Crispr-Based Genome Modification And Regulation - EP3360964

The patent EP3360964 was granted to Sigma Aldrich on Oct 2, 2019. The application was originally filed on Dec 5, 2013 under application number EP18156734A. The patent is currently recorded with a legal status of "Revoked".

EP3360964

SIGMA ALDRICH
Application Number
EP18156734A
Filing Date
Dec 5, 2013
Status
Revoked
Nov 22, 2024
Publication Date
Oct 2, 2019
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (8)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

MATHYS & SQUIREJul 2, 2020WILDINGADMISSIBLE
PATENTANWALTE ISENBRUCK BOSL HORSCHLER PARTG MBBJul 2, 2020SIMMONS & SIMMONS MUNICHADMISSIBLE
SCHLICHJul 2, 2020SCHLICHADMISSIBLE
BASFJul 1, 2020EISENFUHR SPEISERADMISSIBLE
PATENT BOUTIQUEMar 2, 2020PATENT BOUTIQUEADMISSIBLE
GRUNDFeb 4, 2020GRUNDADMISSIBLE
BAYER BAYERDec 23, 2019COHAUSZ & FLORACKADMISSIBLE
VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBBNov 22, 2019VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBBADMISSIBLE

Patent Citations (21) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
OPPOSITIONEP2800811
OPPOSITIONEP3138910
OPPOSITIONEP3138911
OPPOSITIONEP3241902
OPPOSITIONEP3401400
OPPOSITIONUS2005220796
OPPOSITIONUS2010076057
OPPOSITIONWO2013176772
OPPOSITIONWO2014065596
OPPOSITIONWO2014089290
OPPOSITIONWO2014093595
OPPOSITIONWO2014093622
OPPOSITIONWO2014093712
OPPOSITIONWO2014099750
SEARCHUS2010076057
SEARCHWO2011146121
SEARCHWO2013142578
SEARCHWO2013176772
SEARCHWO2014065596
SEARCHWO2014093655
SEARCHWO2014099744

Non-Patent Literature (NPL) Citations (214) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- BEERLI et al., Nat. Biotechnol., (20020000), vol. 20, pages 135 - 141
DESCRIPTION- BELFORT et al., Nucleic Acids Res., (19970000), vol. 25, pages 3379 - 3388
DESCRIPTION- CHOO et al., Curr. Opin. Struct. Biol., (20000000), vol. 10, pages 411 - 416
DESCRIPTION- CONG et al., Science, vol. 339, pages 819 - 823
DESCRIPTION- DAYHOFF, Atlas of Protein Sequences and Structure, National Biomedical Research Foundation, vol. 5, pages 353 - 358
DESCRIPTION- DOYON et al., Nat. Biotechnol., (20080000), vol. 26, pages 702 - 708
DESCRIPTION- DOYON et al., Nat. Methods, (20110000), vol. 8, pages 74 - 81
DESCRIPTION- GRIBSKOV, Nucl. Acids Res., (19860000), vol. 14, no. 6, pages 6745 - 6763
DESCRIPTION- ISALAN et al., Nat. Biotechnol., (20010000), vol. 19, pages 656 - 660
DESCRIPTION- ISELI et al., PLos One, vol. 2, no. 6, page e579
DESCRIPTION- JINEK et al., Science, vol. 337, pages 816 - 821
DESCRIPTION- LANGE et al., J. Biol. Chem., (20070000), vol. 282, pages 5101 - 5105
DESCRIPTION- LOMBARDO et al., Nat. Biotechnology, (20070000), vol. 25, pages 1298 - 1306
DESCRIPTION- MILLER et al., Nat. Biotechnol, (20070000), vol. 25, pages 778 - 785
DESCRIPTION- MOEHLE et al., PNAS, (20070000), vol. 104, pages 3055 - 3060
DESCRIPTION- PABO et al., Ann. Rev. Biochem., (20010000), vol. 70, pages 313 - 340
DESCRIPTION- SANTIAGO et al., PNAS, (20080000), vol. 105, pages 5809 - 5814
DESCRIPTION- SANTIAGO et al., Proc. Natl. Acad. Sci. USA, (20080000), vol. 105, pages 5809 - 5814
DESCRIPTION- SEGAL et al., Curr. Opin. Biotechnol., (20010000), vol. 12, pages 632 - 637
DESCRIPTION- SMITH; WATERMAN, Advances in Applied Mathematics, (19810000), vol. 2, pages 482 - 489
DESCRIPTION- SZCZPEK et al., Nat. Biotechnol, (20070000), vol. 25, pages 786 - 793
DESCRIPTION- URNOV et al., Nature, (20050000), vol. 435, pages 646 - 651
DESCRIPTION- ZHANG et al., J. Biol. Chem., (20000000), vol. 275, no. 43, pages 33850 - 33860
OPPOSITION- Addgene entry for plasmid pMJ806
