Cytek Biosciences, Inc. v. Beckman Coulter, Inc. et al. - PGR2025-00088

Petitioner's Opposition to PO's Request for Discretionary Denial

Petitioner's Updated Exhibit List

Excerpts from the Opening Invalidity Expert Report of Fedor A. Ilkov, Ph.D. [Redacted Version], served in Beckman Coulter, Inc. v. Cytek Biosciences, Inc., C.A. No. 24-945 (D. Del. Dec. 19, 2025)

Memorandum from Scott R. Boalick, Chief Administrative Patent Judge re Guidance on USPTO’s recission of “Interim Procedure for Discretionary Denials in AIA Post-Grant Proceedings with Parallel District Court Litigation,” dated March 24, 2025

Teleconference Transcript from Beckman Coulter, Inc. v. Cytek Biosciences, Inc., C.A. No. 24-945 (D. Del. March 24, 2025)

Plaintiff Beckman Coulter, Inc.’s Letter to the Honorable Eleanor G. Tennyson Regarding Discovery Dispute [Public Version], filed in Beckman Coulter, Inc. v. Cytek Biosciences, Inc., C.A. No. 24-945 (D. Del. March 27, 2025), D.I. 67

Memorandum from John A Squires, Under Secretary of Commerce for Intellectual Property and Director of the United States Patent and Trademark Office re Voluntary Search Disclosure Declarations as a Favorable Factor in Institution Decisions, dated November 17, 2025

Excerpts of the Prosecution history of U.S. Patent No. 9,746,412

Patent Owner's Preliminary Response

File History for U.S. Patent No. 10,330,582

BD LSRFortessa Cell Analyzer User’s Guide

582 Reexam Request

Declaration of David Schaafsma

Shapiro, Practical Flow Cytometry (2003) – Part 1

Shapiro, Practical Flow Cytometry (2003) – Part 2

Nebeling, Fiber Network Engineering (July 3, 2002)

Telecomm Standardization Sector of ITU, Recommendation G.694.2 (Dec. 2003)

Telecomm Standardization Sector of ITU, Recommendation G.694.1 (June 2002)

Arumugam, 57 Pramana J. Physics 849 (2001)

Saleh, Fundamentals of Photonics 2d. Ed. 2007

Smith, Modern Optical Engineering (3d ed. 2000)

Welford, Optics (3d ed. 1990)

Azadeh, Fiber Optics Engineering (2009)

Cytek 112 Contentions Ex. A 10,330,582

Robinson Flow Cytometry 2022

Cytek Bio Aurora Website

File History for U.S. Patent No. 12,174,106

Patent Owner’s Opposition to PT MTS & Request for In Camera Review

December 4, 2025 Email from A. Cohen to D. Knight

December 8, 2025 Email from R. Chen to A. Cohen

December 12, 2025 Email from A. Cohen to R. Chen

December 16, 2025 Email from A. Cohen to R. Chen

December 18, 2025 Email from A. Cohen to Director Squires

Petitioner's Updated Power of Attorney

Petitioner's Updated Mandatory Notice re Lead and Backup Counsel

Redacted Paper #7 - Search Disclosure Declaration for US Pat. No. 12,174,107 B2

Certificate of Service of Paper #7 - Search Disclosure Declaration

Patent Owner's Request for Discretionary Denial Brief

About Beckman Coulter

CytoFLEX Flow Cytometer

Beckman Coulter Patents

Cytek Form S-1 Registration Statement (2021)

Information Disclosure Statement for Application No. 15/817,237 to U.S. Patent No. 10,436,697 (May 7, 2019)

Information Disclosure Statement for Application No. 15/942,430 to U.S. Patent No. 11,333,597 (June 17, 2021)

Transcript of Scheduling Conference

ORDER, C.A. No. 24-945, D.I. 124 (D. Del. July 30, 2025)

Transcript of Markman Hearing of August 21, 2025

Transcript of Markman Hearing of September 17, 2025

Capewell, U.S. Patent Pub. No. 2004/0165828

File History for U.S. Patent No. 9,746,412

DocketNavigator, Time-to-Trial Statistics for District of Delaware (Sept. 2025)

