| DESCRIPTION | - AKASHI ET AL., NATURE, (2000), vol. 404, no. 6774, page 193 |
| DESCRIPTION | - BULLINGER ET AL., BLOOD, (2008), vol. 111, pages 4490 - 4495 |
| DESCRIPTION | - CHEN ET AL., IMMUNOL REV, (1997), vol. 157, pages 41 - 51 |
| DESCRIPTION | - KONDO ET AL., ANNU REV IMMUNOL., (2003), vol. 21, pages 759 - 806 |
| DESCRIPTION | - KONDO ET AL., CELL, (1997), vol. 91, no. 5, pages 661 - 7 |
| DESCRIPTION | - MAJETI ET AL., CELL STEM CELL, (2007), vol. 1, pages 635 - 645 |
| DESCRIPTION | - MIKAYE K ET AL., J EXP MED, (1991), vol. 173, no. 3, pages 599 - 607 |
| DESCRIPTION | - MORRISON ET AL., CELL, (1999), vol. 96, pages 737 - 49 |
| DESCRIPTION | - MOTEGI S ET AL., EMBO J., vol. 22, no. 11, pages 2634 - 2644 |
| DESCRIPTION | - SUBRAMANIAN ET AL., BLOOD, (2006), vol. 107, pages 2548 - 2556 |
| DESCRIPTION | - VALK ET AL., N ENGL J MED, (2004), vol. 350, pages 1617 - 1628 |
| DESCRIPTION | - WAGERS; WEISSMAN, STEM CELLS, (2006), vol. 24, no. 4, pages 1087 - 94 |
| DESCRIPTION | - WRIGHT DE ET AL., J EXP MED, (2002), vol. 195, no. 9, pages 1145 - 54 |
| OPPOSITION | - Anonymous, "Clinical Trial of the TQB2928 Injection in Patients With Advanced Cancers", (20220303), pages 1 - 6, ClinicalTrials , URL: https://classic.clinicaltrials.gov/ct2/show/NCT05192512, (20231204), XP093108477 |
| OPPOSITION | - Anonymous, "Gentulizumab in Relapsed/Refractory Acute Myelogenous Leukemia or Myelodysplastic Syndrome", (20200302), pages 1 - 10, ClinicalTrials, URL: https://classic.clinicaltrials.gov/ct2/show/NCT05263271, (20231204), XP093108472 |
| OPPOSITION | - Anonymous, "HL60", Wikipedia, the free encyclopedia, (20200106), URL: https://en.wikipedia.org/wiki/HL60, XP055674017 |
| OPPOSITION | - Anonymous, "Innovent Releases Phase 1a Results of CD47 Monoclonal Antibody (Letaplimab) in Monotherapy for Advanced Malignancies at SITC 2020", (20201110), pages 1 - 5, prnewswire, URL: https://www.prnewswire.com/news-releases/innovent-releases-phase-1a-results-of-cd47-monoclonal-antibody-letaplimab-in-monotherapy-for-advanced-malignancies-at-sitc-2020-301170150.html, (20231204), XP093108468 |
| OPPOSITION | - Anonymous, "L1210 cells", Wikipedia, the free encyclopedia, URL: https://en.wikipedia.org/wiki/L1210_cells, XP055674029 |
| OPPOSITION | - Anonymous, "Scientists Discover New Way To Distinguish Self From Other", Science Daily, (20000619), pages 1 - 4, XP055348264 |
| OPPOSITION | - Anonymous, "Twenty-fifth annual Stanford medical student research symposium & fifth annual pom population health symposium", Stanford School of Medicine Center, (20080521), pages 1 - 7, XP055674125 |
| OPPOSITION | - CAMPBELL, I. G. et al., "An Ovarian Tumor Marker with Homology to Vaccinia Virus Contains an IgV-like Region and Multiple Transmembrane Domains", Cancer Research, (19921000), vol. 52, pages 5416 - 5420, XP055348255 |
| OPPOSITION | - CHAO et al., "Targeting CD 47 eliminates human acute myeloid leukemia stem cells", Presentations at the Stanford Medical Student Research Symposium, (20080514), XP055348747 |
| OPPOSITION | - De Saint-Basile Genevieve, "Wiskott-Aldrich syndrome", (20030501), pages 1 - 3, Orphanet , URL: https://www.orpha.net/data/patho/GB/uk-wiskott.pdf, (20231204), XP093108483 |
| OPPOSITION | - HAGMANN, "A New Way to Keep Immune Cells in Check", Science, (20000000), vol. 288, pages 1945 - 1946, XP055345453 |
| OPPOSITION | - HAGMANN, "A new way to keep immune cells in check", Science, (20000616), vol. 288, no. 5473, pages 1945 - 1946, XP055345453 |
| OPPOSITION | - Hayley Rutger, "Students draw a crowd to annual research and community health symposium", Stanford School of Medicine News, pages 1 - 2, Stanford School of Medicine News, URL: http://med.stanford.edu/news/all-news/2008/05/students-draw-a-crowd-to-annual-research-and-community-health-symposium.html, (20181210), XP055532055 |
| OPPOSITION | - Ian G Campbell et al, "An Ovarian Tumor Marker with Homology to Vaccinia Virus Contains an IgV-like Region and Multiple Transmembrane Domains", CANCER RESEARCH, (19921001), vol. 52, pages 5416 - 5420, XP055348255 |
| OPPOSITION | - IDE et al., "Role for CD 47-SIRPa signaling in xenograft rejection by macrophages", PNAS, (20070320), vol. 104, no. 12, pages 5062 - 5066 |
| OPPOSITION | - ITO M ET AL, "NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models.", CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY 2008 LNKD- PUBMED:18481452, (20080101), vol. 324, pages 53 - 76, XP002603153 |
| OPPOSITION | - JAMIESON et al., "Increased expression of CD 47 is a constant marker in mouse and human myeloid leukemias", Blood, vol. 106, no. 11, (20051116), page 3260, URL: https://ashpublications.org/blood/article/106/11/3260/121483/Increased-Expression-of-CD47-Is-a-Constant-Marker, XP0055668075 |
| OPPOSITION | - LATOUR et al., "Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation", J. Immunology, (20010000), vol. 167, pages 2547 - 2554, XP002457665 |
