Notice filing date accorded to petition | Jul 18, 2025 | PAPER | BOARD |
Patent Owner's Power of Attorney | Jul 17, 2025 | PAPER | PATENT OWNER |
Patent Owner's Mandatory Notice | Jul 17, 2025 | PAPER | PATENT OWNER |
U.S. Patent No. 12,264,345 | Jun 27, 2025 | EXHIBIT | PETITIONER |
File History of U.S. Patent No. 12,264,345 Part 1 | Jun 27, 2025 | EXHIBIT | PETITIONER |
File History of U.S. Patent No. 12,264,345 Part 2 | Jun 27, 2025 | EXHIBIT | PETITIONER |
File History of U.S. Patent No. 12,264,345 Part 3 | Jun 27, 2025 | EXHIBIT | PETITIONER |
U.S. Patent No. US7,767,429 | Jun 27, 2025 | EXHIBIT | PETITIONER |
Chao, Structure of Human Hyaluronidase-1 (2007) | Jun 27, 2025 | EXHIBIT | PETITIONER |
WO/2010/077297, published July 8, 2010 | Jun 27, 2025 | EXHIBIT | PETITIONER |
Stern, The Hyaluronidases: Their Genomics, Structures, & Mechanisms (2006) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Jedzrejas, Structures of Vertebrate Hyaluronidases (2005) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Zhang, Hyaluronidase Activity of Human Hyal1 (2009) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Arming, In vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm (1997) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Bordoli, Protein Structure Homology Modeling Using SWISSMODEL (2008) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Frost, Recombinant Human Hyaluronidase (rHuPH20) (2007) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Branden & Tooze, Introduction to Protein Structure (1999) Part 1 | Jun 27, 2025 | EXHIBIT | PETITIONER |
Branden & Tooze, Introduction to Protein Structure (1999) Part 2 | Jun 27, 2025 | EXHIBIT | PETITIONER |
Steipe, Consensus-Based Engineering of Protein Stability (2004) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Green, Computer Graphics, Homology Modeling, and Bioinformatics (2010) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Chica, Semi-rational Approaches to Engineering Enzyme Activity (2005) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Hardy, Assessment of Contraceptive Vaccines Based on Recombinant Mouse... | Jun 27, 2025 | EXHIBIT | PETITIONER |
Pomering, Restricted Entry of IgG (2002) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Primakoff, Reversible Contraceptive Effect of PH-20 Immunization (1997) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Tung, Mechanism of Infertility in Male Guinea Pigs Immunized with Sperm | Jun 27, 2025 | EXHIBIT | PETITIONER |
Rosengren, Recombinant Human PH20 (2018) | Jun 27, 2025 | EXHIBIT | PETITIONER |
U.S. Patent No. 9,447,401 | Jun 27, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application No. 13/694,731 | Jun 27, 2025 | EXHIBIT | PETITIONER |
Gmachl, The Human Sperm Protein PH-20 Has Hyaluronidase Activity (1993) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Sills, "Retraction," Science, 319:569 (2008) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Yue, Loss of Protein Structure Stability as a Major Causative Factor (2005) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Wang & Moult, SNPs, Protein Structure, and Disease (2001) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Marković-Housley, Crystal Structure of Hyaluronidase (2000) | Jun 27, 2025 | EXHIBIT | PETITIONER |
"Negative Results," Nature: Editorials, 453:258 (2008) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Lins, Analysis of Accessible Surface of Residues in Proteins (2003) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Hayden, Chemistry: Designer Debacle (2008) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Benkert, Toward the Estimation of the Absolute Quality (2010) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Schwede, SWISS-MODEL: An Automated Protein Homology-Modeling Server (2003) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Alberts, Molecular Biology of the Cell, Chapter 3 (2007) | Jun 27, 2025 | EXHIBIT | PETITIONER |
He, NMR Structures of Two Designed Proteins with High Sequence Identity | Jun 27, 2025 | EXHIBIT | PETITIONER |
Alexander, A Minimal Sequence Code for Switching Protein Structure (2009) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Ruan, Design & Characterization of a Protein Fold Switching Network (2023) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Sievers, Fast, Scalable Generation of High-Quality Protein (2011) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Redline Comparison of the ’731 and ’345 Specifications | Jun 27, 2025 | EXHIBIT | PETITIONER |
Beasley & Hecht, Protein Design: The Choice of de Novo Sequences (1997) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Xiong, Periodicity of Polar and Nonpolar Amino Acids (1995) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Hayden, Key Protein-Design Papers Challenged (2009) | Jun 27, 2025 | EXHIBIT | PETITIONER |
KEGG, DRUG: Hyaluronidase (human recombinant) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Pace & Scholtz, A Helix Propensity Scale (1998) | Jun 27, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application No. 61/631,313 | Jun 27, 2025 | EXHIBIT | PETITIONER |
U.S. Patent Application No. 61/796,208 | Jun 27, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011 | Jun 27, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011_header | Jun 27, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011_header_clean | Jun 27, 2025 | EXHIBIT | PETITIONER |
Hom_pre2011.fasta | Jun 27, 2025 | EXHIBIT | PETITIONER |
Ph20_pre2011.aln-clustal_num | Jun 27, 2025 | EXHIBIT | PETITIONER |
Ph20_pre2011 Alignment html | Jun 27, 2025 | EXHIBIT | PETITIONER |
Leisola & Turunen, Protein Engineering: Opportunities and Challenges (2007) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Rosengren, Clinical Immunogenicity of rHuPH20 (2015) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Collection of BLAST Webpages from the Internet Archive | Jun 27, 2025 | EXHIBIT | PETITIONER |
Collection of Clustal Omega Webpages from the Internet Archive | Jun 27, 2025 | EXHIBIT | PETITIONER |
Collection of SWISS-MODEL Webpages from the Internet Archive | Jun 27, 2025 | EXHIBIT | PETITIONER |
Collection of PyMol Webpages from the Internet Archive | Jun 27, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model | Jun 27, 2025 | EXHIBIT | PETITIONER |
Hunnicutt, Sperm Surface Protein PH-20 Is Bifunctional (1996) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Bookbinder, A Recombinant Human Enzyme for Enhanced Interstitial Transport | Jun 27, 2025 | EXHIBIT | PETITIONER |
Goldberg, Protein Degradation and Protection (2003) | Jun 27, 2025 | EXHIBIT | PETITIONER |
Vembar, One Step at a time: endoplasmic reticulum-associated...(2008) | Jun 27, 2025 | EXHIBIT | PETITIONER |
2024 Chemistry Nobel Prize Background | Jun 27, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with M313K Mutation | Jun 27, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with M313A Mutation | Jun 27, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with M313R Mutation | Jun 27, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with M313Y Mutation | Jun 27, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with M313P Mutation | Jun 27, 2025 | EXHIBIT | PETITIONER |
Swiss Model Printout of PH20 Model with M313L Mutation | Jun 27, 2025 | EXHIBIT | PETITIONER |
Declaration of Dr. Sheldon Park | Jun 27, 2025 | EXHIBIT | PETITIONER |
Declaration of Jeffrey P. Kushan | Jun 27, 2025 | EXHIBIT | PETITIONER |
Table Associating ’345 Patent to Corresponding ’731 Application | Jun 27, 2025 | EXHIBIT | PETITIONER |
Declaration of Dr. Michael Hecht | Jun 27, 2025 | EXHIBIT | PETITIONER |
Petition for Post Grant Review of U.S. Patent No. 12,264,345 | Jun 27, 2025 | PAPER | PETITIONER |
Petitioner's Power of Attorney | Jun 27, 2025 | PAPER | PETITIONER |