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U.S. Patent No. 12,037,618 | Apr 15, 2025 | EXHIBIT | PETITIONER |
U.S. Patent No. 7,767,429 | Apr 15, 2025 | EXHIBIT | PETITIONER |
Chao, Structure of Human Huyaluronidase-1 (2007) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Stern, Hyaluronidases: Their Genomics, Structures, and Mechanisms of Action | Apr 15, 2025 | EXHIBIT | PETITIONER |
Jedzrejas, Structures of Vertebrate Hyaluronidases (2005) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Zhang, Hyaluronidase Activity of Human Hyall (2009) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Arming, In vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm (1997) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Bordoli, Protein Structure Homology Modeling Using SWISSMODEL (2008) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Frost, Recombinant Human Hyaluronidase (rHuPH20) (2007) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Brandon & Tooze, Introduction to Protein Structure (1999) Part 1 | Apr 15, 2025 | EXHIBIT | PETITIONER |
Brandon & Tooze, Introduction to Protein Structure (1999) Part 2 | Apr 15, 2025 | EXHIBIT | PETITIONER |
Steipe, Consensus-Based Engineering of Protein Stability (2004) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Green, Computer Graphics, Homology Modeling, and Bioinformatics (2010) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Chica, Semi-rational Approaches to Engineering Enzyme Activity (2005) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Hardy, Assessment of Contraceptive Vaccines Based on Recombinant Mouse Sp. | Apr 15, 2025 | EXHIBIT | PETITIONER |
Pomering, Restricted Entry of IgG (2002) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Primakoff, Reversible Contraceptive Effect of PH-20 Immunization (1997) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Tung, Mechanism of Infertility in Male Guinea Pigs Immunized with Sperm | Apr 15, 2025 | EXHIBIT | PETITIONER |
Rosengren, Recombinant Human PH20 (2018) | Apr 15, 2025 | EXHIBIT | PETITIONER |
U.S. Patent No. 9,447,401 | Apr 15, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application No. 13/694,731 | Apr 15, 2025 | EXHIBIT | PETITIONER |
Gmachl, The Human Sperm Protein PH-20 Has Hyaluronidase Activity (1993) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Sills, “Retraction,” Science, 319:569 (2008) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Yue, Loss of Protein Structure Stability as a Major Causative Factor (2005) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Wang & Moult, SNPs, Protein Structure, and Disease (2001) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Marković-Housley, Crystal Structure of Hyaluronidase (2000) | Apr 15, 2025 | EXHIBIT | PETITIONER |
“Negative Results,” Nature: Editorials, 453:258 (2008) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Lins, Analysis of Accessible Surface of Residues in Proteins (2003) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Hayden, Chemistry: Designer Debacle (2008) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Benkert, Toward the Estimation of the Absolute Quality (2010) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Schwede, SWISS-MODEL: An Automated Protein Homology-Modeling Server (2003) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Alberts, Molecular Biology of the Cell, Chapter 3 (2007) | Apr 15, 2025 | EXHIBIT | PETITIONER |
He, NMR Structures of Two Designed Proteins with High Sequence Identity | Apr 15, 2025 | EXHIBIT | PETITIONER |
Alexander, A Minimal Sequence Code for Switching Protein Structure (2009) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Ruan, Design & Characterization of a Protein Fold Switching Network (2023) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Sievers, Fast, Scalable Generation of High-Quality Protein (2011) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Redline Comparison of the ’731 and ’618 Specifications | Apr 15, 2025 | EXHIBIT | PETITIONER |
Beasley & Hecht, Protein Design: The Choice of de Novo Sequences (1997) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Xiong, Periodicity of Polar and Nonpolar Amino Acids (1995) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Hayden, Key Protein-Design Papers Challenged (2009) | Apr 15, 2025 | EXHIBIT | PETITIONER |
KEGG, DRUG: Hyaluronidase (human recombinant) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Pace & Scholtz, A Helix Propensity Scale (1998) | Apr 15, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application No. 61/631,313 | Apr 15, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application No. 61/796,208 | Apr 15, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011 | Apr 15, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011_header | Apr 15, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011_header_clean | Apr 15, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011.fasta | Apr 15, 2025 | EXHIBIT | PETITIONER |
Ph20_pre2011.aln-clustal_num | Apr 15, 2025 | EXHIBIT | PETITIONER |
Ph20_pre2011 Alignment html | Apr 15, 2025 | EXHIBIT | PETITIONER |
Leisola & Turunen, Protein Engineering: Opportunities and Challenges (2007) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Rosengren, Clinical Immunogenicity of rHuPH20 (2015) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Collection of BLAST Webpages from the Internet Archive | Apr 15, 2025 | EXHIBIT | PETITIONER |
Collection of Clustal Omega Webpages from the Internet Archive | Apr 15, 2025 | EXHIBIT | PETITIONER |
Collection of SWISS-MODEL Webpages from the Internet Archive | Apr 15, 2025 | EXHIBIT | PETITIONER |
Collection of PyMol Webpages from the Internet Archive | Apr 15, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model | Apr 15, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with I309N Mutation | Apr 15, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with I309L Mutation | Apr 15, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with I309M Mutation | Apr 15, 2025 | EXHIBIT | PETITIONER |
2024 Chemistry Nobel Prize Background | Apr 15, 2025 | EXHIBIT | PETITIONER |
Table Associating ’618 Patent to Corresponding '731 Application | Apr 15, 2025 | EXHIBIT | PETITIONER |
WO 2010/077297, published 8 July 2010 | Apr 15, 2025 | EXHIBIT | PETITIONER |
Goldberg, Protein degradation (2003) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Declaration of Jeffrey P. Kushan | Apr 15, 2025 | EXHIBIT | PETITIONER |
Hunnicutt, Sperm Surface Protein PH-20 Is Bifunctional (1996) | Apr 15, 2025 | EXHIBIT | PETITIONER |
Bookbinder, A Recombinant Human Enzyme for Enhanced Interstitial Transport | Apr 15, 2025 | EXHIBIT | PETITIONER |
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Declaration of Dr. Sheldon Park | Apr 15, 2025 | EXHIBIT | PETITIONER |
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