| DESCRIPTION | - BEERLI et al., Nat. Biotechnol., (20020000), vol. 20, pages 135 - 141 |
| DESCRIPTION | - BELFORT et al., "New England Biolabs Catalog", Nucleic Acids Res., (19970000), vol. 25, pages 3379 - 3388 |
| DESCRIPTION | - CHOO et al., Curr. Opin. Struct. Biol., (20000000), vol. 10, pages 411 - 416 |
| DESCRIPTION | - CONG et al., Science, vol. 339, pages 819 - 823 |
| DESCRIPTION | - DAYHOFF, Atlas of Protein Sequences and Structure, National Biomedical Research Foundation, vol. 5, pages 353 - 358 |
| DESCRIPTION | - DOYON et al., Nat. Biotechnol., (20080000), vol. 26, pages 702 - 708 |
| DESCRIPTION | - DOYON et al., Nat. Methods, (20110000), vol. 8, pages 74 - 81 |
| DESCRIPTION | - GRIBSKOV, Nucl. Acids Res., (19860000), vol. 14, no. 6, pages 6745 - 6763 |
| DESCRIPTION | - ISALAN et al., Nat. Biotechnol., (20010000), vol. 19, pages 656 - 660 |
| DESCRIPTION | - ISELI et al., PLos One, vol. 2, no. 6, page e579 |
| DESCRIPTION | - JINEK et al., Science, vol. 337, pages 816 - 821 |
| DESCRIPTION | - LANGE et al., J. Biol. Chem., (20070000), vol. 282, pages 5101 - 5105 |
| DESCRIPTION | - LOMBARDO et al., Nat. Biotechnology, (20070000), vol. 25, pages 1298 - 1306 |
| DESCRIPTION | - MILLER et al., Nat. Biotechnol, (20070000), vol. 25, pages 778 - 785 |
| DESCRIPTION | - MOEHLE et al., PNAS, (20070000), vol. 104, pages 3055 - 3060 |
| DESCRIPTION | - PABO et al., Ann. Rev. Biochem., (20010000), vol. 70, pages 313 - 340 |
| DESCRIPTION | - SANTIAGO et al., PNAS, (20080000), vol. 105, pages 5809 - 5814 |
| DESCRIPTION | - SANTIAGO et al., Proc. Natl. Acad. Sci. USA, (20080000), vol. 105, pages 5809 - 5814 |
| DESCRIPTION | - SEGAL et al., Curr. Opin. Biotechnol., (20010000), vol. 12, pages 632 - 637 |
| DESCRIPTION | - SMITH; WATERMAN, Advances in Applied Mathematics, (19810000), vol. 2, pages 482 - 489 |
| DESCRIPTION | - SZCZPEK et al., Nat. Biotechnol, (20070000), vol. 25, pages 786 - 793 |
| DESCRIPTION | - URNOV et al., Nature, (20050000), vol. 435, pages 646 - 651 |
| DESCRIPTION | - ZHANG et al., J. Biol. Chem., (20000000), vol. 275, no. 43, pages 33850 - 33860 |
| OPPOSITION | - 10-K Annual Report Sigma-Aldrich Corporation, (20120000), pages 1 - 80 |
| OPPOSITION | - ALBERTS, "Chapter 12", Molecular Biology of the Cell fourth edition, New York, USA, Garland Science, (20020000), pages 671 - 676, XP055486976 |
| OPPOSITION | - BONTEMS et al., "Phosphorylation of Varicella-Zoster 2002 Virus IE 63 Protein by Casein Kinases Influences Its Cellular Localization and Gene Regulation Activity", The Journal of Biological Chemistry, vol. 277, no. 23, pages 21050 - 21060, XP055899851 |
| OPPOSITION | - "cNLS Mapper Result - report of predicted NLSs in the S. pyogenes Cas9 sequence generated using the online cNLS mapper algorithm", cNLS Mapper, URL: www.nls- mapper. iab.keio.ac.jp |
| OPPOSITION | - De Souza, "research highlights Improving gene-editing nucleases", Nature Methods, (20120601), vol. 9, no. 6, page 536, XP055784803 |
| OPPOSITION | - FIECK et al., "Modifications of the E. coli Lac repressor for expression in eukaryotic cells: effects of nuclear signal sequences on protein activity and nuclear accumulation", Nucleic Acids Res., (19920000), vol. 20, no. 7, pages 1785 - 1791, XP002095852 |
| OPPOSITION | - FIECK ET AL, "Modifications of the E. coli Lac repressor for expression in eukaryotic cells: effects of nuclear signal sequences on protein activity and nuclear acumulation", Nucleic Acids Research, GB , (19920101), vol. 20, no. 07, ISSN 0305-1048, pages 1785 - 1791, XP002095852 |
| OPPOSITION | - Freitas et al., "Mechanisms and Signals for the Nuclear Import of Proteins", Current Genomics, (20090101), vol. 10, no. 29, pages 550 - 557, XP055502464 |
| OPPOSITION | - Gregory D. Davis Et Al, "Zinc Finger Nucleases for Genome Editing", Genetic Engineering and Biotechnology News, (2010), vol. 30, no. 13, XP055340181 |
| OPPOSITION | - Han et al., "Efficient Intracellular Delivery of GFP by Homeodomains of Drosophila Fushi-tarazu and Engrailed Proteins", MOLECULES AND CELLS, KR , (20010101), vol. 10, no. 6, ISSN 1016-8478, pages 728 - 732, XP019361393 |
| OPPOSITION | - KALDERON D; ET AL, "A SHORT AMINO ACID SEQUENCE ABLE TO SPECIFY NUCLEAR LOCATION", Cell, (19840000), vol. 39, pages 499 - 509, XP002255041 |
| OPPOSITION | - MA, PLoS ONE, (20120000), vol. 7, page e45035 |
| OPPOSITION | - MEDINA et al., "RNA polymerase III-driven expression cassettes in human gene therapy", Current Opinion in Molecular Therapeutics, vol. 1, no. 5, pages 580 - 594, XP001055319 |
