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IP Verse

Merck Sharp & Dohme LLC v. Halozyme, Inc. et al. - PGR2025-00042

Explore the PTAB proceeding PGR2025-00042 filed by Merck Sharp & Dohme LLC against Halozyme, Inc. et al. on Apr 15, 2025. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Case Details

Proceeding Number
PGR2025-00042
Filing Date
Apr 15, 2025
Petitioner
Merck Sharp & Dohme LLC
Respondent
Halozyme, Inc. et al.
Status
Trial Instituted
Respondent Application Number
17327586
Respondent Tech Center
1600
Respondent Patent Number
12037618
Institution Decision Date
Nov 13, 2025

Decision Documents New

Decision documents related to this case provide insights into the outcomes of proceedings. These documents are crucial for understanding the legal determinations and implications for the parties involved.

Document NameFiling DateCategoryFiling Party

Institution Decision: Granting Institution of Post-Grant Review 35 U.S.C. sec. 324

Nov 13, 2025PAPERBOARD

Director Discretionary Decision: Refer

Sep 3, 2025PAPERBOARD

Counsels Involved New

Details of counsels involved in proceeding number PGR2025-00042.

TypeName
Petitioner CounselKushan, Jeffreyet al
Respondent CounselEllison, Eldoraet al

Proceeding Documents

The table below shows documents filed in the case, listing each document name, filing date, document type, and filing party. Tracking these filings indicates the activity of the parties involved in the case, and the types of documents filed can provide insights into the legal strategies being employed.

Document NameFiling DateCategoryFiling Party

Alert me when new update on this case

EX2068 - Simpson Declaration

Jan 15, 2026EXHIBITPATENT OWNER

EX2069 - Simpson CV

Jan 15, 2026EXHIBITPATENT OWNER

EX2070 - Petsko Declaration

Jan 15, 2026EXHIBITPATENT OWNER

EX2071 - Petsko CV

Jan 15, 2026EXHIBITPATENT OWNER

EX2072 - Cherr Declaration

Jan 15, 2026EXHIBITPATENT OWNER

EX2073 - Cherr CV

Jan 15, 2026EXHIBITPATENT OWNER

EX2075 - Moon CV

Jan 15, 2026EXHIBITPATENT OWNER

EX2076 - Hecht Deposition Transcript

Jan 15, 2026EXHIBITPATENT OWNER

EX2077 - Park Deposition Transcript 2025-08-07

Jan 15, 2026EXHIBITPATENT OWNER

EX2078 - Park Deposition Transcript 2025-08-21

Jan 15, 2026EXHIBITPATENT OWNER

EX2079 - Koehl 1999

Jan 15, 2026EXHIBITPATENT OWNER

EX2080 - Pommié 2004

Jan 15, 2026EXHIBITPATENT OWNER

EX2082 - Kyte and Doolittle 1982

Jan 15, 2026EXHIBITPATENT OWNER

EX2083 - Assay Guidance Manual (Part 1 of 6)

Jan 15, 2026EXHIBITPATENT OWNER

EX2083 - Assay Guidance Manual (Part 2 of 6)

Jan 15, 2026EXHIBITPATENT OWNER

EX2083 - Assay Guidance Manual (Part 3 of 6)

Jan 15, 2026EXHIBITPATENT OWNER

EX2083 - Assay Guidance Manual (Part 4 of 6)

Jan 15, 2026EXHIBITPATENT OWNER

EX2083 - Assay Guidance Manual (Part 5 of 6)

Jan 15, 2026EXHIBITPATENT OWNER

EX2083 - Assay Guidance Manual (Part 6 of 6)

Jan 15, 2026EXHIBITPATENT OWNER

EX2084 - The Central Role of Enzymes as Biological Catalysts

Jan 15, 2026EXHIBITPATENT OWNER

EX2085 - French 1983

Jan 15, 2026EXHIBITPATENT OWNER

EX2086 - El-Safory 2010

Jan 15, 2026EXHIBITPATENT OWNER

EX2087 - Lu 2025

Jan 15, 2026EXHIBITPATENT OWNER

EX2088 - Stern & Cóska 2000

Jan 15, 2026EXHIBITPATENT OWNER

EX2089 - Gmachl 1993

Jan 15, 2026EXHIBITPATENT OWNER

EX2090 - Gmachl-Kreil 1993

Jan 15, 2026EXHIBITPATENT OWNER

EX2091 - Davies 1995

Jan 15, 2026EXHIBITPATENT OWNER

EX2092 - Marković-Housley 2000

Jan 15, 2026EXHIBITPATENT OWNER

EX2093 - Baker (US8343487B2)

