EX2068 - Simpson Declaration | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2069 - Simpson CV | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2070 - Petsko Declaration | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2071 - Petsko CV | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2072 - Cherr Declaration | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2073 - Cherr CV | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2074 - Moon Declaration | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2075 - Moon CV | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2076 - Hecht Deposition Transcript | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2077 - Park Deposition Transcript 2025-08-07 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2078 - Park Deposition Transcript 2025-08-21 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2079 - Koehl 1999 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2080 - Pommié 2004 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2082 - Kyte and Doolittle 1982 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2083 - Assay Guidance Manual (Part 1 of 6) | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2083 - Assay Guidance Manual (Part 2 of 6) | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2083 - Assay Guidance Manual (Part 3 of 6) | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2083 - Assay Guidance Manual (Part 4 of 6) | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2083 - Assay Guidance Manual (Part 5 of 6) | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2083 - Assay Guidance Manual (Part 6 of 6) | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2084 - The Central Role of Enzymes as Biological Catalysts | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2085 - French 1983 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2086 - El-Safory 2010 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2087 - Lu 2025 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2088 - Stern & Cóska 2000 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2089 - Gmachl 1993 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2090 - Gmachl-Kreil 1993 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2091 - Davies 1995 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2092 - Marković-Housley 2000 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2093 - Baker (US8343487B2) | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2094 - MULTIDROP 384 Liquid Handling Device Manual 2008 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
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EX2098 - Delpech 1995 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2099 - Takahashi 2003 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2100 - Vines 2001 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2101 - Wassarman 1999 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2102 - Yudin 1988 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2103 - Tollner 2012 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
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EX2105 - Wassarman 2001 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2106 - Bailey 2010 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2107 - Sabeur 1997 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2108 - Hunnicutt 1996 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2109 - Tollner 2008 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2110 - Tollner 2009 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2111 - Yudin BOR 2005 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2112 - Yudin 2005 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2113 - Tollner 2011 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2114 - Frayne 1999 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
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EX2116 - Chamley 2007 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
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EX2121 - Ganesan 2010 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2122 - Mestecky 1999 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2126 - Suri 2005 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2127 - Morrow 2011 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2128 - Hussain 2005 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2129 - Veazey 2003 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2130 - Baloglu 2009 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2131 - Suarez 2006 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2132 - Cauci 2005 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2133 - Flori 2007 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2134 - Mestecky 2010 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2135 - Kim 2005 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2136 - Lardner 2001 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2137 - Lipman 2005 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2138 - Rhee 2012 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2139 - Lycke 2012 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2140 - Rudin 1998 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2141 - Wu 2000 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