| OPPOSITION | - Morgan W F, et al., "Inducible expression and cytogenetic effects of the EcoRI restriction endonuclease in Chinese hamster ovary cells.", MOLECULAR AND CELLULAR BIOLOGY, US , (19881001), vol. 08, no. 10, ISSN 0270-7306, pages 4204 - 4211, XP008014767 |
| OPPOSITION | - "pShooter Vector User Guide", INVITROGEN BY LIFE TECHHNOLOGIES, (20120329), XP055753282 |
| OPPOSITION | - pSVK3 Vector, URL: http://www.addgene.org/vector- database/4288 |
| OPPOSITION | - Redrejo-Rodriguez Modesto, Et Al, "Functional eukaryotic nuclear localization signals are widespread in terminal proteins of bacteriophages", PNAS, (20121106), vol. 109, no. 45, pages 18482 - 14487, XP055810468 |
| OPPOSITION | - RUBEN et al., "Structural and Functional Characterization of Human Immunodeficiency Virus tat Protein", Journal of Virology, (19890100), vol. 63, no. 1, pages 1 - 8, XP009013914 |
| OPPOSITION | - RUBEN S, ET AL., "STRUCTURAL AND FUNCTIONAL CHARACTERIZATION OF HUMAN IMMUNODEFICIENCY VIRUS TAT PROTEIN", Journal of Virology, US , (19890101), vol. 63, no. 01, ISSN 0022-538X, pages 01 - 08, XP009013914 |
| OPPOSITION | - SAUER B., "FUNCTIONAL EXPRESSION OF THE CRE-LOX SITE-SPECIFIC RECOMBINATION SYSTEM IN THE YEAST SACCHAROMYCES CEREVISIAE.", MOLECULAR AND CELLULAR BIOLOGY, US , (19870601), vol. 07., no. 06., ISSN 0270-7306, pages 2087 - 2096., XP000923364 |
| OPPOSITION | - SCHRAMM, Genes Dev., (20020000), vol. 16, pages 2593 - 2620, XP055183585 |
| OPPOSITION | - TRUANT et al., "The Arginine-Rich Domains Present in Human Immunodeficiency Virus Type 1 Tat and Rev Function as Direct Importin beta- Dependent Nuclear Localization Signals", Molecular and Cellular Biology, (19990200), vol. 19, no. 2, pages 1210 - 1217, XP002964815 |
| OPPOSITION | - TRUANT R, CULLEN B R, "The arginine-rich domains present in human immunodeficiency virus type 1 tat and rev function as direct importin B-dependent nuclear localization signals", MOLECULAR AND CELLULAR BIOLOGY, US , (19990201), vol. 19, no. 2, ISSN 0270-7306, pages 1210 - 1217, XP002964815 |
| OPPOSITION | - URL: http://www.addgene.org/vector- database/4288 |
| OPPOSITION | - "Vector information sheet for pHcRed1", Vector information, (20030311), XP055753280 |
| OPPOSITION | - Xu K., "The Next Generation Biotechnology for Apple Improvement and Beyond: The CRISPR/Cas9 Story", New York Fruit Quarterly, (20130101), vol. 21, no. 4, pages 19 - 22, XP055340191 |
| OPPOSITION | - YU et al., "Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila", Genetics, (20130705), vol. 95, no. 1, pages 289 - 91, XP055765469 |
| OPPOSITION | - Zhang et al., "MDV-1 VP22: a transporter that can selectively deliver proteins into cells", Archives of Virology, Vi , (20090604), vol. 154, no. 7, ISSN 1432-8798, pages 1027 - 1034, XP019722961 |
| OPPOSITION | - ZOLKIEWSKA, "ADAM Proteases: Ligand Processing 2008 and Modulation of the Notch Pathway", Cell Mol Life Sci., vol. 65, no. 13, pages 2056 - 2068, XP019619944 |
| OPPOSITION | - Souilhol, et al., "Nas transgenic mouse line allows visualization of Notch pathway activity in vivo", Genesis, (20060601), vol. 44, no. 6, doi:10.1002/dvg.20208, ISSN 1526-954X, pages 277 - 286, XP055502571 |
| OPPOSITION | - Chugh, et al., "Cell-penetrating peptides: Nanocarrier for macromolecule delivery in living cells", IUBMB Life, (20100325), vol. 62, no. 3, doi:10.1002/iub.297, ISSN 15216543, pages 183 - 193, XP055071760 |
| OPPOSITION | - Furutama, et al., "Expression of the IP3R1 promoter-driven nls-lacZ transgene in Purkinje cell parasagittal arrays of developing mouse cerebellum", Journal of Neuroscience Research, US , (20100101), vol. 88, doi:10.1002/jnr.22451, ISSN 0360-4012, pages 2810 - 2825, XP055502574 |
| OPPOSITION | - MI Z, ET AL., "CHARACTERIZATION OF A CLASS OF CATIONIC PEPTIDES ABLE TO FACILITATEEFFICIENT PROTEIN TRANSDUCTION IN VITRO AND IN VIVO", Molecular Therapy, Elsevier Inc, US , (20001001), vol. 02, no. 04, doi:10.1006/mthe.2000.0137, ISSN 1525-0016, pages 339 - 347, XP000998662 |
| OPPOSITION | - Bizzarri et al., "Fluorescence recovery after photobleaching reveals the biochemistry of nucleocytoplasmic exchange", Analytical and Bioanalytical Chemistry, Berlin, DE , (20120515), vol. 403, no. 8, doi:10.1007/s00216-012-6025-4, ISSN 1618-2650, pages 2339 - 2351, XP035069015 |
| OPPOSITION | - PATTERSON, J. Ind. Microbiol. Biotechnol, (20050000), vol. 32, pages 115 - 123, XP002503994 |
