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Merck Sharp & Dohme LLC v. Halozyme, Inc. et al. - PGR2025-00052

Explore the PTAB proceeding PGR2025-00052 filed by Merck Sharp & Dohme LLC against Halozyme, Inc. et al. on Jun 27, 2025. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Case Details

Proceeding Number
PGR2025-00052
Filing Date
Jun 27, 2025
Petitioner
Merck Sharp & Dohme LLC
Respondent
Halozyme, Inc. et al.
Status
Trial Instituted
Respondent Application Number
18778554
Respondent Tech Center
1600
Respondent Patent Number
12264345
Institution Decision Date
Oct 16, 2025

Decision Documents New

Decision documents related to this case provide insights into the outcomes of proceedings. These documents are crucial for understanding the legal determinations and implications for the parties involved.

Document NameFiling DateCategoryFiling Party

Institution Decision: Grant

Oct 16, 2025PAPERBOARD

Counsels Involved New

Details of counsels involved in proceeding number PGR2025-00052.

TypeName
Petitioner CounselKushan, Jeffreyet al
Respondent CounselEllison, Eldoraet al

Proceeding Documents

The table below shows documents filed in the case, listing each document name, filing date, document type, and filing party. Tracking these filings indicates the activity of the parties involved in the case, and the types of documents filed can provide insights into the legal strategies being employed.

Document NameFiling DateCategoryFiling Party

Alert me when new update on this case

Patent Owner's Response

Jan 13, 2026PAPERPATENT OWNER

EX2069 - Simpson CV

Jan 13, 2026EXHIBITPATENT OWNER

EX2071 - Petsko CV

Jan 13, 2026EXHIBITPATENT OWNER

EX2072 - Cherr Declaration

Jan 13, 2026EXHIBITPATENT OWNER

EX2073 - Cherr CV

Jan 13, 2026EXHIBITPATENT OWNER

EX2074 - Moon Declaration

Jan 13, 2026EXHIBITPATENT OWNER

EX2075 - Moon CV

Jan 13, 2026EXHIBITPATENT OWNER

EX2076 - Hecht Deposition Transcript

Jan 13, 2026EXHIBITPATENT OWNER

EX2077 - Park Deposition Transcript 2025-08-07

Jan 13, 2026EXHIBITPATENT OWNER

EX2078 - Park Deposition Transcript 2025-08-21

Jan 13, 2026EXHIBITPATENT OWNER

EX2079 - Koehl 1999

Jan 13, 2026EXHIBITPATENT OWNER

EX2080 - Pommié 2004

Jan 13, 2026EXHIBITPATENT OWNER

EX2082 - Kyte and Doolittle 1982

Jan 13, 2026EXHIBITPATENT OWNER

EX2083 - Assay Guidance Manual (Part 1 of 6)

Jan 13, 2026EXHIBITPATENT OWNER

EX2083 - Assay Guidance Manual (Part 2 of 6)

Jan 13, 2026EXHIBITPATENT OWNER

EX2083 - Assay Guidance Manual (Part 3 of 6)

Jan 13, 2026EXHIBITPATENT OWNER

EX2083 - Assay Guidance Manual (Part 4 of 6)

Jan 13, 2026EXHIBITPATENT OWNER

EX2083 - Assay Guidance Manual (Part 5 of 6)

Jan 13, 2026EXHIBITPATENT OWNER

EX2083 - Assay Guidance Manual (Part 6 of 6)

Jan 13, 2026EXHIBITPATENT OWNER

EX2084 - The Central Role of Enzymes as Biological Catalysts

Jan 13, 2026EXHIBITPATENT OWNER

EX2085 - French 1983

Jan 13, 2026EXHIBITPATENT OWNER

EX2086 - El-Safory 2010

Jan 13, 2026EXHIBITPATENT OWNER

EX2087 - Lu 2025

Jan 13, 2026EXHIBITPATENT OWNER

EX2088 - Stern & Cóska 2000

Jan 13, 2026EXHIBITPATENT OWNER

EX2089 - Gmachl 1993

Jan 13, 2026EXHIBITPATENT OWNER

EX2090 - Gmachl-Kreil 1993

Jan 13, 2026EXHIBITPATENT OWNER

EX2091 - Davies 1995

Jan 13, 2026EXHIBITPATENT OWNER

EX2092 - Marković-Housley 2000

Jan 13, 2026EXHIBITPATENT OWNER

EX2093 - Baker (US8343487B2)

