IP Verse

Merck Sharp & Dohme LLC vs Halozyme, Inc. et al.

Explore the PTAB proceeding PGR2025-00039 filed by Merck Sharp & Dohme LLC against Halozyme, Inc. et al. on Mar 28, 2025. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Case Details

Proceeding Number
PGR2025-00039
Filing Date
Mar 28, 2025
Petitioner
Merck Sharp & Dohme LLC
Respondent
Halozyme, Inc. et al.
Status
Pending
Respondent Application Number
18599428
Respondent Tech Center
1600
Respondent Patent Number
12104185

Proceeding Decision New

Decision documents related to this case provide insights into the outcomes of proceedings. These documents are crucial for understanding the legal determinations and implications for the parties involved.

Document NameFiling DateCategoryFiling Party

Director Discretionary Decision: Refer

Aug 14, 2025PAPERBOARD

Proceeding Documents

The table below shows documents filed in the case, listing each document name, filing date, document type, and filing party. Tracking these filings indicates the activity of the parties involved in the case, and the types of documents filed can provide insights into the legal strategies being employed.


Document NameFiling DateCategoryFiling Party

Alert me when new update on this case

Director Discretionary Decision: Refer

Aug 14, 2025PAPERBOARD

Petitioner's Reply in Support of Petition for Post Grant Review

Aug 8, 2025PAPERPETITIONER

Patent Owner's Updated Power of Attorney

Aug 4, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Aug 4, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Jul 17, 2025PAPERPATENT OWNER

Petitioner's Reply to Patent Owner's Discretionary Denial Brief

Jul 15, 2025PAPERPETITIONER

United States District Court – National Judicial Caseload Profile

Jul 15, 2025EXHIBITPETITIONER

Table Showing Outcomes of Disputed Motions to Stay Pending IPRs in DNJ

Jul 15, 2025EXHIBITPETITIONER

News Release, “Halozyme Raises 2025 Financial Guidance Ranges and Reports Strong First Quarter 2025 Results”

Jul 15, 2025EXHIBITPETITIONER

News Release, “Merck Breaks Ground on New $1 Billion Biologics Center of Excellence in Wilmington, Delaware”

Jul 15, 2025EXHIBITPETITIONER

Halozyme Therapeutics, Inc. Q1 2025 Earnings Call Transcript (May 6, 2025)

Jul 15, 2025EXHIBITPETITIONER

EX2007 - Gifre 2017

Jul 15, 2025EXHIBITPATENT OWNER

EX2008 - Recombinant Drugs - Smithsonian Institution

Jul 15, 2025EXHIBITPATENT OWNER

EX2009 - Naz 2011

Jul 15, 2025EXHIBITPATENT OWNER

EX2010 - Primakoff 1988

Jul 15, 2025EXHIBITPATENT OWNER

EX2011 - Guinea Pig - Merriam-Webster 2010

Jul 15, 2025EXHIBITPATENT OWNER

EX2012 - Nature 2012

Jul 15, 2025EXHIBITPATENT OWNER

EX2013 - Lin 1993

Jul 15, 2025EXHIBITPATENT OWNER

EX2016 - Pils 2005

Jul 15, 2025EXHIBITPATENT OWNER

EX2017 - EP0953574A1

Jul 15, 2025EXHIBITPATENT OWNER

EX2066 - PGR2025-00052 Petition

Jul 15, 2025EXHIBITPATENT OWNER

EX2067 - PGR2025-00052 EX1003 - Hecht Declaration

Jul 15, 2025EXHIBITPATENT OWNER

EX2015 - USP7872107 File History (Part 1 of 3)

Jul 15, 2025EXHIBITPATENT OWNER

EX2015 - USP7872107 File History (Part 2 of 3)

Jul 15, 2025EXHIBITPATENT OWNER

EX2015 - USP7872107 File History (Part 3 of 3)