| OPPOSITION | - Dingwall, C et al., "A polypeptide domain that specifies migration of nucleoplasmin into the nucleus", Cell, Amsterdam NL , (19820901), vol. 30, no. 2, doi:10.1016/0092-8674(82)90242-2, ISSN 0092-8674, pages 449 - 458, XP023875960 |
| OPPOSITION | - KALDERON et al., "A short Amino Acid Sequence Able to Specify Nuclear Location", Cell, (19841200), vol. 38, doi:10.1016/0092-8674(84)90457-4, pages 499 - 509, XP023912340 |
| OPPOSITION | - Thomas, et al., "High frequency targeting of genes to specific sites in the mammalian genome", Cell, Amsterdam NL , (19860214), vol. 44, no. 3, doi:10.1016/0092-8674(86)90463-0, ISSN 0092-8674, pages 419 - 428, XP023871836 |
| OPPOSITION | - FOECKING et al., "Powerful and versatile enhancer-promoter unit for mammalian expression vectors", Gene, (19860000), vol. 45, doi:10.1016/0378-1119(86)90137-X, pages 101 - 105, XP025688566 |
| OPPOSITION | - FOECKING, Gene, (19860000), vol. 45, pages 101 - 105, XP009061501 |
| OPPOSITION | - KIM, ET AL., "USE OF THE HUMAN ELONGATION FACTOR 1ALPHA PROMOTER AS A VERSATILE AND EFFICIENT EXPRESSION SYSTEM", Gene, NL , (19900101), vol. 91, no. 91, doi:10.1016/0378-1119(90)90091-5, ISSN 0378-1119, pages 217 - 223, XP002952510 |
| OPPOSITION | - MARFORI et al., "Molecular basis for specificity of nuclear import and prediction of nuclear localization", Biochim. Biophys. Acta, (20110000), vol. 1813, doi:10.1016/j.bbamcr.2010.10.013, pages 1562 - 1577, XP055378211 |
| OPPOSITION | - PEREZ-PINERA, P., "Advances in Targeted Genome Editing", Current Opinion in Chemical Biology, (20120000), vol. 16, no. 3-4, doi:10.1016/j.cbpa.2012.06.007, pages 268 - 277, XP055065262 |
| OPPOSITION | - WANG, Cell, (20130000), vol. 153, pages 910 - 8, XP028538358 |
| OPPOSITION | - WANG et al., "One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas- mediated genome engineering", Cell, (20130502), vol. 153, no. 4, doi:10.1016/j.cell.2013.04.025, pages 910 - 8, XP028538358 |
| OPPOSITION | - RAN et al., "Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity", Cell, (20130912), vol. 154, doi:10.1016/j.cell.2013.08.021, pages 1380 - 1389, XP055299681 |
| OPPOSITION | - Ran, et al., "Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity.", Cell, NL, (20130912), vol. 154, no. 6, doi:10.1016/j.cell.2013.08.021 , ISSN 0092-8674, pages 1380 - 1389, XP002718603 |
| OPPOSITION | - RAN, F.A. et al., "Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity", Cell, (20130912), vol. 154, doi:10.1016/j.cell.2013.08.021, pages 1380 - 1389, XP055299681 |
| OPPOSITION | - MUSSOLINO, C. et al., "TALE nucleases: tailored genome engineering made easy", Current Opinion Biotechnology, (20120000), vol. 23, no. 5, doi:10.1016/j.copbio.2012.01.013, pages 644 - 650, XP055071668 |
| OPPOSITION | - DO et al., "Identification of multiple nuclear localization signals in murine Elf3, an ETS transcription factor", FEBS Letters, (20060228), vol. 580, no. 7, doi:10.1016/j.febslet.2006.02.049, pages 1865 - 1871, XP028030315 |
| OPPOSITION | - Do, H.J. et al., "Identification of multiple nuclear localization signals in murine Elf3, an ETS transcription factor", FEBS Letters, NL , (20060320), vol. 580, no. 7, doi:10.1016/j.febslet.2006.02.049, ISSN 0014-5793, pages 1865 - 1871, XP005335679 |
| OPPOSITION | - Chen et al., "Transfection and expression of plasmid DNA in plant cells by an arginine‐rich intracellular delivery peptide without protoplast preparation", FEBS Letters, NL , (20070409), vol. 581, no. 9, doi:10.1016/j.febslet.2007.03.076, ISSN 0014-5793, pages 1891 - 1897, XP071249466 |
| OPPOSITION | - Goldfarb, et al., "Importin α: a multipurpose nuclear-transport receptor", Trends in cell biology, XX , (20040901), vol. 14, no. 9, doi:10.1016/j.tcb.2004.07.016, ISSN 0962-8924, pages 505 - 514, XP004552656 |
| OPPOSITION | - Imagawa M.et al., "Two nuclear localization signals are required for nuclear translocation of nuclear factor 1-A", FEBS Letters, NL , (20001103), vol. 484, no. 2, doi:10.1016/S0014-5793(00)02119-0, ISSN 0014-5793, pages 118 - 124, XP004337724 |
| OPPOSITION | - YANG et al., "HIV-1 TAT-mediated protein transduction and subcellular localization using novel expression vectors", FEBS Letters, (20021101), vol. 532, doi:10.1016/S0014-5793(02)03624-4, pages 36 - 44, XP004395339 |
| OPPOSITION | - YANG et al., "HIV TAT-mediated protein transduction and subcellular localization using novel expression vectors", FEBS Letters, (20020000), vol. 532, doi:10.1016/S0014-5793(02)03624-4, pages 36 - 44, XP004395339 |
