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Methods For The Purification Of Proteins Using Caprylic Acid - EP3137186

The patent EP3137186 was granted to Novo Nordisk on Jan 27, 2021. The application was originally filed on Apr 30, 2015 under application number EP15722478A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3137186

NOVO NORDISK
Application Number
EP15722478A
Filing Date
Apr 30, 2015
Status
Granted And Under Opposition
Dec 25, 2020
Grant Date
Jan 27, 2021
External Links
Slate, Register, Google Patents

Patent Summary

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Patent Family

Patent Oppositions (2)

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EUROPEAN OPPOSITIONSOct 27, 2021LEE -
GLAXOSMITHKLINEOct 26, 2021KIMADMISSIBLE

Patent Citations (15) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
EXAMINATIONEP2695620
EXAMINATIONUS4939176
INTERNATIONAL-SEARCH-REPORTEP0374625
INTERNATIONAL-SEARCH-REPORTEP1506810
INTERNATIONAL-SEARCH-REPORTWO2010048192
OPPOSITIONEP0374625
OPPOSITIONEP1506810
OPPOSITIONEP2695620
OPPOSITIONRU2356559
OPPOSITIONUS4939176
OPPOSITIONWO02096215
OPPOSITIONWO2010048192
OPPOSITIONWO2013050104
OPPOSITIONWO2014141150
OPPOSITIONWO2014186350

Non-Patent Literature (NPL) Citations (15) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
EXAMINATION- RAFAEL OTERO-PATIO ET AL, "Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab)] antivenoms, inbites inColombia", TOXICON, ELMSFORD, NY, US, vol. 59, no. 2, doi:10.1016/J.TOXICON.2011.11.017, ISSN 0041-0101, (20111122), pages 344 - 355, (20111129), XP028444133
OPPOSITION- Abhinav A. Shukla, Et Al, "Downstream processing of monoclonal antibodies-Application of platform approaches", Journal of Chromatography B, (20070101), vol. 848, pages 28 - 39, XP055493686-
OPPOSITION- Anonymous, "Committee for proprietary medicinal products (CPMP)", European Agency for the Evaluation of Medicinal Products Human Medicines, (19960214), pages 1 - 14, XP055863002-
OPPOSITION- LUNDBLAD J L, SENG R L, "INACTIVATION OF LIPID-ENVELOPED VIRUSES IN PROTEINS BY CAPRYLATE", Vox Sanguinis, S Kager AG Basel, CH, CH , (19910101), vol. 60, no. 02, ISSN 0042-9007, pages 75 - 81, XP008033429-
OPPOSITION- Newcombe, A.R. ; Cresswell, C. ; Davies, S. ; Watson, K. ; Harris, G. ; O'Donovan, K. ; Francis, R., "Optimised affinity purification of polyclonal antibodies from hyper immunised ovine serum using a synthetic Protein A adsorbent, MAbsorbent^(R) A2P", Journal of Chromatography B, ELSEVIER, AMSTERDAM., NL, NL , (20050125), vol. 814, no. 2, ISSN 1570-0232, pages 209 - 215, XP027626838-
OPPOSITION- BRODSKY et al., "Caprylic Acid Precipitation Method for Impurity Reduction: An Alternative to Conventional Chromatography for Monoclonal Antibody Purification", Biotechnology and Bioengineering, (20120516), vol. 109, no. 10, doi:10.1002/bit.24539, XP071109090
OPPOSITION- Sibylle Herzer; Atul Bhangale; Gregory Barker; Isha Chowdhary; Matthew Conover; Brian W. O'Mara; Lily Tsang; Shi‐Yu Wang; Stanley R. Krystek; Yan Yao; Siegfried Rieble, "Development and scale‐up of the recovery and purification of a domain antibody Fc fusion protein‐comparison of a two and three‐step approach", Biotechnology and Bioengineering, John Wiley, Hoboken, USA, Hoboken, USA, (20150313), vol. 112, no. 7, doi:10.1002/bit.25561, ISSN 0006-3592, pages 1417 - 1428, XP071166230
OPPOSITION- JISKOOT et al., "Two-step purification of a murine monoclonal antibody intended for therapeutic application in man Optimisation of purification conditions and scaling up", J Immunol, (19891113), vol. 124, no. 1, doi:10.1016/0022-1759(89)90196-8, pages 143 - 56, XP023655075
OPPOSITION- DOS SANTOS et al., "PURIFICATION OF F(ab')2 ANTI-SNAKE VENOM BY CAPRYLIC ACID: A FAST METHOD FOR OBTAINING IgG FRAGMENTS WITH HIGH NEUTRALIZATION ACTIVITY, PURITY AND YIELD", Toxicon, (19890000), vol. 27, no. 3, doi:10.1016/0041-0101(89)90177-3, pages 297 - 303, XP025807709
OPPOSITION- TONG et al., "Caprylate as the albumin-selective modifier to improve IgG purification with hydrophobic charge-induction chromatography", J. Chromatogr. A, (20130215), vol. 1285, doi:10.1016/j.chroma.2013.02.023, pages 88 - 96, XP028996084
OPPOSITION- NEWCOMBE et al., "Optimised affinity purification of polyclonal antibodies from hyper immunised ovine serum using a synthetic Protein A adsorbent, MAbsorbent® A2P", Journal of Chromatography B, (20041111), vol. 814, doi:10.1016/j.jchromb.2004.10.027, pages 209 - 215, XP004705795
OPPOSITION- HOBER et al., "Protein A chromatography for antibody purification", Journal of Chromatography B, (20061009), vol. 848, doi:10.1016/j.jchromb.2006.09.030, pages 40 - 47, XP002560075
OPPOSITION- Chhatre, S. Francis, R. Titchener-Hooker, N.J. Newcombe, A.R. Keshavarz-Moore, E., "Evaluation of a novel agarose-based synthetic ligand adsorbent for the recovery of antibodies from ovine serum", Journal of Chromatography B, ELSEVIER, AMSTERDAM., NL, NL , (20071119), vol. 860, no. 2, doi:10.1016/j.jchromb.2007.10.032, ISSN 1570-0232, pages 209 - 217, XP022371228
OPPOSITION- Rafael Otero-Patio; lvaro Segura; Mara Herrera; Yamileth Angulo; Guillermo Len; Jos Mara Gutirrez; Jacqueline Barona; Sebastin Estrada; Andrs Pereaez; Juan Carlos Quintana; Leidy J. Vargas; Juan Pablo Gmez; Abel Daz; Ana Mara Surez; Jorge Fernndez; Patricia Ramrez; Patricia Fabra; Monica Perea; Diego Fernndez; Yobana Arroyo; Dalila Betancur; Lady Pupo; Elkin A. Crdoba; C. Eugenio Ramrez; Ana Berta Arrieta; Alcides Rivero; Diana Carolina Mosquera; Nectty Lorena Conrado; Rosina Ortiz;, "Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab)] antivenoms, inbites inColombia", TOXICON, ELMSFORD, NY, US, US , (20111122), vol. 59, no. 2, doi:10.1016/j.toxicon.2011.11.017, ISSN 0041-0101, pages 344 - 355, XP028444133
OPPOSITION- Brian Kelley, "Industrialization of mAb production technology: The bioprocessing industry at a crossroads", mAbs, Landes Bioscience, US, US , (20090901), vol. 1, no. 5, doi:10.4161/mabs.1.5.9448, ISSN 1942-0862, pages 443 - 452, XP055344464

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