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U.S. Patent No. 12,077,791 | May 7, 2025 | EXHIBIT | PETITIONER |
File History of US Patent No. 12,077,791 Part 1 | May 7, 2025 | EXHIBIT | PETITIONER |
File History of US Patent No. 12,077,791 Part 2 | May 7, 2025 | EXHIBIT | PETITIONER |
File History of US Patent No. 12,077,791 Part 3 | May 7, 2025 | EXHIBIT | PETITIONER |
U.S. Patent No. 7,767,429 | May 7, 2025 | EXHIBIT | PETITIONER |
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Arming, In vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm (1997) | May 7, 2025 | EXHIBIT | PETITIONER |
Bordoli, Protein Structure Homology Modeling Using SWISSMODEL (2008) | May 7, 2025 | EXHIBIT | PETITIONER |
Frost, Recombinant Human Hyaluronidase (rHuPH20) (2007) | May 7, 2025 | EXHIBIT | PETITIONER |
Branden & Tooze, Introduction to Protein Structure (1999) Part 1 | May 7, 2025 | EXHIBIT | PETITIONER |
Branden & Tooze, Introduction to Protein Structure (1999) Part 2 | May 7, 2025 | EXHIBIT | PETITIONER |
Table Associating ’791 Patent to Corresponding ’731 Application | May 7, 2025 | EXHIBIT | PETITIONER |
Steipe, Consensus-Based Engineering of Protein Stability (2004) | May 7, 2025 | EXHIBIT | PETITIONER |
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Chica, Semi-rational Approaches to Engineering Enzyme Activity (2005) | May 7, 2025 | EXHIBIT | PETITIONER |
Hardy, Assessment of Contraceptive Vaccines Based on Recombinant Mouse | May 7, 2025 | EXHIBIT | PETITIONER |
Pomering, Restricted Entry of IgG (2002) | May 7, 2025 | EXHIBIT | PETITIONER |
Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002) | May 7, 2025 | EXHIBIT | PETITIONER |
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Tung, Mechanism of Infertility in Male Guinea Pigs Immunized with Sperm | May 7, 2025 | EXHIBIT | PETITIONER |
Rosengren, Recombinant Human PH20 (2018) | May 7, 2025 | EXHIBIT | PETITIONER |
U.S. Patent No. 9,447,401 | May 7, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application No. 13/694,731 | May 7, 2025 | EXHIBIT | PETITIONER |
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Wang & Moult, SNPs, Protein Structure, and Disease (2001) | May 7, 2025 | EXHIBIT | PETITIONER |
Marković-Housley, Crystal Structure of Hyaluronidase (2000) | May 7, 2025 | EXHIBIT | PETITIONER |
"Negative Results," Nature: Editorials, 453:258 (2008) | May 7, 2025 | EXHIBIT | PETITIONER |
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Hayden, Chemistry: Designer Debacle (2008) | May 7, 2025 | EXHIBIT | PETITIONER |
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Schwede, SWISS-MODEL: An Automated Protein Homology-Modeling Server (2003) | May 7, 2025 | EXHIBIT | PETITIONER |
Alberts, Molecular Biology of the Cell, Chapter 3 (2007) | May 7, 2025 | EXHIBIT | PETITIONER |
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Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008) | May 7, 2025 | EXHIBIT | PETITIONER |
Redline Comparison of the ’731 and ’791 Specifications | May 7, 2025 | EXHIBIT | PETITIONER |
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KEGG, DRUG: Hyaluronidase (human recombinant) | May 7, 2025 | EXHIBIT | PETITIONER |
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U.S. Patent Application No. 61/631,313 | May 7, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application No. 61/796,208 | May 7, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011 | May 7, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011_header | May 7, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011_header_clean | May 7, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011.fasta | May 7, 2025 | EXHIBIT | PETITIONER |
Ph20_pre2011.aln-clustal_num | May 7, 2025 | EXHIBIT | PETITIONER |
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Leisola & Turunen, Protein Engineering: Opportunities and Challenges (2007) | May 7, 2025 | EXHIBIT | PETITIONER |
Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004) | May 7, 2025 | EXHIBIT | PETITIONER |
Rosengren, Clinical Immunogenicity of rHuPH20 (2015) | May 7, 2025 | EXHIBIT | PETITIONER |
Collection of BLAST Webpages from the Internet Archive | May 7, 2025 | EXHIBIT | PETITIONER |
Collection of Clustal Omega Webpages from the Internet Archive | May 7, 2025 | EXHIBIT | PETITIONER |
Collection of SWISS-MODEL Webpages from the Internet Archive | May 7, 2025 | EXHIBIT | PETITIONER |
Collection of PyMol Webpages from the Internet Archive | May 7, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model | May 7, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with I309N Mutation | May 7, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with I309L Mutation | May 7, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with I309M Mutation | May 7, 2025 | EXHIBIT | PETITIONER |
Hunnicutt, Sperm Surface Protein PH-20 Is Bifunctional (1996) | May 7, 2025 | EXHIBIT | PETITIONER |
Bookbinder, A Recombinant Human Enzyme for Enhanced Interstitial...(2006) | May 7, 2025 | EXHIBIT | PETITIONER |
Goldberg, “Protein degradation and protection of against misfolded...(2003) | May 7, 2025 | EXHIBIT | PETITIONER |
Declaration of Jeffrey P. Kushan | May 7, 2025 | EXHIBIT | PETITIONER |
Declaration of Dr. Michael Hecht | May 7, 2025 | EXHIBIT | PETITIONER |
Declaration of Dr. Sheldon Park | May 7, 2025 | EXHIBIT | PETITIONER |
Petition for Post Grant Review of U.S. Patent No. 12,077,791 | May 7, 2025 | PAPER | PETITIONER |
Petitioner's Power of Attorney | May 7, 2025 | PAPER | PETITIONER |