| OPPOSITION | - YANG, Y. et al., "HIV-1 TAT-mediated protein 01.11.2002 transduction and subcellular localization using novel expression vectors", FEBS Letters, (20020000), vol. 532, doi:10.1016/S0014-5793(02)03624-4, pages 36 - 44, XP004395339 |
| OPPOSITION | - YANG Y. et al., "HIV-1 TAT-mediated protein transduction and subcellular localization using novel expression vectors", FEBS Letters, (20020000), vol. 532, doi:10.1016/S0014-5793(02)03624-4, pages 36 - 44, XP004395339 |
| OPPOSITION | - Yang, Y. Ma, J. Song, Z. Wu, M., "HIV-1 TAT-mediated protein transduction and subcellular localization using novel expression vectors", FEBS Letters, ELSEVIER, NL , (20021204), vol. 532, no. 1-2, doi:10.1016/S0014-5793(02)03624-4, ISSN 0014-5793, pages 36 - 44, XP004395339 |
| OPPOSITION | - Van den Ackerveken Guido; Marois Eric; Bonas Ulla, "Recognition of the Bacterial Avirulence Protein AvrBs3 Occurs inside the Host Plant Cell", Cell, NL, (19951227), vol. 87, no. 7, doi:10.1016/S0092-8674(00)81825-5, ISSN 0092-8674, pages 1307 - 1316, XP029186424 |
| OPPOSITION | - PAUL et al., "Localized Expression of Small RNA Inhibitors in Human Cells", Molecular Therapy, (20030000), vol. 7, no. 2, doi:10.1016/S1525-0016(02)00038-2, pages 237 - 247, XP002975767 |
| OPPOSITION | - Manuela Villion, Sylvain Moineau, "The double-edged sword of CRISPR-Cas systems", Cell Research, (20120904), vol. 23, no. 1, doi:10.1038/cr.2012.124, ISSN 10010602, pages 15 - 17, XP055086684 |
| OPPOSITION | - CHANG et al., "Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos", Cell Research, (20130326), vol. 23, no. 4, doi:10.1038/cr.2013.45, page 465, XP055251146 |
| OPPOSITION | - Chang et al., "Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos", Cell Research, Singapore , (20130401), vol. 23, no. 4, doi:10.1038/cr.2013.45, ISSN 1001-0602, pages 465 - 472, XP055251146 |
| OPPOSITION | - SHEN et al., "Generation of gene -modified mice via Cas9/RNA- mediated gene targeting", Cell Research, (20130000), vol. 23, doi:10.1038/cr.2013.46, pages 720 - 723, XP055141533 |
| OPPOSITION | - SHEN et al., "Generation of gene -modified mice via Cas9/RNA-mediated gene targeting", Cell Research, (20130402), vol. 23, doi:10.1038/cr.2013.46, pages 720 - 723, XP055141533 |
| OPPOSITION | - SHEN et al., "Generation of gene -modified mice via Cas9/RNA-mediated gene targeting", Cell Research, (20130402), vol. 23, no. 5, doi:10.1038/cr.2013.46, pages 720 - 723, XP055141533 |
| OPPOSITION | - Shen et al., "Generation of gene-modified mice via Cas9/RNA-mediated gene targeting", Cell Research, Singapore , (20130501), vol. 23, no. 5, doi:10.1038/cr.2013.46, ISSN 1001-0602, pages 720 - 723, XP055141533 |
| OPPOSITION | - CARROLL, D. et al., "Progress and prospects: zinc-finger nucleases as gene therapy agents", Gene Therapy, (20080000), vol. 15, doi:10.1038/gt.2008.145, pages 1463 - 1468, XP055041104 |
| OPPOSITION | - Carroll D, "Progress and prospects: Zinc-finger nucleases as gene therapy agents", Gene Therapy, GB , (20080911), vol. 15, no. 22, doi:10.1038/gt.2008.145, ISSN 0969-7128, pages 1463 - 1468, XP037774186 |
| OPPOSITION | - D Carroll, "Progress and prospects: Zinc-finger nucleases as gene therapy agents", Gene Therapy, Macmillan Press Ltd., (20081101), vol. 15, no. 22, doi:10.1038/gt.2008.145, ISSN 09697128, pages 1463 - 1468, XP055041104 |
| OPPOSITION | - Lei, et al., "Gene Editing of Human Embryonic Stem Cells via an Engineered Baculoviral Vector Carrying Zinc-finger Nucleases", Molecular Therapy, US , (20110501), vol. 19, no. 5, doi:10.1038/mt.2011.12, ISSN 1525-0016, pages 942 - 950, XP055639632 |
| OPPOSITION | - CARROLL, "A CRISPR Approach to Gene Targeting", Molecular Therapy, (20120901), vol. 20, no. 9, doi:10.1038/mt.2012.171, pages 1658 - 1660, XP055106489 |
| OPPOSITION | - CARROLL, "A CRISPR approach to gene targeting", Molecular Therapy, (20120909), vol. 20, no. 9, doi:10.1038/mt.2012.171, pages 1658 - 1660, XP055106489 |
| OPPOSITION | - CARROLL, D., "A CRISPR approach to gene targeting", Molecular Therapy, (20120900), vol. 20, no. 9, doi:10.1038/mt.2012.171, page 1658, XP055106489 |
| OPPOSITION | - Carroll D., "A CRISPR Approach to Gene Targeting", Molecular Therapy, (20120901), vol. 20, no. 9, doi:10.1038/mt.2012.171, ISSN 15250016, pages 1658 - 1660, XP055106489 |
| OPPOSITION | - Dana Carroll, "A CRISPR Approach to Gene Targeting", Molecular Therapy, No longer published by Elsevier, (20120901), vol. 20, no. 9, doi:10.1038/mt.2012.171, ISSN 15250016, pages 1658 - 1660, XP055106489 |