Jan 15, 2026EXHIBITPATENT OWNER

EX2094 - MULTIDROP 384 Liquid Handling Device Manual 2008

Jan 15, 2026EXHIBITPATENT OWNER

EX2096 - Frost 1997

Jan 15, 2026EXHIBITPATENT OWNER

EX2097 - Bookbinder (US20050260186A1)

Jan 15, 2026EXHIBITPATENT OWNER

EX2098 - Delpech 1995

Jan 15, 2026EXHIBITPATENT OWNER

EX2099 - Takahashi 2003

Jan 15, 2026EXHIBITPATENT OWNER

EX2100 - Vines 2001

Jan 15, 2026EXHIBITPATENT OWNER

EX2101 - Wassarman 1999

Jan 15, 2026EXHIBITPATENT OWNER

EX2102 - Yudin 1988

Jan 15, 2026EXHIBITPATENT OWNER

EX2103 - Tollner 2012

Jan 15, 2026EXHIBITPATENT OWNER

EX2104 - Visconti 1998

Jan 15, 2026EXHIBITPATENT OWNER

EX2105 - Wassarman 2001

Jan 15, 2026EXHIBITPATENT OWNER

EX2106 - Bailey 2010

Jan 15, 2026EXHIBITPATENT OWNER

EX2107 - Sabeur 1997

Jan 15, 2026EXHIBITPATENT OWNER

EX2108 - Hunnicutt 1996

Jan 15, 2026EXHIBITPATENT OWNER

EX2109 - Tollner 2008

Jan 15, 2026EXHIBITPATENT OWNER

EX2110 - Tollner 2009

Jan 15, 2026EXHIBITPATENT OWNER

EX2111 - Yudin BOR 2005

Jan 15, 2026EXHIBITPATENT OWNER

EX2112 - Yudin 2005

Jan 15, 2026EXHIBITPATENT OWNER

EX2113 - Tollner 2011

Jan 15, 2026EXHIBITPATENT OWNER

EX2114 - Frayne 1999

Jan 15, 2026EXHIBITPATENT OWNER

EX2115 - Yanagimachi 1975

Jan 15, 2026EXHIBITPATENT OWNER

EX2116 - Chamley 2007

Jan 15, 2026EXHIBITPATENT OWNER

EX2117 - Kremer 1992

Jan 15, 2026EXHIBITPATENT OWNER

EX2118 - Primakoff 1983

Jan 15, 2026EXHIBITPATENT OWNER

EX2119 - Myles and Primakoff 1984

Jan 15, 2026EXHIBITPATENT OWNER

EX2120 - Chan 1999

Jan 15, 2026EXHIBITPATENT OWNER

EX2121 - Ganesan 2010

Jan 15, 2026EXHIBITPATENT OWNER

EX2122 - Mestecky 1999

Jan 15, 2026EXHIBITPATENT OWNER

EX2126 - Suri 2005

Jan 15, 2026EXHIBITPATENT OWNER

EX2127 - Morrow 2011

Jan 15, 2026EXHIBITPATENT OWNER

EX2128 - Hussain 2005

Jan 15, 2026EXHIBITPATENT OWNER

EX2129 - Veazey 2003

Jan 15, 2026EXHIBITPATENT OWNER

EX2130 - Baloglu 2009

Jan 15, 2026EXHIBITPATENT OWNER

EX2131 - Suarez 2006

Jan 15, 2026EXHIBITPATENT OWNER

EX2132 - Cauci 2005

Jan 15, 2026EXHIBITPATENT OWNER

EX2133 - Flori 2007

