Merck Sharp & Dohme LLC vs Halozyme, Inc. et al.

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U.S. Patent No. 12,049,692

File History of U.S. Patent No. 12,049,692 Part 1

File History of U.S. Patent No. 12,049,692 Part 2

File History of U.S. Patent No. 12,049,692 Part 3

U.S. Patent No. 7,767,429

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WO/2010/077297, published July 8, 2010

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Zhang, Hyaluronidase Activity of Human Hyal1 (2009)

Arming, In vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm (1997)

Bordoli, Protein Structure Homology Modeling Using SWISSMODEL (2008)

Frost, Recombinant Human Hyaluronidase (rHuPH20) (2007)

Branden & Tooze, Introduction to Protein Structure (1999) Part 1

Branden & Tooze, Introduction to Protein Structure (1999) Part 2

Table Associating ’692 Patent to Corresponding ’731 Application

Steipe, Consensus-Based Engineering of Protein Stability (2004)

Green, Computer Graphics, Homology Modeling, and Bioinformatics (2010)

Chica, Semi-rational Approaches to Engineering Enzyme Activity (2005)

Hardy, Assessment of Contraceptive Vaccines Based on Recombinant... (2004)

Pomering, Restricted Entry of IgG (2002)

Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002)

Primakoff, Reversible Contraceptive Effect of PH-20 Immunization (1997)

Tung, Mechanism of Infertility in Male Guinea Pigs Immunized with... (1997)

Rosengren, Recombinant Human PH20 (2018)

U.S. Patent No. 9,447,401

U.S. Patent Application No. 13/694,731

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Sills, "Retraction," Science, 319:569 (2008)

Yue, Loss of Protein Structure Stability as a Major Causative Factor (2005)

Wang & Moult, SNPs, Protein Structure, and Disease (2001)

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"Negative Results," Nature: Editorials, 453:258 (2008)

Lins, Analysis of Accessible Surface of Residues in Proteins (2003)

Hayden, Chemistry: Designer Debacle (2008)

Benkert, Toward the Estimation of the Absolute Quality (2010)

Schwede, SWISS-MODEL: An Automated Protein Homology-Modeling Server (2003)

Alberts, Molecular Biology of the Cell, Chapter 3 (2007)

He, NMR Structures of Two Designed Proteins with High Sequence Identity

Alexander, A Minimal Sequence Code for Switching Protein Structure (2009)

Ruan, Design & Characterization of a Protein Fold Switching Network (2023)

Sievers, Fast, Scalable Generation of High-Quality Protein (2011)

Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008)

Redline Comparison of the ’731 and ’692 Specifications

Beasley & Hecht, Protein Design: The Choice of de Novo Sequences (1997)

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Hayden, Key Protein-Design Papers Challenged (2009)

KEGG, DRUG: Hyaluronidase (human recombinant)

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U.S. Patent Application No. 61/631,313

U.S. Patent Application No. 61/796,208

Hom_pre2011

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Hom_pre2011.fasta

Ph20_pre2011.aln-clustal_num

Ph20_pre2011 Alignment html

Leisola & Turunen, Protein Engineering: Opportunities and Challenges (2007)

Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004)

Rosengren, Clinical Immunogenicity of rHuPH20 (2015)

Collection of BLAST Webpages from the Internet Archive

Collection of Clustal Omega Webpages from the Internet Archive

Collection of SWISS-MODEL Webpages from the Internet Archive

Collection of PyMol Webpages from the Internet Archive

Declaration of Jeffrey P. Kushan

Swiss Model Printout of PH20 Model

Swiss Model Printout of PH20 Model with M313K Mutation

Swiss Model Printout of PH20 Model with M313A Mutation

Swiss Model Printout of PH20 Model with M313R Mutation

Swiss Model Printout of PH20 Model with M313Y Mutation

Swiss Model Printout of PH20 Model with M313P Mutation

Swiss Model Printout of PH20 Model with M313L Mutation

Hunnicutt, Sperm Surface Protein PH-20 Is Bifunctional (1996)

2024 Chemistry Nobel Prize Background

Bookbinder, A Recombinant Human Enzyme for Enhanced Interstitial Transport

Declaration of Dr. Michael Hecht

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Petition for Post Grant Review of U.S. Patent No. 12,091,692

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Goldberg, Protein degradation and protection (2003)