| DESCRIPTION | - AHMAD ET AL., CANCER RES., (1992), vol. 52, pages 4817 - 4820 |
| DESCRIPTION | - AMRANN ET AL., GENE, (1988), vol. 69, pages 301 - 315 |
| DESCRIPTION | - ANDERSON, SCIENCE, (1992), vol. 256, pages 808 - 813 |
| DESCRIPTION | - A.R. GRUBER ET AL., CELL, (2008), vol. 106, no. 1, pages 23 - 24 |
| DESCRIPTION | - BAE, T.; SCHNEEWIND, O., "Allelic replacement in Staphylococcus aureus with inducible counter-selection", PLASMID, (2006), vol. 55, pages 58 - 63 |
| DESCRIPTION | - BALDARI ET AL., EMBO J., (1987), vol. 6, pages 229 - 234 |
| DESCRIPTION | - BANEIJI ET AL., CELL, (1983), vol. 33, pages 729 - 740 |
| DESCRIPTION | - BARRANGOU, R., "RNA-mediated programmable DNA cleavage", NAT. BIOTECHNOL., (2012), vol. 30, pages 836 - 838 |
| DESCRIPTION | - BEHR ET AL., BIOCONJUGATE CHEM., (1994), vol. 5, pages 382 - 389 |
| DESCRIPTION | - BIKARD, D.; HATOUM-ASLAN, A.; MUCIDA, D.; MARRAFFINI, L.A., "CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection", CELL HOST MICROBE, (2012), vol. 12, pages 177 - 186 |
| DESCRIPTION | - BLAESE ET AL., CANCER GENE THER., (1995), vol. 2, pages 291 - 297 |
| DESCRIPTION | - BOGDANOVE, A.J.; VOYTAS, D.F., "TAL effectors: customizable proteins for DNA targeting", SCIENCE, (2011), vol. 333, pages 1843 - 1846 |
| DESCRIPTION | - BOSHART ET AL., CELL, (1985), vol. 41, pages 521 - 530 |
| DESCRIPTION | - BROUNS, S.J. ET AL., "Small CRISPR RNAs guide antiviral defense in prokaryotes", SCIENCE, (2008), vol. 321, pages 960 - 964 |
| DESCRIPTION | - BROUNS, S., "J. Molecular biology. A Swiss army knife of immunity", SCIENCE, (2012), vol. 337, pages 808 - 809 |
| DESCRIPTION | - BUCHSCHER ET AL., J. VIROL., (1992), vol. 66, pages 2731 - 2739 |
| DESCRIPTION | - BYRNE; RUDDLE, PROC. NEAL. ACAD. SCI. USA, (1989), vol. 86, pages 5473 - 5477 |
| DESCRIPTION | - CALAME; EATON, ADV. IMMUNOL., (1988), vol. 43, pages 235 - 275 |
| DESCRIPTION | - CAMPES; TILGHMAN, GENES DEV., (1989), vol. 3, pages 537 - 546 |
| DESCRIPTION | - CARROLL, D., "A CRISPR Approach to Gene Targeting", MOL. THER., (2012), vol. 20, pages 1658 - 1660 |
| DESCRIPTION | - CARTE, J.; WANG, R.; LI, H.; TERNS, R.M.; TERNS, M.P., "Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes", GENES DEV., (2008), vol. 22, pages 3489 - 3496 |
| DESCRIPTION | - COSTANTINO, N.; COURT, D.L., "Enhanced levels of lambda Red-mediated recombinants in mismatch repair mutants", PROC. NATL. ACAD. SCI. U.S.A., (2003), vol. 100, pages 15748 - 15753 |
| DESCRIPTION | - CRYSTAL, SCIENCE, (1995), vol. 270, pages 404 - 410 |
| DESCRIPTION | - DELTCHEVA, E. ET AL., "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", NATURE, (2011), vol. 471, pages 602 - 607 |
| DESCRIPTION | - DEVEAU, H. ET AL., "Phage response to CRISPR-encoded resistance in Streptococcus therniophilus", J. BACTERIOL., (2008), vol. 190, pages 1390 - 1400 |
| DESCRIPTION | - DEVEAU, H.; GARNEAU, J.E.; MOINEAU, S., "CRISPR-Cas system and its role in phage-bacteria interactions", ANNU. REV. MICROBIOL., (2010), vol. 64, pages 475 - 493 |
| DESCRIPTION | - DILLON, TIBTECH, (1993), vol. 11, pages 167 - 175 |
| DESCRIPTION | - EDGAR, R.; QIMRON, U., "The Escherichia coli CRISPR system protects from lambda lysogenization, lysogens, and prophage induction", J. BACTERIOL., (2010), vol. 192, pages 6291 - 6294 |
| DESCRIPTION | - EDLUND ET AL., SCIENCE, (1985), vol. 230, pages 912 - 916 |
| DESCRIPTION | - FISCHER, S. ET AL., "An archaeal immune system can detect multiple Protospacer Adjacent Motifs (PAMs) to target invader DNA", J. BIOL. CHEM., (2012), vol. 287, pages 33351 - 33363 |
| DESCRIPTION | - GAO ET AL., GENE THERAPY, (1995), vol. 2, pages 710 - 722 |
| DESCRIPTION | - GASIUNAS, PROC. NATL. ACAD. SCI. USA, (2012), vol. 109, page E2579 |
| DESCRIPTION | - GIBSON, D.G. ET AL., "Enzymatic assembly of DNA molecules up to several hundred kilobases", NAT METHODS, (2009), vol. 6, pages 343 - 345 |
| DESCRIPTION | - GIULIANO AVANZINI, JEFFREY L. NOEBELS, Genetics of Epilepsy and Genetic Epilepsies, MARIANI FOUNDATION PAEDIATRIC NEUROLOGY, (2009), page 20 |
| DESCRIPTION | - GOEDDEL, GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, ACADEMIC PRESS, (1990), vol. 185 |
| DESCRIPTION | - GROENEN ET AL., MOL. MICROBIOL., (1993), vol. 10, pages 1057 - 1065 |
| DESCRIPTION | - GRUBER ET AL., NUCLEIC ACIDS RESEARCH, (2008), vol. 36, page W70 |
| DESCRIPTION | - GUDBERGSDOTTIR, S. ET AL., "Dynamic properties of the Sulfolobus CRISPR-Cas and CRISPR/Cmr systems when challenged with vector-borne viral and plasmid genes and protospacers", MOL. MICROBIOL., (2011), vol. 79, pages 35 - 49 |
| DESCRIPTION | - GUSCHIN ET AL., METHODS MOL BIOL, (2010), vol. 649, page 247 |
| DESCRIPTION | - HATOUM-ASLAN, A.; MANIV, I.; MARRAFFINI, L.A., "Mature clustered, regularly interspaced, short palindromic repeats RNA (crRNA) length is measured by a ruler mechanism anchored at the precursor processing site", PROC. NEAL. ACAD. SCI. U.S.A., (2011), vol. 108, pages 21218 - 21222 |
| DESCRIPTION | - HAURWITZ, R.E.; JINEK, M.; WIEDENHEFT, B.; ZHOU, K.; DOUDNA, J.A., "Sequence- and structure-specific RNA processing by a CRISPR endonuclease", SCIENCE, (2010), vol. 329, pages 1355 - 1358 |
| DESCRIPTION | - HAVARSTEIN, L.S.; COOMARASWAMY, G.; MORRISON, D.A., "An unmodified heptadecapeptide pheromone induces competence for genetic transformation in Streptococcus pneumoniae", PROC. NEAL. ACAD. SCI. U.S.A., (1995), vol. 92, pages 11140 - 11144 |
| DESCRIPTION | - HERMONAT; MUZYCZKA, PNAS, (1984), vol. 81, pages 6466 - 6470 |
| DESCRIPTION | - HOE ET AL., EMERG. INFECT. DIS., (1999), vol. 5, pages 254 - 263 |
| DESCRIPTION | - HORINOUCHI, S.; WEISBLUM, B., "Nucleotide sequence and functional map of pC 194, a plasmid that specifies inducible chloramphenicol resistance", J. BACTERIOL., (1982), vol. 150, pages 815 - 825 |
