The detailed information for PTAB case with proceeding number PGR2025-00006 filed by Merck Sharp & Dohme LLC against Halozyme, Inc. et al. on Dec 10, 2024. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Case Details

Proceeding Number
PGR2025-00006
Filing Date
Dec 10, 2024
Petitioner
Merck Sharp & Dohme LLC
Respondent
Halozyme, Inc. et al.
Status
Trial Instituted
Respondent Application Number
18340802
Respondent Tech Center
1600
Respondent Patent Number
12152262
Institution Decision Date
Jun 16, 2025

Proceeding Documents

The table below shows documents filed in the case, listing each document name, filing date, document type, and filing party. Tracking these filings indicates the activity of the parties involved in the case, and the types of documents filed can provide insights into the legal strategies being employed.


Document NameFiling DateCategoryFiling Party

Alert me when new update on this case

Patent Owner's Notice of Park Deposition

Jul 28, 2025PAPERPATENT OWNER

Notice of Joint Stipulation to Modify Due Dates

Jul 24, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Jul 17, 2025PAPERPATENT OWNER

Authorized Response to Director Review Request

Jul 8, 2025PAPERPETITIONER

Patent Owner's Objections to Evidence

Jul 1, 2025PAPERPATENT OWNER

Petitioner's Objections to Evidence

Jul 1, 2025PAPERPETITIONER

Petitioner's Updated Mandatory Notices

Jun 30, 2025PAPERPETITIONER

EX2060 - District Court Complaint

Jun 30, 2025EXHIBITPATENT OWNER

Patent Owner's Request for Director Review of the Institution Decision

Jun 30, 2025PAPERPATENT OWNER

Exhibit 3100

Jun 30, 2025EXHIBITBOARD

Patent Owner's Updated Power of Attorney

Jun 20, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Jun 20, 2025PAPERPATENT OWNER

Order: Scheduling Order

Jun 17, 2025PAPERBOARD

Institution Decision: Granting Institution of Post Grant Review

Jun 16, 2025PAPERBOARD

EXPUNGED

Jun 16, 2025PAPERBOARD

Director Discretionary Decision: Refer

Jun 12, 2025PAPERBOARD

Petitioner's Reply to Patent Owner's Discretionary Denial Brief

May 23, 2025PAPERPETITIONER

United States District Court – National Judicial Caseload Profile

May 23, 2025EXHIBITPETITIONER

Table Showing Outcomes of Disputed Motions to Stay Pending IPRs in DNJ

May 23, 2025EXHIBITPETITIONER

News Release, "Halozyme Raises 2025 Financial Guidance Ranges and Reports Strong First Quarter 2025 Results."

May 23, 2025EXHIBITPETITIONER

News Release, "Merck Breaks Ground on New $1 Billion Biologics Center of Excellence in Wilmington, Delaware."

May 23, 2025EXHIBITPETITIONER

Halozyme Therapeutics, Inc. Q1 2025 Earnings Call Transcript (May 6, 2025)

May 23, 2025EXHIBITPETITIONER

Patent Owner's Sur-Reply to Petitioner's Reply to Patent Owner's Preliminary Response

