Small Liposomes For Delivery Of Immunogen-Encoding Rna - EP2611467

The patent EP2611467 was granted to Glaxosmithkline on Jul 20, 2022. The application was originally filed on Aug 31, 2011 under application number EP11755497A. The patent is currently recorded with a legal status of "Revoked".

EP2611467

GLAXOSMITHKLINE
Application Number
EP11755497A
Filing Date
Aug 31, 2011
Status
Revoked
Jan 24, 2025
Grant Date
Jul 20, 2022
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (5)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

JG OPPOSITIONSApr 20, 2023MEWBURN ELLISADMISSIBLE
MARGARET DIXONApr 20, 2023MEWBURN ELLISADMISSIBLE
HOPFNERApr 18, 2023HOPFNERADMISSIBLE
WEICKMANN & WEICKMANNApr 18, 2023WEICKMANN & WEICKMANN PARTMBBADMISSIBLE
SANOFIApr 17, 2023ELKINGTON AND FIFEADMISSIBLE

Patent Citations (25) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
INTERNATIONAL-SEARCH-REPORTEP0786522
INTERNATIONAL-SEARCH-REPORTEP1637144
INTERNATIONAL-SEARCH-REPORTJP2007112768
INTERNATIONAL-SEARCH-REPORTUS5750390
INTERNATIONAL-SEARCH-REPORTUS5972704
INTERNATIONAL-SEARCH-REPORTWO9952503
OPPOSITIONWO02095023
OPPOSITIONWO2005120152
OPPOSITIONWO2005121348
OPPOSITIONWO2006078294
OPPOSITIONWO2007047749
OPPOSITIONWO2011005799
OPPOSITIONWO2011008974
OPPOSITIONWO2011068810
OPPOSITIONWO2012006369
OPPOSITIONWO2012006372
OPPOSITIONWO2012006376
OPPOSITIONWO2012006377
OPPOSITIONWO2012006378
OPPOSITIONWO2012030901
OPPOSITIONWO2014160243
OPPOSITIONWO2017004143
OPPOSITIONWO2017075531
OPPOSITIONWO2022137133
OPPOSITIONWO9011092

Non-Patent Literature (NPL) Citations (82) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
OPPOSITION- Anonymous, "Spikevax ( COVID-19 mRNA Vaccine (nucleoside modified) ) An overview of Spikevax, including its adapted vaccine, and why it is authorised in the EU", EUROPEAN MEDICINES AGENCY SCIENCE MEDICINES HEALTH, NL, NL, (20220101), pages 1 - 5, (20230928), XP093087018-
OPPOSITION- Anonymous, " Zetasizer llano User manual MAN0485 Issue 1.1", ZETASIZER NANO SERIES ZETA POTENTIAL MOLECULAR WEIGHT MOLECULAR SIZE USER MANUAL, Malvern , (20130401), pages 1 - 250, XP093148215-
OPPOSITION- CHOWDARY et al., "Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL", Nature Structural & Molecular Biology, (20100700), vol. 17, no. 7, pages 882 - 889, XP093031567-
OPPOSITION- Collins P L, "Human Respiratory Syncytial Virus", Encyclopedia of Virology, (20080101), pages 543 - 550, XP093031553-
OPPOSITION- Dolgin Elie, "TRIAL SETTLES DEBATE OVER BEST DESIGN FOR MRNA IN COVID VACCINES Ingredients for the messenger RNA vaccine made by CureVac", Nature, (20230119), vol. 613, no. 7944, pages 419 - 420, XP093087012-
OPPOSITION- Duggan Sean T, Plosker Greg L, "Intanza® 15 µg Intradermal Seasonal Influenza Vaccine", Drugs Aging, (20100701), vol. 27, no. 7, pages 597 - 605, XP093031560-
OPPOSITION- Excerpt from Moderna's 2018 10-K-
OPPOSITION- FRAENKEL-CONRAT et al., FRAENKEL-CONRAT et al., FRAENKEL-CONRAT Heinz ; Kimball Paul C., Virology, Englewood Cliffs, N.J. 07632 USA, PRENTICE-HALL, INC., (19820000), pages 35, 124 - 126, 128-130, 285-292, 390, ISBN 0 -13-942144-0-
OPPOSITION- GHILDYAL et al., FEMS Microbiol Rev, (20060000), vol. 30, pages 692 - 705-
