IP Verse

Merck Sharp & Dohme LLC vs Halozyme, Inc. et al.

The detailed information for PTAB case with proceeding number PGR2025-00003 filed by Merck Sharp & Dohme LLC against Halozyme, Inc. et al. on Nov 12, 2024. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Case Details

Proceeding Number
PGR2025-00003
Filing Date
Nov 12, 2024
Petitioner
Merck Sharp & Dohme LLC
Respondent
Halozyme, Inc. et al.
Status
Trial Instituted
Respondent Application Number
18338189
Respondent Tech Center
1600
Respondent Patent Number
11952600
Institution Decision Date
Jun 2, 2025

Proceeding Documents

The table below shows documents filed in the case, listing each document name, filing date, document type, and filing party. Tracking these filings indicates the activity of the parties involved in the case, and the types of documents filed can provide insights into the legal strategies being employed.


Document NameFiling DateCategoryFiling Party

Alert me when new update on this case

Patent Owner's Notice of Park Deposition

Jul 28, 2025PAPERPATENT OWNER

Notice of Joint Stipulation to Modify Due Dates

Jul 24, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Jul 17, 2025PAPERPATENT OWNER

Petitioner's Updated Mandatory Notices

Jun 30, 2025PAPERPETITIONER

Authorized Response to Director Review Request

Jun 25, 2025PAPERPETITIONER

Exhibit 3100

Jun 17, 2025EXHIBITBOARD

EX2036 - District Court Complaint

Jun 16, 2025EXHIBITPATENT OWNER

Patent Owner's Request for Director Review

Jun 16, 2025PAPERPATENT OWNER

Patent Owner's Objections to Evidence

Jun 16, 2025PAPERPATENT OWNER

Petitioner's Objections to Evidence

Jun 16, 2025PAPERPETITIONER

Patent Owner's Updated Mandatory Notices

Jun 13, 2025PAPERPATENT OWNER

Patent Owner's Updated Power of Attorney

Jun 13, 2025PAPERPATENT OWNER

Institution Decision: Grant

Jun 2, 2025PAPERBOARD

Order: Scheduling Order

Jun 2, 2025PAPERBOARD

Patent Owner's Updated Power of Attorney

May 21, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

May 21, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

May 5, 2025PAPERPATENT OWNER

Petitioner's Updates to Mandatory Notices

Apr 30, 2025PAPERPETITIONER

Patent Owner's Updated Mandatory Notices

Apr 18, 2025PAPERPATENT OWNER

Petitioner's Updates to Mandatory Notices

Apr 16, 2025PAPERPETITIONER

Patent Owner's Updated Mandatory Notices

Apr 10, 2025PAPERPATENT OWNER

Patent Owner's Sur-Reply to Petitioner's Reply to Patent Owner's Preliminary Response

Apr 7, 2025PAPERPATENT OWNER

Granting Petitioner’s Motion for Pro Hac Vice Admission of Leif E. Peterson, II 37 C.F.R. § 42.10

