IP Verse

Method For Producing Rna Compositions - EP3283059

The patent EP3283059 was granted to Curevac on Jan 3, 2024. The application was originally filed on Apr 13, 2016 under application number EP16716474A. The patent is currently recorded with a legal status of "Revoked".

EP3283059

CUREVAC
Application Number
EP16716474A
Filing Date
Apr 13, 2016
Status
Revoked
Jul 25, 2025
Grant Date
Jan 3, 2024
External Links
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Patent Summary

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Patent Oppositions (7)

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BIONTECHOct 4, 2024THOMANNADMISSIBLE
ETHERNA IMMUNOTHERAPIESOct 3, 2024ARNOLD & SIEDSMAADMISSIBLE
JAMES POOLEOct 3, 2024CARPMAELS & RANSFORDADMISSIBLE
MICHALSKI HUTTERMANN & PARTNER PATENTANWALTE MBBOct 3, 2024MICHALSKI HUTTERMANN & PARTNER PATENTANWALTE MBBADMISSIBLE
SANOFIOct 3, 2024CARPMAELS & RANSFORDADMISSIBLE
SEQIRUS UKOct 1, 2024CARPMAELS & RANSFORDADMISSIBLE
GRUNDSep 30, 2024GRUNDADMISSIBLE

Patent Citations (29) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
INTERNATIONAL-SEARCH-REPORTWO2009144230
INTERNATIONAL-SEARCH-REPORTWO2012094574
OPPOSITIONEP1083232
OPPOSITIONEP3283059
OPPOSITIONFR3023483
OPPOSITIONUS2011077284
OPPOSITIONUS2012276209
OPPOSITIONUS2013303587
OPPOSITIONUS7901708
OPPOSITIONWO0136583
OPPOSITIONWO2006074546
OPPOSITIONWO2009144230
OPPOSITIONWO2011140627
OPPOSITIONWO2012031043
OPPOSITIONWO2012094574
OPPOSITIONWO2012170889
OPPOSITIONWO2012170930
OPPOSITIONWO2013006825
OPPOSITIONWO2013087083
OPPOSITIONWO2013126564
OPPOSITIONWO2013148541
OPPOSITIONWO2014172045
OPPOSITIONWO2015011633
OPPOSITIONWO2015048020
OPPOSITIONWO2015057998
OPPOSITIONWO2016000792
OPPOSITIONWO2016010840
OPPOSITIONWO2016165825
OPPOSITIONWO9940771

