IP Verse

Retroviral Transduction Using Poloxamers - EP2820138

The patent EP2820138 was granted to Helmholtz Zentrum Mnchen Deutsches Forschungszentrum FR Gesundheit UND Umwelt on Oct 28, 2020. The application was originally filed on Feb 28, 2013 under application number EP13706283A. The patent is currently recorded with a legal status of "Opposition Rejected".

EP2820138

HELMHOLTZ ZENTRUM MNCHEN DEUTSCHES FORSCHUNGSZENTRUM FR GESUNDHEIT UND UMWELT
Application Number
EP13706283A
Filing Date
Feb 28, 2013
Status
Opposition Rejected
Feb 7, 2025
Grant Date
Oct 28, 2020
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

KONIG SZYNKA TILMANN VON RENESSEJul 27, 2021KONIG SZYNKA TILMANN VON RENESSE DUSSELDORFADMISSIBLE
KONIG SZYNKA TILMANN VON RENESSEJul 27, 2021KONIG SZYNKA TILMANN VON RENESSE PATENTANWALTE PARTNERSCHAFT MBB DUSSELDORFADMISSIBLE

Patent Citations (5) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
INTERNATIONAL-SEARCH-REPORTWO0165911
INTERNATIONAL-SEARCH-REPORTWO2006086775
OPPOSITIONWO2013127964
OPPOSITIONWO2018148502
OTHERWO2018148502

Non-Patent Literature (NPL) Citations (68) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ANASTASOV, N. ET AL., "C/EBPbeta expression in ALK-positive anaplastic large cell lymphomas is required for cell proliferation and is induced by the STAT3 signaling pathway", HAEMATOLOGICA, (2010), vol. 95, pages 760 - 767-
DESCRIPTION- ANASTASOV, N. ET AL., "Efficient shRNA delivery into B and T lymphoma cells using lentiviral vector-mediated transfer", J. HEMATOP., (2009), vol. 2, pages 9 - 19-
DESCRIPTION- AUBIN, R.J.; WEINFELD, M.; PATERSON, M.C, "Factors influencing efficiency and reproducibility of polybrene-assisted gene transfer", SOMAT. CELL MOL. GENET., (1988), vol. 14, pages 155 - 167-
DESCRIPTION- BATRAKOVA, E.V. ET AL., "Mechanism of pluronic effect on P-glycoprotein efflux system in blood-brain barrier: contributions of energy depletion and membrane fluidization", J. PHARMACOL. EXP. THER., (2001), vol. 299, pages 483 - 493-
DESCRIPTION- BISCHOF ET AL., "Flexibility in cell targeting by pseudotyping lentiviral vectors", METHODS MOL BIOL, (2010), vol. 614, pages 53 - 68-
DESCRIPTION- CARTER, K.C.; GALLAGHER, G.; BAILLIE, A.J.; ALEXANDER, J, "The induction of protective immunity to Leishmania major in the BALB/c mouse by interleukin 4 treatment", EUR. J. LMMUNOL., (1989), vol. 19, pages 779 - 782-
DESCRIPTION- CASTRO, B.A.; WEISS, C.D.; WIVIOTT, L.D.; LEVY, J.A, "Optimal conditions for recovery of the human immunodeficiency virus from peripheral blood mononuclear cells", J. CLIN. MICROBIOL., (1988), vol. 26, pages 2371 - 2376-
DESCRIPTION- CHU ET AL., "Efficient and Stable Gene Expression into Human Osteoclasts Using an HIV-1-Based Lentiviral Vector", DNA CELL BIOL, (200806), vol. 27, no. 6, pages 315 - 320-
DESCRIPTION- DULL, T. ET AL., "A third-generation lentivirus vector with a conditional packaging system", J. VIROL., (1998), vol. 72, pages 8463 - 8471-
DESCRIPTION- GEBHART, C.L. ET AL., "Design and formulation of polyplexes based on pluronic- polyethyleneimine conjugates for gene transfer", BIOCONJUG. CHEM., (2002), vol. 13, pages 937 - 944-