Mar 24, 2025PAPERBOARD

Reply in Support of Petition for Post Grant Review

Mar 24, 2025PAPERPETITIONER

Patent Owner's Updated Mandatory Notices

Mar 18, 2025PAPERPATENT OWNER

Petitioner's Motion for Pro Hac Vice Admission of Leif E. Peterson, II

Mar 17, 2025PAPERPETITIONER

Declaration of Leif E. Peterson

Mar 17, 2025EXHIBITPETITIONER

Patent Owner Preliminary Response

Mar 7, 2025PAPERPATENT OWNER

EX2001 - Triggs-Raine Declaration

Mar 7, 2025EXHIBITPATENT OWNER

EX2002 - Triggs-Raine CV

Mar 7, 2025EXHIBITPATENT OWNER

EX2003 - Statutory Disclaimer

Mar 7, 2025EXHIBITPATENT OWNER

EX2004 - Fierce Pharma

Mar 7, 2025EXHIBITPATENT OWNER

EX2005 - LinkedIn Profiles

Mar 7, 2025EXHIBITPATENT OWNER

EX2006 - Sequence Listing

Mar 7, 2025EXHIBITPATENT OWNER

EX2007 - Gifre 2017

Mar 7, 2025EXHIBITPATENT OWNER

EX2008 - Recombinant Drugs - Smithsonian Institution

Mar 7, 2025EXHIBITPATENT OWNER

EX2009 - Naz 2011

Mar 7, 2025EXHIBITPATENT OWNER

EX2010 - Primakoff 1988

Mar 7, 2025EXHIBITPATENT OWNER

EX2011 - Guinea Pig - Merriam-Webster 2010

Mar 7, 2025EXHIBITPATENT OWNER

EX2012 - Nature 2012

Mar 7, 2025EXHIBITPATENT OWNER

EX2013 - Lin 1993

Mar 7, 2025EXHIBITPATENT OWNER

EX2015 - USP7872107 File History (Part 1 of 3)

Mar 7, 2025EXHIBITPATENT OWNER

EX2015 - USP7872107 File History (Part 2 of 3)

Mar 7, 2025EXHIBITPATENT OWNER

EX2015 - USP7872107 File History (Part 3 of 3)

Mar 7, 2025EXHIBITPATENT OWNER

EX2016 - Pils 2005

Mar 7, 2025EXHIBITPATENT OWNER

EX2018 - Duterme 2009

Mar 7, 2025EXHIBITPATENT OWNER

EX2019 - Atmuri 2008

Mar 7, 2025EXHIBITPATENT OWNER

EX2020 - Hemming 2008

Mar 7, 2025EXHIBITPATENT OWNER

EX2021 - Miller 2008

Mar 7, 2025EXHIBITPATENT OWNER

EX2022 - Kaneiwa 2010

Mar 7, 2025EXHIBITPATENT OWNER

EX2023 - PGR2025-00004 Petition

Mar 7, 2025EXHIBITPATENT OWNER

EX2024 - PGR2025-00006 Petition

Mar 7, 2025EXHIBITPATENT OWNER

EX2025 - PGR2025-00009 Petition

Mar 7, 2025EXHIBITPATENT OWNER

EX2026 - PGR2025-00017 Petition

Mar 7, 2025EXHIBITPATENT OWNER

EX2027 - PGR2025-00030 Petition

Mar 7, 2025EXHIBITPATENT OWNER

EX2028 - PGR2025-00024 Petition

Mar 7, 2025EXHIBITPATENT OWNER

EX2029 - PGR2025-00004 EX1003 - Hecht Declaration

Mar 7, 2025EXHIBITPATENT OWNER

EX2030 - PGR2025-00006 EX1003 - Hecht Declaration

Mar 7, 2025EXHIBITPATENT OWNER

EX2031 - PGR2025-00009 EX1003 - Hecht Declaration

Mar 7, 2025EXHIBITPATENT OWNER

EX2032 - PGR2025-00017 EX1003 - Hecht Declaration

Mar 7, 2025EXHIBITPATENT OWNER

EX2033 - PGR2025-00030 EX1003 - Hecht Declaration

Mar 7, 2025EXHIBITPATENT OWNER

EX2034 - PGR2025-00024 EX1003 - Hecht Declaration

Mar 7, 2025EXHIBITPATENT OWNER

EX2035 - Lokeshwar 2002

Mar 7, 2025EXHIBITPATENT OWNER

EX2017 - EP0953574A1

Mar 7, 2025EXHIBITPATENT OWNER

Patent Owner's Updated Mandatory Notices

Mar 4, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Feb 18, 2025PAPERPATENT OWNER

Petitioner's Updates to Mandatory Notices

Feb 6, 2025PAPERPETITIONER

Patent Owner's Updated Mandatory Notices

Jan 29, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Jan 15, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Dec 20, 2024PAPERPATENT OWNER

Notice: NOTICE OF FILING DATE ACCORDED TO PETITION AND TIME FOR FILING PATENT OWNER PRELIMINARY RESPONSE

Dec 9, 2024PAPERBOARD

Patent Owner's Power of Attorney

Dec 3, 2024PAPERPATENT OWNER

Patent Owner's Mandatory Notices

Dec 3, 2024PAPERPATENT OWNER

U.S. Patent No. 7,767,429

Nov 12, 2024EXHIBITPETITIONER

Chao, Structure of Human Hyaluronidase-1 (2007)

