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Targeting Bcl11A Enhancer Functional Regions For Fetal Hemoglobin Reinduction - EP3294873

The patent EP3294873 was granted to Massachusetts Institute OF Technology on Sep 18, 2024. The application was originally filed on May 6, 2016 under application number EP16793259A. The patent is currently recorded with a legal status of "Patent Maintained As Amended".

EP3294873

MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Application Number
EP16793259A
Filing Date
May 6, 2016
Status
Patent Maintained As Amended
Aug 15, 2024
Grant Date
Sep 18, 2024
External Links
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JG OPPOSITIONSMay 19, 2021MATHYS & SQUIREADMISSIBLE

Patent Citations (18) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS8021867
DESCRIPTIONUS8119381
DESCRIPTIONUS8124369
DESCRIPTIONUS8129134
DESCRIPTIONUS8133697
DESCRIPTIONUS8143015
DESCRIPTIONUS8143016
DESCRIPTIONUS8148098
DESCRIPTIONUS8163514
DESCRIPTIONUS8304222
EXAMINATIONUS2015132269
EXAMINATIONWO2017115268
EXAMINATIONWO2017182881
INTERNATIONAL-SEARCH-REPORTWO2012073047
INTERNATIONAL-SEARCH-REPORTWO2014085593
OPPOSITIONWO2014085593
OPPOSITIONWO2014186585
SEARCHWO2015065964

Non-Patent Literature (NPL) Citations (53) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
EXAMINATION- "BCL11A gene editing gRNA spacer, SEQ ID 6657.", Geneseq, (20171130), Database accession no. BEJ64224, URL: EBI
EXAMINATION- "Chromosome-11 French HPFH region sgRNA targeting RNA domain, SEQ ID 1690.", Geneseq, (20170824), Database accession no. BEC40217, URL: EBI
EXAMINATION- "Human BCL11A enhancer region (+55 region) fragment, SEQ ID 175.", Geneseq, (20151231), Database accession no. BCH28316, URL: EBI
OPPOSITION- Andreas Reik, 1 Kai-Hsin Chang,2 Jeff Vierstra,2 Nikoletta Psatha,2 Sandra Stehling-Sun,2 Yuanyue Zhou,1 Colleen M. O’neil,1 Andrea Mich,1 Jeffrey C. Miller,1 Gary Lee,1 Siyuan Tan,3 Haiyan Jiang,3 George Stamatoyannopoulos,2 Thalia Papayannopoulou,2 Edward J. Rebar,1 Philip D. Gregory,1 John A. Stamatoyannopoulos,2 Fyodor D. Urnov, "53. From GWAS To the Clinic: Genome-Editing the Human BCL11A Erythroid Enhancer for Fetal Globin Elevation in the Hemoglobinopathies", Molecular Therapy, (20150501), vol. 23, no. Suppl. 1, pages S23 - S24, XP055955133
OPPOSITION- Anonymous, "Addgene: CRISPR in the Lab: A Practical Guide", Internet Archive Wayback Machine, (20150504), pages 1 - 6, Internet Archive Wayback Machine , URL: https://web.archive.org/web/20150504075703/https://www.addgene.org/CRISPR/guide/, (20220825), XP055955135
OPPOSITION- Anonymous, "Enhancer (genetics) - Wikipedia", (20150419), pages 1 - 8, URL: https://en.wikipedia.org/w/index.php?title=Enhancer_(genetics)&oldid=657120611, (20220825), XP055955140
OPPOSITION- Anonymous, "MONOCLONAL ANTIBODIES DIRECTED TO HUMAN FETAL HEMOGLOBIN (HbF)", Life Technologies Corporation, (20130101), page 34pp, Life Technologies Corporation, URL: http://tools.thermofisher.com/content/sfs/manuals/L13011_ms_x_huHbF_mab_man.pdf, (20220825), XP055955136
OPPOSITION- Bauer et al., Blood (2013);122(21 ):437
OPPOSITION- Bauer et al., Science (2013); 342: 253-257 and Supplementary Material
OPPOSITION- Declaration of Dr. Bauer, signed 6 December 2021, including CV;
OPPOSITION- Entry relating to Tari W. Mills from the USPTO Office of Enrollment and Discipline; available from https://oedci.uspto.gov/OEDCl/practitionerSearchEntry; accessed on November 9, 2021.