Non-Patent Literature (NPL) Citations (38) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
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OPPOSITION- Alex K.K. Leung, Yuen Yi C. Tam, Pieter R. Cullis, "Lipid Nanoparticles for Short Interfering RNA Delivery", Alex K.K. Leung, Yuen Yi C. Tam, Pieter R. Cullis, Leaf Huang , Dexi Liu , Ernst Wagner, Advances in Genetics, US , Academic Press , (20140101), vol. 88, pages 71 - 110, doi:10.1016/B978-0-12-800148-6.00004-3, ISSN 0065-2660, XP055540398
OPPOSITION- Qin, C., Li, H , Xiao, Q , Liu, Y , Zhu, J., Du, Y, "Water-solubility of chitosan and its antimicrobial activity", Carbohydrate Polymers, GB , (20060303), vol. 63, no. 3, doi:10.1016/j.carbpol.2005.09.023, ISSN 0144-8617, pages 367 - 374, XP025087598
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OPPOSITION- Perche et al., "Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA", Nanomedicine: Nanotechnology, Biology, and Medicine, (2011), vol. 7, doi:10.1016/j.nano.2010.12.010, XP055682326
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OPPOSITION- Cabaret François, Bonnot Sylvain, Fradette Louis, Tanguy Philippe A., "Mixing Time Analysis Using Colorimetric Methods and Image Processing", Industrial & Engineering Chemistry Research, (20070701), vol. 46, no. 14, doi:10.1021/ie0613265, ISSN 0888-5885, pages 5032 - 5042, XP093231323
OPPOSITION- Cabaret François, Bonnot Sylvain, Fradette Louis, Tanguy Philippe A., "Mixing Time Analysis Using Colorimetric Methods and Image Processing", Industrial & Engineering Chemistry Research, American Chemical Society, (20070701), vol. 46, no. 14, doi:10.1021/ie0613265, ISSN 0888-5885, pages 5032 - 5042, XP093231323
OPPOSITION- Chen Delai, Love Kevin T., Chen Yi, Eltoukhy Ahmed A., Kastrup Christian, Sahay Gaurav, Jeon Alvin, Dong Yizhou, Whitehead Kathryn A., Anderson Daniel G., "Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation - supplementary information", Journal of the American Chemical Society, American Chemical Society, (20120425), vol. 134, no. 16, doi:10.1021/ja301621z, ISSN 0002-7863, pages S1 - S5, XP055845883
OPPOSITION- Chen et al., "Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation", Journal of the American Chemical Society, (2012), vol. 134, doi:10.1021/ja301621z, XP055845883
OPPOSITION- Alex K. K. Leung, Ismail M. Hafez, Svetlana Baoukina, Nathan M. Belliveau, Igor V. Zhigaltsev, Elham Afshinmanesh, D. Peter Tieleman, Carl L. Hansen, Michael J. Hope, Pieter R. Cullis, "Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core", The Journal of Physical Chemistry C, American Chemical Society, US, US , (20120830), vol. 116, no. 34, doi:10.1021/jp303267y, ISSN 1932-7447, pages 18440 - 18450, XP055301926
OPPOSITION- Igor V. Zhigaltsev, Nathan Belliveau, Ismail Hafez, Alex K. K. Leung, Jens Huft, Carl Hansen, Pieter R. Cullis, "Bottom-Up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores Using Millisecond Microfluidic Mixing", Langmuir, American Chemical Society, (20120221), vol. 28, no. 7, doi:10.1021/la204833h, ISSN 07437463, pages 3633 - 3640, XP055150435
OPPOSITION- Gindy Marian E., Difelice Katherine, Kumar Varun, Prud’homme Robert K., Celano Robert, Haas R. Matthew, Smith Jeffrey S., Boardman David, "Mechanism of Macromolecular Structure Evolution in Self-Assembled Lipid Nanoparticles for siRNA Delivery", Langmuir, US , (20140429), vol. 30, no. 16, doi:10.1021/la500630h, ISSN 0743-7463, pages 4613 - 4622, XP093231558
OPPOSITION- Lim et al., "Ultra-High Throughput Synthesis of Nanoparticles with Homogeneous Size Distribution Using a Coaxial Turbulent Jet Mixer", ACS Nano, (2014), vol. 8, doi:10.1021/nn501371n, XP055779239
OPPOSITION- Lim Jong-Min, Swami Archana, Gilson Laura M., Chopra Sunandini, Choi Sungyoung, Wu Jun, Langer Robert, Karnik Rohit, Farokhzad Omid C., "Ultra-High Throughput Synthesis of Nanoparticles with Homogeneous Size Distribution Using a Coaxial Turbulent Jet Mixer", ACS Nano, American Chemical Society, US, US , (20140624), vol. 8, no. 6, doi:10.1021/nn501371n, ISSN 1936-0851, pages 6056 - 6065, XP055779239
