Notice: Power of Attorney | Jun 18, 2026 | PAPER | PETITIONER |
U.S. Patent No. 12,569,491 to Howerton et al. | Jun 18, 2026 | EXHIBIT | PETITIONER |
Prosecution History of the ‘491 Patent (“the Prosecution History”) | Jun 18, 2026 | EXHIBIT | PETITIONER |
PCT Publication WO/2015/112642 to Grigoriadis et al. | Jun 18, 2026 | EXHIBIT | PETITIONER |
Final Written Decision, Paper 64, PGR2021-00088 | Jun 18, 2026 | EXHIBIT | PETITIONER |
U.S. Publication No. 2017/0020877 to Grigoriadis et al. | Jun 18, 2026 | EXHIBIT | PETITIONER |
Final Written Decision, Paper 62, No. PGR2022-00025 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Turcu 2016 | Jun 18, 2026 | EXHIBIT | PETITIONER |
CRENESSITY (crinecerfont) Prescribing Label, Dec 13, 2024 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Neurocrine Biosciences, Inc., Q4 2025 Earnings Release | Jun 18, 2026 | EXHIBIT | PETITIONER |
Speiser 2010 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Turcu & Auchus 2015 | Jun 18, 2026 | EXHIBIT | PETITIONER |
El Maouche 2017 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Merke & Bornstein 2005 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Speiser 2018 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Fahmy 2017 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Griebel 2002 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Gully 2002 | Jun 18, 2026 | EXHIBIT | PETITIONER |
European Pat. No. 3 784 233 to Alexis Howerton, et al. | Jun 18, 2026 | EXHIBIT | PETITIONER |
Merke & Auchus 2020 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Turcu & Auchus 2016 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Webb & Krone 2015 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Neurocrine March 20, 2021 Press Release | Jun 18, 2026 | EXHIBIT | PETITIONER |
Decision of EPO Opposition Division, revoking EP 3 784 233, Dec. 12, 2025 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Williams 2013 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Director Review Request in PGR2021-00088, Paper 65 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Director Review Request in PGR2022-00025, Paper 63 | Jun 18, 2026 | EXHIBIT | PETITIONER |
PubChem Compound Summary for CID 5282340, Crinecerfont 2026 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Director Review Decision in PGR2021-00088, Paper 66 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Director Review Decision in PGR2022-00025, Paper 64 | Jun 18, 2026 | EXHIBIT | PETITIONER |
U.S. Patent No. 10,849,908 to Alexis Howerton et al. | Jun 18, 2026 | EXHIBIT | PETITIONER |
U.S. Patent No. 11,007,201 to Alexis Howerton et al. | Jun 18, 2026 | EXHIBIT | PETITIONER |
Zaarour 2014 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Sarafoglou 2023 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Chen 2017 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Sarafoglou 2021 | Jun 18, 2026 | EXHIBIT | PETITIONER |
U.S. Pat. No. 11,304,950 to Alexis Howerton et al. | Jun 18, 2026 | EXHIBIT | PETITIONER |
Spruce March 25, 2019, Press Release | Jun 18, 2026 | EXHIBIT | PETITIONER |
Spruce March 13, 2024, Press Release | Jun 18, 2026 | EXHIBIT | PETITIONER |
Spruce December 10, 2024, Press Release | Jun 18, 2026 | EXHIBIT | PETITIONER |
Turcu & Auchus 2015 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Mallappa & Merke | Jun 18, 2026 | EXHIBIT | PETITIONER |
Auchus 2022 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Claahsen-van der Grinten 2022 | Jun 18, 2026 | EXHIBIT | PETITIONER |
U.S. Pat. 11,304,950 Request and COC issued June 17, 2025 | Jun 18, 2026 | EXHIBIT | PETITIONER |