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EX2143 - Uppada 2011 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
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EX2146 - Johansson 1998 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2147 - Bergquist 1997 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2148 - Neto 2009 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2149 - Rhorer 2009 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2150 - Mielcarek 2000 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2151 - Houghton 2004 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2152 - Wan 2007 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
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EX2157 - Tomita 2011 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
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EX2161 - Veselinovic 2012 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2162 - Schweitzer 2008 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2163 - Gregory Petsko - National Science and Technology Medals Foundation | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2164 - Protein Structure and Function (Part 1 of 4) | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2164 - Protein Structure and Function (Part 2 of 4) | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2164 - Protein Structure and Function (Part 3 of 4) | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2164 - Protein Structure and Function (Part 4 of 4) | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2165 - Wei (US20100143457A1) | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2166 - Petsko Patent Analysis Data | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2167 - Huang 2007 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2168 - Gregory A. Petsko - American Academy of Arts and Sciences | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2169 - Query Input and database selection - BlastTopics 0.1.1 documentation | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2170 - Chain and Duthie 1940 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2171 - Tollner 2004 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2172 - Yudin 2001 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2173 - Yudin 1999 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2174 - Park 2068 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2175 - Park 2069 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2176 - Park 2070 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2177 - E-mail | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2178 - 1LOH pdb file | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2179 - 1FCV pdb file | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2180 - 2PE4 pdb file | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2181 - 8SMN pdb file | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2182 - L317A Swiss Model | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2183 - L317I Swiss Model | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2184 - L317K Swiss Model | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2185 - L317M Swiss Model | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2186 - L317Q, N47A, N219A Swiss Model | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2187 - L317Q, N47A, N131A Swiss Model | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2188 - L317Q, N47A, N131A, N219A Swiss Model | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2189 - L317Q, N131A, N219A | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2190 - Orangutan L317Q Swiss Model | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2191 - PH20 | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2192 - L317Q Swiss Model | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2193 - L317R Swiss Model | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2195 - Chimpanzee L317Q | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
EX2196 - Gibbon L317Q Swiss Model | Jan 12, 2026 | EXHIBIT | PATENT OWNER |
Patent Owner's Response | Jan 12, 2026 | PAPER | PATENT OWNER |
EX2400 - Merck Co - 10Q - 11-05-2025 | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2402 - MERCK_PGR00006 - Sidley MSA (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2403 - MERCK_PGR00056 - Dechert MSA (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2404 - MERCK_PGR00467 - Mark Stewart Offer Letter (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2405 - MERCK_PGR00052 - Hecht Engagement Letter (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2406 - MERCK_PGR00086 - Park Engagement Letter (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2407 - Executive Team - MSD | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2408 - Executive Team - Merck | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2409 - Board of Directors - MSD | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2410 - Board of Directors - Merck | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2411 - Contact Us - MSD | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2412 - Contact Us - Merck | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2413 - Who We Are - MSD | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2414 - Who We Are - Merck | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2415 - Merck Co - 10k - year 2024 | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2416 - USPTO OED Practitioner Search - Mark Stewart registration | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2417 - IPR2024-00240 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2418 - IPR2024-00622 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2419 - IPR2024-00623 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2420 - IPR2024-00624 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2421 - IPR2024-00625 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2422 - IPR2024-00647 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2423 - IPR2024-00648 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2424 - IPR2024-00649 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2425 - IPR2024-00650 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2426 - MERCK_PGR00035 - 20250813 Payment Remittance (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2427 - MERCK_PGR00042 - Dechert T360 Halozyme (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2428 - MERCK_PGR00045 - FW_ Attn_ Accounts Receivable Dept (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2429 - MERCK_PGR00049 - Halozyme - 202000447 - Invoices (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2430 - MERCK_PGR00465 - Mark Stewart Payroll Statement (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2431 - MERCK_PGR00001 - Ginkel Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2432 - MERCK_PGR00002 - Lally Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2433 - MERCK_PGR00003 - Majchrzak Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2434 - MERCK_PGR00004 - Stewart Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2435 - MERCK_PGR00005 - Su Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2436 - MERCK_PGR00036 - 20250903 Payment Remittance_Redacted (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2437 - MERCK_PGR00037 - 20251001 Payment Remittance_Redacted (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2438 - MERCK_PGR00038 - 20251203 Payment Remittance_Redacted (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2439 - MERCK_PGR00040 - 20251215 Payment Remittance_Redacted (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2440 - MERCK_PGR00046 - PAYMENT REMITTANCE DETAIL (Oct 2025) (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2441 - MERCK_PGR00047 - PAYMENT REMITTANCE DETAIL (Sep 2025) (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2442 - MERCK_PGR00048 - Invoice IN00125072310 Review History (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2443 - MERCK_PGR00050 - Invoices 5_1_2024-12_22_2025_2 of 3 (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2444 - MERCK_PGR00051 - Invoices 5_1_2024-12_22_2025_3 of 3 (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2445 - Merck Co - Bylaws | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2401 - E-mail (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
Patent Owner's Motion to Seal | Jan 6, 2026 | PAPER | PATENT OWNER |
Patent Owner's Motion for Additional Discovery (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | PAPER | PATENT OWNER |
Patent Owner's Motion for Additional Discovery (PUBLIC - REDACTED) | Jan 6, 2026 | PAPER | PATENT OWNER |
Notice of Joint Stipulation to Modify Due Dates | Dec 8, 2025 | PAPER | PATENT OWNER |
AMENDED SCHEDULING ORDER | Nov 20, 2025 | PAPER | BOARD |
Patent Owner's Updated Mandatory Notices | Nov 17, 2025 | PAPER | PATENT OWNER |
Notice of Intent to Designate Leif Peterson as Backup Counsel | Nov 11, 2025 | PAPER | PETITIONER |
Declaration of Leif Peterson | Nov 11, 2025 | EXHIBIT | PETITIONER |
Notice of Intent to Designate Sue Wang as Backup Counsel | Nov 11, 2025 | PAPER | PETITIONER |
Declaration of Sue Wang | Nov 11, 2025 | EXHIBIT | PETITIONER |
Notice of Intent to Designate Brian Goldberg as Backup Counsel | Nov 11, 2025 | PAPER | PETITIONER |
Declaration of Brian Goldberg | Nov 11, 2025 | EXHIBIT | PETITIONER |
Notice of Intent to Designate Katherine Helm as Backup Counsel | Nov 11, 2025 | PAPER | PETITIONER |
Declaration of Katherine Helm | Nov 11, 2025 | EXHIBIT | PETITIONER |
Petitioner's Updated Exhibit List | Nov 11, 2025 | PAPER | PETITIONER |
Petitioner's Updated Mandatory Notice | Nov 11, 2025 | PAPER | PETITIONER |
Petitioner's Updated Power of Attorney | Nov 10, 2025 | PAPER | PETITIONER |
Patent Owner's Objections to Evidence | Oct 30, 2025 | PAPER | PATENT OWNER |
Petitioner's Objections to Evidence | Oct 30, 2025 | PAPER | PETITIONER |
Order: SCHEDULING ORDER | Oct 20, 2025 | PAPER | BOARD |
Institution Decision: Granting Institution of Post-Grant Review 35 U.S.C. sec. 324 | Oct 16, 2025 | PAPER | BOARD |
Director Discretionary Decision: Refer | Aug 14, 2025 | PAPER | BOARD |
Petitioner's Reply in Support of Petition for Post Grant Review | Aug 12, 2025 | PAPER | PETITIONER |
Patent Owner's Updated Power of Attorney | Aug 4, 2025 | PAPER | PATENT OWNER |
Patent Owner's Updated Mandatory Notices | Aug 4, 2025 | PAPER | PATENT OWNER |
Petitioner's Reply to Patent Owner's Discretionary Denial Brief | Jul 17, 2025 | PAPER | PETITIONER |
