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EX2070 - Petsko Declaration | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2071 - Petsko CV | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2076 - Hecht Deposition Transcript | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2077 - Park Deposition Transcript 2025-08-07 | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
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EX2083 - Assay Guidance Manual (Part 2 of 6) | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2083 - Assay Guidance Manual (Part 3 of 6) | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2083 - Assay Guidance Manual (Part 4 of 6) | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2083 - Assay Guidance Manual (Part 5 of 6) | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2083 - Assay Guidance Manual (Part 6 of 6) | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
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EX2164 - Protein Structure and Function (Part 2 of 4) | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2164 - Protein Structure and Function (Part 3 of 4) | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2164 - Protein Structure and Function (Part 4 of 4) | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
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EX2168 - Gregory A. Petsko - American Academy of Arts and Sciences | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
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EX2178 - 1LOH pdb file | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2179 - 1FCV pdb file | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2180 - 2PE4 pdb file | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2181 - 8SMN pdb file | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2182 - D320H | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2183 - D320K | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2184 - D320R | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2185 - D320S | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
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EX2187 - N47A_N131A_D320K | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2188 - N47A_N131A_N219A_D320K | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2189 - N131A_N219A_D320K | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2190 - Orangutan_D320K | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
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EX2068 - Simpson Declaration | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2092 - Marković-Housley 2000 | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
EX2093 - Baker (US8343487B2) | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
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EX2177 - E-mail | Jan 8, 2026 | EXHIBIT | PATENT OWNER |
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EX2406 - MERCK_PGR00086 - Park Engagement Letter (CONFIDENTIAL - PROTECTIVE ORDER MATER | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2407 - Executive Team - MSD | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2408 - Executive Team - Merck | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2409 - Board of Directors - MSD | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2410 - Board of Directors - Merck | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2411 - Contact Us - MSD | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2412 - Contact Us - Merck | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2413 - Who We Are - MSD | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2414 - Who We Are - Merck | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
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EX2418 - IPR2024-00622 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2419 - IPR2024-00623 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2420 - IPR2024-00624 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2421 - IPR2024-00625 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2422 - IPR2024-00647 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2423 - IPR2024-00648 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2424 - IPR2024-00649 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2425 - IPR2024-00650 Petition | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
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EX2434 - MERCK_PGR00004 - Stewart Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
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EX2445 - Merck Co - Bylaws | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
EX2401 - E-mail (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | EXHIBIT | PATENT OWNER |
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Patent Owner's Motion for Additional Discovery (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL) | Jan 6, 2026 | PAPER | PATENT OWNER |
Patent Owner's Motion for Additional Discovery (PUBLIC - REDACTED) | Jan 6, 2026 | PAPER | PATENT OWNER |
Notice of Joint Stipulation to Modify Due Dates | Dec 8, 2025 | PAPER | PATENT OWNER |
AMENDED SCHEDULING ORDER | Nov 20, 2025 | PAPER | BOARD |
Patent Owner's Updated Mandatory Notices | Nov 17, 2025 | PAPER | PATENT OWNER |
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Declaration of Leif Peterson | Nov 11, 2025 | EXHIBIT | PETITIONER |
Notice of Intent to Designate Sue Wang as Backup Counsel | Nov 11, 2025 | PAPER | PETITIONER |
Declaration of Sue Wang | Nov 11, 2025 | EXHIBIT | PETITIONER |
Notice of Intent to Designate Brian Goldberg as Backup Counsel | Nov 11, 2025 | PAPER | PETITIONER |
Declaration of Brian Goldberg | Nov 11, 2025 | EXHIBIT | PETITIONER |
Notice of Intent to Designate Katherine Helm as Backup Counsel | Nov 11, 2025 | PAPER | PETITIONER |
Declaration of Katherine Helm | Nov 11, 2025 | EXHIBIT | PETITIONER |
Petitioner's Updated Exhibit List | Nov 11, 2025 | PAPER | PETITIONER |
Petitioner's Updated Mandatory Notices | Nov 11, 2025 | PAPER | PETITIONER |
Petitioner's Updated Power of Attorney | Nov 10, 2025 | PAPER | PETITIONER |
Patent Owner's Objections to Evidence | Oct 16, 2025 | PAPER | PATENT OWNER |
Petitioner's Objections to Evidence | Oct 15, 2025 | PAPER | PETITIONER |
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EXPUNGED | Oct 1, 2025 | PAPER | BOARD |
SCHEDULING ORDER | Oct 1, 2025 | PAPER | BOARD |