Jan 13, 2026EXHIBITPATENT OWNER

EX2094 - MULTIDROP 384 Liquid Handling Device Manual 2008

Jan 13, 2026EXHIBITPATENT OWNER

EX2096 - Frost 1997

Jan 13, 2026EXHIBITPATENT OWNER

EX2097 - Bookbinder (US20050260186A1)

Jan 13, 2026EXHIBITPATENT OWNER

EX2098 - Delpech 1995

Jan 13, 2026EXHIBITPATENT OWNER

EX2099 - Takahashi 2003

Jan 13, 2026EXHIBITPATENT OWNER

EX2100 - Vines 2001

Jan 13, 2026EXHIBITPATENT OWNER

EX2101 - Wassarman 1999

Jan 13, 2026EXHIBITPATENT OWNER

EX2102 - Yudin 1988

Jan 13, 2026EXHIBITPATENT OWNER

EX2103 - Tollner 2012

Jan 13, 2026EXHIBITPATENT OWNER

EX2104 - Visconti 1998

Jan 13, 2026EXHIBITPATENT OWNER

EX2105 - Wassarman 2001

Jan 13, 2026EXHIBITPATENT OWNER

EX2106 - Bailey 2010

Jan 13, 2026EXHIBITPATENT OWNER

EX2107 - Sabeur 1997

Jan 13, 2026EXHIBITPATENT OWNER

EX2108 - Hunnicutt 1996

Jan 13, 2026EXHIBITPATENT OWNER

EX2109 - Tollner 2008

Jan 13, 2026EXHIBITPATENT OWNER

EX2110 - Tollner 2009

Jan 13, 2026EXHIBITPATENT OWNER

EX2111 - Yudin BOR 2005

Jan 13, 2026EXHIBITPATENT OWNER

EX2112 - Yudin 2005

Jan 13, 2026EXHIBITPATENT OWNER

EX2113 - Tollner 2011

Jan 13, 2026EXHIBITPATENT OWNER

EX2114 - Frayne 1999

Jan 13, 2026EXHIBITPATENT OWNER

EX2115 - Yanagimachi 1975

Jan 13, 2026EXHIBITPATENT OWNER

EX2116 - Chamley 2007

Jan 13, 2026EXHIBITPATENT OWNER

EX2117 - Kremer 1992

Jan 13, 2026EXHIBITPATENT OWNER

EX2118 - Primakoff 1983

Jan 13, 2026EXHIBITPATENT OWNER

EX2119 - Myles and Primakoff 1984

Jan 13, 2026EXHIBITPATENT OWNER

EX2120 - Chan 1999

Jan 13, 2026EXHIBITPATENT OWNER

EX2121 - Ganesan 2010

Jan 13, 2026EXHIBITPATENT OWNER

EX2122 - Mestecky 1999

Jan 13, 2026EXHIBITPATENT OWNER

EX2126 - Suri 2005

Jan 13, 2026EXHIBITPATENT OWNER

EX2127 - Morrow 2011

Jan 13, 2026EXHIBITPATENT OWNER

EX2128 - Hussain 2005

Jan 13, 2026EXHIBITPATENT OWNER

EX2129 - Veazey 2003

Jan 13, 2026EXHIBITPATENT OWNER

EX2130 - Baloglu 2009

Jan 13, 2026EXHIBITPATENT OWNER

EX2131 - Suarez 2006

Jan 13, 2026EXHIBITPATENT OWNER

EX2132 - Cauci 2005

Jan 13, 2026EXHIBITPATENT OWNER

EX2133 - Flori 2007