May 22, 2025PAPERPATENT OWNER

Corrected Petition for Post Grant Review

May 22, 2025PAPERPETITIONER

Corrected Declaration of Dr. Sheldon Park

May 22, 2025EXHIBITPETITIONER

Patent Owner's Updated Power of Attorney

May 21, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

May 21, 2025PAPERPATENT OWNER

Order: Granting Petitioner’s Motion to File Corrected Petition and Exhibit 1004

May 16, 2025PAPERBOARD

Ex. 3001

May 16, 2025EXHIBITBOARD

Reply in Support of Petition for Post Grant Review

May 8, 2025PAPERPETITIONER

Patent Owner's Updated Mandatory Notices

May 5, 2025PAPERPATENT OWNER

Petitioner's Updates to Mandatory Notices

Apr 30, 2025PAPERPETITIONER

EX2046 - 2023 Pharma 50

Apr 28, 2025EXHIBITPATENT OWNER

EX2048 - Products List - Merck.com

Apr 28, 2025EXHIBITPATENT OWNER

EX2050 - Merck Market Cap Nasdaq

Apr 28, 2025EXHIBITPATENT OWNER

EX2051 - Halozyme Market Cap Nasdaq

Apr 28, 2025EXHIBITPATENT OWNER

EX2052 - Halozyme News Revenue

Apr 28, 2025EXHIBITPATENT OWNER

EX2053 - Halozyme - Commercial Products

Apr 28, 2025EXHIBITPATENT OWNER

EX2054 - Halozyme - About Us

Apr 28, 2025EXHIBITPATENT OWNER

EX2056 - PGR2025-00042 Petition

Apr 28, 2025EXHIBITPATENT OWNER

EX2057 - PGR2025-00042 EX1003 - Hecht Declaration

Apr 28, 2025EXHIBITPATENT OWNER

EX2058 - District Court Complaint

Apr 28, 2025EXHIBITPATENT OWNER

EX2059 - Alteogen announces amendment to license agreement with MSD

Apr 28, 2025EXHIBITPATENT OWNER

EX2047 - Merck Financial Results

Apr 28, 2025EXHIBITPATENT OWNER

EX2055 - Triggs-Raine Declaration ISO Patent Owner Discretionary Denial Brief

Apr 28, 2025EXHIBITPATENT OWNER

Patent Owner Discretionary Denial Brief

Apr 28, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Apr 18, 2025PAPERPATENT OWNER

Petitioner's Updates to Mandatory Notices

Apr 16, 2025PAPERPETITIONER

Patent Owner's Preliminary Response

Apr 14, 2025PAPERPATENT OWNER

EX2001 - Triggs-Raine Declaration

Apr 14, 2025EXHIBITPATENT OWNER

EX2002 - Triggs-Raine CV

Apr 14, 2025EXHIBITPATENT OWNER

EX2003 - Disclaimer

Apr 14, 2025EXHIBITPATENT OWNER

EX2004 - Fierce Pharma

Apr 14, 2025EXHIBITPATENT OWNER

EX2005 - LinkedIn Profiles

Apr 14, 2025EXHIBITPATENT OWNER

EX2006 - Sequence Listing

Apr 14, 2025EXHIBITPATENT OWNER

EX2007 - Gifre 2017

Apr 14, 2025EXHIBITPATENT OWNER

EX2008 - Recombinant Drugs - Smithsonian Institution

Apr 14, 2025EXHIBITPATENT OWNER

EX2009 - Naz 2011

Apr 14, 2025EXHIBITPATENT OWNER

EX2010 - Primakoff 1988

Apr 14, 2025EXHIBITPATENT OWNER

EX2011 - Guinea Pig - Merriam-Webster 2010

Apr 14, 2025EXHIBITPATENT OWNER

EX2012 - Nature 2012

Apr 14, 2025EXHIBITPATENT OWNER

EX2013 - Lin 1993

Apr 14, 2025EXHIBITPATENT OWNER

EX2015 - USP7872107 File History (Part 1 of 3)

Apr 14, 2025EXHIBITPATENT OWNER

EX2015 - USP7872107 File History (Part 2 of 3)

Apr 14, 2025EXHIBITPATENT OWNER

EX2015 - USP7872107 File History (Part 3 of 3)