| OPPOSITION | - Daniel F Carlson, Scott C Fahrenkrug, Perry B Hackett, "Targeting DNA With Fingers and TALENs", Molecular Therapy — Nucleic Acids, (20120101), vol. 1, no. 1, doi:10.1038/mtna.2011.5, pages 1 - 4, XP055182775 |
| OPPOSITION | - URNOV F D ET AL, "Highly efficient endogenous human gene correction using designed zinc-finger nucleases.", Nature, London, (20050602), vol. 435, no. 7042, doi:10.1038/nature03556, ISSN 0028-0836, pages 646 - 651, XP002411069 |
| OPPOSITION | - URNOV, F.D. et al., "Highly efficient endogenous human gene correction using zinc-finger nucleases", Nature, (20050000), vol. 435, doi:10.1038/nature03556, pages 646 - 651, XP002411069 |
| OPPOSITION | - Garneau, et al., "The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA", Nature, (20101104), vol. 468, no. 7320, doi:10.1038/nature09523, ISSN 00280836, pages 67 - 71, XP055181397 |
| OPPOSITION | - BEDELL, V.M. et al., "In vivo genome editing using a high-efficiency TALEN system", Nature, (20120000), vol. 491, doi:10.1038/nature11537, pages 114 - 118, XP055048281 |
| OPPOSITION | - MIYAGISHI M; TAIRA K, "U6 promoter-driven siRNs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells", Nature Biotechnology, (20020000), vol. 19, no. 5, pages 497 - 500, XP001153719 |
| OPPOSITION | - PORTEUS, M.H. et al., "Gene targeting using zinc finger nucleases", Nature Biotechnology, (20050000), vol. 23, no. 8, doi:10.1038/nbt1125, pages 967 - 973, XP002467422 |
| OPPOSITION | - LOMBARDO ANGELO, ET AL, "Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery.", Nature Biotechnology, New York, (20071101), vol. 25, no. 11, doi:10.1038/nbt1353, ISSN 1087-0156, pages 1298 - 1306, XP002465562 |
| OPPOSITION | - HOCKEMEYER et al., "Highly efficient gene targeting of expressed and silent genes in human ESCs and iPSCs using zinc finger nucleases", Nat. Biotechnol., (20090000), vol. 27, no. 9, doi:10.1038/nbt.1562, pages 851 - 857, XP055642140 |
| OPPOSITION | - MILLER et al., "A TALE nuclease architecture for efficient genome editing", Nature Biotechnology, (20111222), vol. 29, no. 2, doi:10.1038/nbt.1755, pages 143 - 148, XP055568321 |
| OPPOSITION | - MILLER et al., "A TALE nuclease architecture for efficient genome editing", Nature Biotechnology, (20111222), vol. 29, no. 2, doi:10.1038/nbt.1755, pages 143 - 48, XP055568321 |
| OPPOSITION | - Miller, et al, "A TALE nuclease architecture for efficient genome editing", Nature Biotechnology, New York, (20110201), vol. 29, no. 2, doi:10.1038/nbt.1755, ISSN 1087-0156, pages 143 - 148, XP055568321 |
| OPPOSITION | - MILLER, J. C. et al., "A TALE nuclease architecture for efficient genome editing", Nat. Biotechnol., (20101222), vol. 29, doi:10.1038/nbt.1755, page 143, XP055285157 |
| OPPOSITION | - MILLER, J.C. et al., "A TALE nuclease architecture for efficient genome editing", Nature Biotechnology, (20110000), vol. 29, no. 2, doi:10.1038/nbt.1755, pages 143 - 148, XP055568321 |
| OPPOSITION | - Tesson, et al., "Knockout rats generated by embryo microinjection of TALENs.", Nature Biotechnology, New York, (20110801), vol. 29, no. 8, doi:10.1038/NBT.1940, ISSN 1087-0156, pages 695 - 696, XP002681970 |
| OPPOSITION | - REYON, D. et al., "FLASH Assembly of TALENS Enables High-Throughput Genome Editing", Nature Biotechnology, (20120000), vol. 30, no. 5, doi:10.1038/nbt.2170, pages 460 - 465, XP055565802 |
| OPPOSITION | - BARRANGOU, "RNA-mediated programmable DNA cleavage", Nature Biotechnology, (20110000), vol. 30, no. 9, doi:10.1038/nbt.2357, pages 836 - 838, XP055118675 |
| OPPOSITION | - BARRANGOU, "RNA-mediated programmable DNA cleavage", Nature Biotechnology, (20120900), vol. 30, no. 9, doi:10.1038/nbt.2357, pages 836 - 838, XP055118675 |
| OPPOSITION | - BARRANGOU, R., "RNA-mediated programmable DNA cleavage", Nature Biotech., (20120910), vol. 30, no. 9, doi:10.1038/nbt.2357, pages 836 - 838, XP055118675 |
| OPPOSITION | - Barrangou R., "RNA-mediated programmable DNA cleavage", Nature Biotechnology, New York, (20120910), vol. 30, no. 9, doi:10.1038/nbt.2357, ISSN 1087-0156, pages 836 - 838, XP055118675 |
| OPPOSITION | - Rodolphe Barrangou, "RNA-mediated programmable DNA cleavage", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20120910), vol. 30, no. 9, doi:10.1038/nbt.2357, ISSN 1087-0156, pages 836 - 838, XP055118675 |
| OPPOSITION | - HWANG et al., "Efficient genome editing in zebrafish using a CRISPR- Cas system", Nature Biotechnology, (20130129), vol. 31, no. 3, doi:10.1038/nbt.2501, pages 227 - 229, XP055086625 |