| OPPOSITION | - LATOUR S ET AL, "Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation.", The Journal of Immunology, (20010901), vol. 167, no. 5, ISSN 0022-1767, pages 2547 - 2554, XP002457665 |
| OPPOSITION | - L G Poels et al, "Monoclonal Antibody Against Human Ovarian Tumor-Associated Antigens", J. Natl. Cancer Inst., (19860501), vol. 76, no. 5, pages 781 - 791, XP055663185 |
| OPPOSITION | - MAJETI et al., "CD47 Is An Independent Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells", Blood, (20080000), vol. 112, pages 286 - 299, XP009160228 |
| OPPOSITION | - MAJETI et al., "CD 47 is an independent prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells", Blood, (20081116), vol. 112, no. 11, page 766, XP009160228 |
| OPPOSITION | - Majeti Ravindra et al, "CD47 Is An Independent Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells (Abstract 766)", Blood, (20081101), vol. 112, no. 11, ISSN 0006-4971, page 284, XP009160228 |
| OPPOSITION | - MAJETI, R . et al., "CD47 Is An Independent Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells", Blood. 50th Annual Meeting of the American Society of Hematology, (20081100), vol. 112, no. 11, page 284, XP009160228 |
| OPPOSITION | - OLDENBORG et al., "CD 47-signalling regulatory protein a (SIRPa) regulates Fcy and complement receptor-mediated phagocytosis", Journal of Experimental Medicine, (20010402), vol. 193, no. 7, pages 855 - 862, XP055283803 |
| OPPOSITION | - OLDENBORG et al., "Cd47-Signal Regulatory Protein α (Sirpα) Regulates Fcγ and Complement Receptor-Mediated Phagocytosis", J. Exp Med., (20010000), vol. 193, pages 855 - 861, XP055283803 |
| OPPOSITION | - OLDENBORG P-A. et al., "Cd47-Signal Regulatory Protein α (Sirpα) Regulates Fcγ and Complement Receptor-Mediated Phagocytosis", J. Exp. Med., (20010402), vol. 193, no. 7, pages 855 - 862, XP055283803 |
| OPPOSITION | - Per-Arne Oldenborg; ET AL, "Cd47-Signal Regulatory Protein α (Sirpα) Regulates Fcγ and Complement Receptor-Mediated Phagocytosis", The Journal of Experimental Medicine, vol. 193, no. 7, (20010402), URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193364/pdf/010027.pdf, (20160627), XP055283803 |
| OPPOSITION | - PETTERSEN R F, ET AL., "CD47 SIGNALS T CELL DEATH", The Journal of Immunology, (19990101), vol. 162, ISSN 0022-1767, pages 7031 - 7040, XP002940659 |
| OPPOSITION | - POELS, L. G . et al., "Monoclonal Antibody Against Human Ovarian Tumor-Associated Antigens", J. Natl. Cancer Inst., (19860500), vol. 76, no. 5, pages 781 - 791, XP055663185 |
| OPPOSITION | - REBRES et al., "Novel CD 47-dependent intercellular adhesion modulates cell migration", Journal of Cellular Physiology, (20050505), vol. 205, no. 2, pages 182 - 193, XP055345445 |
| OPPOSITION | - REBRES et al., "Novel CD47-Dependent lntercellular Adhesion Modulates Cell Migration", J. Cell. Physiol., (20050000), vol. 205, pages 182 - 193, XP055345445 |
| OPPOSITION | - Rutger, "Students draw a crowd to annual research and community health symposium", News release from Stanford School of Medicine website, (20080521), XP055532055 |
| OPPOSITION | - "Scientists Discover New Way To Distinguish Self From Other", Science Daily, (20000619), URL: https://www.sciencedaily.com/releases/2000/06/000619073418.htm, XP055348264 |
| OPPOSITION | - SEIFFERT et al., "HUMAN SIGNAL-REGULATORY PROTEIN IS EXPRESSED ON NORMAL, BUT NOT ON SUBSETS OF LEUKEMIC MYELOID CELLS AND MEDIATES CELLULAR ADHESION INVOLVING ITS COUNTERRECEPTOR CD47", Blood, (19990000), vol. 94, no. 11, pages 3633 - 3643, XP000973562 |
| OPPOSITION | - SEIFFERT et al., "Human signal-regulatory protein is expressed on normal, but not on subsets of leukemic myeloid cells and mediates cellular adhesion involving its counterreceptor CD 47", Blood, (19991201), vol. 94, no. 11, pages 3633 - 3643, XP000973562 |
| OPPOSITION | - SEIFFERT M, ET AL., "HUMAN SIGNAL-REGULATORY PROTEIN IS EXPRESSED ON NORMAL, BUT NOT ON SUBSETS OF LEUKEMIC MYELOID CELLS AND MEDIATES CELLULAR ADHESION INVOLVING ITS COUNTERRECEPTOR CD47", Blood, (19991201), vol. 94, no. 11, ISSN 0006-4971, pages 3633 - 3643, XP000973562 |
| OPPOSITION | - SHAN et al., "Apoptosis of malignant human B cells by ligation of CD 20 with monoclonal antibodies", Blood, (19980301), vol. 91, no. 5, pages 1644 - 1652, XP002182861 |
| OPPOSITION | - TICCHIONI et al., "Integrin-associated protein ( CD 47) is a comitogenic molecule on CD 3-activated human T cells", The Journal of Immunology, (19970115), vol. 158, no. 2, pages 677 - 684, XP055678630 |
| OPPOSITION | - TUZMAN, "Eat this, don't eat that: CD 47 companies", Biocentury, (20190000), pages 1 - 8, XP055673911 |
| OPPOSITION | - UCHENDU et al., "Preliminary study on the role of protein kinase C in CD 47-mediated phosphatidylserine exposure pathway by Bric 126 in Jurkat T Cells", Der Pharmacia Lettre, (20170913), vol. 9, no. 8, pages 18 - 28, XP055668186 |