Director Discretionary Decision: Refer | Aug 14, 2025 | PAPER | BOARD |
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Patent Owner's Updated Power of Attorney | Aug 4, 2025 | PAPER | PATENT OWNER |
Patent Owner's Updated Mandatory Notices | Aug 4, 2025 | PAPER | PATENT OWNER |
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EX2067 - PGR2025-00052 EX1003 - Hecht Declaration | Jul 15, 2025 | EXHIBIT | PATENT OWNER |
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EX2015 - USP7872107 File History (Part 2 of 3) | Jul 15, 2025 | EXHIBIT | PATENT OWNER |
EX2015 - USP7872107 File History (Part 3 of 3) | Jul 15, 2025 | EXHIBIT | PATENT OWNER |
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EX2024 - PGR2025-00003 Petition | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
EX2025 - PGR2025-00009 Petition | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
EX2026 - PGR2025-00006 Petition | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
EX2027 - PGR2025-00030 Petition | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
EX2028 - PGR2025-00024 Petition | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
EX2029 - PGR2025-00004 EX1003 - Hecht Declaration | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
EX2030 - PGR2025-00003 EX1003 - Hecht Declaration | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
EX2031 - PGR2025-00009 EX1003 - Hecht Declaration | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
EX2032 - PGR2025-00006 EX1003 - Hecht Declaration | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
EX2033 - PGR2025-00030 EX1003 - Hecht Declaration | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
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EX2035 - Lokeshwar 2002 | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
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EX2039 - PGR2025-00017 Petition | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
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EX2058 - District Court Complaint | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
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EX2061 - PGR2025-00046 EX1003 - Hecht Declaration | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
EX2062 - PGR2025-00050 Petition | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
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EX2065 - PGR2025-00053 Petition | Jun 16, 2025 | EXHIBIT | PATENT OWNER |
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Patent Owner's Updated Power of Attorney | Jun 16, 2025 | PAPER | PATENT OWNER |
Patent Owner's Discretionary Denial Brief | Jun 16, 2025 | PAPER | PATENT OWNER |
Patent Owner's Updated Power of Attorney | May 21, 2025 | PAPER | PATENT OWNER |
Patent Owner's Updated Mandatory Notices | May 21, 2025 | PAPER | PATENT OWNER |
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Patent Owner's Updated Mandatory Notices | Apr 18, 2025 | PAPER | PATENT OWNER |
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Patent Owner's Power of Attorney | Apr 10, 2025 | PAPER | PATENT OWNER |
Patent Owner's Mandatory Notices | Apr 10, 2025 | PAPER | PATENT OWNER |
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Alberts, Molecular Biology of the Cell, Chapter 3 (2007) | Mar 28, 2025 | EXHIBIT | PETITIONER |
He, NMR Structures of Two Designed Proteins with High Sequence Identity | Mar 28, 2025 | EXHIBIT | PETITIONER |
Alexander, A Minimal Sequence Code for Switching Protein Structure (2009) | Mar 28, 2025 | EXHIBIT | PETITIONER |
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Sievers, Fast, Scalable Generation of High-Quality Protein (2011) | Mar 28, 2025 | EXHIBIT | PETITIONER |
Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008) | Mar 28, 2025 | EXHIBIT | PETITIONER |
Redline Comparison of the ’731 and ’185 Specifications | Mar 28, 2025 | EXHIBIT | PETITIONER |
Beasley & Hecht, Protein Design: The Choice of de Novo Sequences (1997) | Mar 28, 2025 | EXHIBIT | PETITIONER |
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Hayden, Key Protein-Design Papers Challenged (2009) | Mar 28, 2025 | EXHIBIT | PETITIONER |
KEGG, DRUG: Hyaluronidase (human recombinant) | Mar 28, 2025 | EXHIBIT | PETITIONER |
Pace & Scholtz, A Helix Propensity Scale (1998) | Mar 28, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application No. 61/631,313 | Mar 28, 2025 | EXHIBIT | PETITIONER |
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Hom_pre2011 | Mar 28, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011_header | Mar 28, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011_header_clean | Mar 28, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011.fasta | Mar 28, 2025 | EXHIBIT | PETITIONER |
Ph20_pre2011.aln-clustal_num | Mar 28, 2025 | EXHIBIT | PETITIONER |
Ph20_pre2011 Alignment html | Mar 28, 2025 | EXHIBIT | PETITIONER |
Leisola & Turunen, Protein Engineering: Opportunities and Challenges (2007) | Mar 28, 2025 | EXHIBIT | PETITIONER |
Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004) | Mar 28, 2025 | EXHIBIT | PETITIONER |
Rosengren, Clinical Immunogenicity of rHuPH20 (2015) | Mar 28, 2025 | EXHIBIT | PETITIONER |
Collection of BLAST Webpages from the Internet Archive | Mar 28, 2025 | EXHIBIT | PETITIONER |
Collection of Clustal Omega Webpages from the Internet Archive | Mar 28, 2025 | EXHIBIT | PETITIONER |
Collection of SWISS-MODEL Webpages from the Internet Archive | Mar 28, 2025 | EXHIBIT | PETITIONER |
Collection of PyMol Webpages from the Internet Archive | Mar 28, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model | Mar 28, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with D320K Mutation | Mar 28, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with D320H Mutation | Mar 28, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with D320R Mutation | Mar 28, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with D320S Mutation | Mar 28, 2025 | EXHIBIT | PETITIONER |
Hunnicutt, Sperm Surface Protein PH-20 Is Bifunctional (1996) | Mar 28, 2025 | EXHIBIT | PETITIONER |
Bookbinder, Recombinant Human Enzyme for Transport of Therapeutics (2006) | Mar 28, 2025 | EXHIBIT | PETITIONER |
Declaration of Dr. Michael Hecht | Mar 28, 2025 | EXHIBIT | PETITIONER |
Declaration of Jeffrey P. Kushan | Mar 28, 2025 | EXHIBIT | PETITIONER |
Petition for Post Grant Review of U.S. Patent No. 12,104,185 | Mar 28, 2025 | PAPER | PETITIONER |
Petitioner's Power of Attorney | Mar 28, 2025 | PAPER | PETITIONER |