| OPPOSITION | - HWANG et al., "Efficient genome editing in zebrafish using a CRISPR-Cas system", Nature Biotechnology, (20130129), vol. 31, no. 3, doi:10.1038/nbt.2501, pages 227 - 229, XP055086625 |
| OPPOSITION | - Hwang et al., "Efficient genome editing in zebrafish using a CRISPR-Cas system", Nature Biotechnology, New York, (20130129), vol. 31, no. 3, doi:10.1038/nbt.2501, ISSN 1087-0156, pages 227 - 229, XP055086625 |
| OPPOSITION | - Cho et al, "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease (includes Supplementary information)", Nature Biotechnology, New York, (20130301), vol. 31, no. 3, doi:10.1038/nbt.2507, ISSN 1087-0156, pages 230 - 232+1-11, XP002699850 |
| OPPOSITION | - CHO, S. et al., "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease", Nature Biotechnology, (20130129), vol. 31, pages 230 - 232, XP002699850 |
| OPPOSITION | - Seung Woo Cho et al, "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease (includes Supplementary information)", Nature Biotechnology, Gale Group Inc., New York, New York, (20130301), vol. 31, no. 3, doi:10.1038/nbt.2507, ISSN 1087-0156, pages 230 - 232+1-11, XP002699850 |
| OPPOSITION | - HSU et al., "DNA targeting specificity of RNA-guided Cas9 nucleases", Nature Biotech, (20130721), vol. 31, no. 9, doi:10.1038/nbt.2647, pages 827 - 834, XP055382777 |
| OPPOSITION | - MALI, P. et al., "CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering", Nat. Biotechnol., (20130801), vol. 31, pages 833 - 840, XP055149275 |
| OPPOSITION | - Zuris et al., "Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo", Nature Biotechnology, New York, (2015), vol. 33, no. 1, doi:10.1038/nbt.3081, ISSN 1087-0156, pages 73 - 80, XP055246826 |
| OPPOSITION | - REBAR et al., "Induction of angiogenesis in a mouse model using engineered transcription factors", Nature Medicine, (20021200), vol. 8, no. 12, doi:10.1038/nm795, pages 1427 - 32, XP002993087 |
| OPPOSITION | - REBAR ET AL, "Induction of angiogenesis in a mouse model using engineered transcription factors", Nature Medicine, New York, (20021104), vol. 8, no. 12, doi:10.1038/nm795, ISSN 1078-8956, pages 1427 - 1432, XP002993087 |
| OPPOSITION | - Carroll D et al., "Design, construction and in vitro testing of zinc finger nucleases.", Nature Protocols, GB , (20060101), vol. 1, no. 3, doi:10.1038/nprot.2006.231, ISSN 1750-2799, pages 1329 - 1341, XP001539641 |
| OPPOSITION | - URNOV et al., "Genome editing with engineered zinc finger nucleases", Nat. Rev. Gene, (20100900), vol. 11, doi:10.1038/nrg2842, pages 636 - 646, XP055198280 |
| OPPOSITION | - URNOV et al., "Genome editing with engineered zinc finger nucleases", Nat Rev. Genet, (20100911), vol. 11, doi:10.1038/nrg2842, pages 636 - 646, XP055198280 |
| OPPOSITION | - Urnov, et al., "Genome editing with engineered zinc finger nucleases", Nature Reviews: Genetics, United Kingdom , (20100901), vol. 11, no. 9, doi:10.1038/nrg2842, ISSN 1471-0064, pages 636 - 646, XP008150557 |
| OPPOSITION | - URNOV, F.D. et al., "Genome editing with engineered zinc finger nucleases", Nature Reviews Genetics, (20100000), vol. 11, doi:10.1038/nrg2842, pages 636 - 646, XP055198280 |
| OPPOSITION | - URNOV, F. et al., "Genome editing with engineered zinc finger nucleases", Nat. Rev. Gene, (20100900), vol. 11, doi:10.1038/nrg2842, pages 636 - 646, XP055198280 |
| OPPOSITION | - JOUNG et al., "TALENs: a widely applicable technology for targeted genome editing", Nat. Rev. Mol. Cell Biol., vol. 14, no. 1, doi:10.1038/nrm3486, (20121121), pages 49 - 55, XP055282847 |
| OPPOSITION | - Joung,et al., "TALENs: a widely applicable technology for targeted genome editing", Nature Reviews Molecular Cell Biology, GB, (2012-11-21), vol. 14, no. 1, doi:10.1038/nrm3486, ISSN 1471-0072, pages 49 - 55, XP055282847 |
| OPPOSITION | - JOUNG, J. et al., "TALENS: a widely applicable technology for targeted genome editing", Nat. Rev. Mol. Cell Biol., (20121121), vol. 14, doi:10.1038/nrm3486, pages 49 - 55, XP055282847 |
| OPPOSITION | - Makarova et al., "Evolution and classification of the CRISPR-Cas systems", Nature Reviews Microbiology, GB , (20110509), vol. 9, no. 6, doi:10.1038/nrmicro2577, ISSN 1740-1526, pages 467 - 477, XP009155547 |
| OPPOSITION | - Laumonier, et al., "Lentivirus mediated HO-1 gene transfer enhances myogenic precursor cell survival after autologous transplantation in pig", Molecular Therapy, US , (20080201), vol. 16, no. 2, doi:10.1038/sj.mt.6300354, ISSN 1525-0016, pages 404 - 410, XP008159717 |