Abstract of Title for U.S. Patent No. 8,922,778

Abstract of Title for U.S. Patent No. 8,605,283

Chen, U.S. Patent No. 10,330,582

Denial of Request for Ex Parte Reexam Control Number 90/015,441 (Oct. 6, 2025)

Amended Scheduling Order (D. Del. Nov. 5, 2025)

U.S. Provisional Patent Application No. 61/715,819

Cytek’s 35 U.S.C. § 112 Contentions – Exhibit C

Beckman Coulter Second Election of Asserted Claims (October 1, 2025)

Cytek's Election of Asserted Prior Art Grounds

Petitioner's Search Disclosure Declaration

Petitioner's Motion to Seal & Request for In Camera Review

Petitioner's Updated Exhibit List

Excerpts of the Prosecution history of U.S. Patent No. 9,746,412

Prosecution history of EP24151670

Petitioner's Stipulation

Patent Owner's Mandatory Notices

Patent Owner's Power of Attorney

Notice filing date accorded to Petition

U.S. Patent No. 12,174,107 B2 to Yong Qin Chen (“’107 patent”)

Prosecution History of U.S. Patent No. 12,174,107 B2

Carter & Ormerod, Ch 1, Introduction to the Principles of flow cytometry

U.S. Patent No. 6,683,314 B2 to Clifford A. Oostman, Jr. et al. ("Oostman")

U.S. Patent No. 5,317,162 to Bertram G. Pinsky et al. ("Pinsky")

Excerpts of Howard M. Shapiro, Practical Flow Cytometry ("Shapiro")

WO 2010/101623 A1 to Michael Thomas (“Thomas”)

U.S. Patent No. 8,284,402 B2 to Erich Frazier et al. (“Frazier”)

U.S. Patent No. 4,244,045 to Kiyoshi Nosu et al. (“Nosu”)

U.S. Patent No. 8,537,468 B1 to Xuan Wang et al. (“Wang”)

U.S. Patent No. 6,198,864 B1 to Brian E. Lemoff et al. (“Lemoff”)

U.S. Patent No. 7,212,343 B1 to Chun He et al. (“He”)

U.S. Patent No. 5,835,517 to Vijaysekhar Jayaraman et al. (“Jayaraman”)

U.S. Patent No. 6,201,908 B1 to Eric B. Grann (“Grann”)

U.S. Patent No. 6,542,306 B2 to Timothy D. Goodman (“Goodman”)

Listing of Challenged Claims

Joint Claim Construction Chart filed in Beckman Coulter v. Cytek

Plntf’s Discl of Asserted Claims and Infringement Contentions [Red. Ver.]

Definition of Mirror from Concise Oxford English Dictionary

Excerpts of Course 1 Funds of Light and Lasers, Optics and Photonics Series

Semat & Katz, Ch 38, Mirrors and Lenses, Physics

Wasserman, Geometrical optics and ray tracing, Course Wiki

Complaint filed in Beckman Coulter v. Cytek

Summons in a Civil Action to Cytek, filed in Beckman Coulter v. Cytek

Stip and Order Amending Scheduling Order filed in Beckman Coulter v. Cytek

Excerpts of the Prosecution history of U.S. Patent No. 9,746,412

Diamond, Ch 8: Quality Control Guidelines for Research Flow Cytometry

Doornbos, WBC Differentiation Using a Solid State Flow Cytometer

SensL SPMMini High Gain APD

Menlo Systems APD210/310 High Sensitivity Detector Unit

Thorlabs.com – High-Sensitivity Avalanche Photodetectors website Overview

World Patent No. WO 94/29695 to Oddbjørn Gjelsnes ("Gjelsnes")

Stewart et al., Flow Cytometer in the Infrared: Inexpensive Modification...

Lawrence et al., A 16-channel avalanche photodiode detector array for...

Lawrence et al, A Comparison of Avalanche Photodiode and Photomultiplier...

Zhao et al, High gain avalanche photodiode (APD) arrays in flow cytometer..

