| DESCRIPTION | - GEBAUER ET AL., CURRENT OPIN. CHEM. BIOL., (2009), vol. 13, pages 245 - 255 |
| EXAMINATION | - BENJAMIN WRIGHT ET AL, "A novel seed-train process: using high-density cell banking, a disposable bioreactor, and perfusion technologies", INTERNET CITATION, ISSN 1542-6319, (20150310), pages 1 - 10, URL: http://www.bioprocessintl.com/upstream-processing/upstream-single-use-technologies/novel-seed-train-process-using-high-density-cell-banking-disposable-bioreactor-perfusion-technologies/, (20151007), XP002747479 |
| EXAMINATION | - Gargi Seth ET AL, "Development of a new bioprocess scheme using frozen seed train intermediates to initiate CHO cell culture manufacturing campaigns", Biotechnology and Bioengineering, (20130504), vol. 110, no. 5, doi:10.1002/bit.24808, ISSN 0006-3592, pages 1376 - 1385, XP055168927 |
| EXAMINATION | - Pohlscheidt Michael ET AL, "Optimizing capacity utilization by large scale 3000 L perfusion in seed train bioreactors", Biotechnology Progress, (20120101), doi:10.1002/btpr.1672, ISSN 8756-7938, pages n/a - n/a, XP055049926 |
| EXAMINATION | - CLINCKE M F ET AL, "Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor(TM). Part I. Effect of the cell density on the process", BIOTECHNOLOGY PROGRESS, AMERICAN INSTITUTE OF CHEMICAL ENGINEERS, US, vol. 29, no. 3, doi:10.1002/BTPR.1704, ISSN 8756-7938, (20130501), pages 754 - 767, (20130521), XP002747478 |
| EXAMINATION | - William C. Yang ET AL, "Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality", Biotechnology Progress, (20140501), vol. 30, no. 3, doi:10.1002/btpr.1884, ISSN 8756-7938, pages 616 - 625, XP055168419 |
| EXAMINATION | - TAO Y ET AL, "Development and implementation of a perfusion-based high cell density cell banking process", BIOTECHNOLOGY PROGRESS, AMERICAN INSTITUTE OF CHEMICAL ENGINEERS, US, vol. 27, no. 3, doi:10.1002/BTPR.599, ISSN 8756-7938, (20110501), pages 824 - 829, (20110427), XP002747477 |
| EXAMINATION | - SMELKO J P ET AL, "Performance of high intensity fed-batch mammalian cell cultures in disposable bioreactor systems", BIOTECHNOLOGY PROGRESS, AMERICAN INSTITUTE OF CHEMICAL ENGINEERS, US, vol. 27, no. 5, doi:10.1002/BTPR.634, ISSN 8756-7938, (20110901), pages 1358 - 1364, (20110527), XP002747476 |
| INTERNATIONAL-SEARCH-REPORT | - Wright B., Bruninghaus M., Vrabel M., Walther J. et al., "A novel seed-train process: using high-density cell banking, a disposable bioreactor, and perfusion technologies", BioProcess Intl., vol. March 2015 Supplement, (20150310), URL: http://www.bioprocessintl.com/upstream-processing/upstream-single-use-technologies/novel-seed-train-process-using-high-density-cell-banking-disposable-bioreactor-perfusion-technologies/, (20151007), XP002747479 |
| INTERNATIONAL-SEARCH-REPORT | - GARGI SETH ET AL, "Development of a new bioprocess scheme using frozen seed train intermediates to initiate CHO cell culture manufacturing campaigns", BIOTECHNOLOGY AND BIOENGINEERING, (20130504), vol. 110, no. 5, doi:10.1002/bit.24808, ISSN 0006-3592, pages 1376 - 1385, XP055168927 [Y] 1-76 * the whole document * |
| INTERNATIONAL-SEARCH-REPORT | - POHLSCHEIDT MICHAEL ET AL, "Optimizing capacity utilization by large scale 3000 L perfusion in seed train bioreactors", BIOTECHNOLOGY PROGRESS, (20120101), doi:10.1002/btpr.1672, ISSN 8756-7938, pages n/a - n/a, XP055049926 [A] 1-76 |
