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Use Of Perfusion To Enhance Production Of Fed-Batch Cell Culture In Bioreactors - EP2188371

The patent EP2188371 was granted to Wyeth on Dec 20, 2017. The application was originally filed on Aug 8, 2008 under application number EP08797478A. The patent is currently recorded with a legal status of "Revoked".

EP2188371

WYETH
Application Number
EP08797478A
Filing Date
Aug 8, 2008
Status
Revoked
Dec 21, 2024
Grant Date
Dec 20, 2017
External Links
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Patent Summary

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Patent Family

Patent Oppositions (4)

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EUROPEAN OPPOSITIONSSep 20, 2018BOULT WADE TENNANTADMISSIBLE
GLAXO GROUPSep 20, 2018BHOGALADMISSIBLE
MERCK SHARP & DOHMESep 20, 2018MERCK SHARP & DOHMEADMISSIBLE
F HOFFMANN LA ROCHESep 19, 2018VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBBADMISSIBLE

Patent Citations (20) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
INTERNATIONAL-SEARCH-REPORTUS2006121611
OPPOSITIONEP0201086
OPPOSITIONEP0270905
OPPOSITIONUS2006051747
OPPOSITIONUS2006099685
OPPOSITIONUS2006121568
OPPOSITIONUS2008076155
OPPOSITIONUS5721121
OPPOSITIONUS5976833
OPPOSITIONUS6455298
OPPOSITIONUS6528286
OPPOSITIONUS6890736
OPPOSITIONUS6924124
OPPOSITIONUS7294481
OPPOSITIONWO02101019
OPPOSITIONWO2004104186
OPPOSITIONWO2006026445
OPPOSITIONWO2007016250
OPPOSITIONWO2008063892
OPPOSITIONWO2008131374