Jan 13, 2026EXHIBITPATENT OWNER

EX2134 - Mestecky 2010

Jan 13, 2026EXHIBITPATENT OWNER

EX2135 - Kim 2005

Jan 13, 2026EXHIBITPATENT OWNER

EX2136 - Lardner 2001

Jan 13, 2026EXHIBITPATENT OWNER

EX2137 - Lipman 2005

Jan 13, 2026EXHIBITPATENT OWNER

EX2138 - Rhee 2012

Jan 13, 2026EXHIBITPATENT OWNER

EX2139 - Lycke 2012

Jan 13, 2026EXHIBITPATENT OWNER

EX2140 - Rudin 1998

Jan 13, 2026EXHIBITPATENT OWNER

EX2141 - Wu 2000

Jan 13, 2026EXHIBITPATENT OWNER

EX2142 - Russell 2002

Jan 13, 2026EXHIBITPATENT OWNER

EX2143 - Uppada 2011

Jan 13, 2026EXHIBITPATENT OWNER

EX2145 - Gallichan 1995

Jan 13, 2026EXHIBITPATENT OWNER

EX2146 - Johansson 1998

Jan 13, 2026EXHIBITPATENT OWNER

EX2147 - Bergquist 1997

Jan 13, 2026EXHIBITPATENT OWNER

EX2148 - Neto 2009

Jan 13, 2026EXHIBITPATENT OWNER

EX2149 - Rhorer 2009

Jan 13, 2026EXHIBITPATENT OWNER

EX2150 - Mielcarek 2000

Jan 13, 2026EXHIBITPATENT OWNER

EX2151 - Houghton 2004

Jan 13, 2026EXHIBITPATENT OWNER

EX2152 - Wan 2007

Jan 13, 2026EXHIBITPATENT OWNER

EX2153 - Dieude 2009

Jan 13, 2026EXHIBITPATENT OWNER

EX2154 - Oliver 2003

Jan 13, 2026EXHIBITPATENT OWNER

EX2155 - Trentham 1977

Jan 13, 2026EXHIBITPATENT OWNER

EX2156 - Courtenay 1980

Jan 13, 2026EXHIBITPATENT OWNER

EX2157 - Tomita 2011

Jan 13, 2026EXHIBITPATENT OWNER

EX2158 - Zhang 2012

Jan 13, 2026EXHIBITPATENT OWNER

EX2159 - Zeitlin 1996

Jan 13, 2026EXHIBITPATENT OWNER

EX2160 - Sherwood 1996

Jan 13, 2026EXHIBITPATENT OWNER

EX2161 - Veselinovic 2012

Jan 13, 2026EXHIBITPATENT OWNER

EX2162 - Schweitzer 2008

Jan 13, 2026EXHIBITPATENT OWNER

EX2163 - Gregory Petsko - National Science and Technology Medals Foundation

Jan 13, 2026EXHIBITPATENT OWNER

EX2164 - Protein Structure and Function (Part 1 of 4)

Jan 13, 2026EXHIBITPATENT OWNER

EX2164 - Protein Structure and Function (Part 2 of 4)

Jan 13, 2026EXHIBITPATENT OWNER

EX2164 - Protein Structure and Function (Part 3 of 4)

Jan 13, 2026EXHIBITPATENT OWNER

EX2164 - Protein Structure and Function (Part 4 of 4)

Jan 13, 2026EXHIBITPATENT OWNER

EX2165 - Wei (US20100143457A1)