Jan 15, 2026EXHIBITPATENT OWNER

EX2134 - Mestecky 2010

Jan 15, 2026EXHIBITPATENT OWNER

EX2135 - Kim 2005

Jan 15, 2026EXHIBITPATENT OWNER

EX2136 - Lardner 2001

Jan 15, 2026EXHIBITPATENT OWNER

EX2137 - Lipman 2005

Jan 15, 2026EXHIBITPATENT OWNER

EX2138 - Rhee 2012

Jan 15, 2026EXHIBITPATENT OWNER

EX2139 - Lycke 2012

Jan 15, 2026EXHIBITPATENT OWNER

EX2140 - Rudin 1998

Jan 15, 2026EXHIBITPATENT OWNER

EX2141 - Wu 2000

Jan 15, 2026EXHIBITPATENT OWNER

EX2142 - Russell 2002

Jan 15, 2026EXHIBITPATENT OWNER

EX2143 - Uppada 2011

Jan 15, 2026EXHIBITPATENT OWNER

EX2145 - Gallichan 1995

Jan 15, 2026EXHIBITPATENT OWNER

EX2146 - Johansson 1998

Jan 15, 2026EXHIBITPATENT OWNER

EX2147 - Bergquist 1997

Jan 15, 2026EXHIBITPATENT OWNER

EX2148 - Neto 2009

Jan 15, 2026EXHIBITPATENT OWNER

EX2149 - Rhorer 2009

Jan 15, 2026EXHIBITPATENT OWNER

EX2150 - Mielcarek 2000

Jan 15, 2026EXHIBITPATENT OWNER

EX2151 - Houghton 2004

Jan 15, 2026EXHIBITPATENT OWNER

EX2152 - Wan 2007

Jan 15, 2026EXHIBITPATENT OWNER

EX2153 - Dieude 2009

Jan 15, 2026EXHIBITPATENT OWNER

EX2154 - Oliver 2003

Jan 15, 2026EXHIBITPATENT OWNER

EX2155 - Trentham 1977

Jan 15, 2026EXHIBITPATENT OWNER

EX2156 - Courtenay 1980

Jan 15, 2026EXHIBITPATENT OWNER

EX2157 - Tomita 2011

Jan 15, 2026EXHIBITPATENT OWNER

EX2158 - Zhang 2012

Jan 15, 2026EXHIBITPATENT OWNER

EX2159 - Zeitlin 1996

Jan 15, 2026EXHIBITPATENT OWNER

EX2160 - Sherwood 1996

Jan 15, 2026EXHIBITPATENT OWNER

EX2161 - Veselinovic 2012

Jan 15, 2026EXHIBITPATENT OWNER

EX2162 - Schweitzer 2008

Jan 15, 2026EXHIBITPATENT OWNER

EX2163 - Gregory Petsko - National Science and Technology Medals Foundation

Jan 15, 2026EXHIBITPATENT OWNER

EX2164 - Protein Structure and Function (Part 1 of 4)

Jan 15, 2026EXHIBITPATENT OWNER

EX2164 - Protein Structure and Function (Part 2 of 4)

Jan 15, 2026EXHIBITPATENT OWNER

EX2164 - Protein Structure and Function (Part 3 of 4)

Jan 15, 2026EXHIBITPATENT OWNER

EX2164 - Protein Structure and Function (Part 4 of 4)

Jan 15, 2026EXHIBITPATENT OWNER

EX2165 - Wei (US20100143457A1)