Nov 12, 2024EXHIBITPETITIONER

WO 2010/077297

Nov 12, 2024EXHIBITPETITIONER

Stern, Hyularonidases: Their Genomics, Structures, and Mechanisms of Action

Nov 12, 2024EXHIBITPETITIONER

Jedrzejas, Structures of Verterbrate Hyaluronidases

Nov 12, 2024EXHIBITPETITIONER

Zhang, Hyaluronidase Activity of Human Hyal1

Nov 12, 2024EXHIBITPETITIONER

Arming, In Vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm

Nov 12, 2024EXHIBITPETITIONER

Borodoli, Protein Structure Homology Model (2008)

Nov 12, 2024EXHIBITPETITIONER

Frost, Recombinant Human Hyaluronidase rHuPH20 (2007)

Nov 12, 2024EXHIBITPETITIONER

Brandon & Tooze, Introduction to Protein Structure Pt. 1 (1991)

Nov 12, 2024EXHIBITPETITIONER

Brandon & Tooze, Introduction to Protein Structure Pt. 2 (1991)

Nov 12, 2024EXHIBITPETITIONER

Steipe, Consensus-Based Engineering of Protein (2004)

Nov 12, 2024EXHIBITPETITIONER

Green, Protein Engineering and Design (2010)

Nov 12, 2024EXHIBITPETITIONER

Chica, Semi-Rational Approaches to Engineering Enzyme Activity (2005)

Nov 12, 2024EXHIBITPETITIONER

Hardy, Assessment of Contraceptive Vaccines (2004)

Nov 12, 2024EXHIBITPETITIONER

Pomering, Restricted Entry of IgG into Male and Female Rabbit (2002)

Nov 12, 2024EXHIBITPETITIONER

Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002)

Nov 12, 2024EXHIBITPETITIONER

Primakoff, Reversible Contraceptive Effect of PH-20 Immunization (1997)

Nov 12, 2024EXHIBITPETITIONER

Tung, Mechanism of Infertility in Male Guinea Pigs (1997)

Nov 12, 2024EXHIBITPETITIONER

Rosengren, Recombinant Human PH20: Baseline Analysis (2018)

Nov 12, 2024EXHIBITPETITIONER

U.S. Patent No. 9,447,401

Nov 12, 2024EXHIBITPETITIONER

Gmachl, The Human Sperm Protein PH-20 has Hyaluronidase (1993)

Nov 12, 2024EXHIBITPETITIONER

Yue, Loss of Protein Structure Stability as a Major Causative Factor (2005)

Nov 12, 2024EXHIBITPETITIONER

Wang, SNPs, Protein Structure, and Disease (2001)

Nov 12, 2024EXHIBITPETITIONER

Markovic-Housley, Crystal Structure of Hyaluronidase (2000)

Nov 12, 2024EXHIBITPETITIONER

Nature, Negative Results (2008)

Nov 12, 2024EXHIBITPETITIONER

Lins, Analysis of Accessible Surface of Residues in Proteins (2003)

Nov 12, 2024EXHIBITPETITIONER

Hayden, Designer Debacle (2008)

Nov 12, 2024EXHIBITPETITIONER

Benkert, Toward the Estimation of the Quality of Individual Protein (2010)

Nov 12, 2024EXHIBITPETITIONER

Schwede, SWISS-MODEL (2003)

Nov 12, 2024EXHIBITPETITIONER

Alberts, Molecular Biology of the Cell (2008)

Nov 12, 2024EXHIBITPETITIONER

He, NMR Structures of Two Designed Proteins (2008)

Nov 12, 2024EXHIBITPETITIONER

Alexander, A Minimal Sequence Code for Switching Protein (2009)

Nov 12, 2024EXHIBITPETITIONER

Ruan, Design and Characterization of a Protein Fold (2023)