| DESCRIPTION | - HORTON, R.M., "In Vitro Recombination and Mutagenesis of DNA : SOEing Together Tailor-Made Genes", METHODS MOL. BIOL., (1993), vol. 15, pages 251 - 261 |
| DESCRIPTION | - HORVATH, P.; BARRANGOU, R., "CRISPR-Cas, the immune system of bacteria and archaea", SCIENCE, (2010), vol. 327, pages 167 - 170 |
| DESCRIPTION | - HOSAKA, T. ET AL., "The novel mutation K87E in ribosomal protein S 12 enhances protein synthesis activity during the late growth phase in Escherichia coli", MOL. GENET. GENOMICS, (2004), vol. 271, pages 317 - 324 |
| DESCRIPTION | - HOSKINS, J. ET AL., "Genome of the bacterium Streptococcus pneunioniae strain R6", J. BACTERIOL., (2001), vol. 183, pages 5709 - 5717 |
| DESCRIPTION | - HUSMANN, L.K.; SCOTT, J.R.; LINDAHL, G.; STENBERG, L., "Expression of the Arp protein, a member of the M protein family, is not sufficient to inhibit phagocytosis of Streptococcus pyogenes", INFECTION AND IMMUNITY, (1995), vol. 63, pages 345 - 348 |
| DESCRIPTION | - ISHINO ET AL., J. BACTERIOL., (1987), vol. 169, pages 5429 - 5433 |
| DESCRIPTION | - JANSEN ET AL., MOL. MICROBIOL., (2002), vol. 43, pages 1565 - 1575 |
| DESCRIPTION | - JANSSEN ET AL., OMICS J. INTEG. BIOL., (2002), vol. 6, pages 23 - 33 |
| DESCRIPTION | - JINEK, M. ET AL., "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity", SCIENCE, (2012), vol. 337, pages 816 - 821 |
| DESCRIPTION | - JINEK, SCIENCE, (2012), vol. 337, page 816 |
| DESCRIPTION | - JOHANN ET AL., J. VIROL., (1992), vol. 66, pages 1635 - 1640 |
| DESCRIPTION | - KAUFMAN ET AL., EMBO J., (1987), vol. 6, pages 187 - 195 |
| DESCRIPTION | - KESSEL; GRUSS, SCIENCE, (1990), vol. 249, pages 374 - 379 |
| DESCRIPTION | - KOTIN, HUMAN GENE THERAPY, (1994), vol. 5, pages 793 - 801 |
| DESCRIPTION | - KREMER; PERRICAUDET, BRITISH MEDICAL BULLETIN, (1995), vol. 51, no. 1, pages 31 - 44 |
| DESCRIPTION | - KUIJAN; HERSKOWITZ, CELL, (1982), vol. 30, pages 933 - 943 |
| DESCRIPTION | - LUCKLOW; SUMMERS, VIROLOGY, (1989), vol. 170, pages 31 - 39 |
| DESCRIPTION | - MAKAROVA ET AL., NAT REV MICROBIOL, (2011), vol. 9, page 467 |
| DESCRIPTION | - MAKAROVA, K.S.; ARAVIND, L.; WOLF, Y.I.; KOONIN, E.V., "Unification of Cas protein families and a simple scenario for the origin and evolution ofCRISPR-Cas systems", BIOL. DIRECT., (2011), vol. 6, page 38 |
| DESCRIPTION | - MARRAFFINI, L.A.; DEDENT, A.C.; SCHNEEWIND, O, "Sortases and the art of anchoring proteins to the envelopes of gram-positive bacteria", MICROBIOL. MOL. BIOL. REV., (2006), vol. 70, pages 192 - 221 |
| DESCRIPTION | - MARRAFFINI, L.A.; SONTHEIMER, E.J., "Self versus non-self discrimination during CRISPR RNA-directed immunity", NATURE, (2010), vol. 463, pages 568 - 571 |
| DESCRIPTION | - MASEPOHL ET AL., BIOCHIM. BIOPHYS. ACTA, (1996), vol. 1307, pages 26 - 30 |
| DESCRIPTION | - MCLVOR EI; POLAK U; NAPIERALA M, "New insights into repeat instability: role of RNA*DNA hybrids", RNA BIOL., (201009), vol. 7, no. 5, pages 551 - 8 |
| DESCRIPTION | - ., METHODS IN ENZYMOLOGY, ACADEMIC PRESS, INC. |
| DESCRIPTION | - MILLER ET AL., J. VIROL., (1991), vol. 65, pages 2220 - 2224 |
| DESCRIPTION | - MILLER, NATURE, (1992), vol. 357, pages 455 - 460 |
| DESCRIPTION | - MITANI; CASKEY, TIBTECH, (1993), vol. 11, pages 162 - 166 |
| DESCRIPTION | - MOJICA ET AL., MOL. MICROBIOL., (1995), vol. 17, pages 85 - 93 |
| DESCRIPTION | - MOJICA ET AL., MOL. MICROBIOL., (2000), vol. 36, pages 244 - 246 |
| DESCRIPTION | - MOL. CELL. BIOL., (1988), vol. 8, no. 1, pages 466 - 472 |
| DESCRIPTION | - MORRELL ET AL., "Crop genomics:advances and applications", NAT REV GENET., (20111229), vol. 13, no. 2, pages 85 - 96 |
| DESCRIPTION | - MOTAMEDI, M.R.; SZIGETY, S.K.; ROSENBERG, S.M., "Double-strand-break repair recombination in Escherichia coli: physical evidence for a DNA replication mechanism in vivo", GENES DEV., (1999), vol. 13, pages 2889 - 2903 |
| DESCRIPTION | - MUZYCZKA, J. CLIN. INVEST., (1994), vol. 94, page 1351 |
| DESCRIPTION | - NABEL; FELGNER, TIBTECH, (1993), vol. 11, pages 211 - 217 |
| DESCRIPTION | - NAKAMURA, Y. ET AL., "Codon usage tabulated from the international DNA sequence databases: status for the year 2000", NUCL. ACIDS RES., (2000), vol. 28, page 292 |
| DESCRIPTION | - NAKATA ET AL., J. BACTERIOL, (1989), vol. 171, pages 3553 - 3556 |
| DESCRIPTION | - PA CARR; GM CHURCH, NATURE BIOTECHNOLOGY, (2009), vol. 27, no. 12, pages 1151 - 62 |
| DESCRIPTION | - PINKERT ET AL., GENES DEV., (1987), vol. 1, pages 268 - 277 |
| DESCRIPTION | - PODBIELSKI, A.; SPELLERBERG, B.; WOISCHNIK, M.; POHL, B.; LUTTICKEN, R., "Novel series of plasmid vectors for gene inactivation and expression analysis in group A streptococci (GAS", GENE, (1996), vol. 177, pages 137 - 147 |
| DESCRIPTION | - PROC. NATL. ACAD. SCI. USA., (1981), vol. 78, no. 3, pages 1527 - 31 |
| DESCRIPTION | - QUEEN; BALTIMORE, CELL, (1983), vol. 33, pages 741 - 748 |
| DESCRIPTION | - REMY ET AL., BIOCONJUGATE CHEM., (1994), vol. 5, pages 647 - 654 |
| DESCRIPTION | - SAMULSKI ET AL., J. VIROL., (1989), vol. 63, pages 03822 - 3828 |
| DESCRIPTION | - SAPRANAUSAKS ET AL., CUCLEIC ACIS RESEARCH, (2011), vol. 39, page 9275 |
| DESCRIPTION | - SCHULTZ ET AL., GENE, (1987), vol. 54, pages 113 - 123 |
| DESCRIPTION | - SEED, NATURE, (1987), vol. 329, page 840 |
| DESCRIPTION | - SHARAN, S.K.; THOMASON, L.C.; KUZNETSOV, S.G.; COURT, D.L., "Recombineering: a homologous recombination-based method of genetic engineering", NAT. PROTOC., (2009), vol. 4, pages 206 - 223 |
| DESCRIPTION | - SMITH ET AL., MOL. CELL. BIOL., (1983), vol. 3, pages 2156 - 2165 |
| DESCRIPTION | - SMITH; JOHNSON, GENE, (1988), vol. 67, pages 31 - 40 |
