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The patent EP2462158 was granted to F Hoffmann LA Roche on Jan 10, 2018. The application was filed on Aug 6, 2010 under application number EP10740823A. The patent is currently recorded with a legal status of "Granted And Under Opposition".
Improving the filtration capacity of virus filters during protein purification by using a prefiltration step before virus filtration. The prefiltration step involves subjecting the protein solution to a cation exchange step and an endotoxin removal step in any order. This prefiltration improves the virus filtration capacity compared to just cation exchange or endotoxin removal prior to virus filtration. The prefiltration steps can be done simultaneously in a single module.

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
| Company | Opposition Date | Representative | Opposition Status |
|---|---|---|---|
| BAYER GMBHBAYER PHARMA AKTIENGESELLSCHAFTBAYER ANIMAL HEALTH | Oct 10, 2018 | BIP PATENTS | ADMISSIBLE |
| LEEMING | Oct 10, 2018 | J A KEMP | ADMISSIBLE |
| MAIWALD | Oct 10, 2018 | MAIWALD | ADMISSIBLE |
| MICHALSKI HUTTERMANN & PARTNER PATENTANWALTE MBB | Oct 10, 2018 | MICHALSKI HUTTERMANN & PARTNER PATENTANWALTE MBB | ADMISSIBLE |
| MORPHOSYS | Oct 10, 2018 | SPILLER | ADMISSIBLE |
| NEUEFEIND | Oct 10, 2018 | MAIWALD | ADMISSIBLE |
| POHLMAN | Oct 10, 2018 | POHLMAN | ADMISSIBLE |
| STRAWMAN | Oct 10, 2018 | MURGITROYD | ADMISSIBLE |
| KONIG SZYNKA TILMANN VON RENESSE | Oct 9, 2018 | KONIG SZYNKA TILMANN VON RENESSE PATENTANWALTE PARTNERSCHAFT MBB DUSSELDORF | ADMISSIBLE |
| POTTER CLARKSON | Oct 9, 2018 | POTTER CLARKSON | ADMISSIBLE |
| GRUNECKER PATENT UND RECHTSANWALTE PARTG MBB | Oct 4, 2018 | GRUNECKER PATENT | ADMISSIBLE |
Patent citations refer to prior patents cited during different phases such as opposition or international search.
| Citation Phase | Publication Number |
|---|---|
| DESCRIPTION | EP0003089 |
| DESCRIPTION | EP0404097 |
| DESCRIPTION | US4399216 |
| DESCRIPTION | US4676980 |
| DESCRIPTION | US4816567 |
| DESCRIPTION | US4975278 |
| DESCRIPTION | US5500362 |
| DESCRIPTION | US5545806 |
| DESCRIPTION | US5545807 |
| DESCRIPTION | US5569825 |
| DESCRIPTION | US5625126 |
| DESCRIPTION | US5633425 |
| DESCRIPTION | US5641870 |
| DESCRIPTION | US5661016 |
| DESCRIPTION | US5821337 |
| DESCRIPTION | US7118675 |
| DESCRIPTION | WO8101145 |
| DESCRIPTION | WO8807378 |
| DESCRIPTION | WO8905859 |
| DESCRIPTION | WO9100360 |
| DESCRIPTION | WO9220373 |
| DESCRIPTION | WO9308829 |
| DESCRIPTION | WO9311161 |
| DESCRIPTION | WO9404690 |
| DESCRIPTION | WO9627011 |
| INTERNATIONAL-SEARCH-REPORT | US2003146156 |
| INTERNATIONAL-SEARCH-REPORT | WO2007108955 |
| INTERNATIONAL-SEARCH-REPORT | WO2009017491 |
| OPPOSITION | EP1403274 |
| OPPOSITION | EP1577319 |
| OPPOSITION | EP1614693 |
| OPPOSITION | EP2281000 |
| OPPOSITION | EP2435474 |
| OPPOSITION | EP2473617 |
| OPPOSITION | JPH02198687 |
| OPPOSITION | JPH07116484 |
| OPPOSITION | US2003036638 |
| OPPOSITION | US2003146156 |
| OPPOSITION | US2003229212 |
| OPPOSITION | US2004241878 |
| OPPOSITION | US2006257972 |
| OPPOSITION | US2009148443 |
| OPPOSITION | US5629084 |
| OPPOSITION | US6177548 |
| OPPOSITION | US7001550 |
| OPPOSITION | US7118675 |
| OPPOSITION | US7847071 |
| OPPOSITION | WO03066669 |
| OPPOSITION | WO03102132 |
| OPPOSITION | WO2005073367 |
| OPPOSITION | WO2006042541 |
| OPPOSITION | WO2007108955 |
| OPPOSITION | WO2008025747 |
| OPPOSITION | WO2008036899 |
| OPPOSITION | WO2008073620 |
| OPPOSITION | WO2009017491 |
| OPPOSITION | WO2009085765 |
| OPPOSITION | WO2010138736 |
| OPPOSITION | WO2011031397 |
The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.
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Letter accompanying subsequently filed items
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Jun 18, 2015
Communication from the Examining Division
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Apr 27, 2015
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Apr 27, 2015
Amended claims with annotations
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Apr 27, 2015
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Apr 27, 2015
Letter accompanying subsequently filed items
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Letter accompanying subsequently filed items
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Feb 19, 2015
Oct 27, 2014
Annex to the communication
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Oct 27, 2014
Communication from the Examining Division
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Sep 18, 2012
(Electronic) Receipt
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Jan 23, 2012
Request for entry into the European phase
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Jan 20, 2012
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Jul 11, 2011
Notification of the recording of a change
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Apr 7, 2011
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Copy of the international search report
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Published international application - A1
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Nov 11, 2010
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