Jan 15, 2026EXHIBITPATENT OWNER

EX2166 - Petsko Patent Analysis Data

Jan 15, 2026EXHIBITPATENT OWNER

EX2167 - Huang 2007

Jan 15, 2026EXHIBITPATENT OWNER

EX2168 - Gregory A. Petsko - American Academy of Arts and Sciences

Jan 15, 2026EXHIBITPATENT OWNER

EX2169 - Query Input and database selection - BlastTopics 0.1.1 documentation

Jan 15, 2026EXHIBITPATENT OWNER

EX2170 - Chain and Duthie 1940

Jan 15, 2026EXHIBITPATENT OWNER

EX2171 - Tollner 2004

Jan 15, 2026EXHIBITPATENT OWNER

EX2172 - Yudin 2001

Jan 15, 2026EXHIBITPATENT OWNER

EX2173 - Yudin 1999

Jan 15, 2026EXHIBITPATENT OWNER

EX2174 - Park 2068

Jan 15, 2026EXHIBITPATENT OWNER

EX2175 - Park 2069

Jan 15, 2026EXHIBITPATENT OWNER

EX2176 - Park 2070

Jan 15, 2026EXHIBITPATENT OWNER

EX2177 - E-mail

Jan 15, 2026EXHIBITPATENT OWNER

EX2178 - 1LOH pdb file

Jan 15, 2026EXHIBITPATENT OWNER

EX2179 - 1FCV pdb file

Jan 15, 2026EXHIBITPATENT OWNER

EX2180 - 2PE4 pdb file

Jan 15, 2026EXHIBITPATENT OWNER

EX2181 - 8SMN pdb file

Jan 15, 2026EXHIBITPATENT OWNER

EX2182 - I309L Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2183 - I309N Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2184 - I309E Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2185 - I309G Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2186 - I309H Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2187 - I309M Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2188 - I309Q Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2189 - I309R Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2190 - I309S Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2191 - PH20 Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2192 - I309V Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2193 - I309N, N47A, N219A Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2194 - I309N, N47A, N131A Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2195 - I309N, N47A, N131A, N219A Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2196 - I309N, N131A, N219A Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2197 - Orangutan I309N Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2198 - Chimpanzee I309N Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2199 - Gibbon I309N Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

Patent Owner's Response

Jan 15, 2026PAPERPATENT OWNER

EX2074 - Moon Declaration

Jan 15, 2026EXHIBITPATENT OWNER

EX2200 - I309T Swiss Model

Jan 15, 2026EXHIBITPATENT OWNER

EX2400 - Merck Co - 10Q - 11-05-2025

Jan 6, 2026EXHIBITPATENT OWNER

EX2402 - MERCK_PGR00006 - Sidley MSA (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2403 - MERCK_PGR00056 - Dechert MSA (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2404 - MERCK_PGR00467 - Mark Stewart Offer Letter (CONFIDENTIAL - PROTECTIVE ORDER MA

Jan 6, 2026EXHIBITPATENT OWNER

EX2405 - MERCK_PGR00052 - Hecht Engagement Letter (CONFIDENTIAL - PROTECTIVE ORDER MATE

Jan 6, 2026EXHIBITPATENT OWNER

EX2406 - MERCK_PGR00086 - Park Engagement Letter (CONFIDENTIAL - PROTECTIVE ORDER MATER

Jan 6, 2026EXHIBITPATENT OWNER

EX2407 - Executive Team - MSD

Jan 6, 2026EXHIBITPATENT OWNER

EX2408 - Executive Team - Merck

Jan 6, 2026EXHIBITPATENT OWNER

EX2409 - Board of Directors - MSD

Jan 6, 2026EXHIBITPATENT OWNER

EX2410 - Board of Directors - Merck

Jan 6, 2026EXHIBITPATENT OWNER

EX2411 - Contact Us - MSD

Jan 6, 2026EXHIBITPATENT OWNER

EX2412 - Contact Us - Merck

Jan 6, 2026EXHIBITPATENT OWNER

EX2413 - Who We Are - MSD

Jan 6, 2026EXHIBITPATENT OWNER

EX2414 - Who We Are - Merck

Jan 6, 2026EXHIBITPATENT OWNER

EX2415 - Merck Co - 10k - year 2024

Jan 6, 2026EXHIBITPATENT OWNER

EX2416 - USPTO OED Practitioner Search - Mark Stewart registration

Jan 6, 2026EXHIBITPATENT OWNER

EX2417 - IPR2024-00240 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2418 - IPR2024-00622 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2419 - IPR2024-00623 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2420 - IPR2024-00624 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2421 - IPR2024-00625 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2422 - IPR2024-00647 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2423 - IPR2024-00648 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2424 - IPR2024-00649 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2425 - IPR2024-00650 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2426 - MERCK_PGR00035 - 20250813 Payment Remittance (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2427 - MERCK_PGR00042 - Dechert T360 Halozyme (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2428 - MERCK_PGR00045 - FW_ Attn_ Accounts Receivable Dept (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2429 - MERCK_PGR00049 - Halozyme - 202000447 - Invoices (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2430 - MERCK_PGR00465 - Mark Stewart Payroll Statement (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2431 - MERCK_PGR00001 - Ginkel Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2432 - MERCK_PGR00002 - Lally Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2433 - MERCK_PGR00003 - Majchrzak Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2434 - MERCK_PGR00004 - Stewart Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2435 - MERCK_PGR00005 - Su Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2436 - MERCK_PGR00036 - 20250903 Payment Remittance_Redacted (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2437 - MERCK_PGR00037 - 20251001 Payment Remittance_Redacted (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2438 - MERCK_PGR00038 - 20251203 Payment Remittance_Redacted (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2439 - MERCK_PGR00040 - 20251215 Payment Remittance_Redacted (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2440 - MERCK_PGR00046 - PAYMENT REMITTANCE DETAIL (Oct 2025) (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2441 - MERCK_PGR00047 - PAYMENT REMITTANCE DETAIL (Sep 2025) (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2442 - MERCK_PGR00048 - Invoice IN00125072310 Review History (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2443 - MERCK_PGR00050 - Invoices 5_1_2024-12_22_2025_2 of 3 (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2444 - MERCK_PGR00051 - Invoices 5_1_2024-12_22_2025_3 of 3 (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2445 - Merck Co - Bylaws