Nov 12, 2024EXHIBITPETITIONER

Sievers, Fast, Scalable Generation of High Quality Protein (2011)

Nov 12, 2024EXHIBITPETITIONER

Table Citations from the ’600 Patent (EX1001) to ’731 Application (EX1026)

Nov 12, 2024EXHIBITPETITIONER

Mihel, Protein Structure and Interaction Analyzer (2008)

Nov 12, 2024EXHIBITPETITIONER

Redline Comparison of the ’731 and ’600 Specifications

Nov 12, 2024EXHIBITPETITIONER

Beasley & Hecht, Protein Design (1997)

Nov 12, 2024EXHIBITPETITIONER

Xiong, Periodicity of Polar and Nonpolar Amino Acids (1995)

Nov 12, 2024EXHIBITPETITIONER

Hayden, Key Protein-Design Papers Challenged (2009)

Nov 12, 2024EXHIBITPETITIONER

Kegg Drug: Hyaluronidase (human recombinant)

Nov 12, 2024EXHIBITPETITIONER

Pace, A Helix Propensity Scale Based on Experimental Studies (1998)

Nov 12, 2024EXHIBITPETITIONER

U.S. Patent No. Pub. 61/631,313

Nov 12, 2024EXHIBITPETITIONER

U.S. Patent No. Pub. 61/796,208

Nov 12, 2024EXHIBITPETITIONER

Leisola, Protein Engineering: Opportunities and Challenges (2009)

Nov 12, 2024EXHIBITPETITIONER

Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004)

Nov 12, 2024EXHIBITPETITIONER

Rosengren, Clinical Immunogenicity of rHuPH20 (2015)

Nov 12, 2024EXHIBITPETITIONER

U.S. Patent Application No. 13/694,731

Nov 12, 2024EXHIBITPETITIONER

Sills, “Retraction,” Science, 319:569 (2008)

Nov 12, 2024EXHIBITPETITIONER

Hom_pre2011

Nov 12, 2024EXHIBITPETITIONER

Hom_pre2011_header

Nov 12, 2024EXHIBITPETITIONER

Hom_pre2011_header_clean

Nov 12, 2024EXHIBITPETITIONER

Hom_pre2011.fasta

Nov 12, 2024EXHIBITPETITIONER

Ph20_pre2011.aln-clustal_num

Nov 12, 2024EXHIBITPETITIONER

Ph20_pre2011 Alignment html

Nov 12, 2024EXHIBITPETITIONER

U.S. Patent No. 11,952,600

Nov 12, 2024EXHIBITPETITIONER

Collection of BLAST Webpages from the Internet Archive, navigable from

Nov 12, 2024EXHIBITPETITIONER

Collection of Clustal Omega Webpages from the Internet Archive

Nov 12, 2024EXHIBITPETITIONER

Collection of SWISS-MODEL Webpages from the Internet Archive

Nov 12, 2024EXHIBITPETITIONER

Collection of PyMol Webpages from the Internet Archive

Nov 12, 2024EXHIBITPETITIONER

Swiss Model Printout of PH20 Model

Nov 12, 2024EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with D320K Mutation

Nov 12, 2024EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with D320H Mutation

Nov 12, 2024EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with D320R Mutation

Nov 12, 2024EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with D320S Mutation

Nov 12, 2024EXHIBITPETITIONER

File History of U.S. Patent No. 11,952,600 Pt. 1

Nov 12, 2024EXHIBITPETITIONER

File History of U.S. Patent No. 11,952,600 Pt. 2

Nov 12, 2024EXHIBITPETITIONER

File History of U.S. Patent No. 11,952,600 Pt. 3

Nov 12, 2024EXHIBITPETITIONER

Declaration of Dr. Sheldon Park

Nov 12, 2024EXHIBITPETITIONER

Declaration of Dr. Michael Hecht

Nov 12, 2024EXHIBITPETITIONER

Declaration of Jeffrey P. Kushan

Nov 12, 2024EXHIBITPETITIONER

Petition for Post Grant Review

Nov 12, 2024PAPERPETITIONER

Petitioner's Power of Attorney

Nov 12, 2024PAPERPETITIONER