| OPPOSITION | - VERNON-WILSON E F, ET AL., "CD47 IS A LIGAND FOR RAT MACROPHAGE MEMBRANE SIGNAL REGULATORY PROTEIN SIRP (OX41) AND HUMAN SIRPALPHA1", European Journal of Immunology, Wiley VCH, Weinheim, Weinheim, (20000801), vol. 30, ISSN 0014-2980, pages 2130 - 2137, XP000984773 |
| OPPOSITION | - VERNON-WILSON et al., "CD47 IS A LIGAND FOR RAT MACROPHAGE MEMBRANE SIGNAL REGULATORY PROTEIN SIRP (OX41) AND HUMAN SIRPALPHA1", Eur J Immunol, (20000000), vol. 30, pages 2130 - 2137, XP000984773 |
| OPPOSITION | - XP055532055, Haley Rutger |
| OPPOSITION | - ZHANG et al., "Targeting the cancer biomarker CD 47: a review on the diverse mechanisms of the CD 47 pathway in cancer treatment", Anti-Cancer Agents in Medicinal Chemistry, (20160000), vol. 16, no. 6, pages 658 - 667, XP055668169 |
| OPPOSITION | - Alexandra Pfeiffer et al, "Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts", European Journal of Immunology, Wiley VCH, Weinheim, Weinheim, (20011101), vol. 31, no. 11, doi:10.1002/1521-4141(200111)31:11<3153::AID-IMMU3153>3.0.CO;2-0, ISSN 0014-2980, pages 3153 - 3164, XP055541184 |
| OPPOSITION | - Wang Chaoyu, Sun Chengtao, Li Mengzhen, Xia Bing, Wang Yi, Zhang Li, Zhang Yanyan, Wang Juan, Sun Feifei, Lu Suying, Zhu Jia, Huang Junting, Zhang Yizhuo, "Novel fully human anti‐CD47 antibodies stimulate phagocytosis and promote elimination of AML cells", Journal of Cellular Physiology, US , (20210601), vol. 236, no. 6, doi:10.1002/jcp.30163, ISSN 0021-9541, pages 4470 - 4481, XP093108459 |
| OPPOSITION | - David W. Dawson, Et Al, "Thrombospondin as an Inhibitor of Angiogenesis", Antiangiogenic Agents in Cancer Therapy, Part of the Cancer Drug Discovery and Development book series, Humana Press, (19990101), pages 185 - 203, XP055675823 |
| OPPOSITION | - Narla Rama Krishna; Modi Hardik; Bauer Daniel; Abbasian Mahan; Leisten Jim; Piccotti Joseph R.; Kopytek Stephan; Eckelman Brendan P.; Deveraux Quinn; Timmer John; Zhu Dan; Wong Lilly; Escoubet Laure; Raymon Heather K.; Hariharan Kandasamy, "Modulation of CD47-SIRPα innate immune checkpoint axis with Fc-function detuned anti-CD47 therapeutic antibody", Cancer immunology immunotherapy, Berlin/Heidelberg , (20210710), vol. 71, no. 2, doi:10.1007/s00262-021-03010-6, ISSN 0340-7004, pages 473 - 489, XP037673283 |
| OPPOSITION | - UMETSU et al., "Requirements for activation of human peripheral blood T Cells by mouse monoclonal antibodies to CD 3", Clinical Immunology and immunopathology, (19870000), vol. 43, no. 1, doi:10.1016/0090-1229(87)90156-5, pages 48 - 64 April 1987, XP026197604 |
| OPPOSITION | - WEISSMAN, I. L., "The E. Donnall Thomas Lecture: Normal and Neoplastic Stem Cells", Biology of Blood and Marrow Transplantation, (20080718), vol. 14, no. 8, pages 849 - 858, XP022940656 |
| OPPOSITION | - KIKUCHI, Y. et al., "A bivalent single-chain Fv fragment against CD47 induces apoptosis for leukemic cells", Biochem. Biophys. Res. Commun., (20040319), vol. 315, no. 4, pages 912 - 918, XP004491573 |
| OPPOSITION | - OLSSON, M. et al., "Dose-dependent inhibitory effect of CD47 in macrophage uptake of IgG-opsonized murine erythrocytes", Biochem. Biophys. Res. Comm., (20061130), vol. 352, no. 1, pages 193 - 197, XP005724581 |
| OPPOSITION | - GARDAI et al., "Cell-surface calreticulin initiates clearance of viable apoptotic cells through trans-activation of LRP on the phagocyte", Cell, (20050000), vol. 123, pages 321 - 334, XP002432361 |
| OPPOSITION | - GARDAI et al., "Cell -surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte", Cell, (20051021), vol. 123, doi:10.1016/j.cell.2005.08.032, pages 321 - 334, XP002432361 |
| OPPOSITION | - GARDAI, S. J. et al., "Cell-surface calreticulin initiates clearance of viable apoptotic cells through trans-activation of LRP on the phagocyte", Cell, (20051021), vol. 123, no. 2, pages 321 - 334, XP002432361 |
| OPPOSITION | - GARDAI S.J, ET AL, "Cell-surface calreticulin initiates clearance of viable apoptotic cells through trans-activation of LRP on the phagocyte.", CELL, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20051021), vol. 123, doi:10.1016/j.cell.2005.08.032, ISSN 0092-8674, pages 321 - 334, XP002432361 |
| OPPOSITION | - Ravindra Majeti, Mark P. Chao, Ash A. Alizadeh, Wendy W. Pang, Siddhartha Jaiswal, Kenneth D. Gibbs, Nico Van Rooijen, Irving L. Weissman, "CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells", Cell, Amsterdam NL , (20090701), vol. 138, no. 2, doi:10.1016/j.cell.2009.05.045, ISSN 0092-8674, pages 286 - 299, XP055277135 |
| OPPOSITION | - DESJARLAIS et al., "Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective", Drug Discovery Today, (20071100), vol. 12, no. 21-22, doi:10.1016/j.drudis.2007.08.009, pages 898 - 910, XP022338218 |
| OPPOSITION | - IWAMOTO et al., "The BALB/c-specific polymorphic SIRPA enhances its affinity for human CD 47, inhibiting phagocytosis against human cells to promote xenogeneic engraftment", Experimental Hematology, (20131120), vol. 42, no. 3, doi:10.1016/j.exphem.2013.11.005, pages 163 - 171, XP028632213 |