Jan 6, 2026EXHIBITPATENT OWNER

EX2401 - E-mail (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

Patent Owner's Motion to Seal

Jan 6, 2026PAPERPATENT OWNER

Patent Owner's Motion for Additional Discovery (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026PAPERPATENT OWNER

Patent Owner's Motion for Additional Discovery (PUBLIC - REDACTED)

Jan 6, 2026PAPERPATENT OWNER

Notice of Joint Stipulation to Modify Due Dates

Dec 8, 2025PAPERPATENT OWNER

Petitioner's Objections to Evidence

Nov 26, 2025PAPERPETITIONER

Patent Owner's Objections to Evidence

Nov 26, 2025PAPERPATENT OWNER

SCHEDULING ORDER

Nov 20, 2025PAPERBOARD

Patent Owner's Updated Mandatory Notices

Nov 17, 2025PAPERPATENT OWNER

Institution Decision: Granting Institution of Post-Grant Review 35 U.S.C. sec. 324

Nov 13, 2025PAPERBOARD

Notice of Intent to Designate Leif Peterson as Backup Counsel

Nov 11, 2025PAPERPETITIONER

Declaration of Leif Peterson

Nov 11, 2025EXHIBITPETITIONER

Notice of Intent to Designate Sue Wang as Backup Counsel

Nov 11, 2025PAPERPETITIONER

Declaration of Sue Wang

Nov 11, 2025EXHIBITPETITIONER

Notice of Intent to Designate Brian Goldberg as Backup Counsel

Nov 11, 2025PAPERPETITIONER

Declaration of Brian Goldberg

Nov 11, 2025EXHIBITPETITIONER

Notice of Intent to Designate Katherine Helm as Backup Counsel

Nov 11, 2025PAPERPETITIONER

Declaration of Katherine Helm

Nov 11, 2025EXHIBITPETITIONER

Petitioner's Updated Exhibit List

Nov 11, 2025PAPERPETITIONER

Petitioner's Updated Mandatory Notice

Nov 11, 2025PAPERPETITIONER

Petitioner's Updated Power of Attorney

Nov 10, 2025PAPERPETITIONER

Director Discretionary Decision: Refer

Sep 3, 2025PAPERBOARD

Petitioner's Reply to Patent Owner's Discretionary Denial Brief

Aug 18, 2025PAPERPETITIONER

United States District Court – National Judicial Caseload Profile

Aug 18, 2025EXHIBITPETITIONER

Table Showing Outcomes of Disputed Motions to Stay Pending IPRs in DNJ

Aug 18, 2025EXHIBITPETITIONER

News Release, Halozyme Raises 2025 Financial Guidance Ranges and Reports Strong First Quarter 2025 Results

Aug 18, 2025EXHIBITPETITIONER

News Release, Merck Breaks Ground on New $1 Billion Biologics Center of Excellence in Wilmington, Delaware

Aug 18, 2025EXHIBITPETITIONER

Halozyme Therapeutics, Inc. Q1 2025 Earnings Call Transcript (May 6, 2025)

Aug 18, 2025EXHIBITPETITIONER

Patent Owner's Updated Power of Attorney

Aug 4, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Aug 4, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Jul 17, 2025PAPERPATENT OWNER