OPPOSITION- HASHIMOTO et al., J. Med. Sci., (20170000), vol. 63, no. 3, page 127-
OPPOSITION- HEYES et al., J Controlled Release, (20050000), vol. 107, pages 276 - 287-
OPPOSITION- Immordino Maria Laura; Dosio Franco; Cattel Luigi, "Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential", INTERNATIONAL JOURNAL OF NANOMEDICINE, DOVE MEDICAL PRESS LTD., AUCKLAND, NZ, AUCKLAND, NZ , (20060101), vol. 1, no. 3, ISSN 1176-9114, pages 297 - 315, XP009145524-
OPPOSITION- Lowe Derek, "CureVac Comes Around", Science, (20230101), pages 1 - 3, XP093045422-
OPPOSITION- MacLachlan I., "Liposomal formulations for nucleic acid delivery", MacLachlan I., CROOKE STANLEY T, ANTISENSE DRUG TECHNOLOGY: PRINCIPLES, STRATEGIES, AND APPLICATIONS, 2ND ED., US , CRC PRESS , (20070101), pages 237 - 270, ISBN 978-0-8493-8796-8, XP002584305-
OPPOSITION- MAURER et al., "Native 3D intermediates of membrane fusion in herpes simplex virus 1 entry", Proceedings of the National Academy of Sciences, (20080729), vol. 105, no. 30, pages 10559 - 64, XP093031565-
OPPOSITION- MORRISON, Encyclopedia of Immunology, (19980000), pages 1909 - 1916-
OPPOSITION- Trudy G Morrison, "PARAMYXOVIRUSES, INFECTION AND IMMUNITY", Encyclopedia of Immunology, Worcester, Massachusetts, USA, (19980000), ISBN 0-12-226765-6, pages 1909 - 1916, XP093046089-
OPPOSITION- White David O, Fenner Frank J, Diego San, York New, London Boston, Toronto Sydney Tokyo, "Medical Virology Fourth Edition ", Medical Virology, Academic Press, (19940101), ISBN 0-12-746642-8, pages 3 - 29, 434, XP093046091-
OPPOSITION- Cox S., Pascolo S., "PLASMID DNA AND MESSENGER RNA FOR THERAPY (chap 7.2)", Cox S., Pascolo S., Pascolo S., Plasmid DNA and Messenger RNA for Therapy - Handbook of Pharmaceutical Biotechnology -, USA, John Wiley & Sons,, (20070601), pages 971 - 1011, 9780470117118, doi:10.1002/9780470117118. ch07b, ISBN 9780471213864, XP055626043
OPPOSITION- Shayne Cox, Steve Pascolo, "Chapter 7.2. Plasmid DNA and Messenger RNA for Therapy", Handbook of Pharmaceutical Biotechnology, John Wiley & Sons , (20070601), pages 971 - 1011, doi:10.1002/9780470117118.ch07b, ISBN 978-0-471-21386-4, XP055626043
OPPOSITION- Frederic Martinon, Sivadasan Krishnan, Gerlinde Lenzen, Remy Magne, Elisabeth Gomard, Jean-Gerard Guillet, Jean-Paul Levy, Pierre Meulien, "Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA", Eur J Immunol., (19930000), vol. 23, no. 7, pages 1719 - 1722, XP002660045
OPPOSITION- MARTINON et al., "Induction of virus-specific cytotoxic T lymphocytes in vivo by liposome-entrapped mRNA", Eur. J. Immunol, (19930000), vol. 23, doi:10.1002/eji.1830230749, pages 1719 - 1722, XP002937540
OPPOSITION- ZHANG et al., "The Cytoplasmic Tails of the Influenza Virus Spike Glycoproteins Are Required for Normal Genome Packaging", Virology, (20000000), vol. 269, no. 2, doi:10.1006/viro.2000.0228, pages 325 - 334, XP004450270
OPPOSITION- PASCOLO S., "Vaccination with messenger RNA (mRNA", Handb Exp Pharmacol, (20080000), doi:10.1007/978-3-540-72167-3_11, pages 221 - 35, XP001538300