| INTERNATIONAL-SEARCH-REPORT | - CLINCKE MARIE-FRANCOISE ET AL, "Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor. Part I. Effect of the cell density on the process", BIOTECHNOLOGY PROGRESS, (201305), vol. 29, no. 3, pages 754 - 767, XP002747478 [Y] 1-67 * the whole document * |
| INTERNATIONAL-SEARCH-REPORT | - WILLIAM C. YANG ET AL, "Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality", BIOTECHNOLOGY PROGRESS, (20140501), vol. 30, no. 3, doi:10.1002/btpr.1884, ISSN 8756-7938, pages 616 - 625, XP055168419 [A] 1-67 |
| INTERNATIONAL-SEARCH-REPORT | - TAO YIWEN ET AL, "Development and Implementation of a Perfusion-Based High Cell Density Cell Banking Process", BIOTECHNOLOGY PROGRESS, (201105), vol. 27, no. 3, pages 824 - 829, XP002747477 [Y] 1-67 * the whole document * |
| INTERNATIONAL-SEARCH-REPORT | - SMELKO JOHN PAUL ET AL, "Performance of High Intensity Fed-Batch Mammalian Cell Cultures in Disposable Bioreactor Systems", BIOTECHNOLOGY PROGRESS, (201109), vol. 27, no. 5, pages 1358 - 1364, XP002747476 [Y] 1-67 * the whole document * |
| OPPOSITION | - ADAMS et al., "Increasing efficiency in protein supply and cell production by combining single-use bioreactor technology and perfusion", Biopharm International, (20110000), vol. 24, pages s4 - s11, XP055728888 |
| OPPOSITION | - ADAMS, TH. et al., "Increasing efficiency in protein supply and cell production by combining single-use bioreactor technology and perfusion", BioPharm Internationa, (20110502), vol. 2011, no. 4, XP055728888 |
| OPPOSITION | - Anonymous, "Highly efficient inoculum propagation in perfusion culture using WAVE Bioreactor TM systems", GE Healthcare Life Sciences. Application note 29-0051-80 AA, (20120101), pages 1 - 4, XP055800396 |
| OPPOSITION | - Banik G G, Heath, C A, "An investigation of cell density effects on hybridoma metabolism in a homogeneous perfusion reactor", Bioprocess Engineering, (19940101), vol. 11, pages 229 - 237, XP055800397 |
| OPPOSITION | - Boedeker Berthold G D, "Recombinant Factor VIII (Kogenate) for the Treatment of Hemophilia A: The First and Only World- Wide Licensed Recombinant Protein Produced in High- Throughput Perfusion Culture", Modern Biopharmaceuticals: Recent Success Stories, Wiley, (20130101), pages 429 - 443, XP055799799 |
| OPPOSITION | - BONHAM-CARTER et al., "A Brief History of Perfusion Biomanufacturing", BioProcess Int., (20111001), pages 24 - 30, XP009186201 |
| OPPOSITION | - BONHAM-CARTER, J. et al., "A brief history of perfusion biomanufacturing", Bioprocess International, (20111000), vol. 9, no. 9, pages 24 - 30, XP009186201 |
| OPPOSITION | - Castilho Leda R, "Chapter 6: Continuous Animal Cell Perfusion Processes: The First Step Toward Integrated Continuous Biomanufacturing", Continuous Processing in Pharmaceutical Manufacturing, (20150101), pages 115 - 153, XP055800425 |
| OPPOSITION | - Chmiel Horst, "Kapittel 11: Kultivierung von Säugertierzellen", BioProzesstechnik, Spektrum, (20110101), pages 373 - 425, ISBN 978-3-8274-2476-1, XP055800394 |
| OPPOSITION | - Fenge Christel, Lüllau Elke, "Chapter 6: Cell Culture Bioreactors", Cell Culture Technology for Pharmaceutical and Cell -Based Therapies, CRC Press, (20060101), pages 155 - 224, XP055800410 |