Jul 15, 2025EXHIBITPATENT OWNER

Patent Owner Preliminary Response

Jul 15, 2025PAPERPATENT OWNER

EX2055 - Second Triggs-Raine Declaration

Jul 15, 2025EXHIBITPATENT OWNER

Petitioner's Updated Mandatory Notices

Jun 30, 2025PAPERPETITIONER

EX2001 - Triggs-Raine Dec

Jun 16, 2025EXHIBITPATENT OWNER

EX2002 - Triggs-Raine CV

Jun 16, 2025EXHIBITPATENT OWNER

EX2003 - Disclaimer

Jun 16, 2025EXHIBITPATENT OWNER

EX2004 - Fierce Pharma

Jun 16, 2025EXHIBITPATENT OWNER

EX2005 - LinkedIn Profiles

Jun 16, 2025EXHIBITPATENT OWNER

EX2006 - Sequence Listing

Jun 16, 2025EXHIBITPATENT OWNER

EX2018 - Duterme 2009

Jun 16, 2025EXHIBITPATENT OWNER

EX2019 - Atmuri 2008

Jun 16, 2025EXHIBITPATENT OWNER

EX2020 - Hemming 2008

Jun 16, 2025EXHIBITPATENT OWNER

EX2021 - Miller 2008

Jun 16, 2025EXHIBITPATENT OWNER

EX2022 - Kaneiwa 2010

Jun 16, 2025EXHIBITPATENT OWNER

EX2023 - PGR2025-00004 Petition

Jun 16, 2025EXHIBITPATENT OWNER

EX2024 - PGR2025-00003 Petition

Jun 16, 2025EXHIBITPATENT OWNER

EX2025 - PGR2025-00009 Petition

Jun 16, 2025EXHIBITPATENT OWNER

EX2026 - PGR2025-00006 Petition

Jun 16, 2025EXHIBITPATENT OWNER

EX2027 - PGR2025-00030 Petition

Jun 16, 2025EXHIBITPATENT OWNER

EX2028 - PGR2025-00024 Petition

Jun 16, 2025EXHIBITPATENT OWNER

EX2029 - PGR2025-00004 EX1003 - Hecht Declaration

Jun 16, 2025EXHIBITPATENT OWNER

EX2030 - PGR2025-00003 EX1003 - Hecht Declaration

Jun 16, 2025EXHIBITPATENT OWNER

EX2031 - PGR2025-00009 EX1003 - Hecht Declaration

Jun 16, 2025EXHIBITPATENT OWNER

EX2032 - PGR2025-00006 EX1003 - Hecht Declaration

Jun 16, 2025EXHIBITPATENT OWNER

EX2033 - PGR2025-00030 EX1003 - Hecht Declaration

Jun 16, 2025EXHIBITPATENT OWNER

EX2034 - PGR2025-00024 EX1003 - Hecht Declaration

Jun 16, 2025EXHIBITPATENT OWNER

EX2035 - Lokeshwar 2002

Jun 16, 2025EXHIBITPATENT OWNER

EX2036 - PGR2025-00033 EX1003 - Hecht Declaration

Jun 16, 2025EXHIBITPATENT OWNER

EX2037 - PGR2025-00033 Petition

Jun 16, 2025EXHIBITPATENT OWNER

EX2038 - PGR2025-00017 EX1003 - Hecht Declaration

Jun 16, 2025EXHIBITPATENT OWNER

EX2039 - PGR2025-00017 Petition

Jun 16, 2025EXHIBITPATENT OWNER

EX2046 - 2023 Pharma 50

Jun 16, 2025EXHIBITPATENT OWNER

EX2047 - Merck Financial Results

Jun 16, 2025EXHIBITPATENT OWNER

EX2048 - Products List - Merck.com

Jun 16, 2025EXHIBITPATENT OWNER

EX2050 - Merck Market Cap Nasdaq

Jun 16, 2025EXHIBITPATENT OWNER

EX2051 - Halozyme Market Cap Nasdaq

Jun 16, 2025EXHIBITPATENT OWNER

EX2052 - Halozyme News Revenue

Jun 16, 2025EXHIBITPATENT OWNER

EX2053 - Halozyme - Commercial Products

Jun 16, 2025EXHIBITPATENT OWNER

EX2054 - Halozyme - About Us

Jun 16, 2025EXHIBITPATENT OWNER

EX2056 - PGR2025-00042 Petition

Jun 16, 2025EXHIBITPATENT OWNER

EX2057 - PGR2025-00042 EX1003 - Hecht Declaration

Jun 16, 2025EXHIBITPATENT OWNER

EX2058 - District Court Complaint

Jun 16, 2025EXHIBITPATENT OWNER

EX2059 - Alteogen announces amendment to license agreement with MSD

Jun 16, 2025EXHIBITPATENT OWNER

EX2060 - PGR2025-00046 Petition

Jun 16, 2025EXHIBITPATENT OWNER

EX2061 - PGR2025-00046 EX1003 - Hecht Declaration

Jun 16, 2025EXHIBITPATENT OWNER

EX2062 - PGR2025-00050 Petition

Jun 16, 2025EXHIBITPATENT OWNER

EX2063 - PGR2025-00050 EX1003 - Hecht Declaration

Jun 16, 2025EXHIBITPATENT OWNER

EX2064 - PGR2025-00053 EX1003 - Hecht Declaration

Jun 16, 2025EXHIBITPATENT OWNER

EX2065 - PGR2025-00053 Petition

Jun 16, 2025EXHIBITPATENT OWNER

Patent Owner's Updated Mandatory Notices

Jun 16, 2025PAPERPATENT OWNER