OPPOSITION- Thomas F. Schulz, "Viren - allgemeine Prinzipien", Thomas F. Schulz, Sebastian Suerbaum ; Gerd-Dieter Burchard ; Stefan H. E. Kaufmann ; Thomas F. Schulz, Medizinische Mikrobiologie und Infektiologie, Berlin, Germany, Springer, (20200101), pages 563 - 582, doi:10.1007/978-3-662-61385-6_52, ISBN 978-3-662-61384-9, XP009553252
OPPOSITION- Annette Mankertz, "Paramyxoviren", Annette Mankertz, Sebastian Suerbaum ; Gerd-Dieter Burchard ; Stefan H. E. Kaufmann ; Thomas F. Schulz, Medizinische Mikrobiologie und Infektiologie, Berlin, Germany, Springer, (20200101), pages 635 - 646, doi:10.1007/978-3-662-61385-6_59, ISBN 978-3-662-61384-9, XP009553237
OPPOSITION- Annette Mankertz, "Paramyxoviren", Medizinische Mikrobiologie und Infektiologie, Berlin, Germany, Springer, (20200101), pages 635 - 646, doi:10.1007/978-3-662-61385-6_59, ISBN 978-3-662-61384-9, XP009553237
OPPOSITION- JEFFS et al., "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA", Pharmaceutical Research, (20050000), vol. 22, doi:10.1007/s11095-004-1873-z, pages 362 - 372, XP019370801
OPPOSITION- Lloyd B. Jeffs, Lorne R. Palmer, Ellen G. Ambegia, Cory Giesbrecht, Shannon Ewanick, Ian MacLachlan, "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA", Pharmaceutical Research, (20050300), vol. 22, no. 3, doi:10.1007/S11095-004-1873-Z, pages 362 - 72, XP019370801
OPPOSITION- Lloyd B. Jeffs ; Lorne R. Palmer ; Ellen G. Ambegia ; Cory Giesbrecht ; Shannon Ewanick ; Ian MacLachlan, "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA", Pharmaceutical Research, Kluwer Academic Publishers-Plenum Publishers, NL, NL , (20050301), vol. 22, no. 3, doi:10.1007/s11095-004-1873-z, ISSN 1573-904X, pages 362 - 372, XP019370801
OPPOSITION- Lloyd B. Jeffs ; Lorne R. Palmer ; Ellen G. Ambegia ; Cory Giesbrecht ; Shannon Ewanick ; Ian MacLachlan, "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA", Pharmaceutical Research, NL , (20050301), vol. 22, no. 3, doi:10.1007/s11095-004-1873-z, ISSN 1573-904X, pages 362 - 372, XP019370801
OPPOSITION- ZHOU et al., "Self-replicating Semliki Forest virus RNA as recombinant vaccine", Vaccine, (19940000), vol. 12, no. 16, doi:10.1016/0264-410X(94)90074-4, pages 1510 - 4, XP023937577
OPPOSITION- Minnaert An-Katrien; Vanluchene Helena; Verbeke Rein; Lentacker Ine; De Smedt Stefaan C.; Raemdonck Koen; Sanders Niek N.; Remaut Katrien, "Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across", Advanced Drug Delivery Reviews, Elsevier, Amsterdam , NL , (20210726), vol. 176, doi:10.1016/j.addr.2021.113900, ISSN 0169-409X, XP086773295
OPPOSITION- KIM et al., "Enhanced siRNA delivery using cationic liposomes with new polyarginine- conjugated PEG-lipid", International Journal of Pharmaceutics, (20100000), vol. 392, pages 141 - 147, XP027044515
OPPOSITION- SCHOENMAKER et al., "mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability", Int J Pharm, (20210000), vol. 601, doi:10.1016/j.ijpharm.2021.120586, page 120586, XP055828800
OPPOSITION- HEYES et al., "Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids", J. Controlled Release, (20050000), vol. 107, doi:10.1016/j.jconrel.2005.06.014, pages 276 - 287, XP008157522
OPPOSITION- HEYES et al., "Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids", J. Contr. Release, (20050000), vol. 107, doi:10.1016/j.jconrel.2005.06.014, pages 276 - 287, XP008157522