OPPOSITION- ALBERTS, Molecular Biology of the Cell, (20020000), vol. 54, no. 2, pages 671 - 676, XP055285246
OPPOSITION- "Barrangou. RNA-mediated programmable DNA cleavage", Nature Biotechnology, (20120000), vol. 30, no. 9, pages 836 - 838
OPPOSITION- BARRANUOU, Nature Biotech, (20120000), vol. 30, pages 836 - 838
OPPOSITION- BEUMER, PNAS, (20080000), vol. 105, pages 19821 - 19826
OPPOSITION- BIZZARRI, Anal. Bioanal. Chem., (20120000), vol. 403, pages 2339 - 2351
OPPOSITION- BONTEMS et al., "Phosphorylation of Varicella-Zoster 2002 Virus IE 63 Protein by Casein Kinases Influences Its Cellular Localization and Gene Regulation Activity", The Journal of Biological Chemistry, vol. 777, no. 23, pages 21050 - 21060, XP055899851
OPPOSITION- BROUNS, Science, (20120000), vol. 337, pages 808 - 809
OPPOSITION- BRUNET, PNAS, (20090000), vol. 106, pages 10620 - 10625
OPPOSITION- CAMPEAU, Plos One, (20090000), vol. 4, page e6529
OPPOSITION- CARNEY, Methods in Mol. Biol., (19990000), vol. 113, pages 465 - 471
OPPOSITION- CARROLL, Genetics, (20110000), vol. 188, pages 773 - 782
OPPOSITION- CARROLL, Molecular Therapy, (20120000), vol. 20, page 1658
OPPOSITION- CARROLL, Nature Protocols, (20060000), vol. 1, pages 1329 - 1341
OPPOSITION- CERMAK, Nucleic Acids Res., (20110000), vol. 39, pages 1 - 11
OPPOSITION- CHANG, Cell Research, (20130000), vol. 23, pages 465 - 472
OPPOSITION- CHANG., Development, (20110000), vol. 138, pages 3509 - 3518
OPPOSITION- CHEN, FEBS Letters, (20070000), vol. 581, pages 1891 - 97
OPPOSITION- CHO, Nature Biotechnology, (20130000), vol. 31, pages 230 - 232
OPPOSITION- CHRISTIAN, Genetics, (20100000), vol. 186, pages 757 - 761
OPPOSITION- CHRISTIAN, M. et al., "Targeting DNA Double-Strand Breaks with TAL Effector Nucleases", Genetics, (20100000), vol. 186, pages 757 - 761
OPPOSITION- CHUGH, IUBMB Life, (20100000), vol. 62, pages 183 - 93
OPPOSITION- cNLS Mapper Result - report of predicted NLSs in the S. pyogenes Cas9 sequence generated using the online cNLS mapper algorithm, URL: www.nls- mapper. iab.keio.ac.jp
OPPOSITION- CONG et al., Science, (20130215), vol. 339, pages 819 - 823
OPPOSITION- CONG, L. et al., "Multiplex genome engineering using 03.01.2013 Art. 54 (2) EPC CRISPR/Cas systems", Science, (20130103), vol. 339, pages 819 - 823, XP002779503
OPPOSITION- CONG, Science, (20130000), vol. 339, pages 819 - 823
OPPOSITION- DAI, J. Biol. Chem., (20020000), vol. 277, pages 24390 - 24398
OPPOSITION- DAVIS, G.D. et al., "Zinc Finger Nucleases for Genome Editing", Genetic Engineering & Biotechnology News, (20100000), vol. 30, no. 13
OPPOSITION- Declaration of Dr. Anegon
OPPOSITION- Declaration of Dr. Bao
OPPOSITION- Declaration of Dr. Stirling
OPPOSITION- Deposition of Dr. Simons
OPPOSITION- DEROSSI, The Journal of Biological Biochemistry, (19960000), vol. 271, pages 18188 - 18193
OPPOSITION- DICARLO ., Nucleic Acids Res, (20130000), vol. 41, pages 4336 - 43
OPPOSITION- DINGWALL, Cell, (19820000), vol. 30, pages 449 - 458
OPPOSITION- DINGWALL, J. Cell Biol., (19880000), vol. 107, pages 841 - 849
OPPOSITION- DO, FEBS Lett., (20060000), vol. 580, no. 7, pages 1865 - 71
OPPOSITION- EFTHYMIADIS, JBC, (19980000), vol. 273, pages 1623 - 28
OPPOSITION- FIECK et al., "Modifications of the E. coli Lac repressor for expression in eukaryotic cells: effects of nuclear signal sequences on protein activity and nuclear accumulation", Nucleic Acids Res., (19920000), vol. 20, no. 7, pages 1785 - 1791, XP002095852
OPPOSITION- FIECK, Nucleic Acids Res., (19920000), vol. 29, pages 1785 - 1791