Jan 13, 2026EXHIBITPATENT OWNER

EX2166 - Petsko Patent Analysis Data

Jan 13, 2026EXHIBITPATENT OWNER

EX2167 - Huang 2007

Jan 13, 2026EXHIBITPATENT OWNER

EX2168 - Gregory A. Petsko - American Academy of Arts and Sciences

Jan 13, 2026EXHIBITPATENT OWNER

EX2169 - Query Input and database selection - BlastTopics 0.1.1 documentation

Jan 13, 2026EXHIBITPATENT OWNER

EX2170 - Chain and Duthie 1940

Jan 13, 2026EXHIBITPATENT OWNER

EX2171 - Tollner 2004

Jan 13, 2026EXHIBITPATENT OWNER

EX2172 - Yudin 2001

Jan 13, 2026EXHIBITPATENT OWNER

EX2173 - Yudin 1999

Jan 13, 2026EXHIBITPATENT OWNER

EX2174 - Park 2068

Jan 13, 2026EXHIBITPATENT OWNER

EX2175 - Park 2069

Jan 13, 2026EXHIBITPATENT OWNER

EX2176 - Park 2070

Jan 13, 2026EXHIBITPATENT OWNER

EX2177 - E-mail

Jan 13, 2026EXHIBITPATENT OWNER

EX2178 - 1LOH pdb file

Jan 13, 2026EXHIBITPATENT OWNER

EX2179 - 1FCV pdb file

Jan 13, 2026EXHIBITPATENT OWNER

EX2180 - 2PE4 pdb file

Jan 13, 2026EXHIBITPATENT OWNER

EX2181 - 8SMN pdb file

Jan 13, 2026EXHIBITPATENT OWNER

EX2182 - M313A Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2183 - M313H Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2184 - M313K Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2185 - M313G Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2186 - N47A_N219A_M313K Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2187 - N47A_N131A_M313K Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2188 - N47A_N131A_N219A_M313K Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2189 - N131A_N219A_M313K Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2190 - Orangutan M313K Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2191 - PH20

Jan 13, 2026EXHIBITPATENT OWNER

EX2192 - M313P Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2193 - M313R Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2194 - M313Y Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2195 - Chimpanzee M313K Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2196 - Gibbon M313K Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2197 - M313T Swiss Model

Jan 13, 2026EXHIBITPATENT OWNER

EX2068 - Simpson Declaration

Jan 13, 2026EXHIBITPATENT OWNER

EX2070 - Petsko Declaration

Jan 13, 2026EXHIBITPATENT OWNER

EX2400 - Merck Co - 10Q - 11-05-2025

Jan 6, 2026EXHIBITPATENT OWNER

EX2402 - MERCK_PGR00006 - Sidley MSA (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2403 - MERCK_PGR00056 - Dechert MSA (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2404 - MERCK_PGR00467 - Mark Stewart Offer Letter (CONFIDENTIAL - PROTECTIVE ORDER MA

Jan 6, 2026EXHIBITPATENT OWNER

EX2405 - MERCK_PGR00052 - Hecht Engagement Letter (CONFIDENTIAL - PROTECTIVE ORDER MATE

Jan 6, 2026EXHIBITPATENT OWNER

EX2406 - MERCK_PGR00086 - Park Engagement Letter (CONFIDENTIAL - PROTECTIVE ORDER MATER

Jan 6, 2026EXHIBITPATENT OWNER

EX2407 - Executive Team - MSD

Jan 6, 2026EXHIBITPATENT OWNER

EX2408 - Executive Team - Merck

Jan 6, 2026EXHIBITPATENT OWNER

EX2409 - Board of Directors - MSD

Jan 6, 2026EXHIBITPATENT OWNER

EX2410 - Board of Directors - Merck

Jan 6, 2026EXHIBITPATENT OWNER

EX2411 - Contact Us - MSD

Jan 6, 2026EXHIBITPATENT OWNER

EX2412 - Contact Us - Merck

Jan 6, 2026EXHIBITPATENT OWNER

EX2413 - Who We Are - MSD

Jan 6, 2026EXHIBITPATENT OWNER

EX2414 - Who We Are - Merck

Jan 6, 2026EXHIBITPATENT OWNER

EX2415 - Merck Co - 10k - year 2024

Jan 6, 2026EXHIBITPATENT OWNER

EX2416 - USPTO OED Practitioner Search - Mark Stewart registration

Jan 6, 2026EXHIBITPATENT OWNER

EX2417 - IPR2024-00240 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2418 - IPR2024-00622 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2419 - IPR2024-00623 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2420 - IPR2024-00624 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2421 - IPR2024-00625 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2422 - IPR2024-00647 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2423 - IPR2024-00648 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2424 - IPR2024-00649 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2425 - IPR2024-00650 Petition