Non-Patent Literature (NPL) Citations (71) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
EXAMINATION- D. Müller et al., "Continuous Perfusion versus Discontinuous Fed-Batch", D. Müller et al., E. Lindner-Olsson et al., Animal Cell Technology: From Target to Market, Kluwer Academic Publisher, (20060705), pages 293 - 299-
EXAMINATION- SIMONE M SCHATZ ET AL, "Higher Expression of Fab Antibody Fragments in a CHU Cell Line at Reduced Temperature", BIOTECHNOLOGY AND BIOENGINEERING, WILEY & SONS, HOBOKEN, NJ, US, vol. 84, no. 4, doi:10.1002/BIT.10793, ISSN 0006-3592, (20031120), pages 433 - 438, (20030911), XP007912785
EXAMINATION- SUNG KWAN YOON ET AL, "Effect of culture temperature on follicle-stimulating hormone production by Chinese hamster ovary cells in a perfusion bioreactor", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER, BERLIN, DE, (20070503), vol. 76, no. 1, doi:10.1007/S00253-007-0985-X, ISSN 1432-0614, pages 83 - 89, XP019538802
EXAMINATION- CHEN Z-L ET AL, "Temperature shift as a process optimization step for the production of pro-urokinase by a recombinant Chinese hamster ovary cell line in high-density perfusion culture", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, ELSEVIER, AMSTERDAM, NL, (20040101), vol. 97, no. 4, doi:10.1016/S1389-1723(04)70198-X, ISSN 1389-1723, pages 239 - 243, XP008105293
EXAMINATION- KAZUAKI FURUKAWA ET AL, "Enhancement of productivity of recombinant [alpha]-amidating enzyme by low temperature culture", CYTOTECHNOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, (19990901), vol. 31, no. 1-2, doi:10.1023/A:1008059803038, ISSN 1573-0778, pages 85 - 94, XP019236635
INTERNATIONAL-SEARCH-REPORT- JARDIN BARBARA ANN ET AL, "High cell density fed batch and perfusion processes for stable non-viral expression of secreted alkaline phosphatase (SEAP) using insect cells: Comparison to a batch Sf-9-BEV system", BIOTECHNOLOGY AND BIOENGINEERING, (200706), vol. 97, no. 2, ISSN 0006-3592, pages 332 - 345, XP002500587 [A] 1-40 * abstract *
INTERNATIONAL-SEARCH-REPORT- SUN X ET AL, "High-density transient gene expression in suspension-adapted 293 EBNA1 cells", BIOTECHNOLOGY AND BIOENGINEERING 20080101 US, (20070713), vol. 99, no. 1, ISSN 0006-3592 1097-0290, pages 108 - 116, XP002500586 [X] 1-40 * figure 4 *
INTERNATIONAL-SEARCH-REPORT- KONSTANTINOV KONSTANTIN ET AL, "The "push-to-low" approach for optimization of high-density perfusion cultures of animal cells", ADVANCES IN BIOCHEMICAL ENGINEERING BIOTECHNOLOGY SPRINGER, 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES SERIES : ADVANCES IN BIOCHEMICAL ENGINEERING / BIOTECHNOLOGY (ISSN 0724-6145(PRINT)), (2006), ISSN 3-540-34006-8(H), pages 75 - 98, XP009107388 [A] 1-40 * the whole document *
INTERNATIONAL-SEARCH-REPORT- MEUWLY ET AL, "Conversion of a CHO cell culture process from perfusion to fed-batch technology without altering product quality", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20060503), vol. 123, no. 1, ISSN 0168-1656, pages 106 - 116, XP005398962 [A] 1-40 * abstract *
OPPOSITION- FRANEK, "142 Towards a two-stage continuous production of monoclonal antibodies", Washington D.C-
OPPOSITION- GOMPERTS et al., "The manufacturing process of recombinant factor VIII, recombinate", Transfusion Medicine Reviews, (19920000), vol. VI, no. 4, pages 247 - 251, XP009119861-
OPPOSITION- HILLE R, "Use of short-duration perfusion to enhance productivity in fed-batch bioreactors", Cell culture engineering XI conference held in Queensland-
OPPOSITION- J. E. DOWD, "Predictive control and optimization of bioprocesses for recombinant t-PA protein production by mammalian cells, dissertation", (20000426), pages ii - 176, XP055440356-
OPPOSITION- KOMPALA et al., "Optimization of High Cell Density Perfusion Bioreacotors", Cell Culture Technology For Pharmaceutical And Cell -Based Therapies, pages 387 - 416, XP055519914-
OPPOSITION- OHASHI R et al., "Perfusion Cell Culture in Disposable Bioreactors", Animal Cell Technology: from target to market, (20010000), pages 403 - 409, XP055521880-