OPPOSITION- FISCHER-FANTUZZI, Mol. Cell Biol., (19880000), vol. 8, pages 5495 - 5503
OPPOSITION- FOECKING, Gene, (19860000), vol. 45, pages 101 - 105
OPPOSITION- FREITAS, Current Genomics, (20090000), vol. 10, pages 550 - 557
OPPOSITION- FURUTAMA, J. Neurosci. Res., (20100000), vol. 88, pages 2810 - 2825
OPPOSITION- GARNEAU, Nature, (20100000), vol. 468, page 67
OPPOSITION- GEURTS, Science, (20090000), vol. 325, page 433
OPPOSITION- GOLDFARB, Trends in Cell Biology, (20040000), vol. 14, pages 505 - 514
OPPOSITION- GRATZ, Genetics, (20130000), vol. 194, pages 1029 - 35
OPPOSITION- GREENWALD et al., Investigative Ophthalmology & Visual Science, (20100000), vol. 51, pages 6374 - 6380
OPPOSITION- HAN, Mol. Cells, (20000000), vol. 10, pages 728 - 32
OPPOSITION- HODEL, JBC, (20060000), vol. 281, pages 23545 - 23556
OPPOSITION- HWANG, Nature Biotechnology, (20130000), vol. 31, pages 227 - 229
OPPOSITION- IMAGAWA, FEBS Lett., (20000000), vol. 484, pages 118 - 124
OPPOSITION- JINEK et al., Science, (20120628), vol. 337, pages 816 - 821
OPPOSITION- JINEK , M. et al., eLife, (20130000), vol. 2e00471
OPPOSITION- JINEK, Science, (20120000), vol. 337, pages 816 - 821
OPPOSITION- JOUNG, Nat. Rev. Mol. Cell Biol., (20130000), vol. 14, pages 49 - 55
OPPOSITION- KALDERON, Cell, (19840000), vol. 39, pages 499 - 509
OPPOSITION- KIM, Gene, (19900000), vol. 91, pages 217 - 223
OPPOSITION- LANGE, J. Biol. Chem., (20070000), vol. 282, pages 5101 - 5105
OPPOSITION- LAUMONIER, Mol. Ther., (20080000), vol. 16, pages 404 - 410
OPPOSITION- LEE, G3, (20140000), vol. 4, pages 1291 - 1295
OPPOSITION- LIANG, PNAS, (19980000), vol. 95, pages 5172 - 5177
OPPOSITION- LOMBARDO, Nature Biotech., (20070000), vol. 25, pages 1298 - 1306
OPPOSITION- LUO, Traffic, (20040000), vol. 5, no. 11, pages 847 - 854
OPPOSITION- LVSSENKO, BioTechniques, (20070000), vol. 43, pages 596 - 600
OPPOSITION- MAKAROVA, Nature, (20110000), vol. 9, pages 467 - 77
OPPOSITION- MALI et al., Science, (20130215), vol. 339, pages 823 - 826
OPPOSITION- MALI, Science, (20130000), vol. 339, pages 823 - 26
OPPOSITION- MA, PLoS ONE, (20120000), vol. 7, page e45035
OPPOSITION- MCCONNELL, Molecular Cance r, (20110000), vol. 10, page 75
OPPOSITION- MILLER, Mol. Cell . Biol., (20030000), vol. 23, pages 3550 - 3557
OPPOSITION- MILLER, Nature Biotechnology, (20110000), vol. 29, pages 143 - 148
OPPOSITION- MI, Molecular Therapy, (20000000), vol. 2, pages 339 - 47
OPPOSITION- MOJICA, Microbiology, (20090000), vol. 155, pages 733 - 740
OPPOSITION- MORGAN, Mol. Cell . Biol., (19880000), vol. 8, pages 4204 - 4211
OPPOSITION- NIH grant application
OPPOSITION- NIH policy regarding requests for copies of grant applications
OPPOSITION- NIH RePORTER
OPPOSITION- NLS mapper
OPPOSITION- PARK, J. Biol. Chem., (20020000), vol. 277, pages 31423 - 31429
OPPOSITION- PATTERSON, J. Ind. Microbiol. Biotechnol, (20050000), vol. 32, pages 115 - 123
OPPOSITION- PLANEY, J. Biol. Chem., (20020000), vol. 277, pages 42188 - 42196
OPPOSITION- pSVK3 Vector, URL: http://www.addgene.org/vector- database/4288
OPPOSITION- RAYMOND, PLoS One, (20070000), vol. 2, no. 1, page e162
OPPOSITION- REBAR, Nature Medicine, (20020000), vol. 8, pages 1427 - 32
OPPOSITION- REDREIO-RODRISUEZ, PNAS, (20120000), vol. 109, pages 18482 - 7
OPPOSITION- REISS, PNAS, (19960000), vol. 93, pages 3094 - 3098
OPPOSITION- RUBEN, J. Virol., (19890000), vol. 63, pages 1 - 8
OPPOSITION- SAPRANAUSKAS, Nucleic Acid Research, (20110000), vol. 39, pages 9275 - 82
OPPOSITION- SAUER, Molecular and Cellular Biology, (19870000), vol. 7, pages 2087 - 2096