| OPPOSITION | - Congote, L.F. Temmel, N., "The C-terminal 26-residue peptide of serpin A1 stimulates proliferation of breast and liver cancer cells: role of protein kinase C and CD47", FEBS LETTERS., ELSEVIER, AMSTERDAM., NL, NL, (20041022), vol. 576, no. 3, doi:10.1016/j.febslet.2004.09.035, ISSN 0014-5793, pages 343 - 347, XP004605712 |
| OPPOSITION | - VAN DEN BERG et al., "Innate immune 'self' recognition: a role for CD47-SIRP@a interactions in hematopoietic stem cell transplantation", Trends Immunol., (20080000), vol. 29, pages 203 - 206, XP022635428 |
| OPPOSITION | - VAN DEN BERG, T. K. et al., "Innate immune 'self' recognition: a role for CD47-SIRPalfa interactions in hematopoietic stem cell transplantation", Trends In Immunology, (20080403), vol. 29, no. 5, pages 203 - 206, XP022635428 |
| OPPOSITION | - KIKUCHI et al., "Apoptosis inducing bivalent single-chain antibody fragments against CD47 showed antitumor potency for multiple myeloma", Leukemia Research, (20050000), vol. 29, no. 4, pages 445 - 450, XP004752515 |
| OPPOSITION | - Kikuchi, Y. et al, "Apoptosis inducing bivalent single-chain antibody fragments against CD47 showed antitumor potency for multiple myeloma", LEUKEMIA RESEARCH, US, (20050401), vol. 29, no. 4, doi:10.1016/j.leukres.2004.09.005, ISSN 0145-2126, pages 445 - 450, XP004752515 |
| OPPOSITION | - OLSSON et al., "Target cell CD 47 regulates macrophage activation and erythrophagocytosis", Transfusion Clinique et biologique, (20060329), vol. 13, no. 1- 2, doi:10.1016/j.tracli.2006.02.013, pages 39 - 43, XP028032798 |
| OPPOSITION | - Peter M Henson et al, "Apoptotic cell removal", CURRENT BIOLOGY, CURRENT SCIENCE, GB, GB, (20011001), vol. 11, no. 19, doi:10.1016/S0960-9822(01)00474-2, ISSN 0960-9822, pages R795 - R805, XP055348314 |
| OPPOSITION | - BROWN ERIC J ET AL, "Integrin-associated protein (CD47) and its ligands", TRENDS IN CELL BIOLOGY., ELSEVIER SCIENCE LTD., XX, XX, (20010301), vol. 11, no. 3, doi:10.1016/S0962-8924(00)01906-1, ISSN 0962-8924, pages 130 - 135, XP002413983 |
| OPPOSITION | - BROWN et al., "Integrin-associated protein (CD47) and its ligands", Trends in Cell Biol., (20010000), vol. 11, no. 3, pages 130 - 135, XP002413983 |
| OPPOSITION | - BROWN et al., "Integrin-associated protein ( CD 47) and its ligands", Trends in Cell Biology, (20010301), vol. 11, no. 3, doi:10.1016/S0962-8924(00)01906-1, pages 130 - 135, XP002413983 |
| OPPOSITION | - PLATT, N. et al., "Recognizing death: the phagocytosis of apoptotic cells", Trends in Cell Biology, (19980901), vol. 8, no. 9, pages 365 - 372, XP055673783 |
| OPPOSITION | - Wang Yuchen, Zhao Chenxuan, Liu Yang, Wang Chao, Jiang Haojie, Hu Yiqiao, Wu Jinhui, "Recent Advances of Tumor Therapy Based on the CD47-SIRPα Axis", Molecular Pharmaceutics, US , (20220502), vol. 19, no. 5, doi:10.1021/acs.molpharmaceut.2c00073, ISSN 1543-8384, pages 1273 - 1293, XP093078337 |
| OPPOSITION | - MATEO et al., "CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia", Nature Med, (19990000), vol. 5, pages 1277 - 1284, XP002163073 |
| OPPOSITION | - MATEO et al., "CD 47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia", Nature Medicine, (19991100), vol. 5, no. 11, doi:10.1038/15233, pages 1277 - 1284, XP002942112 |
| OPPOSITION | - MATEO, V. et al., "CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia", Nature Medicine, (19991101), vol. 5, no. 11, pages 1277 - 1284, XP002163073 |
| OPPOSITION | - MATEO V ET AL, "CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia.", Nature Medicine, Nature Pub. Co., New York, New York, (19991101), vol. 5, no. 11, doi:10.1038/15233, ISSN 1078-8956, pages 1277 - 1284, XP002163073 |
| OPPOSITION | - E C Pietsch et al, "Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies", Blood Cancer Journal, vol. 7, no. 2, doi:10.1038/bcj.2017.7, pages 1 - 8, XP055395279 |
| OPPOSITION | - PIETSCH, E. C. et al., "Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies", Blood Cancer Journal, (20170200), vol. 7, pages 1 - 8, XP055395279 |
| OPPOSITION | - PIETSCH et al., "Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodie", Blood Cancer Journal, (20170000), vol. 7, no. 2, pages 1 - 8, XP055395279 |
| OPPOSITION | - KROEMER et al., "Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009", Cell Death Differ., (20090000), vol. 16, pages 3 - 11, XP055348325 |
| OPPOSITION | - TAKIZAWA et al., "Macrophage tolerance: CD 47-SIRP-a-mediated signals matter", Nature Immunology, (20071200), vol. 8, no. 12, doi:10.1038/ni1207-1287, pages 1287 - 1289, XP055094296 |
| OPPOSITION | - TAKIZAWA et al., "Macrophage Tolerance: CD47-SIRP-Mediated Signals Matter", Nature Immunol., (20070000), vol. 8, pages 1287 - 1289, XP055094296 |
| OPPOSITION | - TAKIZAWA, H. et al., "Macrophage Tolerance: CD47-SIRP-Mediated Signals Matter", Nature Immunol, (20071200), vol. 8, pages 1287 - 1289, XP055094296 |