OPPOSITION- Finotti et al., J. Blood Med (2015);6:69-85 (published on 19 February 2015)
OPPOSITION- Frangoul et al.; New England Journal of Medicine; 2021; 384: 252-60; published December 5, 2020;
OPPOSITION- Gilbert et al., Cell (2014); 159(3): 647-661
OPPOSITION- Ginder, Transl Res (2015);165(1 ):115-125 (published in January 2015)
OPPOSITION- Gordon D. Ginder, "Epigenetic regulation of fetal globin gene expression in adult erythroid cells", Translational Research, (20150101), vol. 165, no. 1, pages 115 - 125, XP055955130
OPPOSITION- Human Gene BCL 11 A Description and Page Index obtained from the UCSC Genome Browser (ha19 assembly
OPPOSITION- Hwang et al., Computational and Structural Biotechnology Journal (2020); 18: 1686-1694
OPPOSITION- Internet Archive (https://archive.org/) capture of a webpage from www.addaene.ora dated 4 May 2015
OPPOSITION- Kurita et al., PLOS One (2013);8(3):e59890
OPPOSITION- Li et al., Develop Growth Differ (2014); 56:63-77
OPPOSITION- Matthew C. Canver, Elenoe C. Smith, Falak Sher, Luca Pinello, Neville E. Sanjana, Ophir Shalem, Diane D. Chen, Patrick G. Schupp, Divya S. Vinjamur, Sara P. Garcia, Sidinh Luc, Ryo Kurita, Yukio Nakamura, Yuko Fujiwara, Takahiro Maeda, Guo-Cheng Yuan, Feng Zhang, Stuart H. Orkin, Daniel E. Bauer, "BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis", Nature, Nature Publishing Group UK, London, London, (20151112), vol. 527, doi:10.1038/nature15521, ISSN 0028-0836, pages 192 - 197
OPPOSITION- Molecular Probes (2013), Monoclonal Antibodies Directed to Human Fetal Hemoglobin (HbF)
OPPOSITION- Orkin, Am J Hum Genet (2015); 96: 354-360 (published on 5 March 2015)
OPPOSITION- PCT Request form for PCT /US2016/031224
OPPOSITION- Ran et al., Nat Protoc (2013); 8(11): 2281-2308
OPPOSITION- Reik et al., Mai Therapy (2015);23, Supplement 1 :S23-S24 (published on 1 May 2015)
OPPOSITION- Sankaran and Orkin, Cold Spring Harb Perspect Med (2013); 3: a011643
OPPOSITION- Shalem et al., Nat Rev Genet (2015); 16(5): 299-311 (published on 9 April 2015)
OPPOSITION- Source data published on the internet with D1 at www.nature.com/articles/nature15521
OPPOSITION- Wikipedia page for Enhancer (genetics) dated 19 April 2015
OPPOSITION- Orkin Stuart h., "2014 William Allan Award: A Hematologist’s Pursuit of Hemoglobin Genetics1", The American Journal of Human Genetics, American society of human genetics , Chicago , IL, US, US , (20150305), vol. 96, no. 3, doi:10.1016/j.ajhg.2014.12.007, ISSN 0002-9297, pages 354 - 360, XP055955128
OPPOSITION- Gilbert Luke a., Horlbeck Max a., Adamson Britt, Villalta Jacqueline e., Chen Yuwen, Whitehead Evan h., Guimaraes Carla, Panning Barbara, Ploegh Hidde l., Bassik Michael c., Qi Lei s., Kampmann Martin, Weissman Jonathan s., "Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation /NIH Public Manuscript/", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (20151023), doi:10.1016/j.cell.2014.09.029, ISSN 0092-8674, pages 1 - 26, XP055955137