OPPOSITION- Lim Jong-Min, Swami Archana, Gilson Laura M., Chopra Sunandini, Choi Sungyoung, Wu Jun, Langer Robert, Karnik Rohit, Farokhzad Omid C., "Ultra-High Throughput Synthesis of Nanoparticles with Homogeneous Size Distribution Using a Coaxial Turbulent Jet Mixer", ACS Nano, US , (20140624), vol. 8, no. 6, doi:10.1021/nn501371n, ISSN 1936-0851, pages 6056 - 6065, XP055779239
OPPOSITION- Marc T A, et al, "Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment", Molecular Therapy, Elsevier Inc., US, US , (20100101), vol. 18, no. 1, doi:10.1038/mt.2009.208, ISSN 1525-0016, pages 171 - 180, XP007918345
OPPOSITION- Martin A Maier, Muthusamy Jayaraman, Shigeo Matsuda, Ju Liu, Scott Barros, William Querbes, Ying K Tam, Steven M Ansell, Varun Kumar, June Qin, Xuemei Zhang, Qianfan Wang, Sue Panesar, Renta Hutabarat, Mary Carioto, Julia Hettinger, Pachamuthu Kandasamy, David Butler, Kallanthottathil G Rajeev, Bo Pang, Klaus Charisse, Kevin Fitzgerald, Barbara L Mui, Xinyao Du, Pieter Cullis, Thomas D Madden, Michael J Hope, Muthiah Manoharan, Akin Akinc, "Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics", Molecular Therapy, US , (20130801), vol. 21, no. 8, doi:10.1038/mt.2013.124, ISSN 1525-0016, pages 1570 - 1578, XP055237159
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OPPOSITION- Nathan M Belliveau, Jens Huft, Paulo J C Lin, Sam Chen, Alex K K Leung, Timothy J Leaver, Andre W Wild, Justin B Lee, Robert J Taylor, Ying K Tam, Carl L Hansen, and Pieter R Cullis, "Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA.", NUCLEIC ACIDS AND MOLECULAR BIOLOGY., SPRINGER VERLAG, BERLIN., DE, DE , (20120801), vol. 1, no. 8, doi:10.1038/mtna.2012.28, ISSN 0933-1891, pages e37 - e37-9, XP002715253
OPPOSITION- Sook-San Wong, Webby Richard J, "An mRNA vaccine for influenza", Nature Biotechnology, (20121231), vol. 30, no. 12, doi:10.1038/nbt.2439, pages 1202 - 1204, XP055389920
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OPPOSITION- Geall Andrew J., Verma Ayush, Otten Gillis R., Shaw Christine A., Hekele Armin, Banerjee Kaustuv, Cu Yen, Beard Clayton W., Brito Luis A., Krucker Thomas, O’hagan Derek T., Singh Manmohan, Mason Peter W., Valiante Nicholas M., Dormitzer Philip R., Barnett Susan W., Rappuoli Rino, Ulmer Jeffrey B., Mandl Christian W., "Nonviral delivery of self-amplifying RNA vaccines", Proceedings of the National Academy of Sciences (PNAS), (20120904), vol. 109, no. 36, doi:10.1073/pnas.1209367109, ISSN 0027-8424, pages 14604 - 14609, XP093140807
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OPPOSITION- Nakamura Kazuya, Aihara Keisuke, Ishida Tatsuhiro, "Importance of Process Parameters Influencing the Mean Diameters of siRNA-Containing Lipid Nanoparticles (LNPs) on the in Vitro Activity of Prepared LNPs", Biological & pharmaceutical bulletin, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO., JP, JP , (20220401), vol. 45, no. 4, doi:10.1248/bpb.b21-01016, ISSN 0918-6158, pages 497 - 507, XP093222945
OPPOSITION- Gindy Marian E, Leone Anthony M, Cunningham James J, "Challenges in the pharmaceutical development of lipid-based short interfering ribonucleic acid therapeutics", Expert Opinion on Drug Delivery, GB , (20120201), vol. 9, no. 2, doi:10.1517/17425247.2012.642363, ISSN 1742-5247, pages 171 - 182, XP093231564
OPPOSITION- Liqun Yang, Zhenzhen Liu, Haijun Gong, Rui Zeng, Xuan Liang, Li-Ming Zhang, Yuqing Lan, "Efficient delivery of NF-κB siRNA to human retinal pigment epithelial cells with hyperbranched cationic polysaccharide derivative-based nanoparticles", International Journal of Nanomedicine, doi:10.2147/IJN.S75188, page 2735, XP055196252

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