| OPPOSITION | - TAKENAKA et al., "Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells", Nature Immunol., (20071200), vol. 8, no. 12, doi:10.1038/ni1527, pages 1313 - 1323, XP055539168 |
| OPPOSITION | - Liu Yu’e, Wang Yanjin, Yang Yanrong, Weng Linjun, Wu Qi, Zhang Jin, Zhao Pengcheng, Fang Lan, Shi Yufeng, Wang Ping, "Emerging phagocytosis checkpoints in cancer immunotherapy", Signal Transduction and targeted Therapy, (20230307), vol. 8, no. 1, doi:10.1038/s41392-023-01365-z, ISSN 2059-3635, pages 1 - 42, XP093108444 |
| OPPOSITION | - Matsuo Y. et al, "Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins (11;9) (q23;p22p23)", LEUKEMIA, Nature Publishing Group UK, London, London, (19970101), vol. 11, no. 9, doi:10.1038/sj.leu.2400768, ISSN 0887-6924, pages 1469 - 1477, XP009502888 |
| OPPOSITION | - GOSSEN M., BUJARD H., "TIGHT CONTROL OF GENE EXPRESSION IN MAMMALIAN CELLS BY TETRACYCLINE-RESPONSIVE PROMOTERS.", Proceedings of the National Academy of Sciences, National Academy of Sciences, US, US, (19920615), vol. 89., no. 12., doi:10.1073/pnas.89.12.5547, ISSN 0027-8424, pages 5547 - 5551., XP000564458 |
| OPPOSITION | - GAO AI-GUO ET AL, "Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin.", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US, (19960105), vol. 271, no. 1, doi:10.1074/jbc.271.1.21, ISSN 0021-9258, pages 21 - 24, XP002248145 |
| OPPOSITION | - Yuan Liu, Et Al., "The Role of CD47 in Neutrophil Transmigration : INCREASED RATE OF MIGRATION CORRELATES WITH INCREASED CELL SURFACE EXPRESSION OF CD47", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US, (20011026), vol. 276, no. 43, doi:10.1074/jbc.M104138200, ISSN 0021-9258, pages 40156 - 40166, XP055674346 |
| OPPOSITION | - LIU et al., "Signal Regulatory Protein (SIRPalpha ), a Cellular Ligand for CD47, Regulates Neutrophil Transmigration", Journal of Biological Chemistry, (20020000), vol. 277, pages 10028 - 10036, XP055030073 |
| OPPOSITION | - LIU, Y. et al., "Signal Regulatory Protein (SIRPalpha ), a Cellular Ligand for CD47, Regulates Neutrophil Transmigration", J. Biol. Chem., (20020315), vol. 277, no. 12, pages 10028 - 10036, XP055030073 |
| OPPOSITION | - Y. Liu et al, "Signal Regulatory Protein (SIRPalpha ), a Cellular Ligand for CD47, Regulates Neutrophil Transmigration", Journal of Biological Chemistry, (20020315), vol. 277, no. 12, doi:10.1074/jbc.M109720200, ISSN 00219258, pages 10028 - 10036, XP055030073 |
| OPPOSITION | - BARAZI et al., "- Regulation of integrin function by CD47 ligands. Differential effects on alphavbeta3 and alpha4beta1 integrin-mediated adhesion", Journal of Biological Chemistry, (20020000), vol. 277, no. 45, pages 42859 - 42866, XP002468585 |
| OPPOSITION | - OLDENBORG et al., "ROLE OF CD47 IN ERYTHROID CELLS AND IN AUTOIMMUNITY", Leukemia & Lymphoma, (20040000), vol. 45, pages 1319 - 1327, XP008060559 |
| OPPOSITION | - OLDENBORG, P-A. et al., "ROLE OF CD47 IN ERYTHROID CELLS AND IN AUTOIMMUNITY", Leukemia & Lymphoma, (20040700), vol. 45, no. 7, pages 1319 - 1327, XP008060559 |
| OPPOSITION | - OLDENBORG P-A, "ROLE OF CD47 IN ERYTHROID CELLS AND IN AUTOIMMUNITY", LEUKEMIA AND LYMPHOMA., Informa Healthcare, US, US, (20040701), vol. 45, no. 07, doi:10.1080/1042819042000201989, ISSN 1042-8194, pages 1319 - 1327, XP008060559 |
| OPPOSITION | - OLDENBORG, "Role of CD 47 in erythroid cells and in autoimmunity", Leukemia and Lymphoma, (20040700), vol. 45, no. 7, doi:10.1080/1042819042000201989, pages 1319 - 1327, XP008060559 |
| OPPOSITION | - ARMANT M, ET AL., "CD47 LIGATION SELECTIVELY DOWNREGULATES HUMAN INTERLEUKIN 12 PRODUCTION", The Journal of Experimental Medicine, Rockefeller University Press, US, US, (19991018), vol. 190, no. 08, doi:10.1084/jem.190.8.1175, ISSN 0022-1007, pages 1175 - 1181, XP000984762 |
| OPPOSITION | - BLAZAR, B. R. et al., "Cd47 (Integrin-Associated Protein) Engagement of Dendritic Cell and Macrophage Counterreceptors Is Required to Prevent the Clearance of Donor Lymphohematopoietic Cells", J. Exp. Med., (20010820), vol. 194, no. 4, pages 541 - 550, XP055084225 |
| OPPOSITION | - BLAZAR et al., "Cd47 (Integrin-Associated Protein) Engagement of Dendritic Cell and Macrophage Counterreceptors Is Required to Prevent the Clearance of Donor Lymphohematopoietic Cells", J. Exp. Medicine, (20010000), vol. 194, pages 541 - 549, XP055084225 |
| OPPOSITION | - BLAZAR et al., "CD 47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells", Journal of Experimental Medicine, (20010820), vol. 194, no. 4, pages 541 - 549, XP055084225 |
| OPPOSITION | - Kaur Sukhbir, Cicalese Kyle V, Banerjee Rajdeep, Roberts David D, "Preclinical and clinical development of therapeutic antibodies targeting functions of CD47 in the tumor microenvironment", Antibody Therapeutics, (20200725), vol. 3, no. 3, doi:10.1093/abt/tbaa017, pages 179 - 192, XP055805185 |