| DESCRIPTION | - SOMMNERFELT ET AL., VIROL., (1990), vol. 176, pages 58 - 59 |
| DESCRIPTION | - STODDARD, B.L., "Homing endonuclease structure and function", Q. REV. BIOPHYS, (2005), vol. 38, pages 49 - 95 |
| DESCRIPTION | - STUDIER ET AL., GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, ACADEMIC PRESS, (1990), vol. 185, pages 60 - 89 |
| DESCRIPTION | - SUNG, C.K.; LI, H.; CLAVERYS, J.P.; MORRISON, D.A., "An rpsL cassette, janus, for gene replacement through negative selection in Streptococcus pneumoniae", APPL. ENVIRON. MICROBIOL., (2001), vol. 67, pages 5190 - 5196 |
| DESCRIPTION | - TANGRI S ET AL., "Rationally engineered therapeutic proteins with reduced immunogenicity", J IMMUNOL., (20050315), vol. 174, no. 6, pages 3187 - 96 |
| DESCRIPTION | - TERNS, M.P.; TERNS, R.M., "CRISPR-based adaptive immune systems", CURR. OPIN. MICROBIOL., (2011), vol. 14, pages 321 - 327 |
| DESCRIPTION | - TRATSCHIN ET AL., MOL. CELL. BIOL., (1984), vol. 4, pages 2072 - 2081 |
| DESCRIPTION | - TRATSCHIN ET AL., MOL. CELL. BIOL., (1985), vol. 5, pages 3251 - 3260 |
| DESCRIPTION | - URNOV, F.D.; REBAR, E.J.; HOLMES, M.C.; ZHANG, H.S.; GREGORY, P.D., "Genome editing with engineered zinc finger nucleases", NAT. REV. GENET., (2010), vol. 11, pages 636 - 646 |
| DESCRIPTION | - VAN BRUNT, BIOTECHNOLOGY, (1988), vol. 6, no. 10, pages 1149 - 1154 |
| DESCRIPTION | - VAN DER OOST, J.; JORE, M.M.; WESTRA, E.R.; LUNDGREN, M.; BROUNS, S.J., "CRISPR-based adaptive and heritable immunity in prokaryotes", TRENDS. BIOCHEM. SCI., (2009), vol. 34, pages 401 - 407 |
| DESCRIPTION | - VAN EMBDEN ET AL., J. BACTERIOL., (2000), vol. 182, pages 2393 - 2401 |
| DESCRIPTION | - VIGNE, RESTORATIVE NEUROLOGY AND NEUROSCIENCE, (1995), vol. 8, pages 35 - 36 |
| DESCRIPTION | - WANG, H.H. ET AL., "Genome-scale promoter engineering by coselection MAGE", NAT METHODS, (2012), vol. 9, pages 591 - 593 |
| DESCRIPTION | - WEST ET AL., VIROLOGY, (1987), vol. 160, pages 38 - 47 |
| DESCRIPTION | - WILSON ET AL., J. VIROL., (1989), vol. 63, pages 2374 - 2378 |
| DESCRIPTION | - WINOTO; BALTIMORE, EMBO J., (1989), vol. 8, pages 729 - 733 |
| DESCRIPTION | - YU ET AL., GENE THERAPY, (1994), vol. 1, pages 13 - 26 |
| DESCRIPTION | - ZAHNER, D.; HAKENBECK, R., "The Streptococcus pneumoniae beta-galactosidase is a surface protein", J. BACTERIOL., (2000), vol. 182, pages 5919 - 5921 |
| DESCRIPTION | - ZUKER; STIEGLER, NUCLEIC ACIDS RES., (1981), vol. 9, pages 133 - 148 |
| OPPOSITION | - Anonymous, "Statement of Policy in regard to Intellectual Property", (20200204), (20221123), XP093001099 |
| OPPOSITION | - BIBIKOVA, Science, (20030000), vol. 300, page 764 |
| OPPOSITION | - BODEN, Mol Ther, (20040000), vol. 9, pages 396 - 402 |
| OPPOSITION | - BOGENHAGEN, Cell, (19810000), vol. 24, pages 261 - 270 |
| OPPOSITION | - BRAGLIA, The Journal of Biological Chemistry, (20050000), vol. 280, pages 19551 - 62 |
| OPPOSITION | - CAMACHO et al., "BLAST+: architecture and applications", BMC Bioinformatics, (20091215), vol. 10, page 421, XP021065535 |
| OPPOSITION | - CAMPEAU, Plos One, (20090000), vol. 4, page e6529 |
| OPPOSITION | - Cas9 Nuclease NLS, S. pyogenes, URL: https://www.neb.com/products/m0641-cas9-nuclease-nls-s- pyogenes#pdproperties-usage |
| OPPOSITION | - CERMAK, Nucleic Acids Res, (20110000), vol. 39, pages 1 - 11 |
| OPPOSITION | - Chen, C.P. Chou, J.C. Liu, B.R. Chang, M. Lee, H.J., "Transfection and expression of plasmid DNA in plant cells by an arginine-rich intracellular delivery peptide without protoplast preparation", FEBS Letters, ELSEVIER, AMSTERDAM., NL, NL , (20070421), vol. 581, no. 9, ISSN 0014-5793, pages 1891 - 1897, XP022041897 |
| OPPOSITION | - Chenfei Zhang ; Aijian Qin ; Hongjun Chen ; Xufang Deng ; Yuwen Su ; Kun Qian, "MDV-1 VP22: a transporter that can selectively deliver proteins into cells", Archives of Virology ; Official Journal of the Virology Divisionof the International Union of Microbiological Societies, Springer-Verlag, Vi, Vi , (20090604), vol. 154, no. 7, ISSN 1432-8798, pages 1027 - 1034, XP019722961 |
| OPPOSITION | - CHRISTIAN, Genetics, (20100000), vol. 186, pages 757 - 61 |
| OPPOSITION | - COURA, Virol. J., (20070000), vol. 4, page 99 |
| OPPOSITION | - CRISTEA, Biotechnology and Bioengineering, (20130000), vol. 110, pages 871 - 880 |
| OPPOSITION | - DAI, J Biol Chem, (20020000), vol. 277, pages 24390 - 24398 |
| OPPOSITION | - DINGWALL, CELL, (19820000), vol. 30, pages 449 - 58 |
| OPPOSITION | - DINGWALL, J Cell Biol, (19880000), vol. 107, pages 841 - 849 |
| OPPOSITION | - DO, FEBS Lett, (20060000), vol. 580, pages 1865 - 1871 |
| OPPOSITION | - ESPINOZA, RNA, (20070000), vol. 13, no. 4, pages 583 - 596 |
| OPPOSITION | - FIECK, Nucleic Acids Res, (19920000), vol. 29, pages 1785 - 1791 |
| OPPOSITION | - FISCHER-FANTUZZI, Mol Cell Biol, (19880000), vol. 8, pages 5495 - 5503 |
| OPPOSITION | - FOECKING, Gene, (19860000), vol. 45, pages 101 - 5 |
| OPPOSITION | - FREITAS, Current Genomics, (20090000), vol. 10, pages 550 - 557 |
| OPPOSITION | - GEIDUSCHEK, Ann Rev Biochem, (19880000), vol. 57, pages 873 - 914 |
| OPPOSITION | - GUNNERY, Molecular and Cellular Biology, (19950000), vol. 15, pages 3597 - 07 |
| OPPOSITION | - HAMADA, The Journal of Biological Chemistry, (20000000), vol. 275, pages 29076 - 29081 |
| OPPOSITION | - HÄNDEL, Human Gene Ther, (20120000), vol. 23, pages 321 - 329 |
| OPPOSITION | - HOCKEMEYER, Nature Biotechnology, (20110000), vol. 29, pages 731 - 734 |
| OPPOSITION | - IMAGAWA, FEBS Lett, (20000000), vol. 484, pages 118 - 124 |
| OPPOSITION | - JENSEN, Journal of Biomedical Science, (20110000), vol. 18, page 10 |
| OPPOSITION | - KALDERON, Cell, (19840000), vol. 39, pages 499 - 509 |