| OPPOSITION | - Ge Healthcare Bio-Sciences, "WAVE BioreactorTM 500/1000 System", GE Healthcare Life Sciences data file 29-0237-12 AA ReadyToProcess TM, (20120101), pages 1 - 4, XP055800447 |
| OPPOSITION | - Griffiths J Bryan, "Mammalian Cell Culture Reactors, Scale-Up", Encyclopedia of Bioprocess Technology: Fermentation, Biocatalysis, and Bioseparation, John Wiley and Sons, Inc, (19990101), pages 1594 - 1607, XP055800389 |
| OPPOSITION | - Kloth Claudia, Et Al, "Inoculum Expansion Methods, Recombinant Mammalian Cell Lines", Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, Wiley, (20100101), vol. 5, pages 2988 - 3000, XP055800391 |
| OPPOSITION | - KOMPALA et al., "Optimization of high cell density perfusion bioreactors", Cell Culture Technology for Pharmaceutical and Cell -Based Therapies, (20060000), XP055519914 |
| OPPOSITION | - Langer Eric S, "Trends in Perfusion Bioreactors - The Next Revolution in Bioprocessing?", BioProcess International, (20111101), vol. 9, no. 10, pages 18 - 22, XP055799792 |
| OPPOSITION | - LÖFFELHOLZ, CH. et al., "Dynamic single-use bioreactors used in modern liter-and m3 scale biotechnological processes engineering characteristics and scaling up", Adv Biochem Eng Biotechnol, (20130423), pages 1 - 44, XP055728935 |
| OPPOSITION | - LOFFELHOLZ et al., "Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes: Engineering characteristics and scaling up", Adv Biochem Eng Biotechnol, (20130000), vol. 138, pages 1 - 44, XP055728935 |
| OPPOSITION | - Nelson Kim, "Chapter 16: Facility Design", Cell Culture Technology for Pharmaceutical and Cell -Based Therapies, CRC Press, (20060101), pages 553 - 603, Cell Culture Technology for Pharmaceutical and Cell -Based Therapies, (20210430), XP055800417 |
| OPPOSITION | - New Webster's Dictionary, (19750000), pages 452 - 453 |
| OPPOSITION | - OHASHI et al., "Perfusion cell culture in disposable bioreactors", Animal Cell Technology: From Target to Market, (20010000), pages 403 - 409, XP055521880 |
| OPPOSITION | - OHASHI, R. et al., "Perfusion Cell Culture in Disposable Bioreactors", Animal Cell Technology: from target to market, (20010000), pages 403 - 409, XP055521880 |
| OPPOSITION | - Ongena Kathleen, Et Al, "Determining Cell Number During Cell Culture using the Scepter Cell Counter", JOVE Journal of Visualized Experiments, (20101126), vol. 45, pages 1 - 5, XP055800443 |
| OPPOSITION | - Rios Maribel, "Developing an integrated Continuous Bioprocessing Platform", Interview K. Konstantinov, BioProcess Int., (20121201), pages 1 - 6, Interview K. Konstantinov, (20210430), XP055800439 |
| OPPOSITION | - Su Wei Wen, "Bioreactors, Perfusion", Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, (20090101), pages 1 - 16, XP055800433 |
| OPPOSITION | - Tang Ya-Lie, Et Al, "Perfusion Culture of Hybridoma Cells for Hyperproduction of IgG2a Monoclonal Antibody in a Wave Bioreactor-Perfusion Culture System", Biotechnol. Prog., (20070101), vol. 23, no. 1, pages 255 - 264, XP055800430 |
| OPPOSITION | - WERNER et al., "Innovative, non-stirred bioreactors in scales from milliliters up to 1000 liters for suspension cultures of cells using disposable bags and containers - A Swiss contribution", Chimia, (20100000), vol. 64, no. 11, pages 819 - 823, XP055728902 |
| OPPOSITION | - WERNER, S. et al., "Innovative non-stirred bioreactors in scales from milliliters up 1000 liters for suspension cultures of celles using disposable bags and containers- a swiss contribution", Chimia, (20100000), vol. 11, no. 64, pages 819 - 823, XP055728902 |