EX2001 - Triggs-Raine Declaration

Jul 16, 2025EXHIBITPATENT OWNER

EX2002 - Triggs-Raine CV

Jul 16, 2025EXHIBITPATENT OWNER

EX2003 - Disclaimer

Jul 16, 2025EXHIBITPATENT OWNER

EX2004 - Fierce Pharma

Jul 16, 2025EXHIBITPATENT OWNER

EX2005 - LinkedIn Profiles

Jul 16, 2025EXHIBITPATENT OWNER

EX2006 - Sequence Listing

Jul 16, 2025EXHIBITPATENT OWNER

EX2010 - Primakoff 1988

Jul 16, 2025EXHIBITPATENT OWNER

EX2018 - Duterme 2009

Jul 16, 2025EXHIBITPATENT OWNER

EX2019 - Atmuri 2008

Jul 16, 2025EXHIBITPATENT OWNER

EX2020 - Hemming 2008

Jul 16, 2025EXHIBITPATENT OWNER

EX2021 - Miller 2008

Jul 16, 2025EXHIBITPATENT OWNER

EX2022 - Kaneiwa 2010

Jul 16, 2025EXHIBITPATENT OWNER

EX2023 - PGR2025-00004 Petition

Jul 16, 2025EXHIBITPATENT OWNER

EX2024 - PGR2025-00003 Petition

Jul 16, 2025EXHIBITPATENT OWNER

EX2025 - PGR2025-00009 Petition

Jul 16, 2025EXHIBITPATENT OWNER

EX2027 - PGR2025-00017 Petition

Jul 16, 2025EXHIBITPATENT OWNER

EX2028 - PGR2025-00024 Petition

Jul 16, 2025EXHIBITPATENT OWNER

EX2029 - PGR2025-00004 EX1003 - Hecht Declaration

Jul 16, 2025EXHIBITPATENT OWNER

EX2030 - PGR2025-00003 EX1003 - Hecht Declaration

Jul 16, 2025EXHIBITPATENT OWNER

EX2031 - PGR2025-00009 EX1003 - Hecht Declaration

Jul 16, 2025EXHIBITPATENT OWNER

EX2032 - PGR2025-00006 EX1003 - Hecht Declaration

Jul 16, 2025EXHIBITPATENT OWNER

EX2033 - PGR2025-00017 EX1003 - Hecht Declaration

Jul 16, 2025EXHIBITPATENT OWNER

EX2034 - PGR2025-00024 EX1003 - Hecht Declaration

Jul 16, 2025EXHIBITPATENT OWNER

EX2035 - Lokeshwar 2002

Jul 16, 2025EXHIBITPATENT OWNER

EX2036 - PGR2025-00033 EX1003 - Hecht Declaration

Jul 16, 2025EXHIBITPATENT OWNER

EX2037 - PGR2025-00033 Petition

Jul 16, 2025EXHIBITPATENT OWNER

EX2038 - PGR2025-00039 EX1003 - Hecht Declaration

Jul 16, 2025EXHIBITPATENT OWNER

EX2039 - PGR2025-00039 Petition

Jul 16, 2025EXHIBITPATENT OWNER

EX2046 - 2023 Pharma 50

Jul 16, 2025EXHIBITPATENT OWNER

EX2047 - Merck Financial Results

Jul 16, 2025EXHIBITPATENT OWNER

EX2048 - Products List - Merck.com

Jul 16, 2025EXHIBITPATENT OWNER

EX2050 - Merck Market Cap Nasdaq

Jul 16, 2025EXHIBITPATENT OWNER

EX2051 - Halozyme Market Cap Nasdaq

Jul 16, 2025EXHIBITPATENT OWNER

EX2052 - Halozyme News Revenue

Jul 16, 2025EXHIBITPATENT OWNER

EX2053 - Halozyme - Commercial Products

Jul 16, 2025EXHIBITPATENT OWNER

EX2054 - Halozyme - About Us

Jul 16, 2025EXHIBITPATENT OWNER

EX2056 - PGR2025-00030 Petition

Jul 16, 2025EXHIBITPATENT OWNER

EX2057 - PGR2025-00030 EX1003 - Hecht Declaration

Jul 16, 2025EXHIBITPATENT OWNER

EX2058 - District Court Complaint

Jul 16, 2025EXHIBITPATENT OWNER

EX2059 - Alteogen announces amendment to license agreement with MSD

Jul 16, 2025EXHIBITPATENT OWNER

EX2060 - PGR2025-00046 Petition

Jul 16, 2025EXHIBITPATENT OWNER

EX2061 - PGR2025-00046 EX1003 - Hecht Declaration

Jul 16, 2025EXHIBITPATENT OWNER

EX2062 - PGR2025-00050 Petition

Jul 16, 2025EXHIBITPATENT OWNER

EX2063 - PGR2025-00050 EX1003 - Hecht Declaration

Jul 16, 2025EXHIBITPATENT OWNER

EX2064 - PGR2025-00053 EX1003 - Hecht Declaration