OPPOSITION- SCHRAMM, Genes Dev., (20020000), vol. 16, pages 2593 - 2620
OPPOSITION- SHEN, Cell Research, (20130000), vol. 23, pages 720 - 23
OPPOSITION- SHIEH., Plant Physiol., (19930000), vol. 101, pages 353 - 361
OPPOSITION- SOUILHOL, Genesis, (20060000), vol. 44, pages 277 - 286
OPPOSITION- TESSON, Nat. Biotechnol., (20110000), vol. 29, pages 695 - 696
OPPOSITION- The guide sequence can bind to a chromosomal sequence in Canis lupus
OPPOSITION- THOMAS, Cell, (19860000), vol. 44, pages 419 - 428
OPPOSITION- TINLAND, PNAS, (19920000), vol. 89, pages 7442 - 7446
OPPOSITION- TOVKACH et al., The Plant Journal, (20090000), vol. 57, pages 747 - 757
OPPOSITION- TRUANT, Mol. Cellular Biol., (19990000), vol. 19, pages 1210 - 17
OPPOSITION- URL: http://www.addgene.org/vector-database/4288
OPPOSITION- URNOV, Nat. Rev. Gene, (20100000), vol. 11, pages 636 - 646
OPPOSITION- VAN DEN ACKERVEKEN, Cell, (19960000), vol. 87, pages 1307 - 1316
OPPOSITION- VILLION, Cell Research, (20120000), vol. 23, pages 15 - 17
OPPOSITION- WANG, Cell, (20130000), vol. 153, pages 910 - 8
OPPOSITION- XU, New York Fruit Quarterly, (20130000), vol. 21, pages 19 - 22
OPPOSITION- YANG, FEBS Letters, (20020000), vol. 532, pages 36 - 44
OPPOSITION- Yarris Lynn, "Programmable DNA Scissors Found for Bacterial Immune System. Discovery Could Lead to Editing Tool for Genomes", Berkeley Lab - News Center, (20120628), Berkeley Lab - News Center, URL: https://newscenter.lbl.gov/2012/06/28/programmable-dna-scissors/, (20220405), XP055908918
OPPOSITION- YU et al., "Highly efficient genome modifications 05.07.2013 Art. 54 (2) EPC mediated by CRISPR/Cas9 in Drosophila", Genetics, (20130000), vol. 95, no. 1, pages 289 - 91, XP055765469
OPPOSITION- ZHANG, Arch Viro l, (20090000), vol. 154, pages 1027 - 1034
OPPOSITION- ZURIS, Nat. Biotechnol., (20150000), vol. 33, no. 1, pages 73 - 80
OPPOSITION- MARFORI et al., "Molecular basis for specificity of nuclear import and prediction of nuclear localization", Biochim. Biophys. Acta, (20110000), vol. 1813, doi:10.1016/j.bbamcr.2010.10.013, pages 1562 - 1577, XP055378211
OPPOSITION- PEREZ-PINERA, P., "Advances in Targeted Genome Editing", Current Opinion in Chemical Biology, (20120000), vol. 16, no. 3-4, doi:10.1016/j.cbpa.2012.06.007, pages 268 - 277, XP055065262
OPPOSITION- WANG et al., "One-step generation of mice 02.05.2013 Art. 54 (2) EPC carrying mutations in multiple genes by CRISPR/Cas- [P**] mediated genome engineering", Cell, (20130000), vol. 153, no. 4, pages 910 - 8, XP028538358
OPPOSITION- MUSSOLINO , C. et al., "TALE nucleases: tailored genome engineering made easy", Current Opinion Biotechnology, (20120000), vol. 23, no. 5, doi:10.1016/j.copbio.2012.01.013, pages 644 - 650, XP055071668
OPPOSITION- DO et al., "Identification of multiple nuclear localization signals in murine Elf3, an ETS transcription factor", FEBS Letters, (20060228), vol. 580, no. 7, doi:10.1016/j.febslet.2006.02.049, pages 1865 - 71, XP028030315
OPPOSITION- YANG et al., "HIV TAT-mediated protein transduction and subcellular D8 localization using novel expression vectors", FEBS Letters, (20020000), vol. 532, doi:10.1016/S0014-5793(02)03624-4, pages 36 - 44, XP004395339
OPPOSITION- YANG, Y. et al., "HIV-1 TAT-mediated protein 01.11.2002 Art. 54 (2) EPC transduction and subcellular localization using novel expression vectors", FEBS Letters, (20020000), vol. 532, pages 36 - 44, XP004395339
OPPOSITION- YANG Y. et al., "HIV-1 TAT-mediated protein transduction and subcellular localization using novel expression vectors", FEBS Letters, (20020000), vol. 532, doi:10.1016/S0014-5793(02)03624-4, pages 36 - 44, XP004395339