DESCRIPTION- GRUBER, A.; KAN-MITCHELL, J.; KUHEN, K.L.; MUKAI, T.; WONG-STAAL, F, "Dendritic cells transduced by multiply deleted HIV-1 vectors exhibit normal phenotypes and functions and elicit an HIV-specific cytotoxic T-lymphocyte response in vitro", BLOOD, (2000), vol. 96, pages 1327 - 1333, XP002244584-
DESCRIPTION- HANNIG ET AL., "Surfactant sealing of membranes permeabilized by ionizing radiation", RADIAT. RES., (2000), vol. 154, pages 171 - 177-
DESCRIPTION- HARADA ET AL., MACROMOLECULES, (1995), vol. 28, pages 5294 - 5299-
DESCRIPTION- HARGUS G ET AL., PROC NATL ACAD SCI USA, (2010), vol. 107, pages 15921 - 15926-
DESCRIPTION- HESSE, J.; EBBESEN, P.; KRISTENSEN, G, "Correlation between polyion effect on cell susceptibility to in vitro infection with murine C-type viruses and polyion effect on some membrane-related functions", INTERVIROLOGY, (1984), vol. 9, pages 173 - 183-
DESCRIPTION- JAENISCH R.; YOUNG R., CELL, (2008), vol. 132, pages 567 - 582-
DESCRIPTION- LEE, R.C.; RIVER, L.P.; PAN, F.S.; JI, L.; WOLLMANN, R.L, "Surfactant-induced sealing of electro-permeabilized skeletal muscle membranes in vivo", PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 4524 - 4528-
DESCRIPTION- LU, G.W.; JUN, H.W.; DZIMIANSKI, M.T.; QIU, H.C.; MCCALL, J.W, "Pharmacokinetic studies of methotrexate in plasma and synovial fluid following i.v. bolus and topical routes of administration in dogs", PHARM. RES., (1995), vol. 12, pages 1474 - 1477-
DESCRIPTION- MILLINGTON M; ARNDT A; BOYD M; APPLEGATE T; SHEN S, "Towards a Clinically Relevant Lentiviral Transduction Protocol for Primary Human CD34+ Hematopoietic Stem/Progenitor Cells", PLOS ONE, (2009), vol. 4, no. 7, page E6461-
DESCRIPTION- MILLINGTON, M.; ARNDT, A.; BOYD, M.; APPLEGATE, T.; SHEN, S, "Towards a clinically relevant lentiviral transduction protocol for primary human CD34 hematopoietic stem/progenitor cells", PLOS ONE, (2009), vol. 4, page E6461-
DESCRIPTION- O'CONNELL RM; BALAZS AB; RAO DS; KIVORK C; YANG L; BALTIMORE D, "Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations", PLOS ONE, (20100806), vol. 5, no. 8, page E12009-
DESCRIPTION- ROUAS, R. ET AL., "Lentiviral-mediated gene delivery in human monocyte-derived dendritic cells: optimized design and procedures for highly efficient transduction compatible with clinical constraints", CANCER GENE THER, (2002), vol. 9, pages 715 - 724-
DESCRIPTION- SAHA K; JAENISCH R., CELL STEM CELL, (2009), vol. 5, pages 584 - 595-
DESCRIPTION- STEFANEANU, L.; KOVACS, K, "Effects of drugs on pituitary fine structure in laboratory animals", J. ELECTRON. MICROSC. TECH., (1991), vol. 19, pages 80 - 89-
DESCRIPTION- WURM, M. ET AL., "The influence of semen-derived enhancer of virus infection on the efficiency of retroviral gene transfer", J. GENE MED., (2010), vol. 12, pages 137 - 146-
DESCRIPTION- FUNKE, S. ET AL., "Targeted cell entry of lentiviral vectors", MOL. THER., (2008), vol. 16, doi:doi:doi:10.1038/mt.2008.128, pages 1427 - 1436, XP008155467
DESCRIPTION- KRYLOVA, 0.0. ET AL., "Pluronic L61 accelerates flip-flop and transbilayer doxorubicin permeation", CHEMISTRY, (2003), vol. 9, doi:doi:10.1002/chem.200204621, pages 3930 - 3936, XP055494497
DESCRIPTION- PEC, E.A.; WOUT, Z.G.; JOHNSTON, T.P, "Biological activity of urease formulated in poloxamer 407 after intraperitoneal injection in the rat", J. PHARM. SCI., (1992), vol. 81, doi:doi:10.1002/jps.2600810707, pages 626 - 630, XP009025410