OPPOSITION- PATEL et al., "The Lactate Issue Revisited: Novel Feeding Protocols To Examine Inhibition of Cell Proliferation and Glucose Metabolism in Hematopoietic Cell Cultures", Biotechnol. Prog., (20000000), vol. 16, pages 885 - 892, XP055510772-
OPPOSITION- TAKAGI et al., "Effects of Shifts Up and Down in Osmotic Pressure on Production of Tissue Plasminogen Activator by Chinese Hamster Ovary Cells in Suspension", Journal of Bioscience and Bioengineering, (20010000), vol. 91, no. 5, pages 509 - 514, XP007911578-
OPPOSITION- XIE et al., "Fed-Batch Cultivation of Mammalian Cells for the Production of Recombinant Proteins", Cell Culture Technology For Pharmaceutical And Cell -Based Therapies, pages 349 - 386, XP055519908-
OPPOSITION- YANG et al., "Achievement of high cell density and high antibody productivity by a controlled-fed perfusion bioreactor process", Biotechnology and Bioengineering, (20000000), vol. 69, pages 74 - 82, XP002619089-
OPPOSITION- YANG et al., "Achievement of high cell density and high antibody productivity by a controlled-fed perfusion bioreactor process", Biotechnology and Bioengineering, (20000705), vol. 69, no. 1, pages 74 - 82, XP002619089-
OPPOSITION- OSMAN et al., "The Response of GS-NS0 Myeloma Cells to Single and Multiple pH Perturbations", Biotechnology and Bioengineering, (20011005), vol. 75, no. 1, pages 63 - 73, XP002316579
OPPOSITION- SCHATZ et al., "Higher Expression of Fab Antibody Fragments in a CHU Cell Line at Reduced Temperature", Biotechnology and Bioengineering, (20030000), vol. 84, no. 4, pages 433 - 438, XP007912785
OPPOSITION- SCHATZ et al., "Higher Expression of Fab Antibody Fragments in a CHU Cell Line at Reduced Temperature", Biotechnology and Bioengineering, (20030000), vol. 84, pages 432 - 438, XP007912785
OPPOSITION- HUANG et al., "Process development for a recombinant Chinese hamster ovary (CHO) cell line utilizing a metal induced and amplified metallothionein expression system", Biotechnology and Bioengineering, (20040921), vol. 88, no. 4, pages 437 - 450, XP008064032
OPPOSITION- YOON et al., "Effect of culture pH on erythropoietin production by chinese hamster ovary cells grown in suspension at 32.5 and 37.0 °C", Biotechnology and Bioengineering, (20041229), vol. 89, no. 3, pages 345 - 356, XP002486306
OPPOSITION- ANGEPAT et al., "Accelerating perfusion process optimization by scanning non-steady-state responses", Biotechnology and Bioengineering, (20050000), vol. 92, pages 472 - 478, XP055521740
OPPOSITION- AL-FAGEEH et al., "The Cold-Shock Response in Cultured Mammalian Cells: Harnessing the Response for the Improvement of Recombinant Protein Production", Biotechnology and Bioengineering, (20051202), vol. 93, no. 5, pages 829 - 835, XP007912835
OPPOSITION- TRUMMER et al., "Process parameter shifting: Part II. Biphasic cultivation - A tool for enhancing the volumetric productivity of batch processes using Epo-Fc expressing CHO cells", Biotechnology and Bioengineering, (20060530), vol. 94, no. 6, pages 1044 - 1052, XP002651719
OPPOSITION- TRUMMER et al., "Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo-Fc expressing CHO cells cultivated in controlled batch bioreactors", Biotechnology and Bioengineering, (20060530), vol. 94, no. 6, pages 1033 - 1044, XP002486305
OPPOSITION- YOON et al., "Effect of culture temperature on follicle-stimulating hormone production by Chinese hamster ovary cells in a perfusion bioreactor", Appl Microbiol Biotechno l, (20070503), vol. 76, pages 83 - 89, XP002486305
OPPOSITION- SUN et al., "High-density transient gene expression in suspension-adapted 293 EBNA1 cells", Biotechnology and Bioengineering, (20070713), vol. 99, no. 1, pages 108 - 16, XP002500586
OPPOSITION- SUN et al., "High-density transient gene expression in suspension-adapted 293 EBNA1 cells", Biotechnology and Bioengineering, (20080000), vol. 99, no. 1, pages 108 - 116, XP002500586
OPPOSITION- SUN et al., "High-density transient gene expression in suspension-adapted 293 EBNA1 cells", Biotechnology and Bioengineering, (20080101), vol. 99, no. 1, pages 108 - 116, XP002500586