OPPOSITION- Wang, D. Christopher, M.E. Nagata, L.P. Zabielski, M.A. Li, H. Wong, J.P. Samuel, J., "Intranasal immunization with liposome-encapsulated plasmid DNA encoding influenza virus hemagglutinin elicits mucosal, cellular and humoral immune responses", Journal of clinical virology, ELSEVIER, AMSTERDAM, NL, NL , (20041201), vol. 31, doi:10.1016/j.jcv.2004.09.013, ISSN 1386-6532, pages 99 - 106, XP004660136
OPPOSITION- Kimberly J. Hassett, Kerry E. Benenato, Eric Jacquinet, Aisha Lee, Angela Woods, Olga Yuzhakov, Sunny Himansu, Jessica Deterling, Benjamin M. Geilich, Tatiana Ketova, Cosmin Mihai, Andy Lynn, Iain McFadyen, Melissa J. Moore, Joseph J. Senn, Matthew G. Stanton, Örn Almarsson, Giuseppe Ciaramella, Luis A. Brito, "Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines", Molecular Therapy Nucleic Acids, (20190000), vol. 15, doi:10.1016/j.omtn.2019.01.013, pages 1 - 11, XP055815007
OPPOSITION- ROUX et al., "AIDS virus envelope structure", Curr. Opin. In Structural Biology, (20070000), vol. 17, doi:10.1016/j.sbi.2007.03.008, pages 244 - 252, XP022032067
OPPOSITION- Roux, K.H. Taylor, K.A., "AIDS virus envelope spike structure", Current Opinion in Structural Biology, Elsevier Ltd., GB, GB , (20070417), vol. 17, no. 2, doi:10.1016/j.sbi.2007.03.008, ISSN 0959-440X, pages 244 - 252, XP022032067
OPPOSITION- Jeffrey B. Ulmer; Peter W. Mason; Andrew Geall; Christian W. Mandl;, "RNA-based vaccines", Vaccine, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20120418), vol. 30, no. 30, doi:10.1016/j.vaccine.2012.04.060, ISSN 0264-410X, pages 4414 - 4418, XP028520925
OPPOSITION- Judge, A.D. Bola, G. Lee, A.C.H. MacLachlan, I., "Design of Noninflammatory Synthetic siRNA Mediating Potent Gene Silencing in Vivo", Molecular Therapy, Elsevier Inc., US, US , (20060301), vol. 13, no. 3, doi:10.1016/j.ymthe.2005.11.002, ISSN 1525-0016, pages 494 - 505, XP005300357
OPPOSITION- Norbert Maurer, Kim F. Wong, Holger Stark, Lenore Louie, Deirdre McIntosh, Tabitha Wong, Peter Scherrer, Sean C. Semple, Pieter R. Cullis, "Spontaneous Entrapment of Polynucleotides upon Electrostatic Interaction with Ethanol-Destabilized Cationic Liposomes", Biophysical Journal, (20010500), vol. 80, no. 5, doi:10.1016/S0006-3495(01)76202-9, pages 2310 - 2326, XP055550920
OPPOSITION- Norbert Maurer, Kim F. Wong, Holger Stark, Lenore Louie, Deirdre Mcintosh, Tabitha Wong, Peter Scherrer, Sean C. Semple, Pieter R. Cullis, "Spontaneous Entrapment of Polynucleotides upon Electrostatic Interaction with Ethanol-Destabilized Cationic Liposomes", Biophysical Journal, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20010501), vol. 80, no. 5, doi:10.1016/S0006-3495(01)76202-9, ISSN 0006-3495, pages 2310 - 2326, XP055550920
OPPOSITION- José A. Melero, "Molecular Biology of Human Respiratory Syncytial Virus", Perspectives in Medical Virology, Elsevier , (20060101), vol. 14, pages 1 - 42, doi:10.1016/S0168-7069(06)14001-X, ISSN 0168-7069, XP055244030
OPPOSITION- WONG et al., "DNA vaccination against respiratory influenza virus infection", Vaccine, (20010000), vol. 19, no. 17-19, doi:10.1016/S0264-410X(00)00474-6, pages 2461 - 2467, XP004231066