Jul 16, 2025EXHIBITPATENT OWNER

EX2065 - PGR2025-00053 Petition

Jul 16, 2025EXHIBITPATENT OWNER

EX2066 - PGR2025-00052 Petition

Jul 16, 2025EXHIBITPATENT OWNER

EX2067 - PGR2025-00052 EX1003 - Hecht Declaration

Jul 16, 2025EXHIBITPATENT OWNER

Patent Owner Discretionary Denial Brief

Jul 16, 2025PAPERPATENT OWNER

EX2026 - PGR2025-00006 Petition

Jul 16, 2025EXHIBITPATENT OWNER

Petitioner's Updated Mandatory Notices

Jun 30, 2025PAPERPETITIONER

Patent Owner's Updated Power of Attorney

Jun 20, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

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U.S. Patent No. 12,037,618

Apr 15, 2025EXHIBITPETITIONER

U.S. Patent No. 7,767,429

Apr 15, 2025EXHIBITPETITIONER

Chao, Structure of Human Huyaluronidase-1 (2007)

Apr 15, 2025EXHIBITPETITIONER

Stern, Hyaluronidases: Their Genomics, Structures, and Mechanisms of Action

Apr 15, 2025EXHIBITPETITIONER

Jedzrejas, Structures of Vertebrate Hyaluronidases (2005)

Apr 15, 2025EXHIBITPETITIONER

Zhang, Hyaluronidase Activity of Human Hyall (2009)

Apr 15, 2025EXHIBITPETITIONER

Arming, In vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm (1997)

Apr 15, 2025EXHIBITPETITIONER

Bordoli, Protein Structure Homology Modeling Using SWISSMODEL (2008)

Apr 15, 2025EXHIBITPETITIONER

Frost, Recombinant Human Hyaluronidase (rHuPH20) (2007)

Apr 15, 2025EXHIBITPETITIONER

Brandon & Tooze, Introduction to Protein Structure (1999) Part 1

Apr 15, 2025EXHIBITPETITIONER

Brandon & Tooze, Introduction to Protein Structure (1999) Part 2

Apr 15, 2025EXHIBITPETITIONER

Steipe, Consensus-Based Engineering of Protein Stability (2004)

Apr 15, 2025EXHIBITPETITIONER

Green, Computer Graphics, Homology Modeling, and Bioinformatics (2010)

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Chica, Semi-rational Approaches to Engineering Enzyme Activity (2005)

Apr 15, 2025EXHIBITPETITIONER

Hardy, Assessment of Contraceptive Vaccines Based on Recombinant Mouse Sp.

Apr 15, 2025EXHIBITPETITIONER

Pomering, Restricted Entry of IgG (2002)

Apr 15, 2025EXHIBITPETITIONER

Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002)

Apr 15, 2025EXHIBITPETITIONER

Primakoff, Reversible Contraceptive Effect of PH-20 Immunization (1997)

Apr 15, 2025EXHIBITPETITIONER

Tung, Mechanism of Infertility in Male Guinea Pigs Immunized with Sperm

Apr 15, 2025EXHIBITPETITIONER

Rosengren, Recombinant Human PH20 (2018)

Apr 15, 2025EXHIBITPETITIONER

U.S. Patent No. 9,447,401

Apr 15, 2025EXHIBITPETITIONER

U.S. Patent Application No. 13/694,731

Apr 15, 2025EXHIBITPETITIONER

Gmachl, The Human Sperm Protein PH-20 Has Hyaluronidase Activity (1993)

Apr 15, 2025EXHIBITPETITIONER

Sills, “Retraction,” Science, 319:569 (2008)

Apr 15, 2025EXHIBITPETITIONER

Yue, Loss of Protein Structure Stability as a Major Causative Factor (2005)

Apr 15, 2025EXHIBITPETITIONER

Wang & Moult, SNPs, Protein Structure, and Disease (2001)

Apr 15, 2025EXHIBITPETITIONER

Marković-Housley, Crystal Structure of Hyaluronidase (2000)

Apr 15, 2025EXHIBITPETITIONER

“Negative Results,” Nature: Editorials, 453:258 (2008)