OPPOSITION- AHN et al., "Effect of culture temperature on erythropoietin production and glycosylation in a perfusion culture of recombinant CHO cells", Biotechnology and Bioengineering, (20080000), vol. 101, no. 6, pages 1234 - 1244, XP055510834
OPPOSITION- CHUPPA et al., "Fermentor temperature as a tool for control for high-density perfusion cultures of mammalian cells", Biotechnology and Bioengineering, (19970000), vol. 55, no. 2, pages 328 - 338, XP002155997
OPPOSITION- CHUPPA et al., "Fermentor temperature as a tool for control for high-density perfusion cultures of mammalian cells", Biotechnology and Bioengineering, (19970720), vol. 55, no. 2, pages 328 - 338, XP002155997
OPPOSITION- MULLER et al., "Continuous Perfusion versus Discontinuous Fed-Batch.", Animal Cell Technology: from Target to Market, (20010000), pages 293 - 299, XP003035065
OPPOSITION- MULLER et al., "Continuous Perfusion versus Discontinuous Fed-Batch", Animal Cell Technology: From Target to Market, Springer, vol. 1, pages 293 - 299, XP003035065
OPPOSITION- MULLER et al., "Continuous perfusion versus discontinuous fed-batch", Animal Cell Technology, pages 293 - 299, XP003035065
OPPOSITION- MULLER et al., "Continuous Perfusion versus Discontinuous Fed-Batch", MULLER et al., E Lindner-Olsson, Animal Cell Technology: From Target to Market Kluwer Academic, pages 293 - 299, XP003035065
OPPOSITION- BUTLER, "Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals", Appl. Microbiol. Biotechnology, (20050416), vol. 68, pages 283 - 291, XP002457678
OPPOSITION- Michael Butler, "Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals", Butler Appl. Microbiol. Biotechnol., (20050000), vol. 68, pages 283 - 291, XP002457678
OPPOSITION- YOON et al., "Effect of culture temperature on follicle-stimulating hormone production by Chinese hamster ovary cells in a perfusion bioreactor", Applied Microbiology and Biotechnology, (20070000), vol. 76, pages 83 - 89, XP019538802
OPPOSITION- YOON et al., "Effect of culture temperature on follicle-stimulating hormone production by Chinese hamster ovary cells in a perfusion bioreactor", Appl. Microbiol. Biotechnol., (20070000), vol. 76, pages 83 - 89, XP019538802
OPPOSITION- YOON et al., "Effect of culture temperature on follicle-stimulating hormone production by Chinese hamster ovary cells in a perfusion bioreactor", Appl. Microbiol. Biotechnol., (20070503), vol. 76, pages 83 - 89, XP019538802
OPPOSITION- MEUWLY et al., "Optimization of the medium perfusion rate in a packed-bed bioreactor charged with CHO cells", Cytotechnology, (20040900), vol. 46, pages 37 - 47, XP019236851
OPPOSITION- KUMAR et al., "Proliferation control strategies to improve productivity and survival during CHO based production culture; A summary of recent methods employed and the effects of proliferation control in product secreting CHO cell lines", Cytotechnology, (20070000), vol. 53, pages 33 - 46, XP019499816
OPPOSITION- OGUCHI et al., "pH Condition in temperature shift cultivation enhances cell longevity and specific hMab productivity in CHO culture", Cytotechnology, (20070308), vol. 52, no. 3, pages 199 - 207, XP019499827
OPPOSITION- REUVENY S et al., "Comparison of cell propagation methods for their effect on monoclonal antibody yield in fermentors", J. Immunol. Methods, (19860000), vol. 86, no. 1, pages 61 - 69, XP023676424
OPPOSITION- BIRCH et al., "Antibody production", Advanced Drug Delivery Reviews, (20060000), vol. 58, pages 671 - 685, XP005611421
OPPOSITION- TSAO et al., "Monitoring Chinese hamster ovary cell culture by the analysis of glucose and lactate metabolism", Journal of Biotechnology, (20050000), vol. 118, pages 316 - 327, XP004987759
OPPOSITION- YOON et al., "Adaptation of Chinese hamster ovary cells to low culture temperature: Cell growth and recombinant protein production", Journal of Biotechnology, (20060000), vol. 122, no. 4, pages 463 - 472, XP005357487
OPPOSITION- FENG et al., "Application of ''oxygen uptake rate-amino acids'' associated mode in controlled-fed perfusion culture", Journal of Biotechnology, (20060000), vol. 122, pages 422 - 430, XP005357483