OPPOSITION- JIANG et al., "Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines", Emerging Microbes & Infections, (20120000), vol. 1, doi:10.1038/emi.2012.1, pages 1 - 8, XP093130818
OPPOSITION- KARIKO et al., "Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability", Mol Ther, (20080000), vol. 16, no. 11, doi:10.1038/mt.2008.200, pages 1833 - 40, XP055920956
OPPOSITION- Zimmermann T S, Lee A C H, Akinc A, Bramlage B, Bumcrot D, Fedoruk M N, Harborth J, Heyes J A, Jeffs L B, John M, Judge A D, Lam K, McClintock K, Nechev L V, Palmer L R, Racie T, Röhl I, Seiffert S, Shanmugam S, Sood V, Soutschek J, Toudjarska I, Wheat A J, Yaworski E, Zedalis W, Koteliansky V, Manoharan M, Vornlocher H-P, MacLachlan I, "RNAi-mediated gene silencing in non-human primates", Nature, Nature Publishing Group UK, London, London, (20060504), vol. 441, no. 7089, doi:10.1038/nature04688, ISSN 0028-0836, pages 111 - 114, XP002552050
OPPOSITION- ZHU et al., "Distribution and three-dimensional structure of AIDS virus envelope spikes", Nature, (20060600), vol. 441, no. 7095, doi:10.1038/nature04817, pages 847 - 52, XP037135198
OPPOSITION- Zhu Ping; Liu Jun; Bess Julian; Chertova Elena; Lifson Jeffrey D.; Grisé Henry; Ofek Gilad A.; Taylor Kenneth A.; Roux Kenneth H., "Distribution and three-dimensional structure of AIDS virus envelope spikes", Nature, (20060524), vol. 441, no. 7095, doi:10.1038/nature04817, pages 847 - 852, XP037135198
OPPOSITION- MORRISSEY et al., "Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs", nature biotechnology, (20050800), vol. 23, no. 8, doi:10.1038/nbt1122, pages 1002 - 7, XP008157520
OPPOSITION- Benjamin Petsch, Margit Schnee, Annette B Vogel, Elke Lange, Bernd Hoffmann, Daniel Voss, Thomas Schlake, Andreas Thess, Karl-Josef Kallen, Lothar Stitz, Thomas Kramps, "Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection", Nature Biotechnology, Gale Group Inc., (20120101), vol. 30, no. 12, doi:10.1038/nbt.2436, ISSN 10870156, pages 1210 - 1216, XP055051005
OPPOSITION- Sahin Ugur; Karikó Katalin; Türeci Özlem, "mRNA-based therapeutics — developing a new class of drugs", Nature Reviews Drug Discovery, Nature Publishing Group, GB, GB , (20140919), vol. 13, no. 10, doi:10.1038/nrd4278, ISSN 1474-1776, pages 759 - 780, XP037134862
OPPOSITION- Zolla-Pazner Susan; Cardozo Timothy, "Structure-function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design", Nature Reviews Immunology, Nature Publishing Group UK, London, London, (20100701), vol. 10, no. 7, doi:10.1038/nri2801, ISSN 1474-1733, pages 527 - 535, XP037134940
OPPOSITION- DU et al., "The spike protein of SARS-Co V- a target for vaccine and therapeutic development", Nat Rev Microbiol, (20090300), vol. 7, doi:10.1038/nrmicro2090, pages 226 - 236, XP055302112
OPPOSITION- Akinc Akin; Maier Martin A.; Manoharan Muthiah; Fitzgerald Kevin; Jayaraman Muthusamy; Barros Scott; Ansell Steven; Du Xinyao; Hope Michael J.; Madden Thomas D.; Mui Barbara L.; Semple Sean C.; Tam Ying K.; Ciufolini Marco; Witzigmann Dominik; Kulkarni Jayesh A.; van der Meel Roy; Cullis Pieter R., "The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs", Nature Nanotechnology, Nature Pub. Group, Inc., London, London , (20191201), vol. 14, no. 12, doi:10.1038/s41565-019-0591-y, ISSN 1748-3387, pages 1084 - 1087, XP036953174
