Director Discretionary Decision: Refer | Aug 14, 2025 | PAPER | BOARD |
Petitioner's Reply in Support of Petition for Post Grant Review | Aug 12, 2025 | PAPER | PETITIONER |
Patent Owner's Updated Power of Attorney | Aug 4, 2025 | PAPER | PATENT OWNER |
Patent Owner's Updated Mandatory Notices | Aug 4, 2025 | PAPER | PATENT OWNER |
Petitioner's Reply to Patent Owner's Discretionary Denial Brief | Jul 17, 2025 | PAPER | PETITIONER |
News Release, “Halozyme Raises 2025 Financial Guidance Ranges and Reports Strong First Quarter 2025 Results” | Jul 17, 2025 | EXHIBIT | PETITIONER |
News Release, “Merck Breaks Ground on New $1 Billion Biologics Center of Excellence in Wilmington, Delaware” | Jul 17, 2025 | EXHIBIT | PETITIONER |
Halozyme Therapeutics, Inc. Q1 2025 Earnings Call Transcript (May 6, 2025) | Jul 17, 2025 | EXHIBIT | PETITIONER |
Patent Owner Preliminary Response | Jul 17, 2025 | PAPER | PATENT OWNER |
EX2007 - Gifre 2017 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2008 - Recombinant Drugs - Smithsonian Institution | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2009 - Naz 2011 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2010 - Primakoff 1988 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2011 - Guinea Pig - Merriam-Webster 2010 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2012 - Nature 2012 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2013 - Lin 1993 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2015 - USP7872107 File History (Part 1 of 3) | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2015 - USP7872107 File History (Part 2 of 3) | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2015 - USP7872107 File History (Part 3 of 3) | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2016 - Pils 2005 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2017 - EP0953574A1 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2055 - Second Triggs-Raine Declaration | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2066 - PGR2025-00052 Petition | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2067 - PGR2025-00052 EX1003 - Hecht Declaration | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
Patent Owner's Updated Mandatory Notices | Jul 17, 2025 | PAPER | PATENT OWNER |
Petitioner's Updated Mandatory Notices | Jun 30, 2025 | PAPER | PETITIONER |
EX2001 - Triggs-Raine Dec | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2002 - Triggs-Raine CV | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2003 - Disclaimer | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2004 - Fierce Pharma | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2005 - LinkedIn Profiles | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2006 - Sequence Listing | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2018 - Duterme 2009 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2019 - Atmuri 2008 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2020 - Hemming 2008 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2021 - Miller 2008 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2022 - Kaneiwa 2010 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2023 - PGR2025-00004 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2024 - PGR2025-00003 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2025 - PGR2025-00009 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2026 - PGR2025-00006 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2027 - PGR2025-00030 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2028 - PGR2025-00017 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2029 - PGR2025-00004 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2030 - PGR2025-00003 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2031 - PGR2025-00009 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2032 - PGR2025-00006 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2033 - PGR2025-00030 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2034 - PGR2025-00017 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2035 - Lokeshwar 2002 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2036 - PGR2025-00033 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2037 - PGR2025-00033 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2038 - PGR2025-00039 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2039 - PGR2025-00039 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2046 - 2023 Pharma 50 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2047 - Merck Financial Results | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2048 - Products List - Merck.com | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2050 - Merck Market