PCT/US2019/029486 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Auchus 2024 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Sarafoglou et al. 2024 | Jun 18, 2026 | EXHIBIT | PETITIONER |
U.S. Provisional App. No. 62/663,951 (the “’951 provisional”) | Jun 18, 2026 | EXHIBIT | PETITIONER |
U.S. Provisional App. No. 62/822,815 (the “’815 provisional”) | Jun 18, 2026 | EXHIBIT | PETITIONER |
Neurocrine July 1, 2024, Press Release | Jun 18, 2026 | EXHIBIT | PETITIONER |
Dec. 13, 2024, Neurocrine Press Release | Jun 18, 2026 | EXHIBIT | PETITIONER |
PubChem Compound Summary for CID 134694266, Tildacerfont 2026 | Jun 18, 2026 | EXHIBIT | PETITIONER |
U.S. Pat. No. 6,586,456 to Fontaine, et al. | Jun 18, 2026 | EXHIBIT | PETITIONER |
U.S. App No. 17/081,694, OAR with Chris Barnes Declaration Dec. 13, 2021 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Delfino 2012 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Yu 2015 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Aycan 2013 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Claahsen-van der Grinten 2021 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Reisch 2013 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Mendes-dos-Santos 2018 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Spruce Biosciences Clinical Study Report, SPR001-202 Protocol 2025 | Jun 18, 2026 | EXHIBIT | PETITIONER |
International Publication No. WO 2016/065177 A1 to Howerton et al. | Jun 18, 2026 | EXHIBIT | PETITIONER |
GSK Study | Jun 18, 2026 | EXHIBIT | PETITIONER |
Wilson 2001 | Jun 18, 2026 | EXHIBIT | PETITIONER |
U.S. App. No. 17/081,694, NOA & Reasons for Allowance, Feb 1, 2022 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Smeets 2015 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Claahsen-van der Grinten 2009 | Jun 18, 2026 | EXHIBIT | PETITIONER |
O’Shea 2019 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Tellew 2010 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Chen 2008 | Jun 18, 2026 | EXHIBIT | PETITIONER |
U.S. App. No. 18/941,832 Preliminary amendment filed 5 February 2026 | Jun 18, 2026 | EXHIBIT | PETITIONER |
U.S. App. No. 18/438,060 Claim Amendments Filed 3 April 2026 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Declaration of June Ann Munford (May 22, 2026) | Jun 18, 2026 | EXHIBIT | PETITIONER |
FDA News Release, December 13, 2024 | Jun 18, 2026 | EXHIBIT | PETITIONER |
PubChem Compound Summary for CID 11596613, Verucerfont 2026 | Jun 18, 2026 | EXHIBIT | PETITIONER |
PubChem Compound Summary for CID 24758885, 2026 | Jun 18, 2026 | EXHIBIT | PETITIONER |
PubChem Compound Summary for CID 24898976, 2026 | Jun 18, 2026 | EXHIBIT | PETITIONER |
PubChem Compound Summary for CID 9821250, NBI-30775, 2026 | Jun 18, 2026 | EXHIBIT | PETITIONER |
PubChem Compound Summary for CID 9888194, NBI-34041, 2026 | Jun 18, 2026 | EXHIBIT | PETITIONER |
PubChem Compound Summary for CID 9884878, DMP-904, 2026 | Jun 18, 2026 | EXHIBIT | PETITIONER |
PubChem Compound Summary for CID 177990, Antalarmin 2026 | Jun 18, 2026 | EXHIBIT | PETITIONER |
NCT04457336, ClinicalTrials.gov., Spruce Biosciences | Jun 18, 2026 | EXHIBIT | PETITIONER |
Newfield 2023 | Jun 18, 2026 | EXHIBIT | PETITIONER |
PGR2025-00032, Paper 2 | Jun 18, 2026 | EXHIBIT | PETITIONER |
PGR2025-00032, Paper 8 | Jun 18, 2026 | EXHIBIT | PETITIONER |
Declaration of Ramesh Tharuvai, Ph.D. | Jun 18, 2026 | EXHIBIT | PETITIONER |
Declaration of Maya Lodish, M.D. | Jun 18, 2026 | EXHIBIT | PETITIONER |
Petition: as filed | Jun 18, 2026 | PAPER | PETITIONER |