OPPOSITION- Wheeler J J; Palmer L; Ossanlou M; MacLachlan I; Graham R W; Zhang Y P; Hope M J; Scherrer P; Cullis P R, "Stabilized plasmid-lipid particles: construction and characterization", Gene Therapy, Nature Publishing Group, London, GB, GB , (19990201), vol. 6, no. 2, doi:10.1038/sj.gt.3300821, ISSN 0969-7128, pages 271 - 281, XP037770556
OPPOSITION- SCHIBLI et al., "Class I and class II viral fusion protein structures reveal similar principles in membrane fusion (review", Molecular Membrane Biology, (20040000), vol. 21, doi:10.1080/09687860400017784, pages 361 - 371, XP009064617
OPPOSITION- Judith M. White, Sue E. Delos, Matthew Brecher, Kathryn Schornberg, "Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme", Critical Reviews in Biochemistry and Molecular Biology, CRC PRESS, BOCA RATON, FL., US, US , (20080101), vol. 43, no. 3, doi:10.1080/10409230802058320, ISSN 1040-9238, pages 1 - 50, XP055326252
OPPOSITION- PARDI et al., "Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses", J Exp Med., (20180000), vol. 215, no. 6, doi:10.1084/jem.20171450, pages 1571 - 1588, XP055545604
OPPOSITION- FLEETON et al., "Self-replicative RNA vaccines elicit protection against influenza A virus, Respiratory Syncytial Virus, and a Tickborne Encephalitis Virus", Journal of Infectious Diseases, (20010000), vol. 183, doi:10.1086/319857, pages 1395 - 8, XP002224503
OPPOSITION- FLEETON et al., "Self-Replicative RNA Vaccines Elicit Protection against Influenza A Virus, Respiratory Syncytial Virus, and a Tickborne Encephalitis Virus", The Journal of Infectious Diseases, (20010000), vol. 183, no. 9, doi:10.1086/319857, pages 1395 - 8, XP002224503
OPPOSITION- FLEETON M N,ET AL, "Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus.", Journal of Infectious Diseases, University of Chicago Press, US, US , (20010501), vol. 183, no. 9, doi:10.1086/319857, ISSN 0022-1899, pages 1395 - 1398, XP002224503
OPPOSITION- GEISBERT et al., "Postexposure Protection of Guinea Pigs against a Lethal Ebola Virus Challenge Is Conferred by RNA Interference", J Infect Dis, (20060615), vol. 193, no. 12, doi:10.1086/504267, pages 1650 - 7, XP008078155
OPPOSITION- W.-Z. ZHOU, D.S.B. HOON, S.K.S. HUANG, S. FUJII, K. HASHIMOTO, R. MORISHITA, Y. KANEDA, "RNA Melanoma Vaccine: Induction of Antitumor Immunity by Human Glycoprotein 100 mRNA Immunization", HUMAN GENE THERAPY, (19991101), vol. 10, no. 16, pages 2719 - 2724, XP002660042
OPPOSITION- GHILDYAL et al., "Central role of the respiratory syncytial virus matrix protein in infection", FEMS Microbiol. Rev., (20060000), vol. 30, doi:10.1111/j.1574-6976.2006.00025.x, pages 692 - 705, XP093030624
OPPOSITION- Pilling Andrew, Rosenberg Mark F., Willis Sharon H., Jäger Joachim, Cohen Gary H., Eisenberg Roselyn J., Meredith David M., Holzenburg Andreas, "Three-Dimensional Structure of Herpes Simplex Virus Type 1 Glycoprotein D at 2.4-Nanometer Resolution", Journal of Virology, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, US , (19990901), vol. 73, no. 9, doi:10.1128/JVI.73.9.7830-7834.1999, ISSN 0022-538X, pages 7830 - 7834, XP093142032