| OPPOSITION | - WRIGHT et al., "A Novel Seed-Train Process: Using High-Density Cell Banking, a Disposable Bioreactor, and Perfusion Technologies", Bioprocess Int., (20150310), XP002747479 |
| OPPOSITION | - YANG et al., "Development and application of perfusion culture producing seed cells in WA VE TM bioreactor", Chinese Journal of Biotechnology, (20120000), vol. 28, no. 3, pages 358 - 367, XP055728890 |
| OPPOSITION | - YANG, J. et al., "Development and application of perfusion culture producing seed cells in WAVE bioreactor", J Biotech, (20120325), vol. 28, no. 3, pages 358 - 367, XP055728890 |
| OPPOSITION | - Zhou Weichang and Kantardjeff Anne, "Mammalian Cell Cultures for Biologics Manufacturing", Advances in Biochemical Engineering/ Biotechnology, (20140000), vol. 139, pages 1 - 262 |
| OPPOSITION | - VOISARD, D. et al., "Potential of cell retention techniques for large-scale high-density perfusion culture of suspended mammalian cells", Biotechnology and Bioengineering, (20030630), vol. 82, no. 7, pages 751 - 765, XP002317548 |
| OPPOSITION | - VOISARD et al., "Potential of cell retention techniques for large-scale high-density perfusion culture of suspended mammalian cells", Biotechnology and Bioengineering, (20030000), vol. 82, no. 7, doi:10.1002/bit.10629, pages 751 - 765, XP002317548 |
| OPPOSITION | - KSHIRSAGAR et al., "Controlling Trisulfide Modification in Recombinant Monoclonal Antibody Produced in Fed-Batch Cell Culture", Biotechnology and Bioengineering, (20120000), vol. 109, no. 10, pages 2523 - 2532, XP055559320 |
| OPPOSITION | - WARIKOO et al., "Integrated continuous production of recombinant therapeutic proteins", Biotechnology and Bioengineering, (20120000), vol. 109, doi:10.1002/bit.24584, pages 3018 - 3029, XP055144587 |
| OPPOSITION | - WARIKOO et al., "Integrated Continuous Production of Recombinant Therapeutic Proteins", Biotechnology and Bioengineering, (20120000), vol. 109, no. 12, doi:10.1002/bit.24584, pages 3018 - 3029, XP055144587 |
| OPPOSITION | - POLLOCK et al., "Fed-Batch and Perfusion Culture Processes: 2012 Economic, Environmental, and Operational Feasibility Under Uncertainty", Biotechnol Bioeng, vol. 110, no. 1, pages 206 - 19, XP055728932 |
| OPPOSITION | - POLLOCK et al., "Fed-batch and perfusion culture processes: Economic, environmental, and operational feasibility under uncertainty", Biotechnology and Bioengineering, (20120000), vol. 110, no. 1, pages 206 - 219, XP055728932 |
| OPPOSITION | - POLLOCK, J. et al., "Fed-Batch and perfusion culture processes economic environmental and operational feasibility under uncertainty", Biotechnology and Bioengineering, (20120806), vol. 1, no. 110, pages 206 - 219, XP055728932 |
| OPPOSITION | - SETH et al., "Development of a New Bioprocess Scheme Using Frozen Seed Train Intermediates to Initiate CHO Cell Culture Manufacturing Campaigns", Biotechnology and Bioengineering, (20120000), vol. 110, no. 5, doi:10.1002/bit.24808, pages 1376 - 1385, XP055168927 |
| OPPOSITION | - POHLSCHEIDT et al., "Optimizing capacity utilization by large scale 3000 L perfusion in seed train bioreactors", Biotechnol Prag, (20130100), vol. 29, no. 1, doi:10.1002/btpr.1672, pages 222 - 229, XP055788645 |