| OPPOSITION | - MOEHLE et al., "Targeted gene addition into a Exhibit specified location in the human genome using RR4 designed zinc finger nucleases", Proc. Natl. Acad. Sci., (20070227), vol. 104, no. 9, doi:10.1073/PNAS.0611478104, pages 3055 - 3060, XP002518477 |
| OPPOSITION | - BEUMER K. ET AL, "Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases.", PNAS, Proceedings of the National Academy of Sciences, US , (20081216), vol. 105, no. 50, doi:10.1073/pnas.0810475105, ISSN 1091-6490, pages 19821 - 19826, XP002782686 |
| OPPOSITION | - MAHFOUZ, M.M. et al., "De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double- strand breaks", PNAS, (20110000), vol. 108, no. 6, doi:10.1073/pnas.1019533108, pages 2623 - 2628, XP055007615 |
| OPPOSITION | - Gasiunas, et al., "Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", Proceedings of the National Academy of Sciences, (20120925), vol. 109, no. 39, doi:10.1073/pnas.1208507109, ISSN 0027-8424, pages E2579 - E2586, XP055068588 |
| OPPOSITION | - G. Gasiunas, R. Barrangou, P. Horvath, V. Siksnys, "Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", Proceedings of the National Academy of Sciences, National Academy of Sciences, (20120925), vol. 109, no. 39, doi:10.1073/pnas.1208507109, ISSN 0027-8424, pages E2579 - E2586, XP055068588 |
| OPPOSITION | - Tinland, Et Al, "The T-DNA-linked VirD2 protein contains two distinct functional nuclear localization signals", Proc. Natl. Acad. Sci. ( PNAS ), (19920801), vol. 89, doi:10.1073/pnas.89.16.7442, pages 7442 - 7446, XP055254906 |
| OPPOSITION | - REISS B. ET AL., "RecA protein stimulates homologous recombination in plants", Proceedings of the National Academy of Sciences ( PNAS), (19960402), vol. 93, no. 7, doi:10.1073/pnas.93.7.3094, ISSN 0027-8424, pages 3094 - 3098, XP002023622 |
| OPPOSITION | - REISS et al., "RecA protein stimulates homologous recombination in plants", PNAS, (19960400), vol. 93, doi:10.1073/pnas.93.7.3094, pages 3094 - 98, XP002023622 |
| OPPOSITION | - Liang, et al., "Homology-directed repair is a major double-strand break repair pathway in mammalian cells", PNAS, (19980401), vol. 95, no. 18, doi:10.1073/pnas.95.9.5172, pages 5172 - 5177, XP055502633 |
| OPPOSITION | - DEROSSI, D. et al., "Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent", J. Biol. Chem., (19960000), vol. 271, no. 30, doi:10.1074/jbc.271.30.18188, pages 18188 - 18193, XP002024485 |
| OPPOSITION | - DEROSSI et al., "Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent", J. Biol. Chem., (19960000), vol. 271, doi:10.1074/jbc.271.30.18188, pages 18188 - 18193, XP002024485 |
| OPPOSITION | - DEROSSI, The Journal of Biological Biochemistry, (19960000), vol. 271, pages 18188 - 18193, XP002024485 |
| OPPOSITION | - EFTHYMIADIS A, BRIGGS L J, JANS D A, "The HIV-1 tat nuclear localization sequence confers novel nuclear import properties", Journal of Biological Chemistry, US , (19980116), vol. 273, no. 3, doi:10.1074/jbc.273.3.1623, ISSN 0021-9258, pages 1623 - 1628, XP003000854 |
| OPPOSITION | - EFTHYMIADIS et al., "The HIV-1 Tat Nuclear Localization Sequence Confers Novel Nuclear Import Properties", The Journal of Biological Chemistry, (19980116), vol. 273, no. 3, doi:10.1074/jbc.273.3.1623, pages 1623 - 1628, XP003000854 |
| OPPOSITION | - Y.-S. Dai, Et Al, "The Transcription Factors GATA4 and dHAND Physically Interact to Synergistically Activate Cardiac Gene Expression through a p300-dependent Mechanism", Journal of Biological Chemistry, US , (20020705), vol. 277, no. 27, doi:10.1074/jbc.M202490200, ISSN 0021-9258, pages 24390 - 24398, XP055251716 |
| OPPOSITION | - Park, Et Al, "Regulation of Ribosomal S6 Kinase 2 by Mammalian Target of Rapamycin", Journal of Biological Chemistry, US , (20020823), vol. 277, no. 35, doi:10.1074/jbc.M204080200, ISSN 0021-9258, pages 31423 - 31429, XP055251717 |
| OPPOSITION | - Planey, Et Al, "Inhibition of Glucocorticoid-induced Apoptosis in 697 Pre-B Lymphocytes by the Mineralocorticoid Receptor N-terminal Domain", Journal of Biological Chemistry, US , (20021101), vol. 277, no. 44, doi:10.1074/jbc.M205085200, ISSN 0021-9258, pages 42188 - 42196, XP055251719 |
| OPPOSITION | - Hodel, et al., "Nuclear Localization Signal Receptor Affinity Correlates with in Vivo Localization in Saccharomyces cerevisiae", Journal of Biological Chemistry, US , (20060818), vol. 281, no. 33, doi:10.1074/jbc.M601718200, ISSN 0021-9258, pages 23545 - 23556, XP055502581 |
