The detailed information for PTAB case with proceeding number PGR2025-00052 filed by Merck Sharp & Dohme LLC against Halozyme, Inc. et al. on Jun 27, 2025. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Case Details

Proceeding Number
PGR2025-00052
Filing Date
Jun 27, 2025
Petitioner
Merck Sharp & Dohme LLC
Respondent
Halozyme, Inc. et al.
Status
Pending
Respondent Application Number
18778554
Respondent Tech Center
1600
Respondent Patent Number
12264345

Proceeding Documents

The table below shows documents filed in the case, listing each document name, filing date, document type, and filing party. Tracking these filings indicates the activity of the parties involved in the case, and the types of documents filed can provide insights into the legal strategies being employed.


Document NameFiling DateCategoryFiling Party

Alert me when new update on this case

Notice filing date accorded to petition

Jul 18, 2025PAPERBOARD

Patent Owner's Power of Attorney

Jul 17, 2025PAPERPATENT OWNER

Patent Owner's Mandatory Notice

Jul 17, 2025PAPERPATENT OWNER

U.S. Patent No. 12,264,345

Jun 27, 2025EXHIBITPETITIONER

File History of U.S. Patent No. 12,264,345 Part 1

Jun 27, 2025EXHIBITPETITIONER

File History of U.S. Patent No. 12,264,345 Part 2

Jun 27, 2025EXHIBITPETITIONER

File History of U.S. Patent No. 12,264,345 Part 3

Jun 27, 2025EXHIBITPETITIONER

U.S. Patent No. US7,767,429

Jun 27, 2025EXHIBITPETITIONER

Chao, Structure of Human Hyaluronidase-1 (2007)

Jun 27, 2025EXHIBITPETITIONER

WO/2010/077297, published July 8, 2010

Jun 27, 2025EXHIBITPETITIONER

Stern, The Hyaluronidases: Their Genomics, Structures, & Mechanisms (2006)

Jun 27, 2025EXHIBITPETITIONER

Jedzrejas, Structures of Vertebrate Hyaluronidases (2005)

Jun 27, 2025EXHIBITPETITIONER

Zhang, Hyaluronidase Activity of Human Hyal1 (2009)

Jun 27, 2025EXHIBITPETITIONER

Arming, In vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm (1997)

Jun 27, 2025EXHIBITPETITIONER

Bordoli, Protein Structure Homology Modeling Using SWISSMODEL (2008)

Jun 27, 2025EXHIBITPETITIONER

Frost, Recombinant Human Hyaluronidase (rHuPH20) (2007)

Jun 27, 2025EXHIBITPETITIONER

Branden & Tooze, Introduction to Protein Structure (1999) Part 1

Jun 27, 2025EXHIBITPETITIONER

Branden & Tooze, Introduction to Protein Structure (1999) Part 2

Jun 27, 2025EXHIBITPETITIONER

Steipe, Consensus-Based Engineering of Protein Stability (2004)

Jun 27, 2025EXHIBITPETITIONER

Green, Computer Graphics, Homology Modeling, and Bioinformatics (2010)

Jun 27, 2025EXHIBITPETITIONER

Chica, Semi-rational Approaches to Engineering Enzyme Activity (2005)

Jun 27, 2025EXHIBITPETITIONER

Hardy, Assessment of Contraceptive Vaccines Based on Recombinant Mouse...

Jun 27, 2025EXHIBITPETITIONER

Pomering, Restricted Entry of IgG (2002)

Jun 27, 2025EXHIBITPETITIONER

Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002)

Jun 27, 2025EXHIBITPETITIONER

Primakoff, Reversible Contraceptive Effect of PH-20 Immunization (1997)

Jun 27, 2025EXHIBITPETITIONER

Tung, Mechanism of Infertility in Male Guinea Pigs Immunized with Sperm

Jun 27, 2025EXHIBITPETITIONER

Rosengren, Recombinant Human PH20 (2018)

Jun 27, 2025EXHIBITPETITIONER

U.S. Patent No. 9,447,401

Jun 27, 2025EXHIBITPETITIONER

U.S. Patent Application No. 13/694,731

Jun 27, 2025EXHIBITPETITIONER

Gmachl, The Human Sperm Protein PH-20 Has Hyaluronidase Activity (1993)

Jun 27, 2025EXHIBITPETITIONER

Sills, "Retraction," Science, 319:569 (2008)

Jun 27, 2025EXHIBITPETITIONER

Yue, Loss of Protein Structure Stability as a Major Causative Factor (2005)

Jun 27, 2025EXHIBITPETITIONER

Wang & Moult, SNPs, Protein Structure, and Disease (2001)

Jun 27, 2025EXHIBITPETITIONER

Marković-Housley, Crystal Structure of Hyaluronidase (2000)

Jun 27, 2025EXHIBITPETITIONER

"Negative Results," Nature: Editorials, 453:258 (2008)

Jun 27, 2025EXHIBITPETITIONER

Lins, Analysis of Accessible Surface of Residues in Proteins (2003)