OPPOSITION- CHANG et al., "Genome editing with RNA-guided Cas9 26.03.2013 Art. 54 (2) EPC nuclease in zebrafish embryos", Cell Research [P**, (20130000), vol. 23, no. 4, page 465, XP055251146
OPPOSITION- SHEN et al., "Generation of gene -modified mice via 02.04.2013 Art. 54 (2) EPC Cas9/RNA-mediated gene targeting", Cell Research, (20130000), vol. 23, pages 720 - 723, XP055141533
OPPOSITION- CARROLL, D., "Progress and prospects: Zinc-finger 11.09.2008 Art. 54 (2) EPC nucleases as gene therapy agents", Gene Ther., (20080000), vol. 15, page 1463, XP055041104
OPPOSITION- CARROLL , D., "Progress and prospects: zinc-finger nucleases as gene therapy agents", Gene Therapy, (20080000), vol. 15, doi:10.1038/gt.2008.145, pages 1463 - 1468, XP055041104
OPPOSITION- CARROLL, "Zinc-finger Nucleases as Gene Therapy Agents", Gene Ther., (20081100), vol. 15, no. 22, doi:10.1038/gt.2008.145, pages 1463 - 1468, XP055041104
OPPOSITION- CARROLL, "D. A CRISPR Approach to Gene Targeting", Molecular Therapy, (20120000), vol. 20, no. 9, doi:10.1038/mt.2012.171, pages 1658 - 1660, XP055106489
OPPOSITION- CARROLL, D. et al., "A CRISPR approach to gene targeting'' 09/2012 Art. 54 (2", EPC Molecular Therapy, (20120000), vol. 20, no. 9, page 1658, XP055106489
OPPOSITION- Daniel F Carlson, Scott C Fahrenkrug, Perry B Hackett, "Targeting DNA With Fingers and TALENs", Molecular Therapy — Nucleic Acids, (20120101), vol. 1, no. 1, doi:10.1038/mtna.2011.5, pages 1 - 4, XP055182775
OPPOSITION- URNOV, F.D. et al., "Highly efficient endogenous human gene correction using zinc-finger nucleases", Nature, (20050000), vol. 435, doi:10.1038/nature03556, pages 646 - 651, XP002411069
OPPOSITION- BEDELL, V.M. et al., "In vivo genome editing using a high-efficiency TALEN system", Nature, (20120000), vol. 491, doi:10.1038/nature11537, pages 114 - 118, XP055048281
OPPOSITION- PORTEUS, M.H. et al., "Gene targeting using zinc finger nucleases", Nature Biotechnology, (20050000), vol. 23, no. 8, doi:10.1038/nbt1125, pages 967 - 973, XP002467422
OPPOSITION- HOCKEMEYER et al., "Highly efficient gene targeting of expressed and silent genes in human ESCs and iPSCs using zinc finger nucleases", Nat. Biotechnol., (20090000), vol. 27, no. 9, doi:10.1038/nbt.1562, pages 851 - 857, XP055642140
OPPOSITION- MILLER et al., "A TALE nuclease architecture for efficient genome editing", Nature Biotechnology, (20111222), vol. 29, no. 2, doi:10.1038/nbt.1755, pages 143 - 148, XP055568321
OPPOSITION- MILLER, J. C. et al., "A TALE nuclease architecture for 22.12.2010 Art. 54 (2) EPC efficient genome editing", Nat. Biotechnol., (20110000), vol. 29, page 143, XP055568321
OPPOSITION- MILLER, J.C. et al., "A TALE nuclease architecture for efficient genome editing", Nature Biotechnology, (20110000), vol. 29, no. 2, doi:10.1038/nbt.1755, pages 143 - 148, XP055568321
OPPOSITION- REYON, D. et al., "FLASH Assembly of TALENS Enables High-Throughput Genome Editing", Nature Biotechnology, (20120000), vol. 30, no. 5, doi:10.1038/nbt.2170, pages 460 - 465, XP055565802
OPPOSITION- BARRANGOU, "RNA-mediated programmable DNA cleavage", Nature Biotechnology, (20110000), vol. 30, no. 9, doi:10.1038/nbt.2357, pages 836 - 838, XP055118675
OPPOSITION- BARRANGOU, R., "RNA-mediated programmable DNA 10.09.2012 Art. 54 (2) EPC cleavage", Nature Biotech., (20120000), vol. 30, no. 9, pages 836 - 838, XP055118675
OPPOSITION- HWANG et al., "Efficient genome editing in zebrafish using a CRISPR-Cas system", Nature Biotechnology, (20130129), vol. 31, no. 3, doi:10.1038/nbt.2501, pages 227 - 229, XP055086625