| OPPOSITION | - KETOLA, Cancer Res, (20080000), vol. 68, pages 8342 - 8350 |
| OPPOSITION | - KIM, Nat. Commun., (20170000), vol. 8, page 14500 |
| OPPOSITION | - Kyuhyung Han ; Min-Jae Jeon ; Kyeong-Ae Kim ; Jinseu Park ; Soo Young Choi, "Efficient Intracellular Delivery of GFP by Homeodomains of Drosophila Fushi-tarazu and Engrailed Proteins", MOLECULES AND CELLS, SEOUL, KR, KR , (20010101), vol. 10, no. 6, ISSN 1016-8478, pages 728 - 732, XP019361393 |
| OPPOSITION | - LANGE, J Biol Chem, (20070000), vol. 282, pages 5101 - 5105 |
| OPPOSITION | - LEE, Infection and Immunity, (20030000), vol. 71, pages 1491 - 1496 |
| OPPOSITION | - LEMAY, Chem. Biol., (20060000), vol. 13, no. 8, pages 857 - 868 |
| OPPOSITION | - LIEBER, Annu Rev Biochem, (20100000), vol. 79, pages 181 - 211 |
| OPPOSITION | - LOMBARDO, Nature Biotech, (20070000), vol. 25, pages 1298 - 1306 |
| OPPOSITION | - LUO, Traffic, (20040000), vol. 5, pages 847 - 854 |
| OPPOSITION | - MARESCA, Genome Research, (20130000), vol. 23, pages 539 - 546 |
| OPPOSITION | - MAZABRAUD, J Mol Biol, (19870000), vol. 195, pages 835 - 845 |
| OPPOSITION | - MILLER, Nature Biotechnology, (20110000), vol. 29, pages 143 - 48 |
| OPPOSITION | - MIYAGISHI, Nature Biotechnology, (20020000), vol. 19, pages 497 - 500 |
| OPPOSITION | - PARK, J Biol Chem, (20020000), vol. 277, pages 31423 - 31429 |
| OPPOSITION | - PATTERSON, J Ind Microbiol. Biotechnol, (20050000), vol. 32, pages 115 - 123 |
| OPPOSITION | - PLANEY, J Biol Chem, (20020000), vol. 277, pages 42188 - 42196 |
| OPPOSITION | - PORTEUS, Science, (20030000), vol. 300, page 763 |
| OPPOSITION | - Rao, Et Al, "Significance of mRNA AND siRNA Secondary Structures on RNA Interference Efficiency.", Conference paper from IEEE Kerala Section National Seminar on Bioinformatics, (20050101), Conference paper from IEEE Kerala Section National Seminar on Bioinformatics, (20200224), XP055671088 |
| OPPOSITION | - RAYMOND, PLoS One, (20070000), vol. 2, page e162 |
| OPPOSITION | - REBAR, Nature Medicine, (20020000), vol. 8, pages 1427 - 32 |
| OPPOSITION | - ROBERTS, Cell, (19870000), vol. 50, pages 465 - 475 |
| OPPOSITION | - RUBEN S, ET AL., "STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF HUMAN IMMUNODEFICIENCY VIRUS TAT PROTEIN", Journal of Virology, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, US , (19890101), vol. 63, no. 01, ISSN 0022-538X, pages 01 - 08, XP009013914 |
| OPPOSITION | - SALOMON, The EMBO Journal, (19980000), vol. 17, pages 6086 - 6095 |
| OPPOSITION | - SATO, Biosci Biotechnol Biochem, (20090000), vol. 73, pages 2145 - 2148 |
| OPPOSITION | - SCHOULS, J. Clin. Microbiol., (20030000), vol. 41, pages 15 - 26 |
| OPPOSITION | - SCHRAMM, Genes Dev, (20020000), vol. 16, pages 2593 - 2620 |
| OPPOSITION | - SHIEH, Plant Physiol, (19930000), vol. 101, pages 353 - 361 |
| OPPOSITION | - TINLAND, PNAS, (19920000), vol. 89, pages 7442 - 7446 |
| OPPOSITION | - TRUANT R, CULLEN B R, "The arginine-rich domains present in human immunodeficiency virus type 1 tat and rev function as direct importin B-dependent nuclear localization signals", MOLECULAR AND CELLULAR BIOLOGY, American Society for Pharmacology and Experimental Therapeutics, US, US , (19990201), vol. 19, no. 2, ISSN 0270-7306, pages 1210 - 1217, XP002964815 |
| OPPOSITION | - URL: http://www.addgene.org/vector- database/4288 |
| OPPOSITION | - VAN DEN ACKERVEKEN, Cell, (19960000), vol. 8, pages 1307 - 1316 |
| OPPOSITION | - WALSH et al., "A variant CRISPR-Cas9 system adds versatility to genome engineering", PNAS, (20130924), vol. 110, no. 39, pages 15514 - 15515, XP055338779 |
| OPPOSITION | - WOLFF, Nature Biotechnology, (20010000), vol. 19, pages 1118 - 1120 |
| OPPOSITION | - WU, Molecular Therapy, (20100000), vol. 18, pages 80 - 86 |
| OPPOSITION | - Y. Naito ; K. Nishi ; A. Juni ; K. Ui-Tei, "Functional shRNA expression system with reduced off-target effects", Micro-NanoMechatronics and Human Science, 2009. MHS 2009. International Symposium on, IEEE, Piscataway, NJ, USA, Piscataway, NJ, USA , (20091109), ISBN 978-1-4244-5094-7, pages 291 - 297, XP031579409 |
| OPPOSITION | - ZHU, Virology Journal, (20110000), vol. 8, page 344 |
| OPPOSITION | - Céline Souilhol, Sarah Cormier, Marie Monet, Sandrine Vandormael-Pournin, Anne Joutel, Charles Babinet, Michel Cohen-Tannoudji, "Nas transgenic mouse line allows visualization of Notch pathway activity in vivo", genesis, Wiley-Liss, (20060601), vol. 44, no. 6, doi:10.1002/dvg.20208, ISSN 1526-954X, pages 277 - 286, XP055502571 |
| OPPOSITION | - Archana Chugh, François Eudes, Youn-Seb Shim, "Cell-penetrating peptides: Nanocarrier for macromolecule delivery in living cells", IUBMB Life, Published for the International Union of Biochemistry and Molecular Biology by Taylor & Francis, (20100325), vol. 62, no. 3, doi:10.1002/iub.297, ISSN 15216543, pages 183 - 193, XP055071760 |
| OPPOSITION | - Daisuke Furutama, Morita Noriyuki, Takano Riya, Sekine Yukiko, Sadakata Tetsushi, Shinoda Yo, Hayashi Kanehiro, Mishima Yuriko, Mikoshiba Katsuhiko, Hawkes Richard, Furuichi Teiichi, "Expression of the IP3R1 promoter-driven nls-lacZ transgene in Purkinje cell parasagittal arrays of developing mouse cerebellum", Journal of Neuroscience Research, WILEY-LISS, US, US , (20100101), vol. 88, doi:10.1002/jnr.22451, ISSN 0360-4012, pages 2810 - 2825, XP055502574 |
| OPPOSITION | - MI Z, ET AL., "CHARACTERIZATION OF A CLASS OF CATIONIC PEPTIDES ABLE TO FACILITATEEFFICIENT PROTEIN TRANSDUCTION IN VITRO AND IN VIVO", Molecular Therapy, Elsevier Inc., US, US , (20001001), vol. 02, no. 04, doi:10.1006/mthe.2000.0137, ISSN 1525-0016, pages 339 - 347, XP001004549 |