OPPOSITION- Hwang Gue-Ho, Yu Jihyeon, Yang Soyeon, Son Woo Jae, Lim Kayeong, Kim Heon Seok, Kim Jin-Soo, Bae Sangsu, "CRISPR-sub: Analysis of DNA substitution mutations caused by CRISPR-Cas9 in human cells", COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, Research Network of Computational and Structural Biotechnology, Sweden, Sweden , (20200101), vol. 18, doi:10.1016/j.csbj.2020.06.026, ISSN 2001-0370, pages 1686 - 1694, XP055923680
OPPOSITION- Matthew C. Canver, Elenoe C. Smith, Falak Sher, Luca Pinello, Neville E. Sanjana, Ophir Shalem, Diane D. Chen, Patrick G. Schupp, Divya S. Vinjamur, Sara P. Garcia, Sidinh Luc, Ryo Kurita, Yukio Nakamura, Yuko Fujiwara, Takahiro Maeda, Guo-Cheng Yuan, Feng Zhang, Stuart H. Orkin, Daniel E. Bauer, "BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis", Nature, Nature Publishing Group UK, London, London, (20151112), vol. 527, doi:10.1038/nature15521, ISSN 0028-0836, pages 192 - 197, XP055274680
OPPOSITION- John G Doench, Ella Hartenian, Daniel B Graham, Zuzana Tothova, Mudra Hegde, Ian Smith, Meagan Sullender, Benjamin L Ebert, Ramnik J Xavier, David E Root, "Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20140903), vol. 32, no. 12, doi:10.1038/nbt.3026, ISSN 1087-0156, pages 1262 - 1267, XP055190845
OPPOSITION- Ran F Ann, Hsu Patrick D, Wright Jason, Agarwala Vineeta, Scott David A, Zhang Feng, "Genome engineering using the CRISPR-Cas9 system /HHS Author Manuscript/", Nature Protocols, Nature Publishing Group, GB, GB , (20140330), doi:10.1038/nprot.2013.143, ISSN 1754-2189, pages 1 - 49, XP055955129
OPPOSITION- Shalem Ophir, Sanjana Neville E., Zhang Feng, "High-throughput functional genomics using CRISPR-Cas9 /HHS Author Manuscript/", NATURE REVIEWS GENETICS, Nature Publishing Group, GB, GB , (20151101), doi:10.1038/nrg3899, ISSN 1471-0056, pages 1 - 28, XP055955138
OPPOSITION- V. G. Sankaran, S. H. Orkin, "The Switch from Fetal to Adult Hemoglobin", Cold Spring Harbor Perspectives in Medicine, (20130101), vol. 3, no. 1, doi:10.1101/cshperspect.a011643, pages a011643-1 - a011643-14, XP055341053
OPPOSITION- Hongmei Lisa Li; Takao Nakano; Akitsu Hotta, "Genetic correction using engineered nucleases for gene therapy applications", DEVELOPMENT GROWTH AND DIFFERENTIATION., Richmond, Vic. : Blackwell Publ. Asia, US, US , (20131211), vol. 56, no. 1, doi:10.1111/dgd.12107, ISSN 0012-1592, pages 63 - 77, XP071144200
OPPOSITION- D. E. Bauer, S. C. Kamran, S. Lessard, J. Xu, Y. Fujiwara, C. Lin, Z. Shao, M. C. Canver, E. C. Smith, L. Pinello, P. J. Sabo, J. Vierstra, R. A. Voit, G.-C. Yuan, M. H. Porteus, J. A. Stamatoyannopoulos, G. Lettre, S. H. Orkin, "An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level", Science, American Association for the Advancement of Science, (20131011), vol. 342, no. 6155, doi:10.1126/science.1242088, ISSN 00368075, pages 253 - 257, XP055203754
OPPOSITION- Bauer Daniel E.; Kamran Sophia C.; Lessard Samuel; Xu Jian; Fujiwara Yuko; Lin Carrie; Shao Zhen; Canver Matthew C.; Smith Elenoe C.; Pinello Luca; Sabo Peter J.; Vierstra Jeff; Voit Richard A.; Yuan Guo-Cheng; Porteus Matthew H.; Stamatoyannopoulos John; Lettre Guillaume; Orkin Stuart H., "Fine-Mapping and Genome Editing Reveal An Essential Erythroid Enhancer At The HbF-Associated BCL11A Locus", Blood, American Society of Hematology, US, US , (20131115), vol. 122, no. 21, doi:10.1182/blood.V122.21.437.437, ISSN 0006-4971, page 437, XP086749940