OPPOSITION- CHU et al., "Industrial choices for protein production by large-scale cell culture", Current Opinion in Biotechnology, (20010400), vol. 12, pages 180 - 187, XP003014088
OPPOSITION- CHEN et al., "Temperature shift as a process optimization step for the production of pro-urokinase by a recombinant Chinese hamster ovary cell line in high-density perfusion culture", Journal of Bioscience and Bioengineering, (20040000), vol. 97, no. 4, pages 239 - 243, XP008105293
OPPOSITION- CHEN Z-L et al., "Temperature shift as a process optimization step for the production of pro-urokinase by a recombinant Chinese hamster ovary cell line in high-density perfusion culture", Journal of Bioscience and Bioengineering, (20040000), vol. 97, pages 239 - 243, XP008105293
OPPOSITION- RODRIGUEZ et al., "Enhanced production of monomeric interferon-[beta] by CHO cells through the control of culture conditions", Biotechnol. Prog., (20050000), vol. 21, pages 22 - 30, XP002572995
OPPOSITION- WOODSIDE et al., "Mammalian cell retention devices for stirred perfusion bioreactors", Cytotechnology, (19980000), vol. 28, pages 163 - 175, XP002301951
OPPOSITION- Furukawa et al., "Enhancement of productivity of recombinant [alpha]-amidating enzyme by low temperature culture", Cytotechnology, (19990000), vol. 31, pages 85 - 94, XP019236635
OPPOSITION- FURUKAWA et al., "Enhancement of productivity of recombinant [alpha]-amidating enzyme by low temperature culture", Cytotechnology, (19990000), vol. 31, pages 85 - 94, XP019236635
OPPOSITION- FURUKAWA et al., "Enhancement of productivity of recombinant alpha-amidating enzyme by low temperature culture", Cytotechnology, (19990000), vol. 31, pages 85 - 94, XP019236635
OPPOSITION- HEIDEMANN et al., "A new seed-train expansion method for recombinant mammalian cells.", Cytotechnology, (20020000), vol. 38, pages 99 - 108, XP055225875
OPPOSITION- DOWD et al., "Optimization and control of perfusion cultures using a viable cell probe and cell specific perfusion rates", Cytotechnology, (20030000), vol. 42, no. 1, pages 35 - 45, XP019236785
OPPOSITION- LI et al., "Current therapeutic antibody production and process optimisation", BioProcessing Journal, (20050900), pages 23 - 30, XP055521823
OPPOSITION- KIM et al., "Biphasic culture strategy based on hyperosmotic pressure for improved humanized antibody production in Chinese hamster ovary cell culture", In Vitro Cellular & Developmental Biology, (20020000), vol. 38, no. 6, pages 314 - 319, XP008160821
OPPOSITION- SOU et al., "Evaluation of transfection methods for transient gene expression in Chinese hamster ovary cells", Advances in Bioscience and Biotechnology, (20130000), vol. 4, pages 1013 - 1019, XP055521917
OTHER- SIMONE M SCHATZ ET AL, "HIGHER EXPRESSION OF FAB ANTIBODY FRAGMENTS IN A CHU CELL LINE AT REDUCED TEMPERATURE", BIOTECHNOLOGY AND BIOENGINEERING, (20031120), vol. 84, no. 4, doi:10.1002/BIT.10793, pages 433 - 438, XP007912785
OTHER- DR DETHARDT MÃœLLER ET AL, "CONTINUOUS PERFUSION DISCONTINUOUS FED-BATCH", ANIMAL CELL TECHNOLOGY: FROM TARGET TO MARKET, (2001), vol. 1, pages 293 - 299, XP003035065
OTHER- SUNG KWAN YOON ET AL, "EFFECT OF CULTURE TEMPERATURE ON FOLLICLE-STIMULATING HORMONE PRODUCTION BY CHINESE HAMSTER OVARY CELLS IN A PERFUSION BIOREACTOR", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, (20070503), vol. 76, no. 1, doi:10.1007/S00253-007-0985-X, pages 83 - 89, XP019538802
OTHER- CHEN Z.L. ET AL, "TEMPERATURE SHIFT AS A PROCESS OPTIMIZATION STEP FOR THE PRODUCTION OF PRO-UROKINASE BY A RECOMBINANT CHINESE HAMSTER OVARY CELL LINE IN HIGH-DENSITY PERFUSION CULTURE", JOURNAL OF BIOSCIENCE AND BIOENGINEERING, (200401), vol. 97, no. 4, doi:10.1016/S1389-1723(04)70198-X, pages 239 - 243, XP008105293
OTHER- KAZUAKI FURUKAWA ET AL, "ENHANCEMENT OF PRODUCTIVITY OF RECOMBINANT [ALPHA]-AMIDATING ENZYME BY LOW TEMPERATURE CULTURE", CYTOTECHNOLOGY, (199909), vol. 31, no. 1-2, doi:10.1023/A:1008059803038, pages 85 - 94, XP019236635

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