DESCRIPTION- BARTEL, DP, "MicroRNAs: target recognition and regulatory functions", CELL, (200901), vol. 136, no. 2, doi:doi:10.1016/j.cell.2009.01.002, pages 215 - 233, XP055011377
DESCRIPTION- STRAPPE, P.M.; HAMPTON, D.W.; CACHON-GONZALEZ, B.; FAWCETT, J.W.; LEVER, A, "Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system", EUR. J. PHARM. BIOPHARM., (2005), vol. 61, doi:doi:10.1016/j.ejpb.2005.06.006, pages 126 - 133, XP025317680
DESCRIPTION- DISHART, K.L. ET AL., "Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy", J. MOL. CELL CARDIOL., (2003), vol. 35, doi:doi:10.1016/S0022-2828(03)00136-6, pages 739 - 748, XP055424972
DESCRIPTION- KABANOV, A ET AL., "Pluronic Block Copolymers for Gene Delivery", ADVANCES IN GENETICS, (2005), vol. 53, doi:doi:10.1016/S0065-2660(05)53009-8, pages 231 - 261, XP002679846
DESCRIPTION- KABANOV, A.; ZHU, J.; ALAKHOV, V, "Pluronic Block Copolymers for Gene Delivery", ADV. GENET., (2005), vol. 53, doi:doi:10.1016/S0065-2660(05)53009-8, pages 231 - 261, XP002679846
DESCRIPTION- BUKRINSKY, M.I. ET AL., "A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells", NATURE, (1993), vol. 365, doi:doi:10.1038/365666a0, pages 666 - 669, XP001061604
DESCRIPTION- JACOME ET AL., "Lentiviral-mediated Genetic Correction of Hematopoietic and Mesenchymal Progenitor Cells From Fanconi Anemia Patients", MOL THER, (200906), vol. 17, no. 6, doi:doi:10.1038/mt.2009.26, pages 1083 - 1092, XP055059102
DESCRIPTION- MATRAI J; CHUAH MK; VANDENDRIESSCHE T, "Recent advances in lentiviral vector development and applications", MOL THER, (201003), vol. 18, no. 3, doi:doi:10.1038/mt.2009.319, pages 477 - 90, XP009143103
DESCRIPTION- ROSENBERG, S.A.; RESTIFO, N.P.; YANG, J.C.; MORGAN, R.A.; DUDLEY, M.E, "Adoptive cell transfer: a clinical path to effective cancer immunotherapy", NAT. REV. CANCER, (2008), vol. 8, doi:doi:10.1038/nrc2355, pages 299 - 308, XP002571413
DESCRIPTION- BURNS ET AL., "Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells", PROC NATL ACAD SCI USA., (1993), vol. 90, no. 17, doi:doi:10.1073/pnas.90.17.8033, pages 8033 - 8037, XP002231450
DESCRIPTION- BURNS, J.C. ET AL., "Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells", PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, doi:doi:10.1073/pnas.90.17.8033, pages 8033 - 8037, XP000674727
DESCRIPTION- BURNS, J.C.; FRIEDMANN, T.; DRIEVER, W.; BURRASCANO, M.; YEE, J.K, "Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells", PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, doi:doi:10.1073/pnas.90.17.8033, pages 8033 - 8037, XP000674727
DESCRIPTION- JONES, S. ET AL., "Lentiviral Vector Design for Optimal T Cell Receptor Gene Expression in the Transduction of Peripheral Blood Lymphocytes and Tumor-Infiltrating Lymphocytes", HUM. GENE THER., (2009), vol. 20, doi:doi:10.1089/hum.2008.048, pages 630 - 640, XP055391455
DESCRIPTION- POCZOBUTT ET AL., "Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells", BMC CANCER, (2010), vol. 10, doi:doi:10.1186/1471-2407-10-373, page 373, XP021075195
DESCRIPTION- HUDECEK, M.; ANDERSON, L.D.; NISHIDA, T.; RIDDELL, S.R, "Adoptive T-cell therapy for B-cell malignancies", EXPERT. REV. HEMATOL., (2009), vol. 2, doi:doi:10.1586/ehm.09.47, pages 517 - 532, XP055034818