| OPPOSITION | - Ranieri Bizzarri; Francesco Cardarelli; Michela Serresi; Fabio Beltram, "Fluorescence recovery after photobleaching reveals the biochemistry of nucleocytoplasmic exchange", Analytical and Bioanalytical Chemistry, Springer, Berlin, DE, Berlin, DE , (20120515), vol. 403, no. 8, doi:10.1007/s00216-012-6025-4, ISSN 1618-2650, pages 2339 - 2351, XP035069015 |
| OPPOSITION | - Rémy Séverine, Tesson Laurent, Ménoret Séverine, Usal Claire, Scharenberg Andrew M., Anegon Ignacio, "Zinc-finger nucleases: a powerful tool for genetic engineering of animals", Transgenic Research, Kluwer Academic Publishers-Plenum Publishers, Ne, Ne , (20100601), vol. 19, no. 3, doi:10.1007/s11248-009-9323-7, ISSN 1573-9368, pages 363 - 371, XP019831645 |
| OPPOSITION | - SMITH et al., "Identification of common molecular subsequences", Journal of Molecular Biology, (19810325), vol. 147, no. 1, doi:10.1016/0022-2836(81)90087-5, pages 195 - 197, XP024015032 |
| OPPOSITION | - BOGENHAGEN et al., "Nucleotide sequences in Xenopus 5S DNA required for transcription termination", Cell, (19810000), vol. 24, no. 1, doi:10.1016/0092-8674(81)90522-5, pages 261 - 270, XP023912594 |
| OPPOSITION | - Pablo Perez-Pinera, David G Ousterout, Charles A Gersbach, "Advances in targeted genome editing", Current Opinion in Chemical Biology, Elsevier Current Trends, (20120801), vol. 16, no. 3-4, doi:10.1016/j.cbpa.2012.06.007, ISSN 13675931, pages 268 - 277, XP055065262 |
| OPPOSITION | - Wang Haoyi; Yang Hui; Shivalila Chikdu S.; Dawlaty Meelad M.; Cheng Albert W.; Zhang Feng; Jaenisch Rudolf, "One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (20130509), vol. 153, no. 4, doi:10.1016/j.cell.2013.04.025, ISSN 0092-8674, pages 910 - 918, XP028538358 |
| OPPOSITION | - Luke a. Gilbert, Matthew h. Larson, Leonardo Morsut, Zairan Liu, Gloria a. Brar, Sandra e. Torres, Noam Stern-Ginossar, Onn Brandman, Evan h. Whitehead, Jennifer a. Doudna, Wendell a. Lim, Jonathan s. Weissman, Lei s. Qi, "CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (20130718), vol. 154, no. 2, doi:10.1016/j.cell.2013.06.044, ISSN 0092-8674, pages 442 - 451, XP055115843 |
| OPPOSITION | - Claudio Mussolino, Toni Cathomen, "TALE nucleases: tailored genome engineering made easy", Current Opinion in Biotechnology, Elsevier Current Trends, (20121001), vol. 23, no. 5, doi:10.1016/j.copbio.2012.01.013, ISSN 09581669, pages 644 - 650, XP055071668 |
| OPPOSITION | - Goldfarb, D.S. Corbett, A.H. Mason, D.A. Harreman, M.T. Adam, S.A., "Importin α: a multipurpose nuclear-transport receptor", TRENDS IN CELL BIOLOGY., ELSEVIER SCIENCE LTD., XX, XX , (20040901), vol. 14, no. 9, doi:10.1016/j.tcb.2004.07.016, ISSN 0962-8924, pages 505 - 514, XP004552656 |
| OPPOSITION | - Yang, Y. Ma, J. Song, Z. Wu, M., "HIV-1 TAT-mediated protein transduction and subcellular localization using novel expression vectors", FEBS Letters, ELSEVIER, AMSTERDAM., NL, NL , (20021204), vol. 532, no. 1-2, doi:10.1016/S0014-5793(02)03624-4, ISSN 0014-5793, pages 36 - 44, XP004395339 |
| OPPOSITION | - KARRAN P, "DNA DOUBLE STRAND BREAK REPAIR IN MAMMALIAN CELLS", CURRENT OPINION IN GENETICS & DEVELOPMENT., CURRENT BIOLOGY LTD., XX, XX , (20000401), vol. 10, no. 02, doi:10.1016/S0959-437X(00)00069-1, ISSN 0959-437X, pages 144 - 150, XP001206008 |
| OPPOSITION | - Manuela Villion, Sylvain Moineau, "The double-edged sword of CRISPR-Cas systems", Cell Research, (20130101), vol. 23, no. 1, doi:10.1038/cr.2012.124, ISSN 10010602, pages 15 - 17, XP055086684 |
| OPPOSITION | - Xinli Hu, Nannan Chang, Xuelian Wang, Fengyun Zhou, Xiaohai Zhou, Xiaojun Zhu, Jing-Wei Xiong, "Heritable gene-targeting with gRNA/Cas9 in rats", Cell Research, Springer Singapore, Singapore, Singapore , (20131101), vol. 23, no. 11, doi:10.1038/cr.2013.141, ISSN 1001-0602, pages 1322 - 1325, XP055669081 |
| OPPOSITION | - ELLIS et al., "Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs", Gene Ther., vol. 20, no. 1, doi:10.1038/gt.2011.211, (20120119), pages 35 - 42, XP002730955 |
| OPPOSITION | - WU et al., "Effect of Genome Size on AAV Vector Packaging", Molecular Therapy, vol. 18, no. 1, doi:10.1038/mt.2009.255, (20091110), pages 80 - 86, XP055235504 |
| OPPOSITION | - LAI et al., "Evidence for the Failure of Adeno- associated Virus Serotype 5 to Package a Viral Genome >= 8.2 kb", Molecular Therapy, vol. 18, no. 1, doi:10.1038/mt.2009.256, (20091110), pages 75 - 79, XP055217887 |
| OPPOSITION | - DONG et al., "Characterization of Genome Integrity for Oversized Recombinant AAV Vector", Molecular Therapy, vol. 18, no. 1, doi:10.1038/mt.2009.258, (20091110), pages 87 - 92, XP055183270 |
| OPPOSITION | - HIRSCH et al., "Little Vector, Big Gene Transduction: Fragmented Genome Reassembly of Adeno-associated Virus", Molecular Therapy, (20100101), vol. 18, no. 1, doi:10.1038/mt.2009.280, pages 6 - 8, XP055312618 |
| OPPOSITION | - DELTCHEVA et al., "CRISPR RNA maturation by trans- encoded small RNA and host factor RNase III", Nature, (20110331), vol. 471, no. 7340, doi:10.1038/nature09886, pages 602 - 607, XP055619637 |
| OPPOSITION | - Elitza Deltcheva, Krzysztof Chylinski, Cynthia M. Sharma, Karine Gonzales, Yanjie Chao, Zaid A. Pirzada, Maria R. Eckert, Jörg Vogel, Emmanuelle Charpentier, "CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III", Nature, Nature Publishing Group UK, London, London, (20110331), vol. 471, no. 7340, doi:10.1038/nature09886, ISSN 0028-0836, pages 602 - 607,2pp, XP055068535 |
| OPPOSITION | - Li H, Haurigot V, Doyon Y, Li T, Wong S Y, Bhagwat A S, Malani N, Anguela X M, Sharma R, Ivanciu L, Murphy S L, Finn J D, Khazi F R, Zhou S, Paschon D E, Rebar E J, Bushman F D, Gregory P D, Holmes M C, High K A, "In vivo genome editing restores haemostasis in a mouse model of haemophilia", Nature, Nature Publishing Group UK, London, London, (20110714), vol. 475, no. 7355, doi:10.1038/nature10177, ISSN 0028-0836, pages 217 - 221, XP002688791 |
