The detailed information for PTAB case with proceeding number PGR2025-00050 filed by Merck Sharp & Dohme LLC against Halozyme, Inc. et al. on May 7, 2025. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Case Details

Proceeding Number
PGR2025-00050
Filing Date
May 7, 2025
Petitioner
Merck Sharp & Dohme LLC
Respondent
Halozyme, Inc. et al.
Status
Pending
Respondent Application Number
18339829
Respondent Tech Center
1600
Respondent Patent Number
12077791

Proceeding Documents

The table below shows documents filed in the case, listing each document name, filing date, document type, and filing party. Tracking these filings indicates the activity of the parties involved in the case, and the types of documents filed can provide insights into the legal strategies being employed.


Document NameFiling DateCategoryFiling Party

Alert me when new update on this case

Patent Owner's Updated Mandatory Notices

Jul 17, 2025PAPERPATENT OWNER

Petitioner's Updated Mandatory Notices

Jun 30, 2025PAPERPETITIONER

Patent Owner's Updated Power of Attorney

Jun 20, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Jun 20, 2025PAPERPATENT OWNER

Notice: Notice filing date accorded

Jun 12, 2025PAPERBOARD

Patent Owner's Power of Attorney

May 21, 2025PAPERPATENT OWNER

Patent Owner's Mandatory Notices

May 21, 2025PAPERPATENT OWNER

U.S. Patent No. 12,077,791

May 7, 2025EXHIBITPETITIONER

File History of US Patent No. 12,077,791 Part 1

May 7, 2025EXHIBITPETITIONER

File History of US Patent No. 12,077,791 Part 2

May 7, 2025EXHIBITPETITIONER

File History of US Patent No. 12,077,791 Part 3

May 7, 2025EXHIBITPETITIONER

U.S. Patent No. 7,767,429

May 7, 2025EXHIBITPETITIONER

Chao, Structure of Human Hyaluronidase-1 (2007)

May 7, 2025EXHIBITPETITIONER

WO/2010/077297, published July 8, 2010

May 7, 2025EXHIBITPETITIONER

Stern, The Hyaluronidases: Their Genomics, Structures, & Mechanisms (2006)

May 7, 2025EXHIBITPETITIONER

Jedzrejas, Structures of Vertebrate Hyaluronidases (2005)

May 7, 2025EXHIBITPETITIONER

Zhang, Hyaluronidase Activity of Human Hyal1 (2009)

May 7, 2025EXHIBITPETITIONER

Arming, In vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm (1997)

May 7, 2025EXHIBITPETITIONER

Bordoli, Protein Structure Homology Modeling Using SWISSMODEL (2008)

May 7, 2025EXHIBITPETITIONER

Frost, Recombinant Human Hyaluronidase (rHuPH20) (2007)

May 7, 2025EXHIBITPETITIONER

Branden & Tooze, Introduction to Protein Structure (1999) Part 1

May 7, 2025EXHIBITPETITIONER

Branden & Tooze, Introduction to Protein Structure (1999) Part 2

May 7, 2025EXHIBITPETITIONER

Table Associating ’791 Patent to Corresponding ’731 Application

May 7, 2025EXHIBITPETITIONER

Steipe, Consensus-Based Engineering of Protein Stability (2004)

May 7, 2025EXHIBITPETITIONER

Green, Computer Graphics, Homology Modeling, and Bioinformatics (2010)

May 7, 2025EXHIBITPETITIONER

Chica, Semi-rational Approaches to Engineering Enzyme Activity (2005)

May 7, 2025EXHIBITPETITIONER

Hardy, Assessment of Contraceptive Vaccines Based on Recombinant Mouse

May 7, 2025EXHIBITPETITIONER

Pomering, Restricted Entry of IgG (2002)

May 7, 2025EXHIBITPETITIONER

Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002)

May 7, 2025EXHIBITPETITIONER

Primakoff, Reversible Contraceptive Effect of PH-20 Immunization (1997)

May 7, 2025EXHIBITPETITIONER

Tung, Mechanism of Infertility in Male Guinea Pigs Immunized with Sperm

May 7, 2025EXHIBITPETITIONER

Rosengren, Recombinant Human PH20 (2018)

May 7, 2025EXHIBITPETITIONER

U.S. Patent No. 9,447,401

May 7, 2025EXHIBITPETITIONER

U.S. Patent Application No. 13/694,731

May 7, 2025EXHIBITPETITIONER

2024 Chemistry Nobel Prize Background

May 7, 2025EXHIBITPETITIONER

Gmachl, The Human Sperm Protein PH-20 Has Hyaluronidase Activity (1993)

May 7, 2025EXHIBITPETITIONER

Sills, "Retraction," Science, 319:569 (2008)

May 7, 2025EXHIBITPETITIONER

Yue, Loss of Protein Structure Stability as a Major Causative Factor (2005)