| OPPOSITION | - POHLSCHEIDT et al., "Optimizing Capacity Utilization by Large Scale 3000 L Perfusion in Seed Train Bioreactors", Biotechnol. Prog., (20130000), vol. 29, doi:10.1002/btpr.1672, pages 222 - 229, XP055788645 |
| OPPOSITION | - POHLSCHEIDT, M. et al., "Optimizing capacity utilization by large scale 3000 L perfusion in seed train bioreactors", Biotechnol Prog, (20130117), vol. 1, no. 29, pages 222 - 229, XP055049926 |
| OPPOSITION | - CLINCKE et al., "Very High Density of Chinese Hamster Ovary Cells in Perfusion by Alternating Tangential Flow or Tangential Flow Filtration in WAVE Bioreactor? -Part II: Applications for Antibody Production and Cryopreservation", Biotechnol. Prog., (20130000), vol. 29, doi:10.1002/btpr.1703, pages 768 - 777, XP055168922 |
| OPPOSITION | - CLINCKE et al., "Very High Density of CHO in Perfusion by ATF or TFF in WAVE Bioreactor?. Part II. Applications for Antibody Production and Cryopreservation", Biotechnol. Prog., (20130000), vol. 29, no. 3, pages 768 - 777, XP055168922 |
| OPPOSITION | - CLINCKE et al., "Very High Density of CHO Cells in Perfusion by ATF or TFF in WAVE Bioreactor?. Part I . Effect of the Cell Density on the Process", Biotechnol. Prog., (20130000), vol. 29, doi:10.1002/btpr.1704, pages 754 - 767, XP055532937 |
| OPPOSITION | - CLINCKE et al., "Very High Density of CHO in Perfusion by ATF or TFF in WAVE Bioreactor?. Part I. Effect of the Cell Density on the Process", Biotechnol. Prog., (20130000), vol. 29, no. 3, doi:10.1002/btpr.1704, pages 754 - 767, XP055532937 |
| OPPOSITION | - PADAWER et al., "Case Study: an accelerated 8-day monoclonal antibody production process based on high seeding densities", Biotechnol Prog., (20130000), vol. 29, no. 3, doi:10.1002/btpr.1719, pages 829 - 32, XP002735825 |
| OPPOSITION | - YANG et al., "Perfusion Seed Cultures Improve Biopharmaceutical Fed-Batch Production Capacity and Product Quality", Biotechnol. Prog., (20140215), vol. 30, no. 3, pages 616 - 624, XP055168419 |
| OPPOSITION | - YANG et al., "Perfusion Seed Cultures Improve Biopharmaceutical Fed-Batch Production Capacity and Product Quality", Biotechnol. Prog., vol. 30, no. 3, doi:10.1002/btpr.1884, (20140200), pages 616 - 625, XP055168419 |
| OPPOSITION | - YANG, W. C. et al., "Perfusion seed cultures improve biopharmaceutical fed-batch production capacity and product quality", Biotechnol Prog, (20140215), vol. 30, no. 3, pages 616 - 625, XP055168419 |
| OPPOSITION | - HECHT et al., "Efficiency Improvement of an Antibody Production Process by Increasing the Inoculum Density", Biotechnol. Prog., (20140214), vol. 30, no. 3, pages 607 - 615, XP055728925 |
| OPPOSITION | - HECHT et al., "Efficiency Improvement of an Antibody Production Process by Increasing the Inoculum Density", Biotechn. Prog., (20140200), vol. 30, no. 3, pages 607 - 615, XP055728925 |
| OPPOSITION | - HECHT, V. et al., "efficiency improvement of an antibody production process by increasing the inoculum density", Biotechnol Prog, (20140214), vol. 30, no. 3, pages 607 - 615, XP055728925 |
| OPPOSITION | - TAO et al., "Development and Implementation of a Perfusion-Based High Cell Density Cell Banking Process", Biotechnol. Prog., (20110000), vol. 27, no. 3, doi:10.1002/btpr.599, pages 824 - 829, XP002747477 |