Patent Owner's Updated Power of Attorney

Jun 16, 2025PAPERPATENT OWNER

Patent Owner's Discretionary Denial Brief

Jun 16, 2025PAPERPATENT OWNER

Patent Owner's Updated Power of Attorney

May 21, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

May 21, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

May 5, 2025PAPERPATENT OWNER

Petitioner's Updates to Mandatory Notices

Apr 30, 2025PAPERPETITIONER

Patent Owner's Updated Mandatory Notices

Apr 18, 2025PAPERPATENT OWNER

Petitioner's Updates to Mandatory Notices

Apr 16, 2025PAPERPETITIONER

Notice: Notice filing date accorded

Apr 15, 2025PAPERBOARD

Patent Owner's Power of Attorney

Apr 10, 2025PAPERPATENT OWNER

Patent Owner's Mandatory Notices

Apr 10, 2025PAPERPATENT OWNER

U.S. Patent No. 12,104,185

Mar 28, 2025EXHIBITPETITIONER

File History of U.S. Patent No. 12,104,185 Part 1

Mar 28, 2025EXHIBITPETITIONER

File History of U.S. Patent No. 12,104,185 Part 2

Mar 28, 2025EXHIBITPETITIONER

File History of U.S. Patent No. 12,104,185 Part 3

Mar 28, 2025EXHIBITPETITIONER

Declaration of Dr. Sheldon Park

Mar 28, 2025EXHIBITPETITIONER

U.S. Patent No. US7,767,429

Mar 28, 2025EXHIBITPETITIONER

Chao, Structure of Human Hyaluronidase-1 (2007)

Mar 28, 2025EXHIBITPETITIONER

WO/2010/077297, published July 8, 2010

Mar 28, 2025EXHIBITPETITIONER

Stern, The Hyaluronidases: Their Genomics, Structures, & Mechanisms (2006)

Mar 28, 2025EXHIBITPETITIONER

Jedzrejas, Structures of Vertebrate Hyaluronidases (2005)

Mar 28, 2025EXHIBITPETITIONER

Zhang, Hyaluronidase Activity of Human Hyal1 (2009)

Mar 28, 2025EXHIBITPETITIONER

Arming, In vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm (1997)

Mar 28, 2025EXHIBITPETITIONER

Bordoli, Protein Structure Homology Modeling Using SWISSMODEL (2008)

Mar 28, 2025EXHIBITPETITIONER

Frost, Recombinant Human Hyaluronidase (rHuPH20) (2007)

Mar 28, 2025EXHIBITPETITIONER

Branden & Tooze, Introduction to Protein Structure (1999) Part 1

Mar 28, 2025EXHIBITPETITIONER

Branden & Tooze, Introduction to Protein Structure (1999) Part 2

Mar 28, 2025EXHIBITPETITIONER

Table Associating ’185 Patent to Corresponding ’731 Application

Mar 28, 2025EXHIBITPETITIONER

Steipe, Consensus-Based Engineering of Protein Stability (2004)

Mar 28, 2025EXHIBITPETITIONER

Green, Computer Graphics, Homology Modeling, and Bioinformatics (2010)

Mar 28, 2025EXHIBITPETITIONER

Chica, Semi-rational Approaches to Engineering Enzyme Activity (2005)

Mar 28, 2025EXHIBITPETITIONER

Hardy, Assessment of Contraceptive Vaccines Based on Recombinant Mouse Sper

Mar 28, 2025EXHIBITPETITIONER

Pomering, Restricted Entry of IgG (2002)

Mar 28, 2025EXHIBITPETITIONER

Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002)

Mar 28, 2025EXHIBITPETITIONER

Primakoff, Reversible Contraceptive Effect of PH-20 Immunization (1997)

Mar 28, 2025EXHIBITPETITIONER

Tung, Mechanism of Infertility in Male Guinea Pigs Immunized with Sperm

Mar 28, 2025EXHIBITPETITIONER

Rosengren, Recombinant Human PH20 (2018)

Mar 28, 2025EXHIBITPETITIONER

U.S. Patent No. 9,447,401

Mar 28, 2025EXHIBITPETITIONER

U.S. Patent Application No. 13/694,731

Mar 28, 2025EXHIBITPETITIONER

Gmachl, The Human Sperm Protein PH-20 Has Hyaluronidase Activity (1993)

Mar 28, 2025EXHIBITPETITIONER

Sills, "Retraction," Science, 319:569 (2008)

Mar 28, 2025EXHIBITPETITIONER

Yue, Loss of Protein Structure Stability as a Major Causative Factor (2005)

Mar 28, 2025EXHIBITPETITIONER

Wang & Moult, SNPs, Protein Structure, and Disease (2001)