Cap Nasdaq | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2051 - Halozyme Market Cap Nasdaq | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2052 - Halozyme News Revenue | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2053 - Halozyme - Commercial Products | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2054 - Halozyme - About Us | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2056 - PGR2025-00042 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2057 - PGR2025-00042 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2058 - District Court Complaint | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2059 - Alteogen announces amendment to license agreement with MSD | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2060 - PGR2025-00046 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2061 - PGR2025-00046 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2062 - PGR2025-00050 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2063 - PGR2025-00050 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2064 - PGR2025-00053 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2065 - PGR2025-00053 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
Patent Owner's Updated Power of Attorney | Jun 17, 2025 | PAPER | PATENT OWNER |
Patent Owner's Updated Mandatory Notices | Jun 17, 2025 | PAPER | PATENT OWNER |
Patent Owner's Discretionary Denial Brief | Jun 17, 2025 | PAPER | PATENT OWNER |
Patent Owner's Updated Power of Attorney | May 21, 2025 | PAPER | PATENT OWNER |
Patent Owner's Updated Mandatory Notices | May 21, 2025 | PAPER | PATENT OWNER |
Patent Owner's Updated Mandatory Notices | May 5, 2025 | PAPER | PATENT OWNER |
Petitioner's Updates to Mandatory Notices | Apr 30, 2025 | PAPER | PETITIONER |
Patent Owner's Updated Mandatory Notices | Apr 18, 2025 | PAPER | PATENT OWNER |
NOTICE OF FILING DATE ACCORDED TO PETITION | Apr 17, 2025 | PAPER | BOARD |
Petitioner's Updates to Mandatory Notices | Apr 16, 2025 | PAPER | PETITIONER |
Patent Owner's Updated Mandatory Notices | Apr 10, 2025 | PAPER | PATENT OWNER |
Patent Owner's Updated Mandatory Notices | Mar 18, 2025 | PAPER | PATENT OWNER |
Patent Owner's Power of Attorney | Mar 4, 2025 | PAPER | PATENT OWNER |
Patent Owner's Mandatory Notices | Mar 4, 2025 | PAPER | PATENT OWNER |
U.S. Patent No. 12,060,590 | Feb 21, 2025 | EXHIBIT | PETITIONER |
File History of U.S. Patent No. 12,060,590 Part 1 | Feb 21, 2025 | EXHIBIT | PETITIONER |
File History of U.S. Patent No. 12,060,590 Part 2 | Feb 21, 2025 | EXHIBIT | PETITIONER |
File History of U.S. Patent No. 12,060,590 Part 3 | Feb 21, 2025 | EXHIBIT | PETITIONER |
U.S. Patent No. US7,767,429 | Feb 21, 2025 | EXHIBIT | PETITIONER |
Chao, Structure of Human Hyaluronidase-1 (2007) | Feb 21, 2025 | EXHIBIT | PETITIONER |
WO/2010/077297, published July 8, 2010 | Feb 21, 2025 | EXHIBIT | PETITIONER |
Stern, The Hyaluronidases: Their Genomics, Structures, & Mechanisms (2006) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Jedzrejas, Structures of Vertebrate Hyaluronidases (2005) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Zhang, Hyaluronidase Activity of Human Hyal1 (2009) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Arming, In vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm (1997) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Bordoli, Protein Structure Homology Modeling Using SWISSMODEL (2008) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Frost, Recombinant Human Hyaluronidase (rHuPH20) (2007) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Branden & Tooze, Introduction to Protein Structure (1999) Part 1 | Feb 21, 2025 | EXHIBIT | PETITIONER |
Branden & Tooze, Introduction to Protein Structure (1999) Part 2 | Feb 21, 2025 | EXHIBIT | PETITIONER |
Steipe, Consensus-Based Engineering of Protein Stability (2004) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Green, Computer Graphics, Homology Modeling, and Bioinformatics (2010) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Chica, Semi-rational Approaches to Engineering Enzyme Activity (2005) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Hardy, Assessment of Contraceptive Vaccines Based on Recombinant Mouse Sper | Feb 21, 2025 | EXHIBIT | PETITIONER |
Pomering, Restricted Entry of IgG (2002) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Primakoff, Reversible Contraceptive Effect of PH-20 Immunization (1997) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Tung, Mechanism of Infertility in Male Guinea Pigs Immunized with Sperm | Feb 21, 2025 | EXHIBIT | PETITIONER |
Rosengren, Recombinant Human PH20 (2018) | Feb 21, 2025 | EXHIBIT | PETITIONER |