OPPOSITION- CHO, S. et al., "Targeted genome engineering in 29.01.2013 Art. 54 (2) EPC human cells with the Cas9 RNA-guided [P*] endonuclease", Nature Biotechnology, (20130000), vol. 31, pages 230 - 232, XP002699850
OPPOSITION- Seung Woo Cho, Sojung Kim, Jong Min Kim, Jin-Soo Kim, "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease (includes Supplementary information)", Nature Biotechnology, Gale Group Inc., New York, us, us, (20130301), vol. 31, no. 3, doi:10.1038/nbt.2507, ISSN 1087-0156, pages 230 - 232+1-11, XP002699850
OPPOSITION- HSU et al., "DNA targeting specificity of RNA-guided 21.07.2013 Art. 54 (2) EPC Cas9 nucleases", Nature Biotech, (20130000), vol. 31, no. 9, pages 827 - 834, XP055382777
OPPOSITION- REBAR et al., "Induction of angiogenesis in a mouse 2002 Art. 54 (2) EPC model using engineered transcription factors", Nature Medicine, (20020000), vol. 8, pages 1427 - 32, XP002993087
OPPOSITION- URNOV et al., "Genome editing with engineered zinc finger nucleases", Nat Rev. Genet, (20100911), vol. 11, doi:10.1038/nrg2842, pages 636 - 646, XP055198280
OPPOSITION- URNOV , F.D. et al., "Genome editing with engineered zinc finger nucleases", Nature Reviews Genetics, (20100000), vol. 11, doi:10.1038/nrg2842, pages 636 - 646, XP055198280
OPPOSITION- URNOV, F. et al., "Genome editing with engineered 09/2010 Art. 54 (2) EPC zinc finger nucleases", Nat. Rev. Gene, (20100000), vol. 11, pages 636 - 646, XP008150557
OPPOSITION- JOUNG, J. et al., "TALENS: a widely 21.11.2012 Art. 54 (2) EPC applicable technology for targeted genome editing", Nat. Rev. Mol. Cell Biol., (20120000), vol. 14, pages 49 - 55, XP055282847
OPPOSITION- MAHFOUZ, M.M. et al., "De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double- strand breaks", PNAS, (20110000), vol. 108, no. 6, doi:10.1073/pnas.1019533108, pages 2623 - 2628, XP055007615
OPPOSITION- GASIUNAS, G. et al., "Cas9-crRNA ribonucleoprotein 04.09.2012 Art. 54 (2) EPC complex mediates specific DNA cleavage for adaptive immunity in bacteria", Proc. Nat. Acad. Sci., (20120000), pages E2579 - E2586, XP055068588
OPPOSITION- DEROSSI, D. et al., "Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent", J. Biol. Chem., (19960000), vol. 271, no. 30, doi:10.1074/jbc.271.30.18188, pages 18188 - 18193, XP002024485
OPPOSITION- DEROSSI et al., "Cell internalization of the third helix of the D6 Antennapedia homeodomain is receptor-independent", J. Biol. Chem., (19960000), vol. 271, doi:10.1074/jbc.271.30.18188, pages 18188 - 18193, XP002024485
OPPOSITION- HANDEL, E.M. et al., "Versatile and Efficient Genome Editing in Human Cells by Combining Zinc-Finger Nucleases With Adeno-Associated Viral Vectors", Human Gene Therapy, (20120000), vol. 23, doi:10.1089/hum.2011.140, pages 321 - 329, XP002730956
OPPOSITION- LI, T. et al., "Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes", Nucleic Acids Research, (20110000), vol. 39, no. 14, doi:10.1093/NAR/GKR188, pages 6315 - 6325, XP002681969
OPPOSITION- CERMAK et al., "Efficient design and assembly of 2011 Art. 54 (2) EPC custom TALEN and other TAL effector-based constructs for DNA targeting", Nucleic Acids Res, (20110000), vol. 39, pages 1 - 11, XP002659530
OPPOSITION- CERMAK et al., "Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting", Nucleic Acids Research, (20110404), vol. 39, no. 12, doi:10.1093/nar/gkr218, pages 1 - 11, XP055130093
OPPOSITION- CERMAK, T. et al., "Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting", Nucleic Acids Research, (20110000), vol. 39, no. 12, doi:10.1093/nar/gkr218, page e82, XP055130093