May 7, 2025EXHIBITPETITIONER

Wang & Moult, SNPs, Protein Structure, and Disease (2001)

May 7, 2025EXHIBITPETITIONER

Marković-Housley, Crystal Structure of Hyaluronidase (2000)

May 7, 2025EXHIBITPETITIONER

"Negative Results," Nature: Editorials, 453:258 (2008)

May 7, 2025EXHIBITPETITIONER

Lins, Analysis of Accessible Surface of Residues in Proteins (2003)

May 7, 2025EXHIBITPETITIONER

Hayden, Chemistry: Designer Debacle (2008)

May 7, 2025EXHIBITPETITIONER

Benkert, Toward the Estimation of the Absolute Quality (2010)

May 7, 2025EXHIBITPETITIONER

Schwede, SWISS-MODEL: An Automated Protein Homology-Modeling Server (2003)

May 7, 2025EXHIBITPETITIONER

Alberts, Molecular Biology of the Cell, Chapter 3 (2007)

May 7, 2025EXHIBITPETITIONER

He, NMR Structures of Two Designed Proteins with High Sequence Identity

May 7, 2025EXHIBITPETITIONER

Alexander, A Minimal Sequence Code for Switching Protein Structure (2009)

May 7, 2025EXHIBITPETITIONER

Ruan, Design & Characterization of a Protein Fold Switching Network (2023)

May 7, 2025EXHIBITPETITIONER

Sievers, Fast, Scalable Generation of High-Quality Protein (2011)

May 7, 2025EXHIBITPETITIONER

Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008)

May 7, 2025EXHIBITPETITIONER

Redline Comparison of the ’731 and ’791 Specifications

May 7, 2025EXHIBITPETITIONER

Beasley & Hecht, Protein Design: The Choice of de Novo Sequences (1997)

May 7, 2025EXHIBITPETITIONER

Xiong, Periodicity of Polar and Nonpolar Amino Acids (1995)

May 7, 2025EXHIBITPETITIONER

Hayden, Key Protein-Design Papers Challenged (2009)

May 7, 2025EXHIBITPETITIONER

KEGG, DRUG: Hyaluronidase (human recombinant)

May 7, 2025EXHIBITPETITIONER

Pace & Scholtz, A Helix Propensity Scale (1998)

May 7, 2025EXHIBITPETITIONER

U.S. Patent Application No. 61/631,313

May 7, 2025EXHIBITPETITIONER

U.S. Patent Application No. 61/796,208

May 7, 2025EXHIBITPETITIONER

Hom_pre2011

May 7, 2025EXHIBITPETITIONER

Hom_pre2011_header

May 7, 2025EXHIBITPETITIONER

Hom_pre2011_header_clean

May 7, 2025EXHIBITPETITIONER

Hom_pre2011.fasta

May 7, 2025EXHIBITPETITIONER

Ph20_pre2011.aln-clustal_num

May 7, 2025EXHIBITPETITIONER

Ph20_pre2011 Alignment html

May 7, 2025EXHIBITPETITIONER

Leisola & Turunen, Protein Engineering: Opportunities and Challenges (2007)

May 7, 2025EXHIBITPETITIONER

Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004)

May 7, 2025EXHIBITPETITIONER

Rosengren, Clinical Immunogenicity of rHuPH20 (2015)

May 7, 2025EXHIBITPETITIONER

Collection of BLAST Webpages from the Internet Archive

May 7, 2025EXHIBITPETITIONER

Collection of Clustal Omega Webpages from the Internet Archive

May 7, 2025EXHIBITPETITIONER

Collection of SWISS-MODEL Webpages from the Internet Archive

May 7, 2025EXHIBITPETITIONER

Collection of PyMol Webpages from the Internet Archive

May 7, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model

May 7, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with I309N Mutation

May 7, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with I309L Mutation

May 7, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with I309M Mutation

May 7, 2025EXHIBITPETITIONER

Hunnicutt, Sperm Surface Protein PH-20 Is Bifunctional (1996)

May 7, 2025EXHIBITPETITIONER

Bookbinder, A Recombinant Human Enzyme for Enhanced Interstitial...(2006)

May 7, 2025EXHIBITPETITIONER

Goldberg, “Protein degradation and protection of against misfolded...(2003)

May 7, 2025EXHIBITPETITIONER

Declaration of Jeffrey P. Kushan

May 7, 2025EXHIBITPETITIONER

Declaration of Dr. Michael Hecht

May 7, 2025EXHIBITPETITIONER

Declaration of Dr. Sheldon Park

May 7, 2025EXHIBITPETITIONER

Petition for Post Grant Review of U.S. Patent No. 12,077,791

May 7, 2025PAPERPETITIONER

Petitioner's Power of Attorney

May 7, 2025PAPERPETITIONER