| OPPOSITION | - Takimoto C.H., Chao M.P., Gibbs C., Mccamish M.A., Liu J., Chen J.Y., Majeti R., Weissman I.L., "The Macrophage ‘Do not eat me’ signal, CD47, is a clinically validated cancer immunotherapy target", Annals of Oncology, (20190301), vol. 30, no. 3, doi:10.1093/annonc/mdz006, ISSN 0923-7534, pages 486 - 489, XP093108437 |
| OPPOSITION | - Kipp Weiskopf et al, "Engineered SIRP[alpha] variants as immunotherapeutic adjuvants to anticancer antibodies.", Science, American Association for the Advancement of Science, US, US, (20130705), vol. 341, no. 6141, doi:10.1126/science.1238856, ISSN 1095-9203, pages 88 - 91, XP002745510 |
| OPPOSITION | - WEISKOPF et al., "Engineered SIRP[alpha] variants as immunotherapeutic adjuvants to anticancer antibodies", Science, (20130000), vol. 341, pages 88 - 91, XP002745510 |
| OPPOSITION | - OLDENBORG et al., "Role of CD47 as a Marker of Self on Red Blood Cells", Science, (20000000), vol. 288, pages 2051 - 2054, XP055304810 |
| OPPOSITION | - OLDENBORG et al., "Role of CD 47 as a marker of self on red blood cells", Science, (20000616), vol. 288, no. 5473, doi:10.1126/science.288.5473.2051, pages 2051 - 2054, XP055304810 |
| OPPOSITION | - OLDENBORG, P-A. et al., "Role of CD47 as a Marker of Self on Red Blood Cells", Science, (20000616), vol. 288, no. 5473, pages 2051 - 2054, XP055304810 |
| OPPOSITION | - P.-A. Oldenborg, "Role of CD47 as a Marker of Self on Red Blood Cells", Science, American Association for the Advancement of Science, US, US, (20000616), vol. 288, no. 5473, doi:10.1126/science.288.5473.2051, ISSN 0036-8075, pages 2051 - 2054, XP055304810 |
| OPPOSITION | - MANNA et al., "CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A", Cancer Research, (20040000), vol. 64, no. 3, pages 1026 - 1036, XP055030076 |
| OPPOSITION | - Partha Manna, William Frazier, "CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A.", Cancer research, American Association for Cancer Research, (20040201), vol. 64, no. 3, doi:10.1158/0008-5472.CAN-03-1708, ISSN 00085472, pages 1026 - 1036, XP055030076 |
| OPPOSITION | - CIOFFI et al., "Inhibition of CD 47 effectively targets pancreatic cancer stem cells via dual mechanisms", Clinical Cancer Research, (20150223), vol. 21, no. 10, doi:10.1158/1078-0432.CCR-14-1399, pages 2325 - 2337, XP055232939 |
| OPPOSITION | - PETROVA, P. S. et al., "TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding", Clin. Cancer Res., (20170215), vol. 23, no. 4, pages 1068 - 1079, XP055540513 |
| OPPOSITION | - Kipp Weiskopf et al, "CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer", JOURNAL OF CLINICAL INVESTIGATION, B M J Group, GB, GB, (20160701), vol. 126, no. 7, doi:10.1172/JCI81603, ISSN 0021-9738, pages 2610 - 2620, XP055480649 |
| OPPOSITION | - WEISKOPF et al., "CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer", J Clin Invest., (20160000), vol. 126, no. 7, pages 2610 - 2620, XP055480649 |
| OPPOSITION | - ITO M, ET AL., "NOD/SCID/GAMMAcnull mouse: an excellent recipient mouse model for engraftment of human cells", Blood, (20021101), vol. 100, no. 9, doi:10.1182/blood-2001-12-0207, ISSN 0006-4971, pages 3175 - 3182, XP002981771 |
| OPPOSITION | - MATEO et al., "Mechanisms of CD 47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organisation", Blood, (20020615), vol. 100, no. 8, doi:10.1182/blood-2001-12-0217, pages 2882 - 2890, XP055125010 |
| OPPOSITION | - MATEO et al., "Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization", Blood, (20020000), vol. 100, no. 8, pages 2882 - 2890, XP055125010 |
| OPPOSITION | - V. Mateo et al, "Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization", Blood, (20020926), vol. 100, no. 8, doi:10.1182/blood-2001-12-0217, ISSN 0006-4971, pages 2882 - 2890, XP055125010 |
| OPPOSITION | - OLSSON et al., "Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia", Blood, (20050000), vol. 105, pages 3577 - 3582, XP055347748 |
| OPPOSITION | - OLSSON et al., "Platelet homeostasis is regulated by platelet expression of CD 47 under normal conditions and in passive immune thrombocytopenia", Blood, (20050501), vol. 105, no. 9, doi:10.1182/blood-2004-08-2980, pages 3577 - 3582, XP055347748 |
| OPPOSITION | - OLSSON, M. et al., "Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia", Blood, (20050501), vol. 105, no. 9, pages 3577 - 3582, XP055347748 |
| OPPOSITION | - SUBRAMANIAN et al., "Species- and cell type-specific interactions between CD 47 and human SIRPa", Blood, (20051115), vol. 107, no. 6, doi:10.1182/blood-2005-04-1463, pages 2548 - 2556, XP002608759 |
| OPPOSITION | - SUBRAMANIAN S., ET AL, "Species- and cell type-specific interactions between CD47 and human SIRP[alpha]", Blood, (20060315), vol. 107, no. 6, doi:10.1182/blood-2005-04-1463, ISSN 0006-4971, pages 2548 - 2556, XP002608759 |
| OPPOSITION | - WANG et al., "Attenuation of phagocytosis of xenogeneic cells by manipulating CD47", Blood, (20070000), vol. 109, pages 836 - 842, XP002608757 |