OPPOSITION- DICARLO, J. et al., "Genome engineering in 04.03.2013 Art. 54 (2) EPC Saccharomyces cerevisiae using CRISPR/Cas systems", Nucl Acid Res., (20130000), vol. 41, no. 7, pages 4336 - 4343, XP055086617
OPPOSITION- SHIEH et al., "Nuclear Targeting of the maize R protein requires two nuclear localization sequences", Plant Physiol., (19930000), vol. 101, no. 2, doi:10.1104/pp.101.2.353, pages 353 - 361, XP055241771
OPPOSITION- LUO et al., "Multiple nuclear localization sequences allow modulation of 5-lipoxygenase nuclear import", Traffic, (20040000), vol. 5, no. 11, doi:10.1111/j.1600-0854.2004.00227.x, pages 847 - 54, XP055267791
OPPOSITION- JINEK et al., "A Programmable Dual-RNA-Guided DNA Endonuclease in D1 Adaptive Bacterial Immunity", Science, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, pages 816 - 821, XP055549487
OPPOSITION- JINEK, M. et al., "A programmable dual-RNA-guided 28.06.2012 Art. 54 (2) EPC DNA endonuclease in adaptive bacterial immunity", Science, vol. 337, pages 816 - 821, XP055067740
OPPOSITION- JINEK, M. et al., "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity", Science, (20120000), vol. 337, doi:10.1126/science.1225829, pages 816 - 821, XP055549487
OPPOSITION- BROUNS, "A Swiss Army Knife of Immunity", Science, (20120628), vol. 337, no. 6096, doi:10.1126/science.1227253, pages 808 - 809, XP055113718
OPPOSITION- BROUNS, S., "A Swiss army knife of immunity", Science, (20120817), vol. 337, doi:10.1126/science.1227253, pages 808 - 809, XP055113718
OPPOSITION- BROUNS, S.J.J. A, "Swiss Army Knife of Immunity", Science, (20120000), vol. 337, doi:10.1126/science.1227253, pages 808 - 809, XP055113718
OPPOSITION- CONG et al., "Multiplex genome engineering using CRISPR/Cas D10 systems", Science, (20130103), vol. 339, doi:10.1126/science.1231143, pages 819 - 823, XP055300065
OPPOSITION- CONG, L. et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (20130000), vol. 339, doi:10.1126/science.1231143, pages 819 - 823, XP055458249
OPPOSITION- MALI et al., "RNA-guided human genome engineering via Cas9", Science, (20130103), vol. 339, doi:10.1126/science.1232033, pages 823 - 826, XP055362871
OPPOSITION- MALI, P. et al., "RNA-guided human genome 03.01.2013 Art. 54 (2) EPC engineering via Cas9", Science, (20130000), vol. 339, pages 823 - 826, XP055111247
OPPOSITION- MALI, P. et al., "RNA-guided human genome engineering via Cas9", Science, (20130000), vol. 339, doi:10.1126/science.1232033, pages 823 - 826, XP055469277
OPPOSITION- L. FISCHER-FANTUZZI et al., "Cell -dependent efficiency of reiterated nuclear signals in a mutant simian virus 40 oncoprotein targeted to the nucleus", Mol Cell Biol., (19880000), vol. 8, no. 12, doi:10.1128/MCB.8.12.549, pages 5495 - 5503, XP009140368
OPPOSITION- Chun-Yen Yang;Chih-Wen Sun, "Sequence analysis and protein interactions of Arabidopsis CIA2 and CIL proteins", Botanical Studies, BioMed Central Ltd, London, UK, London, UK , (20200618), vol. 61, no. 1, doi:10.1186/s40529-020-00297-z, pages 1 - 13, XP021278227
OPPOSITION- RAYMOND et al., "High-Efficiency FLP and (DC31 Site-Specific Recombination in Mammalian Cells", PLoS ONE, (20070117), vol. 2, no. 1, doi:10.1371/journal.pone.0000162, XP055069825
OPPOSITION- CHRISTIAN, M. et al., "Targeting DNA double-strand 26.07.2010 Art. 54 (2) EPC breaks with TAL effector nucleases", Genetics, (20100000), vol. 186, page 757, XP002632806
OPPOSITION- Michelle Christian et al, "Targeting DNA Double-Strand Breaks with TAL Effector Nucleases (plus supporting information)", GENETICS, GENETICS SOCIETY OF AMERICA, AUSTIN, TX, US, US, (20101001), vol. 186, no. 2, doi:10.1534/GENETICS.110.120717, ISSN 0016-6731, pages 757 - 761, 1SI-8SI, XP002632806