U.S. Patent No. 8,188,438 B2 to Dongqing Li ("Li-438")

Canadian Patent No. 2 771 324 to Paul Patt ("Patt-324")

U.S. Patent No. 7,580,120 B2 to Yuichi Hamada et al. ("Hamada")

World Patent No. 98/59233 to Van S. Chandler ("Chandler-233")

U.S. Patent No. 7,523,637 B2 to Wayne D. Roth et al ("Roth-637")

U.S. Patent No. 7,505,131 B2 to Wayne D. Roth ("Roth-131")

US Pat Appl Publ No 2008/0305481 A1 to Douglas F Whitman et al ("Whitman")

US Pat Appl Pub No 2007/0269345 A1, Adam R. Schilffarth ("Schilffarth-345")

US Pat Appl Pub No 2007/0207513 A1 to Keld Sorensen et al ("Sorensen")

US Pat Appl Pub No 2009/0071225 A1, Adam R. Schilffarth ("Schilffarth-225")

US Pat Appl Pub No 2009/0237658 A1 to Edward Calvin et al ("Calvin")

U.S. Patent No. 6,139,800 to Van S. Chandler ("Chandler")

Luminex 100™ IS User Manual Version 2.3

Luminex FlexMap 3D® User Manual

BD Biosciences Immunocytometry Systems Tech Specifications BD FACSArray

Archived website page for Hamamatsu NIR High Sensitivity Type products

Archived website page for Hamamatsu Short Wavelength Type products

Hamamatsu Si APD S5343 to S5345, S9073 to S9075, Short wavelength type APD

Hamamatsu Si APD S8890 series, Long wavelength type APD

Hamamatsu Si APD S2381 to S2385, S5139, S8611, S3884, S4315 series, Low...

Hamamatsu Products by Division

First Sensor APD Data Sheet Part Description AD800-11 to Order # 500970

Thorlabs, Collimated Light's Non-Zero Beam Divergence, Does collimated...

Edmund Optics, Considerations in Collimation

Affidavit of Mina Ching

U.S. Patent No. 9,746,412 B2 to Yong Qin Chen ("'412")

Prosecution History of PCT/US2013/043453 (the “PCT App.”)

U.S. Patent No. 11,255,772 B2 to Yong Qin Chen (“’772”)

Decl of Dr. David Schaafsma, PhD ISO Beckman Coulter’s Opening CC Brief

How Gas-Ion Lasers Work, Lexel Laser

Barnes, Copper at the Cutting Edge: The Copper Vapor Laser

Argon Lasers, Remanufactured Air-Cooled Argon and Argon/Krypton Lasers

U.S. Patent No. 12,174,106 B2 to Yong Qin Chen (“’106 patent”)

Excerpts from Newport Catalog, incl Focusing and Collimating & Optics Gloss

Newport Catalog, Precision Laser & Optics Products

U.S. Patent No. 10,330,582 B2 to Yong Qin Chen (“’582 patent”)

Néron, Application Note Fiber Coupling Efficiency Calculation, Doric Lenses

Thorlabs, Single Mode Fiber

Thorlabs, 0.22 NA Silica Core, Glass Clad Multimode Optical Fiber, Step Ind

Thorlabs, 0.39 NA TECS-Clad Multimode Optical Fiber, Step Index

Beckman Coulter, Spectral Flow Cytometry: A Detailed Scientific Overview

Thermo Fisher Scientific, Electronics of a Flow Cytometer

Ortolani, Chapter 22 Non-Conventional Flow Cytometry

Beckman Coulter Life Sciences Launches Industry-First Modular Spectral...

Beckman Coulter, CytoFLEX mosaic Spectral Detection Module

U.S. Patent No. 7,280,204 B2 to Joseph Paul Robinson et al. (“Robinson”)

Shapiro and Hercher, Flow Cytometers Using Optical Waveguides in Place...

Markman Hearing Transcript from Beckman Coulter v. Cytek

Newport, Technical Note: Fiber Optic Coupling

Markman Hearing Transcript from Beckman Coulter v. Cytek

First Amended Complaint filed in Beckman Coulter v. Cytek

U.S. Provisional Application 61/911,859 to Yong Qin Chen

Notice: Power of Attorney

Declaration of Fedor A. Ilkov, Ph.D.

Petition: as filed