OPPOSITION- Olivia Corradin;Peter C Scacheri, "Enhancer variants: evaluating functions in common disease", GENOME MEDICINE, (20141028), vol. 6, no. 10, doi:10.1186/s13073-014-0085-3, ISSN 1756-994X, page 85, XP021208823
OPPOSITION- Ryo Kurita, Noriko Suda, Kazuhiro Sudo, Kenichi Miharada, Takashi Hiroyama, Hiroyuki Miyoshi, Kenzaburo Tani, Yukio Nakamura, "Establishment of Immortalized Human Erythroid Progenitor Cell Lines Able to Produce Enucleated Red Blood Cells", PLoS ONE, (201303), vol. 8, no. 3, doi:10.1371/journal.pone.0059890, page e59890, XP055488499
OPPOSITION- Roberto Gambari, Alessia Finotti, Laura Breda, Carsten Lederer, Nicoletta Bianchi, Cristina Zuccato, Marina Klenathous, Stefano Rivella, "Recent trends in the gene therapy of β-thalassemia", Journal of Blood Medicine, (2015), doi:10.2147/JBM.S46256, pages 69 - 85, XP055482908
SEARCH- SEBASTIANI P ET AL, "BCL11Aenhancer haplotypes and fetal hemoglobin in sickle cell anemia", BLOOD CELLS, MOLECULES AND DISEASES, (20150130), vol. 54, no. 3, doi:10.1016/J.BCMD.2015.01.001, ISSN 1079-9796, pages 224 - 230, XP029201175 [A] 1-16 * the whole document *
SEARCH- CARMEN F BJURSTRÖM ET AL, "Reactivating Fetal Hemoglobin Expression in Human Adult Erythroblasts Through BCL11A Knockdown Using Targeted Endonucleases", MOLECULAR THERAPY-NUCLEIC ACIDS, (20160101), vol. 5, doi:10.1038/mtna.2016.52, ISSN 2162-2531, page e351, XP055497327 [XP] 1-16 * the whole document *
SEARCH- MATTHEW C. CANVER ET AL, "BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis", NATURE, United Kingdom, (20150916), vol. 527, no. 7577, doi:10.1038/nature15521, ISSN 0028-0836, pages 192 - 197, XP055274680 [XP] 1-16 * the whole document *
SEARCH- JOHN G DOENCH ET AL, "Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation", NATURE BIOTECHNOLOGY, (20140903), vol. 32, no. 12, doi:10.1038/nbt.3026, ISSN 1087-0156, pages 1262 - 1267, XP055190845 [YD] 3-5,9,13-16 * the whole document *
SEARCH[ ] - JOHN G DOENCH ET AL, "Supplementary material: Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation", NATURE BIOTECHNOLOGY, US, (20140903), vol. 32, no. 12, doi:10.1038/nbt.3026, ISSN 1087-0156, pages 1262 - 1267, XP055294825
SEARCH- D. E. BAUER ET AL, "Supplementary Material: An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level", SCIENCE, US, (20131011), vol. 342, no. 6155, doi:10.1126/science.1242088, ISSN 0036-8075, pages 1 - 39, XP055497414 [X] 1,2,6-8,10-12 * the whole document * [Y] 3-5,9,13-16
SEARCH- T. WANG ET AL, "Genetic Screens in Human Cells Using the CRISPR-Cas9 System", SCIENCE, (20131212), vol. 343, no. 6166, doi:10.1126/science.1246981, ISSN 0036-8075, pages 80 - 84, XP055115509 [YD] 3-5,9,13-16 * the whole document *
SEARCH[ ] - T. WANG ET AL, "Supplementary Material: Genetic Screens in Human Cells Using the CRISPR-Cas9 System", SCIENCE, US, (20131212), vol. 343, no. 6166, doi:10.1126/science.1246981, ISSN 0036-8075, pages 80 - 84, XP055294787

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