| OPPOSITION | - Victoria M. Bedell, Ying Wang, Jarryd M. Campbell, Tanya L. Poshusta, Colby G. Starker, Randall G. Krug Ii, Wenfang Tan, Sumedha G. Penheiter, Alvin C. Ma, Anskar Y. H. Leung, Scott C. Fahrenkrug, Daniel F. Carlson, Daniel F. Voytas, Karl J. Clark, Jeffrey J. Essner, Stephen C. Ekker, "In vivo genome editing using a high-efficiency TALEN system", Nature, ¬Macmillan Journals Ltd., etc.|, (20120101), vol. 491, no. 7422, doi:10.1038/nature11537, ISSN 00280836, pages 114 - 118, XP055048281 |
| OPPOSITION | - Xiaoxia Cui, Diana Ji, Daniel A Fisher, Yumei Wu, David M Briner, Edward J Weinstein, "Targeted integration in rat and mouse embryos with zinc-finger nucleases", Nature Biotechnology, Gale Group Inc., (20110101), vol. 29, no. 1, doi:10.1038/nbt.1731, ISSN 10870156, pages 64 - 67, XP055065200 |
| OPPOSITION | - Laurent Tesson, Claire Usal, Séverine Ménoret, Elo Leung, Brett J Niles, Séverine Remy, Yolanda Santiago, Anna I Vincent, Xiangdong Meng, Lei Zhang, Philip D Gregory, Ignacio Anegon, Gregory J Cost, "Knockout rats generated by embryo microinjection of TALENs.", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20110801), vol. 29, no. 8, doi:10.1038/NBT.1940, ISSN 1087-0156, pages 695 - 696, XP002681970 |
| OPPOSITION | - Rodolphe Barrangou, "RNA-mediated programmable DNA cleavage", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20120910), vol. 30, no. 9, doi:10.1038/nbt.2357, ISSN 1087-0156, pages 836 - 838, XP055118675 |
| OPPOSITION | - HWANG et al., "Efficient genome editing in zebrafish using a CRISPR-Cas system", Nature Biotechnology, (20130129), vol. 31, no. 3, doi:10.1038/nbt.2501, pages 227 - 229, XP055086625 |
| OPPOSITION | - Woong Y Hwang, Yanfang Fu, Deepak Reyon, Morgan L Maeder, Shengdar Q Tsai, Jeffry D Sander, Randall T Peterson, J-R Joanna Yeh, J Keith Joung, "Efficient genome editing in zebrafish using a CRISPR-Cas system", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20130301), vol. 31, no. 3, doi:10.1038/nbt.2501, ISSN 1087-0156, pages 227 - 229, XP055540933 |
| OPPOSITION | - Seung Woo Cho, Sojung Kim, Jong Min Kim, Jin-Soo Kim, "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease (includes Supplementary information)", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20130301), vol. 31, no. 3, doi:10.1038/nbt.2507, ISSN 1087-0156, pages 230 - 232+1-11, XP002699850 |
| OPPOSITION | - Patrick D Hsu, David A Scott, Joshua A Weinstein, F Ann Ran, Silvana Konermann, Vineeta Agarwala, Yinqing Li, Eli J Fine, Xuebing Wu, Ophir Shalem, Thomas J Cradick, Luciano A Marraffini, Gang Bao, Feng Zhang, "DNA targeting specificity of RNA-guided Cas9 nucleases (includes online Methods)", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20130721), vol. 31, no. 9, doi:10.1038/nbt.2647, ISSN 1087-0156, pages 827 - 832+2PP, XP055382777 |
| OPPOSITION | - ESVELT et al., "Orthogonal Cas9 proteins for RNA-guided gene regulation and editing", Nature Methods, (20130929), vol. 10, no. 11, doi:10.1038/nmeth.2681, pages 1116 - 1121, XP055128928 |
| OPPOSITION | - Fyodor D. Urnov, Edward J. Rebar, Michael C. Holmes, H. Steve Zhang & Philip D. Gregory, "Genome editing with engineered zinc finger nucleases", Nature Reviews: Genetics, Nature Publishing Group, United Kingdom, United Kingdom , (20100901), vol. 11, no. 9, doi:10.1038/nrg2842, ISSN 1471-0064, pages 636 - 646, XP008150557 |
| OPPOSITION | - J. Keith Joung, Sander Jeffry D., "TALENs: a widely applicable technology for targeted genome editing", Nature Reviews Molecular Cell Biology, Nature Publishing Group UK, London, London, vol. 14, no. 1, doi:10.1038/nrm3486, ISSN 1471-0072, pages 49 - 55, XP055282847 |
| OPPOSITION | - Makarova Kira S; Haft Daniel H; Barrangou Rodolphe; Brouns Stan J J; Charpentier Emmanuelle; Horvath Philippe; Moineau Sylvain; Mojica Francisco J M; Wolf Yuri I; Yakunin Alexander F; van der Oost John; Koonin Eugene V, "Evolution and classification of the CRISPR-Cas systems", Nature Reviews Microbiology, NATURE PUBLISHING GROUP, GB, GB , (20110509), vol. 9, no. 6, doi:10.1038/nrmicro2577, ISSN 1740-1526, pages 467 - 477, XP009155547 |
| OPPOSITION | - Thomas Laumonier, Sheng Yang, Stephane Konig, Christine Chauveau, Ignacio Anegon, Pierre Hoffmeyer and Jacques Menetrey, "Lentivirus mediated HO-1 gene transfer enhances myogenic precursor cell survival after autologous transplantation in pig", Molecular Therapy, Elsevier Inc., US, US , (20080201), vol. 16, no. 2, doi:10.1038/sj.mt.6300354, ISSN 1525-0016, pages 404 - 410, XP008159717 |
| OPPOSITION | - MOEHLE E A, ET AL, "Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases + corrections", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20070201), vol. 104, no. 9, doi:10.1073/PNAS.0611478104, ISSN 0027-8424, pages 3055 - 3060, 6090, XP002518477 |
| OPPOSITION | - BEUMER KELLY J ET AL, "Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases.", PNAS, Proceedings of the National Academy of Sciences, National Academy of Sciences, US, US , (20081216), vol. 105, no. 50, doi:10.1073/pnas.0810475105, ISSN 1091-6490, pages 19821 - 19826, XP002782686 |
| OPPOSITION | - Feng Liang, Han Mingguang, Romanienko Peter J, Jasin Maria, Radding Charles M, "Homology-directed repair is a major double-strand break repair pathway in mammalian cells", Genetics and approved February, (19980401), vol. 95, no. 18, doi:10.1073/pnas.95.9.5172, pages 5172 - 5177, XP055502633 |
| OPPOSITION | - Daniele Derossi, Sophie Calvet, Alain Trembleau, Alié Brunissen, Gérard Chassaing and Alain Prochiantz, "Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (19960726), vol. 271., no. 30., doi:10.1074/jbc.271.30.18188, ISSN 0021-9258, pages 18188 - 18193, XP002024485 |