U.S. Patent No. 9,447,401 | Feb 21, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application No. 13/694,731 | Feb 21, 2025 | EXHIBIT | PETITIONER |
Gmachl, The Human Sperm Protein PH-20 Has Hyaluronidase Activity (1993) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Sills, "Retraction," Science, 319:569 (2008) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Yue, Loss of Protein Structure Stability as a Major Causative Factor (2005) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Wang & Moult, SNPs, Protein Structure, and Disease (2001) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Marković-Housley, Crystal Structure of Hyaluronidase (2000) | Feb 21, 2025 | EXHIBIT | PETITIONER |
"Negative Results," Nature: Editorials, 453:258 (2008) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Lins, Analysis of Accessible Surface of Residues in Proteins (2003) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Hayden, Chemistry: Designer Debacle (2008) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Benkert, Toward the Estimation of the Absolute Quality (2010) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Schwede, SWISS-MODEL: An Automated Protein Homology-Modeling Server (2003) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Alberts, Molecular Biology of the Cell, Chapter 3 (2007) | Feb 21, 2025 | EXHIBIT | PETITIONER |
He, NMR Structures of Two Designed Proteins with High Sequence Identity | Feb 21, 2025 | EXHIBIT | PETITIONER |
Alexander, A Minimal Sequence Code for Switching Protein Structure (2009) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Ruan, Design & Characterization of a Protein Fold Switching Network (2023) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Sievers, Fast, Scalable Generation of High-Quality Protein (2011) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Redline Comparison of the ’731 and ’590 Specifications | Feb 21, 2025 | EXHIBIT | PETITIONER |
Beasley & Hecht, Protein Design: The Choice of de Novo Sequences (1997) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Xiong, Periodicity of Polar and Nonpolar Amino Acids (1995) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Hayden, Key Protein-Design Papers Challenged (2009) | Feb 21, 2025 | EXHIBIT | PETITIONER |
KEGG, DRUG: Hyaluronidase (human recombinant) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Pace & Scholtz, A Helix Propensity Scale (1998) | Feb 21, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application No. 61/631,313 | Feb 21, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application No. 61/796,208 | Feb 21, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011 | Feb 21, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011_header | Feb 21, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011_header_clean | Feb 21, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011.fasta | Feb 21, 2025 | EXHIBIT | PETITIONER |
Ph20_pre2011.aln-clustal_num | Feb 21, 2025 | EXHIBIT | PETITIONER |
Ph20_pre2011 Alignment html | Feb 21, 2025 | EXHIBIT | PETITIONER |
Leisola & Turunen, Protein Engineering: Opportunities and Challenges (2007) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Rosengren, Clinical Immunogenicity of rHuPH20 (2015) | Feb 21, 2025 | EXHIBIT | PETITIONER |
Collection of BLAST Webpages from the Internet Archive | Feb 21, 2025 | EXHIBIT | PETITIONER |
Collection of Clustal Omega Webpages from the Internet Archive | Feb 21, 2025 | EXHIBIT | PETITIONER |
Collection of SWISS-MODEL Webpages from the Internet Archive | Feb 21, 2025 | EXHIBIT | PETITIONER |
Collection of PyMol Webpages from the Internet Archive | Feb 21, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model | Feb 21, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with L307W Mutation | Feb 21, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with L307S Mutation | Feb 21, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with L307T Mutation | Feb 21, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with L307V Mutation | Feb 21, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with L307Y Mutation | Feb 21, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with L307G Mutation | Feb 21, 2025 | EXHIBIT | PETITIONER |
Table Associating ’590 Patent to Corresponding ’731 Application | Feb 21, 2025 | EXHIBIT | PETITIONER |
Declaration of Dr. Michael Hecht | Feb 21, 2025 | EXHIBIT | PETITIONER |
Declaration of Dr. Sheldon Park | Feb 21, 2025 | EXHIBIT | PETITIONER |
Declaration of Jeffrey P. Kushan | Feb 21, 2025 | EXHIBIT | PETITIONER |
Petition for Post Grant Review of U.S. Patent No. 12,060,590 | Feb 21, 2025 | PAPER | PETITIONER |
Petitioner's Power of Attorney | Feb 21, 2025 | PAPER | PETITIONER |