OPPOSITION- CARROLL, D., "Genome Engineering with Zinc-Finger Nucleases", Genetics, (20110000), vol. 188, doi:10.1534/genetics.111.131433, pages 773 - 782, XP055171682
OPPOSITION- GRATZ et al., "Genome Engineering of Drosophila with 24.05.2013 Art. 54 (2) EPC the CRISPR RNA-Guided Cas9 Nuclease", Genetics [P**, (20130000), vol. 194, page 1029, XP055102690
OPPOSITION- NOGUCHI et al., "PDX-1 containing its own Antennapedia-like protein D5 transduction domain can transduce pancreatic duct and islet cells", Diabetes, (20030000), vol. 52, doi:10.2337/diabetes.52.7.1732, pages 1732 - 1737, XP002549995
OPPOSITION- NOGUCHI, H. et al., "PDX-1 Protein Containing Its Own 07/2003 Art. 54 (2) EPC Antennapedia-Like Protein Transduction Domain Can Transduce Pancreatic Duct and Islet Cells", Diabetes, (20030000), vol. 52, pages 1732 - 1737, XP002354481
OPPOSITION- NOGUCHI HIROFUMI ET AL, "PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells.", Diabetes, US , (20030701), vol. 52, no. 7, doi:10.2337/diabetes.52.7.1732, ISSN 0012-1797, pages 1732 - 1737, XP002354481
OPPOSITION- KUWAYAMA, "Enhancement of homologous recombination efficiency by homologous oligonucleotides", InTech open science, (20120000), doi:10.5772/47779, pages 233 - 244, XP055394404
OPPOSITION- JINEK et al., "RNA-programmed genome editing in human cells", eLife, vol. 2, doi:10.7554/eLife.00471, (20130129), page e00471, URL: http://elifesciences.org/content/2/e00471, XP002699851
OPPOSITION- JINEK, M. et al., "RNA-programmed genome editing in 29.01.2013 Art. 54 (2) EPC human cells", eLife, (20130000), page 2e00471, XP002699851
OPPOSITION- Allison Lange et al, "Classical nuclear localization signals: Definition, function, and interaction with importin [alpha]", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, (20070223), vol. 282, no. 8, doi:10.1074/JBC.R600026200, ISSN 0021-9258, pages 5101 - 5105, XP002674492
SEARCH- LEI S. QI ET AL, "Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression", CELL, US, (20130201), vol. 152, no. 5, doi:10.1016/j.cell.2013.02.022, ISSN 0092-8674, pages 1173 - 1183, XP055299671 [AP] 1-23 * the whole document *
SEARCH- DANA CARROLL, "A CRISPR Approach to Gene Targeting", MOLECULAR THERAPY, (20120901), vol. 20, no. 9, doi:10.1038/mt.2012.171, ISSN 1525-0016, pages 1658 - 1660, XP055106489 [A] 1-23 * the whole document *
SEARCH- G. GASIUNAS ET AL, "PNAS Plus: Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20120925), vol. 109, no. 39, doi:10.1073/pnas.1208507109, ISSN 0027-8424, pages E2579 - E2586, XP055068588 [A] 1-23
SEARCH- R. SAPRANAUSKAS ET AL, "The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli", NUCLEIC ACIDS RESEARCH, GB, (20110803), vol. 39, no. 21, doi:10.1093/nar/gkr606, ISSN 0305-1048, pages 9275 - 9282, XP055265024 [A] 1-23 * the whole document *
SEARCH- M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, US, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055229606 [A] 1-23
SEARCH[ ] - M. JINEK ET AL, "Supplementary Materials for A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, US, (20120628), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 1 - 37, XP055067747
SEARCH- MARTIN JINEK ET AL, "RNA-programmed genome editing in human cells", ELIFE, GB, (20130129), vol. 2, doi:10.7554/eLife.00471, ISSN 2050-084X, pages e00471 - 1, XP055245475 [AP] 1-23

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Get instant alerts for new documents