Jan 6, 2026EXHIBITPATENT OWNER

EX2426 - MERCK_PGR00035 - 20250813 Payment Remittance (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2427 - MERCK_PGR00042 - Dechert T360 Halozyme (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2428 - MERCK_PGR00045 - FW_ Attn_ Accounts Receivable Dept (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2429 - MERCK_PGR00049 - Halozyme - 202000447 - Invoices (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2430 - MERCK_PGR00465 - Mark Stewart Payroll Statement (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2431 - MERCK_PGR00001 - Ginkel Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2432 - MERCK_PGR00002 - Lally Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2433 - MERCK_PGR00003 - Majchrzak Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2434 - MERCK_PGR00004 - Stewart Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2435 - MERCK_PGR00005 - Su Organization Screen Shot (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2436 - MERCK_PGR00036 - 20250903 Payment Remittance_Redacted (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2437 - MERCK_PGR00037 - 20251001 Payment Remittance_Redacted (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2438 - MERCK_PGR00038 - 20251203 Payment Remittance_Redacted (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2439 - MERCK_PGR00040 - 20251215 Payment Remittance_Redacted (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2440 - MERCK_PGR00046 - PAYMENT REMITTANCE DETAIL (Oct 2025) (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2441 - MERCK_PGR00047 - PAYMENT REMITTANCE DETAIL (Sep 2025) (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2442 - MERCK_PGR00048 - Invoice IN00125072310 Review History (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2443 - MERCK_PGR00050 - Invoices 5_1_2024-12_22_2025_2 of 3 (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2444 - MERCK_PGR00051 - Invoices 5_1_2024-12_22_2025_3 of 3 (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

EX2445 - Merck Co - Bylaws

Jan 6, 2026EXHIBITPATENT OWNER

EX2012 - District Court Complaint

Jan 6, 2026EXHIBITPATENT OWNER

EX2401 - E-mail (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026EXHIBITPATENT OWNER

Patent Owner's Motion to Seal

Jan 6, 2026PAPERPATENT OWNER

Patent Owner's Motion for Additional Discovery (CONFIDENTIAL - PROTECTIVE ORDER MATERIAL)

Jan 6, 2026PAPERPATENT OWNER

Patent Owner's Motion for Additional Discovery (PUBLIC - REDACTED)