OPPOSITION- SCHLENDER et al., "Respiratory Syncytial Virus (RSV) Fusion Protein Subunit F2, Not Attachment Protein G, Determines the Specificity of RSV Infectio n", Journal of Virology, (20030000), vol. 77, doi:10.1128/JVI.77.8.4609-4616.2003, pages 4609 - 4616, XP002593949
OPPOSITION- SZOKA et al., "COMPARATIVE PROPERTIES +9154 AND METHODS OF PREPARATION OF LIPID VESICLES (LIPOSOMES)", Annu Rev Biophys Bioeng, (19800000), vol. 9, doi:10.1146/annurev.bb.09.060180.002343, pages 467 - 508, XP000600718
OPPOSITION- BRINGMANN et al., "RNA Vaccines in Cancer Treatment", Journal of Biomedicine and Biotechnology, (20100101), vol. 2010, doi:10.1155/2010/623687, pages 1 - 12, XP002765542
OPPOSITION- Ian Maclachlan, "Liposomal Formulations for Nucleic Acid Delivery : Principles, Strategies, and Applications, Second Edition", Antisense Drug Technology : Principles, Strategies, and Applications, Second Edition, CRC Press , (20070725), pages 237 - 270, doi:10.1201/9780849387951.ch9, ISBN 978-1-4398-3250-9, XP055591157
OPPOSITION- MACLACHLAN, "Liposomal Formulations for Nucleic Acid Delivery", Antisense Drug Technology, (20070000), doi:10.1201/9780849387951.ch9, pages 237 - 270, XP055591157
OPPOSITION- PASCOLO, "Vaccination with Messenger RNA", Methods in Molecular Medicine, (20060000), vol. 127, pages 23 - 40, XP009117840
OPPOSITION- PASCOLO et al., "Messenger RNA-based vaccines", Expert Opin Biol Ther, Ashley Publications Ltd, (20040000), vol. 4, no. 8, doi:10.1517/14712598.4.8.1285, ISSN 1471-2598, pages 1285 - 94, XP009095328
OPPOSITION- PASCOLO S., "Messenger RNA-based vaccines", Expert Opin Biol Ther, (20040800), vol. 4, no. 8, doi:10.1517/14712598.4.8.1285, pages 1285 - 94, XP009095328
OPPOSITION- Deering Raquel P; Kommareddy Sushma; Ulmer Jeffrey B, "Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines.", Expert opinion on drug delivery, Informa Healthcare, UK, UK , (20140601), vol. 11, no. 6, doi:10.1517/17425247.2014.901308, ISSN 1744-7593, pages 885 - 899, XP009183535
OPPOSITION- Morais Pedro, Adachi Hironori, Yu Yi-Tao, "The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines", Frontiers in Cell and Developmental Biology, vol. 9, doi:10.3389/fcell.2021.789427, XP055885272
OPPOSITION- Karl-Josef Kallen, Regina Heidenreich, Margit Schnee, Benjamin Petsch, Thomas Schlake, Andreas Thess, Patrick Baumhof, Birgit Scheel, Sven D Koch, Mariola Fotin-Mleczek, "A novel, disruptive vaccination technology: Self-adjuvanted RNActive® vaccines", Human vaccines & immunotherapeutics, (20131001), vol. 9, no. 10, doi:10.4161/hv.25181, ISSN 21645515, pages 2263 - 2276, XP055126357
OPPOSITION- Thomas Schlake, Andreas Thess, Mariola Fotin-Mleczek, Karl-Josef Kallen, "Developing mRNA-vaccine technologies", RNA BIOLOGY, (20121101), vol. 9, no. 11, doi:10.4161/rna.22269, ISSN 1547-6286, pages 1319 - 1330, XP055561756
OPPOSITION- HASHIMOTO et al., "Neutralizing epitopes of RSV and palivizumab resistance in Japan", Fukushima J. Med. Sci., (20170000), vol. 63, doi:10.5387/fms.2017-09, pages 127 - 134, XP055527102

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents