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Non-Invasive Determination Of Methylome Of Tumor From Plasma - EP3354747

The patent EP3354747 was granted to The Chinese University OF Hong Kong on Feb 17, 2021. The application was originally filed on Sep 20, 2013 under application number EP17202149A. The patent is currently recorded with a legal status of "Revoked".

EP3354747

THE CHINESE UNIVERSITY OF HONG KONG
Application Number
EP17202149A
Filing Date
Sep 20, 2013
Status
Revoked
Nov 10, 2023
Grant Date
Feb 17, 2021
External Links
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JAMES POOLENov 17, 2021CARPMAELS & RANSFORD -
EUROPEAN OPPOSITIONSNov 16, 2021LEONARDADMISSIBLE

Patent Citations (16) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS20100940992-
DESCRIPTIONUS2009029377
DESCRIPTIONUS2011276277
DESCRIPTIONUS6927028
OPPOSITIONEP2380993
OPPOSITIONUS2005221314
OPPOSITIONUS2009162836
OPPOSITIONUS2011028333
OPPOSITIONWO2006128192
OPPOSITIONWO2008155549
OPPOSITIONWO2011038507
OPPOSITIONWO2011150075
OPPOSITIONWO2012031329
OPPOSITIONWO2014043763
SEARCHEP2380993
SEARCHWO2011038507

Non-Patent Literature (NPL) Citations (98) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- AB FLUSBERG et al., Nat Methods, (20100000), vol. 7, pages 461 - 465-
DESCRIPTION- AB SPARKS et al., Am J Obstet Gynecol, (20120000), vol. 206, pages 319.el - 9-
DESCRIPTION- A SRINIVASAN et al., Am J Hum Genet, (20130000), vol. 92, pages 167 - 176-
DESCRIPTION- BA FLUSBERG et al., Nat Methods, (20100000), vol. 7, pages 461 - 465-
DESCRIPTION- B NOVAKOVIC et al., Placenta, (20120000), vol. 33, pages 959 - 970-
DESCRIPTION- B VOGELSTEIN et al., Proc Natl Acad Sci, (19990000), vol. 96, pages 9236 - 9241-
DESCRIPTION- BW FUTSCHER et al., Nat Genet, (20020000), vol. 31, pages 175 - 179-
DESCRIPTION- B ZIMMERMANN et al., Prenat Diagn, (20120000), vol. 32, pages 1233 - 1241-
DESCRIPTION- C CLARK et al., PLoS One, (20120000), vol. 7, page e50233-
DESCRIPTION- CG LIAN et al., Cell, (20120000), vol. 150, pages 1135 - 1146-
DESCRIPTION- DW BIANCHI DW et al., Obstet Gynecol, (20120000), vol. 119, pages 890 - 901-
DESCRIPTION- DWY TSUI et al., PLoS One, (20100000), vol. 5, page e15069-
DESCRIPTION- EA PAPAGEORGIOU et al., Am J Pathol, (20090000), vol. 174, pages 1609 - 1618-
DESCRIPTION- E GEBHART et al., Cytogenet Genome Res, (20040000), vol. 104, pages 352 - 358-
DESCRIPTION- EZ CHEN et al., PLoS One, (20110000), vol. 6, page e21791-
DESCRIPTION- GAMA-SOSA MA et al., Nucleic Acids Res, (19830000), vol. 11, pages 6883 - 6894-
DESCRIPTION- G HANNUM et al., Mol Cell, (20130000), vol. 49, pages 359 - 367-
DESCRIPTION- GJ LIAO et al., PLoS One, (20120000), vol. 7, page e38154-
DESCRIPTION- H HIURA et al., Hum Reprod, (20120000), vol. 27, pages 2541 - 2548-
DESCRIPTION- JG HERMAN et al., N Engl J Med, (20030000), vol. 349, pages 2042 - 2054-
DESCRIPTION- J SHIM et al., Sci Rep, (20130000), vol. 3, page 1389-
DESCRIPTION- KCA CHAN, Clin Chem, (20130000), vol. 59, pages 211 - 224-
DESCRIPTION- KCA CHAN, Clin Chem, (20130000), vol. 59, pages 211 - 24-
DESCRIPTION- KCA CHAN et al., Clin Chem, (20040000), vol. 50, pages 88 - 92-
DESCRIPTION- KCA CHAN et al., Clin Chem, (20130000), vol. 59, pages 211 - 224-
DESCRIPTION- KCA CHAN et al., Clin Chem, (20130000), vol. 59, pages 211 - 24-
DESCRIPTION- KCA CHAN et al., Clin Chem, vol. 59, pages 211 - 224-
DESCRIPTION- KE HAWORTH et al., Epigenomics, (20130000), vol. 5, pages 37 - 49-
DESCRIPTION- LG ACEVEDO et al., Epigenomics, (20110000), vol. 3, pages 93 - 101-
DESCRIPTION- L LAURENT et al., Genome Res, (20100000), vol. 20, pages 320 - 331-
DESCRIPTION- LLM POON et al., Clin Chem, (20020000), vol. 48, pages 35 - 41-
DESCRIPTION- MA GAMA-SOSA et al., Nucleic Acids Res, (19830000), vol. 11, pages 6883 - 6894-
DESCRIPTION- M EHRLICH et al., Oncogene, (20020000), vol. 21, pages 5400 - 5413-
DESCRIPTION- M ESTELLER et al., Nat Rev Genet, (20070000), vol. 8, pages 286 - 298-
DESCRIPTION- M FROMMER et al., Proc Natl Acad Sci, (19920000), vol. 89, pages 1827 - 31-
DESCRIPTION- M GARDINER-GARDEN et al., J Mol Biol, (19870000), vol. 196, pages 261 - 282-
DESCRIPTION- MJ BOOTH et al., Nature Protocols, (20130000), vol. 8, pages 1841 - 1851-
DESCRIPTION- MJ BOOTH et al., Science, (20120000), vol. 336, pages 934 - 937-
DESCRIPTION- M KRZYWINSKI et al., Genome Res, (20090000), vol. 19, pages 1639 - 1645-
DESCRIPTION- M KULIS et al., Nat Genet, (20120000), vol. 44, pages 1236 - 1242-
DESCRIPTION- ML CHEN et al., Clin Chem, (20130000), vol. 59, pages 824 - 832-
DESCRIPTION- M YU et al., Nat Protoc, (20120000), vol. 7, pages 2159 - 2170-
DESCRIPTION- N HAJJ et al., Diabetes-
DESCRIPTION- PA FUJITA et al., Nucleic Acids Res, (20110000), vol. 39, pages D876 - 882-
DESCRIPTION- PA JONES et al., Cell, (20070000), vol. 128, pages 683 - 692-
DESCRIPTION- P TANGKIJVANICH et al., Clin Chim Acta, (20070000), vol. 379, pages 127 - 133-
DESCRIPTION- RJ LEARY et al., Sci Transl Med, (20120000), vol. 4, page 162ra154-
DESCRIPTION- R LI et al., Bioinformatics, (20090000), vol. 25, pages 1966 - 1967-
DESCRIPTION- R LISTER et al., Cell, (20080000), vol. 133, pages 523 - 536-
DESCRIPTION- R LISTER et al., Nature, (20090000), vol. 462, pages 315 - 322-
DESCRIPTION- RWK CHIU et al., Am J Pathol, (20070000), vol. 170, pages 941 - 950-
DESCRIPTION- RWK CHIU et al., BMJ, (20110000), vol. 342, page c7401-
DESCRIPTION- RWK CHIU et al., Proc Natl Acad Sci, (20080000), vol. 105, pages 20458 - 20463-
DESCRIPTION- SB BAYLIN et al., Nat Rev Cancer, (20110000), vol. 11, pages 726 - 734-
DESCRIPTION- SCY YU et al., PLoS One, (20130000), vol. 8, page e60968-
DESCRIPTION- S.S.C. CHIM et al., Clin Chem, (20080000), vol. 54, pages 500 - 511-
DESCRIPTION- SSC CHIM et al., Clin Chem, (20080000), vol. 54, pages 500 - 511-
DESCRIPTION- SSC CHIM et al., Proc Natl Acad Sci, (20050000), vol. 102, pages 14753 - 14758-
DESCRIPTION- SSC CHIM et al., Proc Natl Acad Sci USA, (20050000), vol. 102, pages 14753 - 14758-
DESCRIPTION- T CHU et al., PLoS One, (20110000), vol. 6, page e14723-
DESCRIPTION- TM SNYDER et al., Proc Natl Acad Sci, (20110000), vol. 108, pages 6229 - 6234-
DESCRIPTION- WOODFINE et al., Epigenetics Chromatin, (20110000), vol. 4, page 1-
DESCRIPTION- X JIANG et al., FASEB J, (20120000), vol. 26, pages 3563 - 3574-
DESCRIPTION- Y LI et al., PLoS Biol, (20100000), vol. 8, page e1000533-
DESCRIPTION- YMD LO et al., Am J Hum Genet, (19980000), vol. 62, pages 768 - 775-
DESCRIPTION- YMD LO et al., Lancet, (19980000), vol. 351, pages 1329 - 1330-
DESCRIPTION- YMD LO et al., Proc Natl Acad Sci, (20070000), vol. 104, pages 13116 - 13121-
DESCRIPTION- YMD LO et al., Sci Transl Med, (20100000), vol. 2, page 61ra91-
DESCRIPTION- YMD LO, Lancet, (19980000), vol. 351, pages 1329 - 1330-
DESCRIPTION- YW ZHENG, Clin Chem, (20120000), vol. 58, pages 549 - 558-
DESCRIPTION- YW ZHENG et al., Clin Chem, (20120000), vol. 58, pages 549 - 558-
DESCRIPTION- YYN LUI et al., Clin Chem, (20020000), vol. 48, pages 421 - 7-
OPPOSITION- ESTELLER ET et al., "A Gene Hypermethylation Profile of Human Cancer", Cancer Res., (20110415), vol. 61, no. 8, pages 3225 - 3229, XP055875812-
OPPOSITION- GREEN MR et al., Molecular Cloning, A Laboratory Manual, (20120615), pages 1 - 210-
OPPOSITION- QURESHI et al., "Utility of DNA methylation markers for diagnosing cancer", Int J Surg, (20100000), vol. 8, no. 3, pages 194 - 198, XP027003413-
OPPOSITION- Watanabe Yoshihisa, "Methylation of DNA in cancer", Advances in clinical chemistry, (20100101), vol. 52, pages 145 - 167, XP055878833-
OPPOSITION- WONG et al., "Epigenetic Tumor Markers in Plasma and Serum: Biology and Applications to Molecular Diagnosis and Disease Monitoring", Ann n YAcadSci, (20010000), vol. 945, pages 36 - 50, XP008019950-
OPPOSITION- LEVENSON VICTOR V, "Biomarkers for early detection of breast cancer: what, when, and where?", Biochimica et Biophysica Acta, Elsevier, AMSTERDAM, NL, AMSTERDAM, NL , (20070601), vol. 1770, no. 6, doi:10.1016/J.BBAGEN.2007.01.017, ISSN 0304-4165, pages 847 - 856, XP002541100
OPPOSITION- Noushmehr Houtan, Weisenberger Daniel J., Diefes Kristin, Phillips Heidi S., Pujara Kanan, Berman Benjamin P., Pan Fei, Pelloski Christopher E., Sulman Erik P., Bhat Krishna P., Verhaak Roel G.W., Hoadley Katherine A., Hayes D. Neil, Perou Charles M., Schmidt Heather K., Ding Li, Wilson Richard K., Van Den Berg David, Shen Hui, Bengtsson Henrik, Neuvial Pierre, Cope Leslie M., Buckley Jonathan, Herman James G., Baylin Stephen B., Laird Peter W., Aldape Kenneth, "Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma", CANCER CELL, CELL PRESS, US, US , (20100501), vol. 17, no. 5, doi:10.1016/j.ccr.2010.03.017, ISSN 1535-6108, pages 510 - 522, XP055875819
OPPOSITION- FIGUEROA et al., "Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation", Cancer Cell, (20100000), vol. 18, no. 6, doi:10.1016/j.ccr.2010.11.015, pages 553 - 567, XP055353425
OPPOSITION- Ziegler Annemarie, Zangemeister-Wittke Uwe, Stahel Rolf A, "Circulating DNA: a new diagnostic gold mine?", Cancer Treatment Reviews, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20021001), vol. 28, no. 5, doi:10.1016/S0305-7372(02)00077-4, ISSN 0305-7372, pages 255 - 271, XP055878809
OPPOSITION- Yang Qiong, Et Al, "Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation", Nature Communications, (20120101), vol. 3, no. 1, doi:10.1038/ncomms2209, pages 1 - 8, XP055878820
OPPOSITION- BOCK et al., "Analysing and interpreting DNA methylation data", Nat Rev Genet, (20120000), vol. 13, no. 10, doi:10.1038/nrg3273, pages 705 - 719, XP055050740
OPPOSITION- HERMAN J G, ET AL, "Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.", Proceedings of the National Academy of Sciences, National Academy of Sciences, (19960903), vol. 93, no. 18, doi:10.1073/pnas.93.18.9821, ISSN 0027-8424, pages 9821 - 9826, XP002542477
OPPOSITION- Shamay Meir, Et Al, "CpG Methylation as a Tool to Characterize Cell-Free Kaposi Sarcoma Herpesvirus DNA", Journal of Infectious Diseases, University of Chicago Press, US, US , (20120401), vol. 205, no. 7, doi:10.1093/infdis/jis032, ISSN 0022-1899, pages 1095 - 1099, XP055878823
OPPOSITION- VARLEY et al., "Bisulfite Patch PCR enables multiplexed sequencing of promoter methylation across cancer samples", Genome Research, (20100000), vol. 20, doi:10.1101/gr.101212.109, pages 1279 - 1287, XP055815221
OPPOSITION- Laurent Louise, Et Al, "Dynamic changes in the human methylome during differentiation", Genome Research, Cold Spring Harbor Laboratory Press, US, US , (20100301), vol. 20, no. 3, doi:10.1101/gr.101907.109, ISSN 1088-9051, pages 320 - 331, XP055878828
OPPOSITION- KORSHUNOVA et al., "Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer-associatEd cytosine-methylation patterns obtained from tissue and serum DNA", Genome Research, (20080000), vol. 18, doi:10.1101/gr.6883307, pages 19 - 29, XP055396258
OPPOSITION- JIANG et al., "Methy-Pipe: An Integrated Bioinformatics Data Analysis Pipeline for Whole Genome Methylome Analysis", 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshop, (20100000), doi:10.1109/BIBMW.2010.5703866, pages 585 - 590, XP031885588
OPPOSITION- Sceusi Eric L., Loose David S., Wray Curtis J., "Clinical implications of DNA methylation in hepatocellular carcinoma", HPB, ISIS MEDICAL MEDIA, OXFORD, GB, GB , (20110601), vol. 13, no. 6, doi:10.1111/j.1477-2574.2011.00303.x, ISSN 1365-182X, pages 369 - 376, XP055875811
OPPOSITION- Maunakea Alika K., Chepelev Iouri, Zhao Keji, "Epigenome Mapping in Normal and Disease States", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, US , (20100806), vol. 107, no. 3, doi:10.1161/CIRCRESAHA.110.222463, ISSN 0009-7330, pages 327 - 339, XP055875810
OPPOSITION- AKALIN et al., "methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles", Genome Biology, (20121003), vol. 13, doi:10.1186/gb-2012-13-10-r87, page R87, XP021108527
OPPOSITION- SHAMES DAVID S, ET AL, "A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies.", PLOS MEDICINE, Public Library of Science, US, US , (20061201), vol. 3, no. 12, doi:10.1371/journal.pmed.0030486, ISSN 1549-1676, pages 2244 - 2263, XP002527542
OPPOSITION- Mikeska Thomas, Bock Christoph, Do Hongdo, Dobrovic Alexander, "DNA methylation biomarkers in cancer: progress towards clinical implementation", Expert Reviews in Molecular Diagnostics, FUTURE DRUGS, LONDON, GB, GB , (20120601), vol. 12, no. 5, doi:10.1586/erm.12.45, ISSN 1473-7159, pages 473 - 487, XP055878813
OPPOSITION- ZHAI et al., "Genome-wide DNA Methylation Profiling of Cell -Free Serum DNA in Esophageal Adenocarcinoma and Barrett Esophagus", Neoplasia, (20120100), vol. 14, doi:10.1593/neo.111626, pages 29 - 33, XP055318524
OPPOSITION- Vlassov V., Laktionov P., Rykova E., "Circulating Nucleic Acids as a Potential Source for Cancer Biomarkers", CURRENT MOLECULAR MEDICINE, BENTHAM SCIENCE PUBLISHERS, NL, NL , (20100301), vol. 10, no. 2, doi:10.2174/156652410790963295, ISSN 1566-5240, pages 142 - 165, XP055878810
OPPOSITION- Irahara Natsumi, Nosho Katsuhiko, Baba Yoshifumi, Shima Kaori, Lindeman Neal I., Hazra Aditi, Schernhammer Eva S., Hunter David J., Fuchs Charles S., Ogino Shuji, "Precision of Pyrosequencing Assay to Measure LINE-1 Methylation in Colon Cancer, Normal Colonic Mucosa, and Peripheral Blood Cells", The Journal of Molecular Diagnostics, American Society for Investigative Pathology and the Association for Molecular Pathology, (20100301), vol. 12, no. 2, doi:10.2353/jmoldx.2010.090106, ISSN 1525-1578, pages 177 - 183, XP055875815
OPPOSITION- Hongchuan Jin, Yanning Ma, Qi Shen, Xian Wang, "Circulating Methylated DNA as Biomarkers for Cancer Detection", Methylation - From DNA, RNA and Histones to Diseases and Treatment, InTech , (20121128), doi:10.5772/51419, ISBN 978-953-51-0881-8, XP055479454

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