| OPPOSITION | - EFTHYMIADIS A, BRIGGS L J, JANS D A, "The HIV-1 tat nuclear localization sequence confers novel nuclear import properties", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (19980116), vol. 273, no. 3, doi:10.1074/jbc.273.3.1623, ISSN 0021-9258, pages 1623 - 1628, XP003000854 |
| OPPOSITION | - Alec E. Hodel, Michelle T. Harreman, Kanika F. Pulliam, Mary Elizabeth Harben, Jordan S. Holmes, Mary R. Hodel, Keith M. Berland, Anita H. Corbett, "Nuclear Localization Signal Receptor Affinity Correlates with in Vivo Localization in Saccharomyces cerevisiae", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20060818), vol. 281, no. 33, doi:10.1074/jbc.M601718200, ISSN 0021-9258, pages 23545 - 23556, XP055502581 |
| OPPOSITION | - HANDEL et al., "Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors", Human Gene Ther, (20111007), vol. 23, doi:10.1089/hum.2011.140, pages 321 - 329, XP002730956 |
| OPPOSITION | - WANG et al., "A web-based design center for vector-based siRNA and siRNA cassette", Bioinformatics, (20040304), vol. 20, no. 11, doi:10.1093/bioinformatics/bth164, pages 1818 - 1820, XP002316491 |
| OPPOSITION | - Holger Puchta, "The repair of double-strand breaks in plants: mechanisms and consequences for genome evolution", JOURNAL OF EXPERIMENTAL BOTANY, OXFORD UNIVERSITY PRESS, GB, GB , (20041122), vol. 56, no. 409, doi:10.1093/jxb/eri025, ISSN 0022-0957, pages 1 - 14, XP002394840 |
| OPPOSITION | - GRISSA et al., "CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats", Nucleic Acids Res., (20070700), vol. 35, doi:10.1093/nar/gkm360, pages W52 - W57, XP002490217 |
| OPPOSITION | - S. J. Orlando, Santiago Y., Dekelver R. C., Freyvert Y., Boydston E. A., Moehle E. A., Choi V. M., Gopalan S. M., Lou J. F., Li J., Miller J. C., Holmes M. C., Gregory P. D., Urnov F. D., Cost G. J., "Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology", Nucleic Acids Research, Oxford University Press, GB, GB , (20100801), vol. 38, no. 15, doi:10.1093/nar/gkq512, ISSN 0305-1048, pages e152 - e152 - 15, XP055076783 |
| OPPOSITION | - James E Dicarlo, Norville J E; Mali P; Rios X; Aach J; Church G M, "Supplemental Data to Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems", Nucleic Acids Research, Oxford University Press, GB, GB , (20130401), vol. 41, no. 7, doi:10.1093/nar/gkt135, ISSN 0305-1048, pages 1 - 5, XP055604254 |
| OPPOSITION | - AGUDELO et al., "Versatile and robust genome editing with Streptococcus thermophilus CRISPR1- Cas9", Genome Res., vol. 30, doi:10.1101/gr.255414.119, (20200103), pages 107 - 117, XP055752359 |
| OPPOSITION | - GEURTS ARON M ET AL, "Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases", Science, American Association for the Advancement of Science, US, US , (20090724), vol. 325, no. 5939, doi:10.1126/SCIENCE.1172447, ISSN 0036-8075, page 433, XP002580718 |
| OPPOSITION | - JINEK et al., "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity", Science, (20120628), vol. 337, doi:10.1126/science.1225829, pages 816 - 821, XP055229606 |
| OPPOSITION | - JINEK et al., "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, (20120817), vol. 337, doi:10.1126/science.1225829, pages 816 - 821, XP055229606 |
| OPPOSITION | - M. Jinek, K. Chylinski, I. Fonfara, M. Hauer, J. A. Doudna, E. Charpentier, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, American Association for the Advancement of Science, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 00368075, pages 816 - 821, XP055067740 |
| OPPOSITION | - BROUNS, "A Swiss Army Knife of Immunity", Science, (20120817), vol. 337, doi:10.1126/science.1227253, pages 808 - 809, XP055113718 |
| OPPOSITION | - S. J. J. Brouns, "A Swiss Army Knife of Immunity", Science, American Association for the Advancement of Science, (20120817), vol. 337, no. 6096, doi:10.1126/science.1227253, ISSN 00368075, pages 808 - 809, XP055113718 |
| OPPOSITION | - CONG et al., "Multiplex genome engineering using CRISPR/Cas systems", Science, (20130103), vol. 339, doi:10.1126/science.1231143, pages 819 - 823, XP055300065 |
| OPPOSITION | - CONG et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, vol. 339, doi:10.1126/science.1231143, (20130103), pages 819 - 823, XP055300065 |
| OPPOSITION | - S. Cong Et Al, "Multiplex genome engineering using CRISPR/Cas systems", Science, American Association for the Advancement of Science, US, US , (20130103), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055300065 |
| OPPOSITION | - MALI et al., "RNA-guided human genome engineering via Cas9", Science, (20130103), vol. 339, doi:10.1126/science.1232033, pages 823 - 826, XP055362871 |
| OPPOSITION | - Mali P; Yang L; Esvelt K M; Aach J; Guell M; Dicarlo J E; Norville J E; Church G M, "RNA Guided Human Genome Engineering via Cas9", Science, American Association for the Advancement of Science, US, US , (20130215), vol. 339, no. 6121, doi:10.1126/science.1232033, ISSN 0036-8075, pages 823 - 826, XP055469277 |
| OPPOSITION | - ROUET P., SMIH F., JASIN M., "Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease.", MOLECULAR AND CELLULAR BIOLOGY, American Society for Pharmacology and Experimental Therapeutics, US, US , (19941201), vol. 14., no. 12., doi:10.1128/mcb.14.12.8096, ISSN 0270-7306, pages 8096 - 8106, XP000572018 |
| OPPOSITION | - D. G. Miller, L. M. Petek, D. W. Russell, "Human Gene Targeting by Adeno-Associated Virus Vectors Is Enhanced by DNA Double-Strand Breaks", MOLECULAR AND CELLULAR BIOLOGY, American Society for Pharmacology and Experimental Therapeutics, US, US , (20030515), vol. 23, no. 10, doi:10.1128/MCB.23.10.3550-3557.2003, ISSN 0270-7306, pages 3550 - 3557, XP055502623 |