United States District Court – National Judicial Caseload Profile | Jul 17, 2025 | EXHIBIT | PETITIONER |
Table Showing Outcomes of Disputed Motions to Stay Pending IPRs in DNJ | Jul 17, 2025 | EXHIBIT | PETITIONER |
News Release, “Halozyme Raises 2025 Financial Guidance Ranges and Reports Strong First Quarter 2025 Results” | Jul 17, 2025 | EXHIBIT | PETITIONER |
News Release, “Merck Breaks Ground on New $1 Billion Biologics Center of Excellence in Wilmington, Delaware” | Jul 17, 2025 | EXHIBIT | PETITIONER |
Halozyme Therapeutics, Inc. Q1 2025 Earnings Call Transcript (May 6, 2025) | Jul 17, 2025 | EXHIBIT | PETITIONER |
Patent Owner Preliminary Response | Jul 17, 2025 | PAPER | PATENT OWNER |
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EX2008 - Recombinant Drugs - Smithsonian Institution | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2009 - Naz 2011 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2010 - Primakoff 1988 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2011 - Guinea Pig - Merriam-Webster 2010 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2012 - Nature 2012 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2013 - Lin 1993 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2015 - USP7872107 File History (Part 1 of 3) | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2015 - USP7872107 File History (Part 2 of 3) | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2015 - USP7872107 File History (Part 3 of 3) | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2016 - Pils 2005 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2017 - EP0953574A1 | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2055 - Second Triggs-Raine Declaration | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2066 - PGR2025-00052 Petition | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
EX2067 - PGR2025-00052 EX1003 - Hecht Declaration | Jul 17, 2025 | EXHIBIT | PATENT OWNER |
Patent Owner's Updated Mandatory Notices | Jul 17, 2025 | PAPER | PATENT OWNER |
Petitioner's Updated Mandatory Notices | Jun 30, 2025 | PAPER | PETITIONER |
EX2001 - Triggs-Raine Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2002 - Triggs-Raine CV | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2003 - Disclaimer | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2005 - LinkedIn Profiles | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2006 - Sequence Listing | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2018 - Duterme 2009 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2019 - Atmuri 2008 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2020 - Hemming 2008 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2021 - Miller 2008 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2022 - Kaneiwa 2010 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2023 - PGR2025-00004 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2024 - PGR2025-00003 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2025 - PGR2025-00009 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2026 - PGR2025-00006 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2027 - Pet. for -00017 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2028 - PGR2025-00024 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2029 - PGR2025-00004 Declaration of Hecht | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2030 - PGR2025-00003 Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2031 - PGR2025-00009 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2032 - PGR2025-00006 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2033 - PGR2025-00017 Declaration of Hecht | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2034 - PGR2025-00024 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2035 - Lokeshwar 2002 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2036 - PGR2025-00033 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2037 - PGR2025-00033 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2038 - PGR2025-00039 Declaration of Hecht | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2039 - PGR2025-00039 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2046 - 2023 Pharma 50 | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2047 - Merck Financial Results | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2048 - Products List - Merck.com | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2050 - Merck Market Cap Nasdaq | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2051 - Halozyme Market Cap Nasdaq | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2052 - Halozyme News Revenue | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2053 - Halozyme - Commercial Products | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2054 - Halozyme - About Us | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2056 - PGR2025-00042 Petition | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
EX2057 - PGR2025-00042 EX1003 - Hecht Declaration | Jun 17, 2025 | EXHIBIT | PATENT OWNER |
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U.S. Patent No. 12,054,758 | Feb 4, 2025 | EXHIBIT | PETITIONER |
File History of U.S. Patent No. 12,054,758 Part 1 | Feb 4, 2025 | EXHIBIT | PETITIONER |