Apr 15, 2025EXHIBITPETITIONER

Lins, Analysis of Accessible Surface of Residues in Proteins (2003)

Apr 15, 2025EXHIBITPETITIONER

Hayden, Chemistry: Designer Debacle (2008)

Apr 15, 2025EXHIBITPETITIONER

Benkert, Toward the Estimation of the Absolute Quality (2010)

Apr 15, 2025EXHIBITPETITIONER

Schwede, SWISS-MODEL: An Automated Protein Homology-Modeling Server (2003)

Apr 15, 2025EXHIBITPETITIONER

Alberts, Molecular Biology of the Cell, Chapter 3 (2007)

Apr 15, 2025EXHIBITPETITIONER

He, NMR Structures of Two Designed Proteins with High Sequence Identity

Apr 15, 2025EXHIBITPETITIONER

Alexander, A Minimal Sequence Code for Switching Protein Structure (2009)

Apr 15, 2025EXHIBITPETITIONER

Ruan, Design & Characterization of a Protein Fold Switching Network (2023)

Apr 15, 2025EXHIBITPETITIONER

Sievers, Fast, Scalable Generation of High-Quality Protein (2011)

Apr 15, 2025EXHIBITPETITIONER

Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008)

Apr 15, 2025EXHIBITPETITIONER

Redline Comparison of the ’731 and ’618 Specifications

Apr 15, 2025EXHIBITPETITIONER

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Apr 15, 2025EXHIBITPETITIONER

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Apr 15, 2025EXHIBITPETITIONER

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Apr 15, 2025EXHIBITPETITIONER

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Apr 15, 2025EXHIBITPETITIONER

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Apr 15, 2025EXHIBITPETITIONER

U.S. Patent Application No. 61/631,313

Apr 15, 2025EXHIBITPETITIONER

U.S. Patent Application No. 61/796,208

Apr 15, 2025EXHIBITPETITIONER

Hom_pre2011

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Hom_pre2011_header

Apr 15, 2025EXHIBITPETITIONER

Hom_pre2011_header_clean

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Hom_pre2011.fasta

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Ph20_pre2011.aln-clustal_num

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Ph20_pre2011 Alignment html

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Leisola & Turunen, Protein Engineering: Opportunities and Challenges (2007)

Apr 15, 2025EXHIBITPETITIONER

Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004)

Apr 15, 2025EXHIBITPETITIONER

Rosengren, Clinical Immunogenicity of rHuPH20 (2015)

Apr 15, 2025EXHIBITPETITIONER

Collection of BLAST Webpages from the Internet Archive

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Collection of Clustal Omega Webpages from the Internet Archive

Apr 15, 2025EXHIBITPETITIONER

Collection of SWISS-MODEL Webpages from the Internet Archive

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Collection of PyMol Webpages from the Internet Archive

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Swiss Model Printout of PH20 Model

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Swiss Model Printout of PH20 Model with I309N Mutation

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Swiss Model Printout of PH20 Model with I309L Mutation

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Swiss Model Printout of PH20 Model with I309M Mutation

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2024 Chemistry Nobel Prize Background

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Table Associating ’618 Patent to Corresponding '731 Application

Apr 15, 2025EXHIBITPETITIONER

WO 2010/077297, published 8 July 2010

Apr 15, 2025EXHIBITPETITIONER

Goldberg, Protein degradation (2003)

Apr 15, 2025EXHIBITPETITIONER

Declaration of Jeffrey P. Kushan

Apr 15, 2025EXHIBITPETITIONER

Hunnicutt, Sperm Surface Protein PH-20 Is Bifunctional (1996)

Apr 15, 2025EXHIBITPETITIONER

Bookbinder, A Recombinant Human Enzyme for Enhanced Interstitial Transport

Apr 15, 2025EXHIBITPETITIONER

Declaration of Dr. Michael Hecht

Apr 15, 2025EXHIBITPETITIONER

File History of U.S. Patent No. 12,037,618 Part One

Apr 15, 2025EXHIBITPETITIONER

File History of U.S. Patent No. 12,037,618 Part Two

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File History of U.S. Patent No. 12,037,618 Part Three

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Declaration of Dr. Sheldon Park

Apr 15, 2025EXHIBITPETITIONER

Petition for Post Grant Review

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Petitioner's Power of Attorney

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