| OPPOSITION | - WANG H., ET AL, "Attenuation of phagocytosis of xenogeneic cells by manipulating CD47", Blood, (20070115), vol. 109, no. 2, doi:10.1182/blood-2006-04-019794, ISSN 0006-4971, pages 836 - 842, XP002608757 |
| OPPOSITION | - ZHAO et al., "Is targeting of CD47-SIRP enough for treating hematopoietic malignancy?", Blood, (20120000), vol. 119, no. 18, pages 4333 - 4335, XP055116565 |
| OPPOSITION | - JAMIESON et al., "Increased expression of CD 47 is a constant marker in mouse and human myeloid leukemias", Blood, (20050000), vol. 106, pages 1 - 5, XP055668075 |
| OPPOSITION | - Jamieson, Et Al., "Increased expression of CD 47 is a constant marker in mouse and human myeloid leukemias", Blood, (20051116), vol. 106, no. 11, pages 1 - 5, XP055668075 |
| OPPOSITION | - P.-A. Oldenborg, Et Al., "Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice", Blood, (20020515), vol. 99, no. 10, doi:10.1182/blood.V99.10.3500, ISSN 0006-4971, pages 3500 - 3504, XP055674279 |
| OPPOSITION | - Qu Tailong, Li Baiyong, Wang Yifei, "Targeting CD47/SIRP[alpha] as a therapeutic strategy, where we are and where we are headed", Biomarker research, (20220413), vol. 10, doi:10.1186/s40364-022-00373-5, pages 1 - 18, XP093028950 |
| OPPOSITION | - Lajos Pusztai, "Molecular markers for treatment decision", Breast Cancer, A clinical guide to therapy, 3rd Ed., Taylor & Francis Group, (20060101), page 81, XP055676013 |
| OPPOSITION | - TROUNSON, "Stem cells, plasticity and cancer - uncomfortable bed fellows", DEVELOPMENT, (20040600), vol. 131, no. 12, doi:10.1242/dev.01233, pages 2763 - 2768, XP055348759 |
| OPPOSITION | - KAUDER, S. E. et al., "ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile", PLOS one, (20180822), vol. 13, no. 8, pages 1 - 33, XP055635503 |
| OPPOSITION | - S. E. Strome et al, "A Mechanistic Perspective of Monoclonal Antibodies in Cancer Therapy Beyond Target-Related Effects", The Oncologist, AlphaMed Press, (20070901), vol. 12, no. 9, doi:10.1634/theoncologist.12-9-1084, ISSN 10837159, pages 1084 - 1095, XP055052443 |
| OPPOSITION | - STROME et al., "A mechanistic perspective of monoclonal antibodies in cancer therapy beyond target-related effects", The Oncologist, (20070900), vol. 12, doi:10.1634/theoncologist.12-9-1084, pages 1084 - 1095, XP055052443 |
| OPPOSITION | - Lucy E. Métayer, Anna Vilalta, G.A. Amos Burke, Guy C. Brown, "Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis", Oncotarget, (20170905), vol. 8, no. 37, doi:10.18632/oncotarget.18492, pages 60892 - 60903, XP055456424 |
| OPPOSITION | - METAYER et al., "Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis", Oncotarget, (20170000), vol. 8, no. 37, pages 60892 - 60903, XP055456424 |
| OPPOSITION | - METAYER, L. E. et al., "Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis", Oncotarget, (20170905), vol. 8, no. 37, pages 60892 - 60903, XP055456424 |
| OPPOSITION | - Melo Garcia Luciana, Barabé Frédéric, "Harnessing Macrophages through the Blockage of CD47: Implications for Acute Myeloid Leukemia", Cancers, CH , (20211213), vol. 13, no. 24, doi:10.3390/cancers13246258, ISSN 2072-6694, pages 1 - 13, XP093108451 |
| OPPOSITION | - Gallazzi Marco, Ucciero Maghalie Anais Marie, Faraci Danilo Giuseppe, Mahmoud Abdurraouf Mokhtar, Al Essa Wael, Gaidano Gianluca, Mouhssine Samir, Crisà Elena, "New Frontiers in Monoclonal Antibodies for the Targeted Therapy of Acute Myeloid Leukemia and Myelodysplastic Syndromes", International journal of molecular sciences, Basel, CH , (20200101), vol. 23, no. 14, doi:10.3390/ijms23147542, ISSN 1422-0067, pages 1 - 16, XP093108456 |
| OPPOSITION | - Shinsuke Uno et al, "Antitumor activity of a monoclonal antibody against CD47 in xenograft models of human leukemia", Oncology Reports, (20070501), vol. 17, no. 5, doi:10.3892/or.17.5.1189, ISSN 1021-335X, pages 1189 - 1194, XP055127957 |
| OPPOSITION | - UNO et al., "Antitumor activity of a monoclonal antibody against CD 47 in xenograft models of human leukemia", Oncology Reports, (20070501), vol. 17, no. 5, doi:10.3892/or.17.5.1189, pages 1189 - 1194, XP055127957 |
| OPPOSITION | - UNO et al., "Antitumor activity of a monoclonal antibody against CD47 in xenograft models of human leukemia", Oncol. Reports, (20070000), vol. 17, pages 1189 - 1194, XP055127957 |
| OPPOSITION | - UNO, S. et al., "Antitumor activity of a monoclonal antibody against CD47 in xenograft models of human leukemia", Oncology Reports, (20070500), vol. 17, no. 5, pages 1189 - 1194, XP055127957 |
| OPPOSITION | - Demeure, Et Al., "CD47 Engagement Inhibits Cytokine Production and Maturation of Human Dendritic Cells", J Immunol, (20000101), vol. 164, pages 2193 - 2199, XP055674307 |
| OPPOSITION | - Avice, Et Al., "CD47 Ligation Selectively Inhibits the Development of Human Naive T Cells into Th1 Effectors", J Immunol, (20000101), vol. 165, pages 4624 - 4631, XP055674308 |
| OPPOSITION | - Zhuqing Li, Et Al., "Thrombospondin-1 Inhibits TCR-Mediated T Lymphocyte Early Activation", The Journal of Immunology, (20010215), vol. 166, no. 4, doi:10.4049/jimmunol.166.4.2427, ISSN 0022-1767, pages 2427 - 2436, XP055674363 |