File History of U.S. Patent No. 12,054,758 Part 2 | Feb 4, 2025 | EXHIBIT | PETITIONER |
U.S. Patent No. 7,767,429 | Feb 4, 2025 | EXHIBIT | PETITIONER |
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Zhang, Hyaluronidase Activity of Human Hyal1 (2009) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Arming, In vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm (1997) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Bordoli, Protein Structure Homology Modeling Using SWISSMODEL (2008) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Frost, Recombinant Human Hyaluronidase (rHuPH20) (2007) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Brandon & Tooze, Introduction to Protein Structure (1999) Part 1 | Feb 4, 2025 | EXHIBIT | PETITIONER |
Brandon & Tooze, Introduction to Protein Structure (1999) Part 2 | Feb 4, 2025 | EXHIBIT | PETITIONER |
Steipe, Consensus-Based Engineering of Protein Stability (2004) | Feb 4, 2025 | EXHIBIT | PETITIONER |
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Chica, Semi-rational Approaches to Engineering Enzyme Activity (2005) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Hardy, Assessment of Contraceptive Vaccines Based on Recombinant Mouse Sper | Feb 4, 2025 | EXHIBIT | PETITIONER |
Pomering, Restricted Entry of IgG (2002) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Primakoff, Reversible Contraceptive Effect of PH-20 Immunization (1997) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Tung, Mechanism of Infertility in Male Guinea Pigs Immunized with Sperm | Feb 4, 2025 | EXHIBIT | PETITIONER |
Rosengren, Recombinant Human PH20 (2018) | Feb 4, 2025 | EXHIBIT | PETITIONER |
U.S. Patent No. 9,447,401 | Feb 4, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application No. 13/694,731 | Feb 4, 2025 | EXHIBIT | PETITIONER |
Gmachl, The Human Sperm Protein PH-20 Has Hyaluronidase Activity (1993) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Sills, "Retraction," Science, 319:569 (2008) | Feb 4, 2025 | EXHIBIT | PETITIONER |
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Wang & Moult, SNPs, Protein Structure, and Disease (2001) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Marković-Housley, Crystal Structure of Hyaluronidase (2000) | Feb 4, 2025 | EXHIBIT | PETITIONER |
"Negative Results," Nature: Editorials, 453:258 (2008) | Feb 4, 2025 | EXHIBIT | PETITIONER |
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Schwede, SWISS-MODEL: An Automated Protein Homology-Modeling Server (2003) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Alberts, Molecular Biology of the Cell, Chapter 3 (2007) | Feb 4, 2025 | EXHIBIT | PETITIONER |
He, NMR Structures of Two Designed Proteins with High Sequence Identity | Feb 4, 2025 | EXHIBIT | PETITIONER |
Alexander, A Minimal Sequence Code for Switching Protein Structure (2009) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Ruan, Design & Characterization of a Protein Fold Switching Network (2023) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Sievers, Fast, Scalable Generation of High-Quality Protein (2011) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Redline Comparison of the ’731 and ’758 Specifications | Feb 4, 2025 | EXHIBIT | PETITIONER |
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Hayden, Key Protein-Design Papers Challenged (2009) | Feb 4, 2025 | EXHIBIT | PETITIONER |
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Hom_pre2011_header | Feb 4, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011_header_clean | Feb 4, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011.fasta | Feb 4, 2025 | EXHIBIT | PETITIONER |
Ph20_pre2011.aln-clustal_num | Feb 4, 2025 | EXHIBIT | PETITIONER |
Ph20_pre2011 Alignment html | Feb 4, 2025 | EXHIBIT | PETITIONER |
Leisola & Turunen, Protein Engineering: Opportunities and Challenges 2007 | Feb 4, 2025 | EXHIBIT | PETITIONER |
Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Rosengren, Clinical Immunogenicity of rHuPH20 (2015) | Feb 4, 2025 | EXHIBIT | PETITIONER |
Collection of BLAST Webpages from the Internet Archive | Feb 4, 2025 | EXHIBIT | PETITIONER |
Collection of Clustal Omega Webpages from the Internet Archive | Feb 4, 2025 | EXHIBIT | PETITIONER |
Collection of SWISS-MODEL Webpages from the Internet Archive | Feb 4, 2025 | EXHIBIT | PETITIONER |
Collection of PyMol Webpages from the Internet Archive | Feb 4, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model | Feb 4, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with L317Q Mutation | Feb 4, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with L317R Mutation | Feb 4, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with L317M Mutation | Feb 4, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with L317I Mutation | Feb 4, 2025 | EXHIBIT | PETITIONER |
Declaration of Dr. Michael Hecht | Feb 4, 2025 | EXHIBIT | PETITIONER |
Declaration of Dr. Sheldon Park | Feb 4, 2025 | EXHIBIT | PETITIONER |
Table Associating ’758 Patent to Corresponding ’731 Application | Feb 4, 2025 | EXHIBIT | PETITIONER |
Declaration of Jeffrey P. Kushan | Feb 4, 2025 | EXHIBIT | PETITIONER |
Petition for Post Grant Review of U.S. Patent No. 12,054,758 | Feb 4, 2025 | PAPER | PETITIONER |
Petitioner's Power of Attorney | Feb 4, 2025 | PAPER | PETITIONER |