Jun 27, 2025EXHIBITPETITIONER

Hayden, Chemistry: Designer Debacle (2008)

Jun 27, 2025EXHIBITPETITIONER

Benkert, Toward the Estimation of the Absolute Quality (2010)

Jun 27, 2025EXHIBITPETITIONER

Schwede, SWISS-MODEL: An Automated Protein Homology-Modeling Server (2003)

Jun 27, 2025EXHIBITPETITIONER

Alberts, Molecular Biology of the Cell, Chapter 3 (2007)

Jun 27, 2025EXHIBITPETITIONER

He, NMR Structures of Two Designed Proteins with High Sequence Identity

Jun 27, 2025EXHIBITPETITIONER

Alexander, A Minimal Sequence Code for Switching Protein Structure (2009)

Jun 27, 2025EXHIBITPETITIONER

Ruan, Design & Characterization of a Protein Fold Switching Network (2023)

Jun 27, 2025EXHIBITPETITIONER

Sievers, Fast, Scalable Generation of High-Quality Protein (2011)

Jun 27, 2025EXHIBITPETITIONER

Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008)

Jun 27, 2025EXHIBITPETITIONER

Redline Comparison of the ’731 and ’345 Specifications

Jun 27, 2025EXHIBITPETITIONER

Beasley & Hecht, Protein Design: The Choice of de Novo Sequences (1997)

Jun 27, 2025EXHIBITPETITIONER

Xiong, Periodicity of Polar and Nonpolar Amino Acids (1995)

Jun 27, 2025EXHIBITPETITIONER

Hayden, Key Protein-Design Papers Challenged (2009)

Jun 27, 2025EXHIBITPETITIONER

KEGG, DRUG: Hyaluronidase (human recombinant)

Jun 27, 2025EXHIBITPETITIONER

Pace & Scholtz, A Helix Propensity Scale (1998)

Jun 27, 2025EXHIBITPETITIONER

U.S. Patent Application No. 61/631,313

Jun 27, 2025EXHIBITPETITIONER

U.S. Patent Application No. 61/796,208

Jun 27, 2025EXHIBITPETITIONER

Hom_pre2011

Jun 27, 2025EXHIBITPETITIONER

Hom_pre2011_header

Jun 27, 2025EXHIBITPETITIONER

Hom_pre2011_header_clean

Jun 27, 2025EXHIBITPETITIONER

Hom_pre2011.fasta

Jun 27, 2025EXHIBITPETITIONER

Ph20_pre2011.aln-clustal_num

Jun 27, 2025EXHIBITPETITIONER

Ph20_pre2011 Alignment html

Jun 27, 2025EXHIBITPETITIONER

Leisola & Turunen, Protein Engineering: Opportunities and Challenges (2007)

Jun 27, 2025EXHIBITPETITIONER

Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004)

Jun 27, 2025EXHIBITPETITIONER

Rosengren, Clinical Immunogenicity of rHuPH20 (2015)

Jun 27, 2025EXHIBITPETITIONER

Collection of BLAST Webpages from the Internet Archive

Jun 27, 2025EXHIBITPETITIONER

Collection of Clustal Omega Webpages from the Internet Archive

Jun 27, 2025EXHIBITPETITIONER

Collection of SWISS-MODEL Webpages from the Internet Archive

Jun 27, 2025EXHIBITPETITIONER

Collection of PyMol Webpages from the Internet Archive

Jun 27, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model

Jun 27, 2025EXHIBITPETITIONER

Hunnicutt, Sperm Surface Protein PH-20 Is Bifunctional (1996)

Jun 27, 2025EXHIBITPETITIONER

Bookbinder, A Recombinant Human Enzyme for Enhanced Interstitial Transport

Jun 27, 2025EXHIBITPETITIONER

Goldberg, Protein Degradation and Protection (2003)

Jun 27, 2025EXHIBITPETITIONER

Vembar, One Step at a time: endoplasmic reticulum-associated...(2008)

Jun 27, 2025EXHIBITPETITIONER

2024 Chemistry Nobel Prize Background

Jun 27, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with M313K Mutation

Jun 27, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with M313A Mutation

Jun 27, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with M313R Mutation

Jun 27, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with M313Y Mutation

Jun 27, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with M313P Mutation

Jun 27, 2025EXHIBITPETITIONER

Swiss Model Printout of PH20 Model with M313L Mutation

Jun 27, 2025EXHIBITPETITIONER

Declaration of Dr. Sheldon Park

Jun 27, 2025EXHIBITPETITIONER

Declaration of Jeffrey P. Kushan

Jun 27, 2025EXHIBITPETITIONER

Table Associating ’345 Patent to Corresponding ’731 Application

Jun 27, 2025EXHIBITPETITIONER

Declaration of Dr. Michael Hecht

Jun 27, 2025EXHIBITPETITIONER

Petition for Post Grant Review of U.S. Patent No. 12,264,345

Jun 27, 2025PAPERPETITIONER

Petitioner's Power of Attorney

Jun 27, 2025PAPERPETITIONER