Apr 14, 2025EXHIBITPATENT OWNER

EX2016 - Pils 2005

Apr 14, 2025EXHIBITPATENT OWNER

EX2017 - EP0953574A1

Apr 14, 2025EXHIBITPATENT OWNER

EX2018 - Duterme 2009

Apr 14, 2025EXHIBITPATENT OWNER

EX2019 - Atmuri 2008

Apr 14, 2025EXHIBITPATENT OWNER

EX2020 - Hemming 2008

Apr 14, 2025EXHIBITPATENT OWNER

EX2021 - Miller 2008

Apr 14, 2025EXHIBITPATENT OWNER

EX2022 - Kaneiwa 2010

Apr 14, 2025EXHIBITPATENT OWNER

EX2023 - PGR2025-00004 Petition

Apr 14, 2025EXHIBITPATENT OWNER

EX2024 - PGR2025-00003 Petition

Apr 14, 2025EXHIBITPATENT OWNER

EX2025 - PGR2025-00009 Petition

Apr 14, 2025EXHIBITPATENT OWNER

EX2026 - PGR2025-00017 Petition

Apr 14, 2025EXHIBITPATENT OWNER

EX2027 - PGR2025-00030 Petition

Apr 14, 2025EXHIBITPATENT OWNER

EX2028 - PGR2025-00024 Petition

Apr 14, 2025EXHIBITPATENT OWNER

EX2029 - PGR2025-00004 EX1003 - Hecht Declaration

Apr 14, 2025EXHIBITPATENT OWNER

EX2030 - PGR2025-00003 EX1003 - Hecht Declaration

Apr 14, 2025EXHIBITPATENT OWNER

EX2031 - PGR2025-00009 EX1003 - Hecht Declaration

Apr 14, 2025EXHIBITPATENT OWNER

EX2032 - PGR2025-00017 EX1003 - Hecht Declaration

Apr 14, 2025EXHIBITPATENT OWNER

EX2033 - PGR2025-00030 EX1003 - Hecht Declaration

Apr 14, 2025EXHIBITPATENT OWNER

EX2034 - PGR2025-00024 EX1003 - Hecht Declaration

Apr 14, 2025EXHIBITPATENT OWNER

EX2035 - Lokeshwar 2002

Apr 14, 2025EXHIBITPATENT OWNER

EX2036 - PGR2025-00033 EX1003 - Hecht Declaration

Apr 14, 2025EXHIBITPATENT OWNER

EX2037 - PGR2025-00033 Petition

Apr 14, 2025EXHIBITPATENT OWNER

EX2038 - PGR2025-00039 EX1003 - Hecht Declaration

Apr 14, 2025EXHIBITPATENT OWNER

EX2039 - PGR2025-00039 Petition

Apr 14, 2025EXHIBITPATENT OWNER

Petitioner's Unopposed Motion to Correct

Apr 11, 2025PAPERPETITIONER

Patent Owner's Updated Mandatory Notices

Apr 10, 2025PAPERPATENT OWNER

Order: Granting Petitioner's Motions for Pro Hac Vice Admission of Leif E. Peterson, II - 37 CFR 42.10

Apr 2, 2025PAPERBOARD

Petitioner's Motion for Pro Hac Vice Admission of Leif E. Peterson, II

Mar 24, 2025PAPERPETITIONER

Declaration of Leif E. Peterson, II

Mar 24, 2025EXHIBITPETITIONER

Patent Owner's Updated Mandatory Notices

Mar 18, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Mar 4, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Feb 18, 2025PAPERPATENT OWNER

Petitioner's Updates to Mandatory Notices

Feb 6, 2025PAPERPETITIONER

Patent Owner's Updated Mandatory Notices

Jan 29, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Jan 15, 2025PAPERPATENT OWNER

Notice: NOTICE OF FILING DATE ACCORDED TO PETITION AND TIME FOR FILING PATENT OWNER PRELIMINARY RESPONSE

Jan 13, 2025PAPERBOARD

Patent Owner's Power of Attorney

Dec 20, 2024PAPERPATENT OWNER

Patent Owner's Mandatory Notices

Dec 20, 2024PAPERPATENT OWNER

U.S. Patent No. 12,152,262

Dec 10, 2024EXHIBITPETITIONER

U.S. Patent No. 7,767,429

Dec 10, 2024EXHIBITPETITIONER

Chao, Structure of Human Hyaluronidase-1 (2007)