| OPPOSITION | - ECKER, D. M. et al., "Mammalian cell culture capacity for biopharmaceutical manufacturing", Adv Biochem Eng Biotechnol, (20130609), pages 185 - 225, XP055728942 |
| OPPOSITION | - ECKER et al., Adv Biochem Eng Biotechnol, (20130000), vol. 139, pages 185 - 225, XP055728942 |
| OPPOSITION | - ABU-ABSI et al., "Cell Culture Process Operations for Recombinant Protein Production", Mammalian Cell Cultures for Biologics Manufacturing, (20131024), pages 35 - 68, XP055728889 |
| OPPOSITION | - ABU-ABSI, S. et al., "Cell Culture Process Operations for Recombinant Protein Production", Adv Biochem Eng Biotechnol, (20131024), vol. 139, pages 35 - 68, XP055728889 |
| OPPOSITION | - OZTURK, "Equipment for Large-Scale Mammalian Cell Culture", Mammalian Cell Cultures for Biologics Manufacturing, (20140000), doi:10.1007/10_2013_259, pages 69 - 92, XP009175889 |
| OPPOSITION | - OZTURK, S. S, "Equipment for large-scale Mammalian cell culture", Adv Biochem Eng Biotechnol, (20130905), pages 69 - 92, XP009175889 |
| OPPOSITION | - BIRCH et al., "Antibody production", Advanced Drug Delivery, (20060000), vol. 58, doi:10.1016/j.addr.2005.12.006, pages 671 - 685, XP024892148 |
| OPPOSITION | - ERIKSSON et al., "The Manufacturing Process for B-Domain Deleted Recombinant Factor VIII", Semin Hematol, (20010000), vol. 38, no. 4, doi:10.1016/S0037-1963(01)90105-2, pages 24 - 31, XP009080746 |
| OPPOSITION | - HEIDEMANN et al., "A new seed-train expansion method for recombinant mammalian cell lines", Cytotechnology, (20020000), vol. 38, doi:10.1023/A:1021114300958, pages 99 - 108, XP055225875 |
| OPPOSITION | - WURM, "Production of recombinant protein therapeutics in cultivated mammalian cells", Nature Biotechnology, (20040000), vol. 22, no. 11, pages 1393 - 1398, XP002514352 |
| OPPOSITION | - RAJA et al., "Challenges in scaling up a perfusion process", BMC Proceedings, (20110000), vol. 5, no. 8, doi:10.1186/1753-6561-5-S8-P122, page P122, XP021114374 |
| OPPOSITION | - DUVAR et al., "Developing an upstream process for a monoclonal antibody including medium optimization", BMC Proceedings, (20130600), vol. 7, no. 6, page 34, XP021170331 |
| OPPOSITION | - DUVAR, S. ET et al., "Developing an upstream process for a monoclonal antibody including medium optimization", BMC Proceedings, (20130600), vol. 7, no. supp 6, page 34, XP021170331 |
| OPPOSITION | - Christian Kaisermayer;Jianjun Yang, "Highly efficient inoculum propagation in perfusion culture using WAVE Bioreactorâ„¢ systems", BMC Proceedings, London UK, (20131204), vol. 7, no. Suppl 6, doi:10.1186/1753-6561-7-S6-P7, ISSN 1753-6561, page P7, XP021170370 |
| OPPOSITION | - KAISERMAYER, CH. et al., "Highly efficient inoculum propagation in perfusion culture using WAVE bioreactor systems", BMC Proceedings, (20130600), vol. 6, no. 7, page 7, XP021170370 |
| OPPOSITION | - KAISERMAYER et al., "Highly efficient inoculum propagation in perfusion culture using WAVE bioreactosTM systems", BMC Proceedings, (20130600), vol. 7, no. 6, page 7, XP021170370 |
| OPPOSITION | - OOSTERHUIS et al., "Single-use bioreactors for microbial cultivation", Pharmaceutical Bioprocessing, (20130000), vol. 1, no. 2, pages 167 - 177, XP055728896 |
| OPPOSITION | - OOSTERHUIS, N. M. G. et al., "Single-use bioreactors for microbial cultivation", Pharmaceutical Bioprocessing, (20130000), vol. 2, no. 1, pages 167 - 177, XP055728896 |