INTERNATIONAL-SEARCH-REPORT- STRAPPE P M ET AL, "Delivery of a lentiviral vector in a Pluronic F127 gel to cells of the central nervous system", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 61, no. 3, ISSN 0939-6411, (20051001), pages 126 - 133, (20051001), XP027805084 [ID] 1-4,6,10,11,13 * the whole document * [Y] 5-
INTERNATIONAL-SEARCH-REPORT- INES HÖFIG ET AL, "Poloxamer synperonic F108 improves cellular transduction with lentiviral vectors", THE JOURNAL OF GENE MEDICINE, (20120801), vol. 14, no. 8, doi:10.1002/jgm.2653, ISSN 1099-498X, pages 549 - 560, XP055061427 [XP] 1-15 * the whole document *
INTERNATIONAL-SEARCH-REPORT- SRIADIBHATLA SRIKANTH ET AL, "Transcriptional activation of gene expression by pluronic block copolymers in stably and transiently transfected cells.", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY, (200604), vol. 13, no. 4, ISSN 1525-0016, pages 804 - 813, XP005358615 [A] 1-15 * abstract * * table 2 *
INTERNATIONAL-SEARCH-REPORT- KABANOV, A ET AL., "Pluronic Block Copolymers for Gene Delivery", ADVANCES IN GENETICS, (2005), vol. 53, pages 231 - 261, XP002679846 [ID] 1-4,6,10,11,13 * page 240, paragraph l - page 242, paragraph 1 *
INTERNATIONAL-SEARCH-REPORT- BURNS J C ET AL, "Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (19930101), vol. 90, no. 17, doi:10.1073/PNAS.90.17.8033, ISSN 0027-8424, pages 8033 - 8037, XP002231450 [YD] 5 * the whole document *
INTERNATIONAL-SEARCH-REPORT- WANG ET AL, "Polymers for viral gene delivery", EXPERT OPINION ON DRUG DELIVERY, (20080401), vol. 5, no. 4, ISSN 1742-5247, pages 385 - 401, XP009161111 [A] 1-15 * figures 1,2; table 1 *
OPPOSITION- Amirache, Et Al., "Mystery solved: VSV-G-LVs do not allow efficient qene transfer into unstimulated T cells, B cells, and HSCs because they lack LDL receptor", Blood, (20140101), vol. 123, no. 9, pages 1422 - 1424, XP055933750-
OPPOSITION- Anonymous, "Fluorine/ Gelatine", Webster Comprehensive Dictionary, (00000000), vol. 1, pages 487 - 454, XP055933723-
OPPOSITION- Anonymous, "Poloxamere", Europaisches Arzneibuch 7th Edition, (20110101), pages 4177 - 4178, XP055933739-
OPPOSITION- Anson Donald S, "Retroviral-Mediated Gene Transduction", Methods in Molecular Biology Genomics Protocols Edited, © Humana Press Inc, (20010101), vol. 175, no. 28, pages 471 - 494, XP055933733-
OPPOSITION- Ward Carl Thomas, "Molecular weight and molecular weight distributions in synthetic polymers", American Chemical Society and Division of Chemical Education, Inc., (19811101), vol. 58, no. 11, pages 867 - 879, XP055933760-
OPPOSITION- Gilles Dumortier ; Jean Louis Grossiord ; Florence Agnely ; Jean Claude Chaumeil, "A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics", PHARMACEUTICAL RESEARCH, Kluwer Academic Publishers-Plenum Publishers, NL, NL , (20061111), vol. 23, no. 12, doi:10.1007/s11095-006-9104-4, ISSN 1573-904X, pages 2709 - 2728, XP019453318
OPPOSITION- Warren Denning, Suvendu Das, Siqi Guo, Jun Xu, John C. Kappes, Zdenek Hel, "Optimization of the Transductional Efficiency of Lentiviral Vectors: Effect of Sera and Polycations", Molecular Biotechnology, Springer US, New York, New York, (20130301), vol. 53, no. 3, doi:10.1007/s12033-012-9528-5, ISSN 1073-6085, pages 308 - 314, XP055319481