Jan 6, 2026PAPERPATENT OWNER

Notice of Joint Stipulation to Modify Due Dates

Dec 8, 2025PAPERPATENT OWNER

AMENDED SCHEDULING ORDER

Nov 20, 2025PAPERBOARD

Patent Owner's Updated Mandatory Notices

Nov 17, 2025PAPERPATENT OWNER

Notice of Intent to Designate Leif Peterson as Backup Counsel

Nov 11, 2025PAPERPETITIONER

Declaration of Leif Peterson

Nov 11, 2025EXHIBITPETITIONER

Notice of Intent to Designate Sue Wang as Backup Counsel

Nov 11, 2025PAPERPETITIONER

Declaration of Sue Wang

Nov 11, 2025EXHIBITPETITIONER

Notice of Intent to Designate Brian Goldberg as Backup Counsel

Nov 11, 2025PAPERPETITIONER

Declaration of Brian Goldberg

Nov 11, 2025EXHIBITPETITIONER

Notice of Intent to Designate Katherine Helm as Backup Counsel

Nov 11, 2025PAPERPETITIONER

Declaration of Katherine Helm

Nov 11, 2025EXHIBITPETITIONER

Petitioner's Updated Exhibit List

Nov 11, 2025PAPERPETITIONER

Petitioner's Updated Mandatory Notice

Nov 11, 2025PAPERPETITIONER

Petitioner's Updated Power of Attorney

Nov 10, 2025PAPERPETITIONER

Patent Owner's Objections to Evidence

Oct 30, 2025PAPERPATENT OWNER

Order: SCHEDULING ORDER

Oct 20, 2025PAPERBOARD

Institution Decision: Grant

Oct 16, 2025PAPERBOARD

EXPUNGED

Sep 24, 2025PAPERBOARD

EXPUNGED

Sep 24, 2025PAPERBOARD

Notice: Referral to Board Panel

Sep 24, 2025PAPERBOARD

Patent Owner's Waiver of Patent Owner Preliminary Response

Aug 20, 2025PAPERPATENT OWNER

Patent Owner's Updated Power of Attorney

Aug 4, 2025PAPERPATENT OWNER

Patent Owner's Updated Mandatory Notices

Aug 4, 2025PAPERPATENT OWNER

Notice filing date accorded to petition

Jul 18, 2025PAPERBOARD

Patent Owner's Power of Attorney

Jul 17, 2025PAPERPATENT OWNER

Patent Owner's Mandatory Notice

Jul 17, 2025PAPERPATENT OWNER

U.S. Patent No. 12,264,345

Jun 27, 2025EXHIBITPETITIONER

File History of U.S. Patent No. 12,264,345 Part 1

Jun 27, 2025EXHIBITPETITIONER

File History of U.S. Patent No. 12,264,345 Part 2

Jun 27, 2025EXHIBITPETITIONER

File History of U.S. Patent No. 12,264,345 Part 3

Jun 27, 2025EXHIBITPETITIONER

U.S. Patent No. US7,767,429

Jun 27, 2025EXHIBITPETITIONER

Chao, Structure of Human Hyaluronidase-1 (2007)

Jun 27, 2025EXHIBITPETITIONER

WO/2010/077297, published July 8, 2010

Jun 27, 2025EXHIBITPETITIONER

Stern, The Hyaluronidases: Their Genomics, Structures, & Mechanisms (2006)

Jun 27, 2025EXHIBITPETITIONER

Jedzrejas, Structures of Vertebrate Hyaluronidases (2005)

Jun 27, 2025EXHIBITPETITIONER

Zhang, Hyaluronidase Activity of Human Hyal1 (2009)

Jun 27, 2025EXHIBITPETITIONER

Arming, In vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm (1997)

Jun 27, 2025EXHIBITPETITIONER

Bordoli, Protein Structure Homology Modeling Using SWISSMODEL (2008)

Jun 27, 2025EXHIBITPETITIONER

Frost, Recombinant Human Hyaluronidase (rHuPH20) (2007)

Jun 27, 2025EXHIBITPETITIONER

Branden & Tooze, Introduction to Protein Structure (1999) Part 1

Jun 27, 2025EXHIBITPETITIONER

Branden & Tooze, Introduction to Protein Structure (1999) Part 2

Jun 27, 2025EXHIBITPETITIONER

Steipe, Consensus-Based Engineering of Protein Stability (2004)

Jun 27, 2025EXHIBITPETITIONER

Green, Computer Graphics, Homology Modeling, and Bioinformatics (2010)

Jun 27, 2025EXHIBITPETITIONER

Chica, Semi-rational Approaches to Engineering Enzyme Activity (2005)

Jun 27, 2025EXHIBITPETITIONER

Hardy, Assessment of Contraceptive Vaccines Based on Recombinant Mouse...

Jun 27, 2025EXHIBITPETITIONER

Pomering, Restricted Entry of IgG (2002)

Jun 27, 2025EXHIBITPETITIONER

Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002)

Jun 27, 2025EXHIBITPETITIONER

Primakoff, Reversible Contraceptive Effect of PH-20 Immunization (1997)

Jun 27, 2025EXHIBITPETITIONER

Tung, Mechanism of Infertility in Male Guinea Pigs Immunized with Sperm

Jun 27, 2025EXHIBITPETITIONER

Rosengren, Recombinant Human PH20 (2018)

Jun 27, 2025EXHIBITPETITIONER

U.S. Patent No. 9,447,401

Jun 27, 2025EXHIBITPETITIONER

U.S. Patent Application No. 13/694,731

Jun 27, 2025EXHIBITPETITIONER

Gmachl, The Human Sperm Protein PH-20 Has Hyaluronidase Activity (1993)

Jun 27, 2025EXHIBITPETITIONER

Sills, "Retraction," Science, 319:569 (2008)

Jun 27, 2025EXHIBITPETITIONER

Yue, Loss of Protein Structure Stability as a Major Causative Factor (2005)

Jun 27, 2025EXHIBITPETITIONER

Wang & Moult, SNPs, Protein Structure, and Disease (2001)

Jun 27, 2025EXHIBITPETITIONER

Marković-Housley, Crystal Structure of Hyaluronidase (2000)

Jun 27, 2025EXHIBITPETITIONER

"Negative Results," Nature: Editorials, 453:258 (2008)

Jun 27, 2025EXHIBITPETITIONER

Lins, Analysis of Accessible Surface of Residues in Proteins (2003)

Jun 27, 2025EXHIBITPETITIONER

Hayden, Chemistry: Designer Debacle (2008)

Jun 27, 2025EXHIBITPETITIONER

Benkert, Toward the Estimation of the Absolute Quality (2010)

Jun 27, 2025EXHIBITPETITIONER

Schwede, SWISS-MODEL: An Automated Protein Homology-Modeling Server (2003)

Jun 27, 2025EXHIBITPETITIONER

Alberts, Molecular Biology of the Cell, Chapter 3 (2007)

Jun 27, 2025EXHIBITPETITIONER

He, NMR Structures of Two Designed Proteins with High Sequence Identity

Jun 27, 2025EXHIBITPETITIONER

Alexander, A Minimal Sequence Code for Switching Protein Structure (2009)

Jun 27, 2025EXHIBITPETITIONER

Ruan, Design & Characterization of a Protein Fold Switching Network (2023)

Jun 27, 2025EXHIBITPETITIONER

Sievers, Fast, Scalable Generation of High-Quality Protein (2011)

Jun 27, 2025EXHIBITPETITIONER

Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008)

Jun 27, 2025EXHIBITPETITIONER

Redline Comparison of the ’731 and ’345 Specifications

Jun 27, 2025EXHIBITPETITIONER

Beasley & Hecht, Protein Design: The Choice of de Novo Sequences (1997)

Jun 27, 2025EXHIBITPETITIONER

Xiong, Periodicity of Polar and Nonpolar Amino Acids (1995)

Jun 27, 2025EXHIBITPETITIONER

Hayden, Key Protein-Design Papers Challenged (2009)

Jun 27, 2025EXHIBITPETITIONER

KEGG, DRUG: Hyaluronidase (human recombinant)

Jun 27, 2025EXHIBITPETITIONER

Pace & Scholtz, A Helix Propensity Scale (1998)

Jun 27, 2025EXHIBITPETITIONER

U.S. Patent Application No. 61/631,313

Jun 27, 2025EXHIBITPETITIONER

U.S. Patent Application No. 61/796,208

Jun 27, 2025EXHIBITPETITIONER

Hom_pre2011

Jun 27, 2025EXHIBITPETITIONER

Hom_pre2011_header

Jun 27, 2025EXHIBITPETITIONER

Hom_pre2011_header_clean

Jun 27, 2025EXHIBITPETITIONER

Hom_pre2011.fasta

Jun 27, 2025EXHIBITPETITIONER

Ph20_pre2011.aln-clustal_num

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Ph20_pre2011 Alignment html

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Leisola & Turunen, Protein Engineering: Opportunities and Challenges (2007)

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Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004)

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Rosengren, Clinical Immunogenicity of rHuPH20 (2015)

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Collection of BLAST Webpages from the Internet Archive

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Collection of Clustal Omega Webpages from the Internet Archive

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Collection of SWISS-MODEL Webpages from the Internet Archive

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Collection of PyMol Webpages from the Internet Archive

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Swiss Model Printout of PH20 Model

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Hunnicutt, Sperm Surface Protein PH-20 Is Bifunctional (1996)

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Bookbinder, A Recombinant Human Enzyme for Enhanced Interstitial Transport

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Goldberg, Protein Degradation and Protection (2003)

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Vembar, One Step at a time: endoplasmic reticulum-associated...(2008)

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2024 Chemistry Nobel Prize Background

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Swiss Model Printout of PH20 Model with M313K Mutation

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Swiss Model Printout of PH20 Model with M313A Mutation

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Swiss Model Printout of PH20 Model with M313R Mutation

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Swiss Model Printout of PH20 Model with M313Y Mutation

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Swiss Model Printout of PH20 Model with M313P Mutation

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Swiss Model Printout of PH20 Model with M313L Mutation

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Declaration of Dr. Sheldon Park

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Declaration of Jeffrey P. Kushan

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Table Associating ’345 Patent to Corresponding ’731 Application

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Declaration of Dr. Michael Hecht

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Petition for Post Grant Review of U.S. Patent No. 12,264,345

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Petitioner's Power of Attorney

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