Dec 10, 2024EXHIBITPETITIONER

WO 2010/077297, published 8 July 2010

Dec 10, 2024EXHIBITPETITIONER

Stern, The Hyaluronidases: Their Genomics, Structures, and Mechanisms

Dec 10, 2024EXHIBITPETITIONER

Jedzrejas, Structures of Vertebrate Hyaluronidases (2005)

Dec 10, 2024EXHIBITPETITIONER

Zhang, Hyaluronidase Activity of Human Hyal1 (2009)

Dec 10, 2024EXHIBITPETITIONER

Arming, In vitro mutagenesis of PH-20 hyaluronidase from human sperm

Dec 10, 2024EXHIBITPETITIONER

Bordoli, Protein structure homology modeling using SWISS-MODEL workspace

Dec 10, 2024EXHIBITPETITIONER

Frost, Recombinant human hyaluronidase (rHuPH20) (2007)

Dec 10, 2024EXHIBITPETITIONER

Brandon & Tooze, Introduction to Protein Structure (1999) Part 1

Dec 10, 2024EXHIBITPETITIONER

Brandon & Tooze, Introduction to Protein Structure (1999) Part 2

Dec 10, 2024EXHIBITPETITIONER

Steipe, Consensus-Based Engineering of Protein Stability (2004)

Dec 10, 2024EXHIBITPETITIONER

Green, Computer Graphics, Homology Modeling, and Bioinformatics (2010)

Dec 10, 2024EXHIBITPETITIONER

Chica, Semi-rational approaches to engineering enzyme activity (2005)

Dec 10, 2024EXHIBITPETITIONER

Hardy,Assessment of contraceptive vaccines based on recombinant mouse sperm

Dec 10, 2024EXHIBITPETITIONER

Pomering, Restricted Entry of IgG (2002)

Dec 10, 2024EXHIBITPETITIONER

Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002)

Dec 10, 2024EXHIBITPETITIONER

Primakoff, Reversible Contraceptive Effect of PH-20 Immunization

Dec 10, 2024EXHIBITPETITIONER

Tung, Mechanism of Infertility in Male Guinea Pigs Immunized with Sperm

Dec 10, 2024EXHIBITPETITIONER

Rosengren, Recombinant Human PH20 (2018)

Dec 10, 2024EXHIBITPETITIONER

U.S. Patent No. 9,447,401

Dec 10, 2024EXHIBITPETITIONER

U.S. Patent Application No. 13/694,731

Dec 10, 2024EXHIBITPETITIONER

Gmachl, The human sperm protein PH-20 has hyaluronidase activity (1993)

Dec 10, 2024EXHIBITPETITIONER

Sills, “Retraction,” Science, 319:569 (2008)

Dec 10, 2024EXHIBITPETITIONER

Yue, Loss of Protein Structure Stability as a Major Causative Factor

Dec 10, 2024EXHIBITPETITIONER

Wang & Moult, SNPs, Protein Structure, and Disease (2001)

Dec 10, 2024EXHIBITPETITIONER

Marković-Housley, Crystal Structure of Hyaluronidase

Dec 10, 2024EXHIBITPETITIONER

“Negative Results,” Nature: Editorials, 453:258 (2008)

Dec 10, 2024EXHIBITPETITIONER

Lins, Analysis of Accessible Surface of Residues in Proteins (2003)

Dec 10, 2024EXHIBITPETITIONER

Hayden, Chemistry: Designer Debacle (2008)

Dec 10, 2024EXHIBITPETITIONER

Benkert, Toward the Estimation of the Absolute Quality (2010)

Dec 10, 2024EXHIBITPETITIONER

Schwede, SWISS-MODEL: An Automated Protein Homology-Modeling Server (2003)

Dec 10, 2024EXHIBITPETITIONER

Alberts, Molecular Biology of the Cell, Chapter 3 (2007)