| OPPOSITION | - Avice, Et Al., "Role of CD47 in the Induction of Human Naive T Cell Anergy", J Immunol, (20010101), vol. 167, pages 2459 - 2468, XP055674312 |
| OPPOSITION | - MANNA et al., "The Mechanism of CD47-Dependent Killing of T Cells: Heterotrimeric Gi-Dependent Inhibition of Protein Kinase A", J. Immunology, (20030000), vol. 170, no. 7, pages 3544 - 3553, XP055116597 |
| OPPOSITION | - MANNA et al., "The mechanism of CD 47-dependent killing of T Cells: heterotrimeric Gi-dependent inhibition of protein kinase A", The Journal of Immunology, (20030401), vol. 170, doi:10.4049/jimmunol.170.7.3544, pages 3544 - 3553, XP055116597 |
| OPPOSITION | - KUROSAKA et al., "Silent Cleanup of Very Early Apoptotic Cells by Macrophages", J. Immunol, (20030000), vol. 171, no. 9, pages 4672 - 4679, XP055674151 |
| OPPOSITION | - VAN BEEK et al., "Signal Regulatory Proteins in the Immune System", J. Immunology, (20050000), vol. 175, pages 7781 - 7787, XP055348305 |
| OTHER | - CHAO et al., "Targeting CD47 Eliminates Human Acute Myeloid Leukemia Stem Cells", 25th Annual Stanford Medical Student Research Symposium & Fifth Annual POM Population Health Symposium, (20080514), XP055532050 |
| OTHER | - Hayley Rutger, "Students draw a crowd to annual research and community health symposium", Stanford School of Medicine News, (20080520), URL: http://med.stanford.edu/news/all-news/2008/05/students-draw-a-crowd-to-annual-research-and-community-health-symposium.html, XP055532055 |
| OTHER | - Pietsch et al., "Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies", Blood Cancer Journal, vol. 7, (20170000), XP055395279 |
| OTHER | - Lucy E. Métayer, Anna Vilalta, G.A. Amos Burke, Guy C. Brown, "Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis", Oncotarget, vol. 8, no. 37, (20170000), pages 60892 - 60903, XP055456424 |
| SEARCH | - MAJETI RAVINDRA ET AL, "CD47 Is An Independent Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, (20081101), vol. 112, no. 11, ISSN 0006-4971, page 284, XP009160228 [PI] 1-14 * the whole document * |
| SEARCH | - PETTERSEN R F ET AL, "CD47 SIGNALS T CELL DEATH", THE JOURNAL OF IMMUNOLOGY, THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS, US, (19990101), vol. 162, ISSN 0022-1767, pages 7031 - 7040, XP002940659 [A] 1-14 * the whole document * |
| SEARCH | [ ] - RAVINDRA MAJETI1 ET AL, "CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells", DEVELOPMENTAL CELL, CELL PRESS, CAMBRIDGE, MA, US, vol. 138, no. 2, doi:10.1016/J.CELL.2009.05.045, ISSN 1097-4172, (20090723), pages 286 - 299, (20090723), XP002632714 [ ] * the whole document * |
| SEARCH | [ ] - JAISWAL S ET AL, "Macrophages as mediators of tumor immunosurveillance", TRENDS IN IMMUNOLOGY, ELSEVIER LTD. * TRENDS JOURNALS, GB, vol. 31, no. 6, doi:10.1016/J.IT.2010.04.001, ISSN 1471-4906, (20100601), pages 212 - 219, (20100601), XP027079216 [ ] * the whole document * |
| SEARCH | [ ] - X. W. ZHAO ET AL, "CD47-signal regulatory protein- (SIRP ) interactions form a barrier for antibody-mediated tumor cell destruction", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20111108), vol. 108, no. 45, doi:10.1073/pnas.1106550108, ISSN 0027-8424, pages 18342 - 18347, XP055055636 [ ] * Whole document, esp. fig.2 * |
| SEARCH | [ ] - S. B. WILLINGHAM ET AL, "The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20120326), vol. 109, no. 17, doi:10.1073/pnas.1121623109, ISSN 0027-8424, pages 6662 - 6667, XP055029983 [ ] * the whole document * |
| SEARCH | - Y. LIU ET AL, "Signal Regulatory Protein (SIRPalpha ), a Cellular Ligand for CD47, Regulates Neutrophil Transmigration", JOURNAL OF BIOLOGICAL CHEMISTRY, (20020315), vol. 277, no. 12, doi:10.1074/jbc.M109720200, ISSN 0021-9258, pages 10028 - 10036, XP055030073 [A] 1-14 * the whole document * |
| SEARCH | - PARTHA MANNA ET AL, "CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A.", CANCER RESEARCH, (20040201), vol. 64, no. 3, ISSN 0008-5472, pages 1026 - 1036, XP055030076 [X] 1-14 * The whole document, esp. Example 2 * |
| SEARCH | [ ] - M. P. CHAO ET AL, "Therapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia", CANCER RESEARCH, (20110215), vol. 71, no. 4, doi:10.1158/0008-5472.CAN-10-2238, ISSN 0008-5472, pages 1374 - 1384, XP055029988 [ ] * the whole document * |
| SEARCH | [ ] - X. W. ZHAO ET AL, "Is targeting of CD47-SIRP enough for treating hematopoietic malignancy?", BLOOD, (20120503), vol. 119, no. 18, doi:10.1182/blood-2011-11-391367, ISSN 0006-4971, pages 4333 - 4334, XP055116565 [ ] * the whole document * |
| SEARCH | - P. P. MANNA ET AL, "The Mechanism of CD47-Dependent Killing of T Cells: Heterotrimeric Gi-Dependent Inhibition of Protein Kinase A", THE JOURNAL OF IMMUNOLOGY, (20030401), vol. 170, no. 7, doi:10.4049/jimmunol.170.7.3544, ISSN 0022-1767, pages 3544 - 3553, XP055116597 [X] 1-14 * the whole document * |