Mar 28, 2025EXHIBITPETITIONER

Marković-Housley, Crystal Structure of Hyaluronidase (2000)

Mar 28, 2025EXHIBITPETITIONER

"Negative Results," Nature: Editorials, 453:258 (2008)

Mar 28, 2025EXHIBITPETITIONER

Lins, Analysis of Accessible Surface of Residues in Proteins (2003)

Mar 28, 2025EXHIBITPETITIONER

Hayden, Chemistry: Designer Debacle (2008)

Mar 28, 2025EXHIBITPETITIONER

Benkert, Toward the Estimation of the Absolute Quality (2010)

Mar 28, 2025EXHIBITPETITIONER

Schwede, SWISS-MODEL: An Automated Protein Homology-Modeling Server (2003)

Mar 28, 2025EXHIBITPETITIONER

Alberts, Molecular Biology of the Cell, Chapter 3 (2007)

Mar 28, 2025EXHIBITPETITIONER

He, NMR Structures of Two Designed Proteins with High Sequence Identity

Mar 28, 2025EXHIBITPETITIONER

Alexander, A Minimal Sequence Code for Switching Protein Structure (2009)

Mar 28, 2025EXHIBITPETITIONER

Ruan, Design & Characterization of a Protein Fold Switching Network (2023)

Mar 28, 2025EXHIBITPETITIONER

Sievers, Fast, Scalable Generation of High-Quality Protein (2011)

Mar 28, 2025EXHIBITPETITIONER

Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008)

Mar 28, 2025EXHIBITPETITIONER

Redline Comparison of the ’731 and ’185 Specifications

Mar 28, 2025EXHIBITPETITIONER

Beasley & Hecht, Protein Design: The Choice of de Novo Sequences (1997)

Mar 28, 2025EXHIBITPETITIONER

Xiong, Periodicity of Polar and Nonpolar Amino Acids (1995)

Mar 28, 2025EXHIBITPETITIONER

Hayden, Key Protein-Design Papers Challenged (2009)

Mar 28, 2025EXHIBITPETITIONER

KEGG, DRUG: Hyaluronidase (human recombinant)

Mar 28, 2025EXHIBITPETITIONER

Pace & Scholtz, A Helix Propensity Scale (1998)

Mar 28, 2025EXHIBITPETITIONER

U.S. Patent Application No. 61/631,313

Mar 28, 2025EXHIBITPETITIONER

U.S. Patent Application No. 61/796,208

Mar 28, 2025EXHIBITPETITIONER

Hom_pre2011

Mar 28, 2025EXHIBITPETITIONER

Hom_pre2011_header

Mar 28, 2025EXHIBITPETITIONER

Hom_pre2011_header_clean

Mar 28, 2025EXHIBITPETITIONER

Hom_pre2011.fasta

Mar 28, 2025EXHIBITPETITIONER

Ph20_pre2011.aln-clustal_num

Mar 28, 2025EXHIBITPETITIONER

Ph20_pre2011 Alignment html

Mar 28, 2025EXHIBITPETITIONER

Leisola & Turunen, Protein Engineering: Opportunities and Challenges (2007)

Mar 28, 2025EXHIBITPETITIONER

Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004)

Mar 28, 2025EXHIBITPETITIONER

Rosengren, Clinical Immunogenicity of rHuPH20 (2015)

Mar 28, 2025EXHIBITPETITIONER

Collection of BLAST Webpages from the Internet Archive

Mar 28, 2025EXHIBITPETITIONER

Collection of Clustal Omega Webpages from the Internet Archive

Mar 28, 2025EXHIBITPETITIONER

Collection of SWISS-MODEL Webpages from the Internet Archive

Mar 28, 2025EXHIBITPETITIONER

Collection of PyMol Webpages from the Internet Archive

Mar 28, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model

Mar 28, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with D320K Mutation

Mar 28, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with D320H Mutation

Mar 28, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with D320R Mutation

Mar 28, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with D320S Mutation

Mar 28, 2025EXHIBITPETITIONER

Hunnicutt, Sperm Surface Protein PH-20 Is Bifunctional (1996)

Mar 28, 2025EXHIBITPETITIONER

Bookbinder, Recombinant Human Enzyme for Transport of Therapeutics (2006)

Mar 28, 2025EXHIBITPETITIONER

Declaration of Dr. Michael Hecht

Mar 28, 2025EXHIBITPETITIONER

Declaration of Jeffrey P. Kushan

Mar 28, 2025EXHIBITPETITIONER

Petition for Post Grant Review of U.S. Patent No. 12,104,185

Mar 28, 2025PAPERPETITIONER

Petitioner's Power of Attorney

Mar 28, 2025PAPERPETITIONER