Dec 10, 2024EXHIBITPETITIONER

He, NMR Structures of Two Designed Proteins with High Sequence Identity

Dec 10, 2024EXHIBITPETITIONER

Alexander, A Minimal Sequence Code for Switching Protein Structure

Dec 10, 2024EXHIBITPETITIONER

Ruan, Design and Characterization of a Protein Fold Switching Network

Dec 10, 2024EXHIBITPETITIONER

Sievers, Fast, Scalable Generation of High-Quality Protein (2011)

Dec 10, 2024EXHIBITPETITIONER

Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008)

Dec 10, 2024EXHIBITPETITIONER

Redline Comparison of the ’731 and ’262 Specifications

Dec 10, 2024EXHIBITPETITIONER

Beasley & Hecht, Protein Design: The Choice of de Novo Sequences (1997)

Dec 10, 2024EXHIBITPETITIONER

Xiong, Periodicity of Polar and Nonpolar Amino Acids (1995)

Dec 10, 2024EXHIBITPETITIONER

Hayden, Key Protein-Design Papers Challenged (2009)

Dec 10, 2024EXHIBITPETITIONER

KEGG, DRUG: Hyaluronidase (human recombinant)

Dec 10, 2024EXHIBITPETITIONER

Pace & Scholtz, A Helix Propensity Scale (1998)

Dec 10, 2024EXHIBITPETITIONER

U.S. Patent Application No. 61/631,313

Dec 10, 2024EXHIBITPETITIONER

U.S. Patent Application No. 61/796,208

Dec 10, 2024EXHIBITPETITIONER

Hom_pre2011

Dec 10, 2024EXHIBITPETITIONER

Hom_pre2011_header

Dec 10, 2024EXHIBITPETITIONER

Hom_pre2011_header_clean

Dec 10, 2024EXHIBITPETITIONER

Hom_pre2011.fasta

Dec 10, 2024EXHIBITPETITIONER

Ph20_pre2011.aln-clustal_num

Dec 10, 2024EXHIBITPETITIONER

Ph20_pre2011 Alignment html

Dec 10, 2024EXHIBITPETITIONER

Leisola & Turunen, Protein Engineering: Opportunities and Challenges (2007)

Dec 10, 2024EXHIBITPETITIONER

Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004)

Dec 10, 2024EXHIBITPETITIONER

Rosengren, Clinical Immunogenicity of rHuPH20 (2015)

Dec 10, 2024EXHIBITPETITIONER

Collection of BLAST Webpages from the Internet Archive

Dec 10, 2024EXHIBITPETITIONER

Collection of Clustal Omega Webpages from the Internet Archive

Dec 10, 2024EXHIBITPETITIONER

Collection of SWISS-MODEL Webpages from the Internet Archive

Dec 10, 2024EXHIBITPETITIONER

Collection of PyMol Webpages from the Internet Archive

Dec 10, 2024EXHIBITPETITIONER

Swiss Model Printout of PH20 Model

Dec 10, 2024EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with L317Q Mutation

Dec 10, 2024EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with L317R Mutation

Dec 10, 2024EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with L317M Mutation

Dec 10, 2024EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with L317S Mutation

Dec 10, 2024EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with L317I Mutation

Dec 10, 2024EXHIBITPETITIONER

File History of U.S. Patent No. 12,152,262 - Part 1

Dec 10, 2024EXHIBITPETITIONER

File History of U.S. Patent No. 12,152,262 - Part 2

Dec 10, 2024EXHIBITPETITIONER

File History of U.S. Patent No. 12,152,262 - Part 3

Dec 10, 2024EXHIBITPETITIONER

Declaration of Dr. Michael Hecht

Dec 10, 2024EXHIBITPETITIONER

EXPUNGED

Dec 10, 2024EXHIBITPETITIONER

Declaration of Jeffrey P. Kushan

Dec 10, 2024EXHIBITPETITIONER

Table of ’262 Patent Citations and Corresponding ’731 Appl. Citations

Dec 10, 2024EXHIBITPETITIONER

Petition for Post Grant Review

Dec 10, 2024PAPERPETITIONER

Petitioner's Power of Attorney

Dec 10, 2024PAPERPETITIONER