| OPPOSITION | - N Rudin, J E Haber, "Efficient repair of HO-induced chromosomal breaks in Saccharomyces cerevisiae by recombination between flanking homologous sequences", Molecular and Cellular Biology, American Society for Microbiology, United States, United States , doi:10.1128/MCB.8.9.3918, (19880901), pages 3918 - 3928, Molecular and Cellular Biology, URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC365451/pdf/molcellb00069-0358.pdf, XP055502440 |
| OPPOSITION | - Jensen Nanna M; Dalsgaard Trine; Jakobsen Maria; Nielsen Roni R; SÃ ̧rensen Charlotte B; Bolund Lars; Jensen Thomas G, "An update on targeted gene repair in mammalian cells: methods and mechanisms", Journal of Biomedical Science, Kluwer Academic Publishers, Do, Do , (20110202), vol. 18, no. 1, doi:10.1186/1423-0127-18-10, ISSN 1423-0127, pages 1 - 10, XP021085735 |
| OPPOSITION | - Brice V McConnell;Karen Koto;Arthur Gutierrez-Hartmann, "Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression", MOLECULAR CANCER, BIOMED CENTRAL, LONDON, GB, GB , (20110618), vol. 10, no. 1, doi:10.1186/1476-4598-10-75, ISSN 1476-4598, pages 1 - 13, XP021103688 |
| OPPOSITION | - Kira S Makarova;L Aravind;Yuri I Wolf;Eugene V Koonin, "Unification of Cas protein families and a simple scenario for the origin and evolution of CRISPR-Cas systems", Biology Direct, BioMed Central, (20110714), vol. 6, no. 1, doi:10.1186/1745-6150-6-38, ISSN 1745-6150, pages 1 - 27, XP021105829 |
| OPPOSITION | - Chieh Chang, Yi-Wen Hsieh, Bluma J. Lesch, Cornelia I. Bargmann, Chiou-Fen Chuang, "Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans", Development, The Company of Biologists Ltd., GB, GB , (20110815), vol. 138, no. 16, doi:10.1242/dev.069740, ISSN 0950-1991, pages 3509 - 3518, XP055502632 |
| OPPOSITION | - D. Carroll, "Genome Engineering With Zinc-Finger Nucleases", Genetics, Genetics Society of America [etc.], (20110801), vol. 188, no. 4, doi:10.1534/genetics.111.131433, ISSN 00166731, pages 773 - 782, XP055036700 |
| OPPOSITION | - S. J. Gratz, A. M. Cummings, J. N. Nguyen, D. C. Hamm, L. K. Donohue, M. M. Harrison, J. Wildonger, K. M. O'connor-Giles, "Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease", Genetics, Genetics Society of America [etc.], (20130801), vol. 194, no. 4, doi:10.1534/genetics.113.152710, ISSN 00166731, pages 1029 - 1035, XP055102690 |
| OPPOSITION | - Z. Yu, M. Ren, Z. Wang, B. Zhang, Y. S. Rong, R. Jiao, G. Gao, "Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila (includes Supporting Information)", GENETICS, GENETICS SOCIETY OF AMERICA, AUSTIN, TX, US, US , (20130901), vol. 195, no. 1, doi:10.1534/genetics.113.153825, ISSN 0016-6731, pages 289 - 291,1-14, XP055242275 |
| OPPOSITION | - Nicholas Lyssenko, Hanna-Rose Wendy, Schlegel Robert, "Cognate putative nuclear localization signal effects strong nuclear localization of a GFP reporter and facilitates gene expression studies in Caenorhabditis elegans", Biotechniques, Informa Healthcare, US, US , (20071101), vol. 43, no. 5, doi:10.2144/000112615, ISSN 0736-6205, pages 596 - 600, XP055268137 |
| OPPOSITION | - NOGUCHI HIROFUMI ET AL, "PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells.", Diabetes, American Diabetes Association, US, US , (20030701), vol. 52, no. 7, doi:10.2337/diabetes.52.7.1732, ISSN 0012-1797, pages 1732 - 1737, XP002354481 |
| OPPOSITION | - CHYLINSKI et al., "The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems", RNA Biology, vol. 10, no. 5, doi:10.4161/rna.24321, (20130405), pages 726 - 737, XP055116068 |
| OPPOSITION | - JINEK et al., "RNA- programmed genome editing in human cells", eLife, vol. 2, doi:10.7554/eLife.00471, (20130129), page e00471, URL: http://elifesciences.org/content/2/e00471, XP002699851 |
| OPPOSITION | - Martin Jinek, Alexandra East, Aaron Cheng, Steven Lin, Enbo Ma, Jennifer Doudna, "RNA-programmed genome editing in human cells", eLife, eLife Sciences Publications Ltd., GB, GB , (20130129), vol. 2, doi:10.7554/eLife.00471, ISSN 2050-084X, pages 1 - 9, XP055245475 |
| SEARCH | - WANG HAOYI ET AL, "One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering", CELL, (20130509), vol. 153, no. 4, doi:10.1016/J.CELL.2013.04.025, ISSN 0092-8674, pages 910 - 918, XP028538358 [IP] 1-27 * abstract * |
| SEARCH | - LUKE A. GILBERT ET AL, "CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes", CELL, (20130701), vol. 154, no. 2, doi:10.1016/j.cell.2013.06.044, ISSN 0092-8674, pages 442 - 451, XP055115843 [IP] 1-27 * abstract * |
| SEARCH | - GAJ THOMAS ET AL, "ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering", TRENDS IN BIOTECHNOLOGY, (20130701), vol. 31, no. 7, doi:10.1016/J.TIBTECH.2013.04.004, ISSN 0167-7799, pages 397 - 405, XP028571313 [IP] 1-27 * the whole document * |
| SEARCH | - M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055067740 [A] 1-27 * the whole document * |
| SEARCH | [Â ] - M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity (Supplementary Material)", SCIENCE, (20120628), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055067747 [Â ] * figures S7, S8, S11; table S1 * |
| SEARCH | - L. CONG ET AL, "Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130215), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055102030 [XP] 1-27 * abstract * * page 820, column l * |
| SEARCH | - L. CONG ET AL, "Supplementary Material to : Multiplex Genome Engineering Using CRISPR/Cas Systems", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055067744 [P] * figures S1, S8 * |
| SEARCH | - KRZYSZTOF CHYLINSKI ET AL, "The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems", RNA BIOLOGY, (20130501), vol. 10, no. 5, doi:10.4161/rna.24321, ISSN 1547-6286, pages 726 - 737, XP055116068 [IP] 1-27 * the whole document * |