OPPOSITION- Morille Marie, Passirani Catherine, Dufort Sandrine, Bastiat Guillaume, Pitard Bruno, Coll Jean-Luc, Benoit Jean-Pierre, "Tumor transfection after systemic injection of DNA lipid nanocapsules", Biomaterials, Elsevier, AMSTERDAM, NL, AMSTERDAM, NL , (20110301), vol. 32, no. 9, doi:10.1016/j.biomaterials.2010.11.063, ISSN 0142-9612, pages 2327 - 2333, XP055933743
OPPOSITION- DISHART et al., "Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy", Mol Cell Cardiol, (20030000), vol. 35, doi:10.1016/S0022-2828(03)00136-6, pages 739 - 748, XP055424972
OPPOSITION- Kate L. Dishart, Et Al.,, "Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy", Journal of Molecular and Cellular Cardiology, (20030101), vol. 35, doi:10.1016/S0022-2828(03)00136-6, pages 739 - 748, XP055424972
OPPOSITION- Alexander Kabanov, Jian Zhu, Valery Alakhov, "Pluronic Block Copolymers for Gene Delivery", Advances in Genetics, Academic Press, US, US , (20050101), vol. 53, doi:10.1016/S0065-2660(05)53009-8, ISSN 0065-2660, pages 231 - 261, XP002679846
OPPOSITION- ROBBINS et al., "Viral vectors for gene thera", Pharmacol Ther, (19980000), vol. 80, no. 1, doi:10.1016/S0163-7258(98)00020-5, pages 35 - 47, XP002927113
OPPOSITION- ROBBINS P D, GHIVIZZANI C, "VIRAL VECTORS FOR GENE THERAPY", Pharmacology & Therapeutics, ELSEVIER., GB, GB , (19980101), vol. 80, no. 01, doi:10.1016/S0163-7258(98)00020-5, ISSN 0163-7258, pages 35 - 47, XP002927113
OPPOSITION- BURNS J C ET AL, "Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells.", Proceedings of the National Academy of Sciences, National Academy of Sciences, (19930101), vol. 90, no. 17, doi:10.1073/pnas.90.17.8033, ISSN 0027-8424, pages 8033 - 8037, XP002231450
OPPOSITION- Singh-Joy, Et Al., "Safety Assessment of Poloxamers 101, 105, 108, 122, 123, 124, 181, 182, 183, 184, 185, 188, 212, 215, 217, 231, 234, 235, 237, 238, 282, 284, 288, 331, 333, 334, 335, 338, 401, 402, 403, and 407, Poloxamer 105 Benzoate, and Poloxamer 182 Dibenzoate as Used in Cosmetics", INTERNATIONAL JOURNAL OF TOXICOLOGY, Sage Publications, Inc., US, US , (20080301), vol. 27, no. 2_suppl, doi:10.1080/10915810802244595, ISSN 1091-5818, pages 93 - 128, XP055933718
OPPOSITION- Gough Peter J, Raines Elaine W, Williams Lippincott, Wilkins, "Advances in retroviral transduction of hematopoietic stem cells for the gene therapy of atherosclerosis", Curr Opin Lipidol Current Opinion in Lipidology, (20030101), vol. 14, no. 14, doi:10.1097/01.mol.0000092620.86399.b5, pages 491 - 497, XP055933737
OPPOSITION- Yang Shicheng, Rosenberg Steven A., Morgan Richard A., "Clinical-scale Lentiviral Vector Transduction of PBL for TCR Gene Therapy and Potential for Expression in Less-differentiated Cells", Journal of Immunotherapy, Lippincott Williams & Wilkins, US, US , (20081101), vol. 31, no. 9, doi:10.1097/CJI.0b013e31818817c5, ISSN 1524-9557, pages 830 - 839, XP055933755
OPPOSITION- James Cronin, Zhang Xian-Yang, Reiser Jakob, "Altering the Tropism of Lentiviral Vectors through Pseudotyping", Current Gene Therapy, (20050801), vol. 5, no. 4, doi:10.2174/1566523054546224, ISSN 15665232, pages 387 - 398, XP055199682
OTHER- DISHART et al., "Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy", Journal of Molecular and Cellular Cardiology, (20030000), vol. 35, pages 739 - 748, XP055424972

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents