov 11, 2019 | PAPER | PETITIONER |
Exhibit 1042 - Mani Deposition Transcript | Nov 11, 2019 | EXHIBIT | PETITIONER |
Exhibit 1043 - Second Braun Declaration | Nov 11, 2019 | EXHIBIT | PETITIONER |
Exhibit 1046 - Dunn | Nov 11, 2019 | EXHIBIT | PETITIONER |
Petitioner's Supplemental Mandatory Notices | Nov 11, 2019 | PAPER | PETITIONER |
Petitioner Reply | Nov 11, 2019 | PAPER | PETITIONER |
Exhibit 1041 - Fares | Nov 11, 2019 | EXHIBIT | PETITIONER |
Exhibit 1044 - Sanchez | Nov 11, 2019 | EXHIBIT | PETITIONER |
Exhibit 1045 - Ridaura | Nov 11, 2019 | EXHIBIT | PETITIONER |
Exhibit 1047 - Blanco | Nov 11, 2019 | EXHIBIT | PETITIONER |
Exhibit 1048 - Maleki | Nov 11, 2019 | EXHIBIT | PETITIONER |
Exhibit 1049 - DiLuccia | Nov 11, 2019 | EXHIBIT | PETITIONER |
Second Joint Notice of Stipulation to Adjust Schedule | Nov 4, 2019 | PAPER | PATENT OWNER |
Petitioner's Notice of Deposition of Sridhar Mani, M.D. | Sep 4, 2019 | PAPER | PETITIONER |
ORDER - Denial of POP Request | Aug 19, 2019 | PAPER | BOARD |
Ex. 2008 Zou 2008.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2010 Megaraj 2014.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2012 Woo 2012.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2013 Brignone 2009.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Declaration of Sridhar Mani, M.D. | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2009 Romagne 2009.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2011 Kohrt 2014.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2016 Beavis 2013.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2017 Derre 2010.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2018 Loo 2012.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2023 Bahig 2019.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2029 Alexandrov 2013.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2030 Schumacher 2015.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2031 Vesely 2013.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2032 Brown 2014.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2034 Shih 2014.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2036 Mellman 2011.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2037 Berger 2008.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2038 Sampson 2015.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2041 Lesokhin 2014.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2043 Hamanishi 2014.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2045 Seiwert 2015.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2051 Garon 2014.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2053 Hamid 2013.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2014 Le Mercier 2014.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2015 Sakuishi 2010.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2019 Curran 2010.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2020 Wolchok 2013.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2021 Das 2015.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2022 O'Reilly 2019.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2024 Butterfield 2004.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2025 Vogelstein 2013.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2026 Segal 2008.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2027 Coulie 2014.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2028 Blankenstein 2013.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2033 Transcript of Deposition of Jonathan Braun, M.D., Ph.D..pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2035 Sharma 2015.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2039 Schaff 2014.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2040 Le 2013.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2042 Slovin 2013.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2044 El-Khoueiry 2015.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2046 Segal 2015.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2047 Le 2015 S3.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2048 Antonia 2015.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2049 Powles 2014.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2050 Antonia 2013.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2052 Hodi 2010.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2056 Herbst 2014.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2058 Nobel Prize Announcement 2019 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2062 Topalian 2012 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2063 McDermott 2013 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2066 Dinarello 2007 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2069 Perse 2011 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2073 Skelly 2011 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2074 Peng 2011 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Patent Owner Updated Exhibit List | Aug 1, 2019 | PAPER | PATENT OWNER |
Ex. 2054 Kefford 2014.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2055 Ansell 2015.pdf | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2057 OPDIVO product label 2015 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2059 Fu 2013 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2060 Catt 2011 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2061 Lipson 2013 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2064 Robert 2015 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2065 Mesoscale 2019 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2067 Cavaillon 2001 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2068 Legendre 2010 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2070 Hirayama 1990 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2071 Hansen 2014 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2072 Lawley 2012 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2075 Pulverer 2014 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2076 Uvardi 2008 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Ex. 2077 Detre 1995 | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Patent Owner Updated Mandatory Notices | Aug 1, 2019 | PAPER | PATENT OWNER |
Appendix A to Declaration of Sridhar Mani, M.D. | Aug 1, 2019 | EXHIBIT | PATENT OWNER |
Patent Owner Response | Aug 1, 2019 | PAPER | PATENT OWNER |
Patent Owner's Notice of Deposition of Jonathan G. Braun, MD, PhD | Jun 5, 2019 | PAPER | PATENT OWNER |
Joint Notice of Stipulation to Adjust Schedule and Request to Correct Due Dates 6-8 | May 15, 2019 | PAPER | PATENT OWNER |
Ex. 3001 | May 2, 2019 | EXHIBIT | BOARD |
Notification of POP Request | May 2, 2019 | PAPER | BOARD |
Patent Owner's Objections to Evidence | Apr 29, 2019 | PAPER | PATENT OWNER |
Patent Owner Request for Rehearing | Apr 29, 2019 | PAPER | PATENT OWNER |
Scheduling Order | Apr 15, 2019 | PAPER | BOARD |
Trial Instituted Document | Apr 15, 2019 | PAPER | BOARD |
Ex 2002 - Rodes et al. 2014 | Jan 16, 2019 | EXHIBIT | PATENT OWNER |
Ex 2004 - Menard 2008 | Jan 16, 2019 | EXHIBIT | PATENT OWNER |
Ex 2005 - Sivan et al. 2015 | Jan 16, 2019 | EXHIBIT | PATENT OWNER |
Ex 2006 - Scopus citation review | Jan 16, 2019 | EXHIBIT | PATENT OWNER |
Patent Owner Preliminary Response | Jan 16, 2019 | PAPER | PATENT OWNER |
Patent Owner's Exhibit List | Jan 16, 2019 | PAPER | PATENT OWNER |
Ex 2001 - Kim et al. 2013 | Jan 16, 2019 | EXHIBIT | PATENT OWNER |
Ex 2003 - Garrido et al. 2013 | Jan 16, 2019 | EXHIBIT | PATENT OWNER |
Patent Owner's Mandatory Notices | Oct 23, 2018 | PAPER | PATENT OWNER |
Patent Owner's Power of Attorney | Oct 23, 2018 | PAPER | PATENT OWNER |
NOTICE OF FILING DATE ACCORDED TO PETITION
AND TIME FOR FILING PATENT OWNER PRELIMINARY RESPONSE | Oct 17, 2018 | PAPER | BOARD |
U.S. Patent No. 9,855,302 | Oct 2, 2018 | EXHIBIT | PETITIONER |
U.S. Publication No. 2009/027401 to Korman et al. | Oct 2, 2018 | EXHIBIT | PETITIONER |
Jagveer Singh et al., Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulated the intermediate biomarkers of colon carcinogenesis, Carcinogenesis (1997) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Suzanne L. Topalian et al., Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab, Journal of Clinical Oncology (Apr. 1, 2014) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Ping Dong et al., The role of intestinal Bifidobacteria on immune system development in young rats, Early Human Development (2010) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Yoshinori Kohwi et al., Antitumor effect of Bifidobacterium Infantis in Mice, Gann (Oct. 1978) | Oct 2, 2018 | EXHIBIT | PETITIONER |
U.S. Publication No. 2010/0028449 to Prakash et al. | Oct 2, 2018 | EXHIBIT | PETITIONER |
D. van der Waaij et al., The Influence of antibiotics on gut colonization, Journal of Antimicrobial Chemotherapy (1986) | Oct 2, 2018 | EXHIBIT | PETITIONER |
U.S. Provisional Patent Application No. 62/248,741 | Oct 2, 2018 | EXHIBIT | PETITIONER |
File History of U.S. Patent No. 9,855,302 (Part 1) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Dheeraj Mohania et al., Modulation of expression of Programmed Death-1 by administration of probiotic Dahi in DMH-induced colorectal carcinogenesis in rats, Acta Biomed (2013) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Do Kyung Lee et al., Anti-proliferative effects of Bifidobacterium adolescentis SPM0212 extract on human colon cancer cell lines, BMC Cancer, (Oct. 2008) | Oct 2, 2018 | EXHIBIT | PETITIONER |
U.S. Provisional Patent Application No. 62/169,112 | Oct 2, 2018 | EXHIBIT | PETITIONER |
File History of U.S. Patent Application No. 15/718,735 | Oct 2, 2018 | EXHIBIT | PETITIONER |
U.S. Publication No. 2012/0276143 to O¿¿¿Mahony et al. | Oct 2, 2018 | EXHIBIT | PETITIONER |
U.S. Publication No. 2007/0258953 to Duncan et al. | Oct 2, 2018 | EXHIBIT | PETITIONER |
Shashank Kumar et al., Drug Targets for Cancer Treatment: An Overview, Medicinal Chemistry (2015) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Targeted Cancer Therapies, National Cancer Institute, https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-factsheet | Oct 2, 2018 | EXHIBIT | PETITIONER |
Andrew M. Scott et al., Monoclonal antibodies in cancer therapy, Cancer Immunity Commentary (May 1, 2012) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Joseph A. DiMasi et al., Economics of New Oncology Drug Development, Journal of Clinical Oncology (Jan. 10, 2007) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Naiyer A. Rizvi et al., Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer, Science (2015) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Julie R. Brahmer et al., Phase I Study-Agent Anti-Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates, Journal of Clinical Oncology (July 1, 2010) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Jocelyn Kaiser, Why a powerful cancer drug only helps some patients, Science(Mar. 12, 2015) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Kenya Honda et al., The Microbiome in Infection Disease and Inflammation, Annual Review of Immunology (2012) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Paul B. Eckburg et al., Diversity of the human intestinal microbial flora, Science (June 10, 2005) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Patricia Lopez et al., Distinct Bifidobacterium strains drive different immune responses in vitro, International Journal of Food Microbiology (2010) | Oct 2, 2018 | EXHIBIT | PETITIONER |
U.S. Publication No. 2008/0193373 to Stritzker et al. | Oct 2, 2018 | EXHIBIT | PETITIONER |
File History of U.S. Patent No. 9,855,302 (Part 2) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Elad Sharon et al, Immune checkpoints in cancer clinical trials, Chinese Journal of Cancer (2014) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Mosby¿¿¿s Medical dictionary 8th ed. (2009) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Dorland¿¿¿s Illustrated Med Diction 31st ed. (2007) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Cyriac Kandoth et al., Mutational landscape and significance across 12 major cancer types, Nature (Oct. 17, 2013) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Henrique Neves et al., Recent advances in the field of anti-cancer immunotherapy, BBA Clinical (2015) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Drew M. Pardoll, The blockade of immune checkpoints in cancer immunotherapy, Nature Reviews Cancer (Apr. 2012) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Satheesh Thungappa et al., Immune checkpoint inhibitors in lung cancer: the holy grail has not yet been found¿¿¿, ESMO Open (2017) | Oct 2, 2018 | EXHIBIT | PETITIONER |
D. T. Le et al., PD-1 Blockade in Tumors with Mismatch-Repair Deficiency, The New England Journal of Medicine (2015) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Alexandra Snyder et al., Genetic basis for clinical response to CTLA-4 blockade in melanoma, The New England Journal of Medicine (2014) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Ivaylo I. Ivanov et al. Intestinal commensal microbes as immune modulators,¿¿¿ Cell Host & Microbe (2012) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Lora V. Hooper et al., Interactions between the microbiota and the immune system, Science (June 8, 2012) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Bandaru S. Reddy et al., Inhibitory effect of Bifidobacterium longum on Colon, Mammary, and Liver Carcinogenesis Induced by 2-Amino-3-methylimidazo[4,5-f]quinolone, a Food Mutagen,¿¿¿ Cancer Research (Sept. 1, 1993) | Oct 2, 2018 | EXHIBIT | PETITIONER |
Declaration of Jonathan Braun, M.D., Ph.D. | Oct 2, 2018 | EXHIBIT | PETITIONER |
Petition for Post Grant Review | Oct 2, 2018 | PAPER | PETITIONER |
Petitioner's Power of Attorney | Oct 2, 2018 | PAPER | PETITIONER |