| OPPOSITION | - Dingwall et al., "The nucleoplasmin nuclear location sequence is larger and more complex than that of SV-40 large T antigen", The journal of cell biology, US , (19880901), vol. 107, no. 3, doi:10.1083/jcb.107.3.841, ISSN 0021-9525, pages 841 - 849, XP055514316 |
| OPPOSITION | - HANDEL, E.M. et al., "Versatile and Efficient Genome Editing in Human Cells by Combining Zinc-Finger Nucleases With Adeno-Associated Viral Vectors", Human Gene Therapy, (20120000), vol. 23, doi:10.1089/hum.2011.140, pages 321 - 329, XP002730956 |
| OPPOSITION | - HÄNDEL et al., "Versatile and Efficient Genome Editing in Human Cells by Combining Zing-Finger Nucleases with Adeno-Associated Viral Vectors", Human Gene Therapy, (20120300), vol. 23, doi:10.1089/hum.2011.140, pages 321 - 329, XP002730956 |
| OPPOSITION | - LI et al., "Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes", Nucleic Acids Research, (20110331), vol. 39, no. 14, doi:10.1093/NAR/GKR188, pages 6315 - 6325, XP002681969 |
| OPPOSITION | - LI, T. et al., "Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes", Nucleic Acids Research, (20110000), vol. 39, no. 14, doi:10.1093/NAR/GKR188, pages 6315 - 6325, XP002681969 |
| OPPOSITION | - CERMAK et al., "Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting", Nucleic Acids Research, (20110414), vol. 39, no. 12, pages e82, 1 - 11, XP055130093 |
| OPPOSITION | - Cermak et al., "Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting.", NUCLEIC ACIDS RESEARCH, GB , (20110701), vol. 39, no. 12, doi:10.1093/nar/gkr218, ISSN 1362-4962, pages 1 - 11, XP002659530 |
| OPPOSITION | - CERMAK, T. et al., "Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting", Nucleic Acids Research, (20110000), vol. 39, no. 12, doi:10.1093/nar/gkr218, page e82, XP055130093 |
| OPPOSITION | - Tomas Cermak et al, "Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting.", NUCLEIC ACIDS RESEARCH, Oxford University Press, GB, GB, (20110701), vol. 39, no. 12, doi:10.1093/nar/gkr218, ISSN 1362-4962, pages 1 - 11, XP002659530 |
| OPPOSITION | - Sapranauskas, et al., "The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli", Nucleic Acids Research, GB , (20111101), vol. 39, no. 21, doi:10.1093/nar/gkr606, ISSN 0305-1048, pages 9275 - 9282, XP055011535 |
| OPPOSITION | - DICARLO et al., "Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas online systems", Nucleic Acids Research, (20130304), vol. 41, no. 7, pages 4336 - 4343, XP055086617 |
| OPPOSITION | - Dicarlo et al, "Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems", Nucleic Acids Research, (20130401), vol. 41, no. 7, doi:10.1093/nar/gkt135, ISSN 03051048, pages 4336 - 4343, XP055086617 |
| OPPOSITION | - DICARLO, J. et al., "Genome engineering in Saccharomyces cerevisiae using CRISPR/Cas systems", Nucl Acid Res., (20130304), vol. 41, no. 7, doi:10.1093/nar/gkt135, pages 4336 - 4343, XP055086617 |
| OPPOSITION | - CHEN et al., "Efficient genome editing in Caenorhabditis elegans by CRISPR-targeted homologous recombination", Nucleic Acids Research, (20130905), vol. 41, no. 20, pages e193, 1 - 6, XP055598257 |
| OPPOSITION | - Mojica, et al., "Short motif sequences determine the targets of the prokaryotic CRISPR defence system", Microbiology, (20090301), vol. 155, no. 3, doi:10.1099/mic.0.023960-0, ISSN 13500872, pages 733 - 740, XP055118366 |
| OPPOSITION | - MALINA et al., "Repurposing CRISPR/Cas9 for in situ functional assays", Genes Dev., (20131201), vol. 27, no. 23, doi:10.1101/gad.227132.113, pages 2602 - 2614, XP055177303 |
| OPPOSITION | - DEKELVER et al., "Functional genomics , Exhibit proteomics, and regulatory DNA analysis in RR5 isogenic settings using zinc finger nuclease- driven transgenesis into a safe harbor locus in the human genome", Genome Research, vol. 20, doi:10.1101/gr.106773.110, (20100527), pages 1133 - 1142, XP055265374 |
| OPPOSITION | - M. Shieh, Et Al, "Nuclear targeting of the maize R protein requires two nuclear localization sequences", PLANT PHYSIOLOGY, (19930201), vol. 101, no. 2, doi:10.1104/pp.101.2.353, pages 353 - 361, XP055241771 |
| OPPOSITION | - SHIEH et al., "Nuclear Targeting of the maize R protein requires two nuclear localization sequences", Plant Physiol., (19930000), vol. 101, doi:10.1104/pp.101.2.353, pages 353 - 361, XP055241771 |
| OPPOSITION | - TOVKACH A, et al., "A toolbox and procedural notes for characterizing novel zinc finger nucleases for genome editing in plant cells", THE PLANT JOURNAL, GB , (20090201), vol. 57, no. 4, doi:10.1111/J.1365-313X.2008.03718.X, ISSN 0960-7412, pages 747 - 757, XP002591473 |
| OPPOSITION | - Luo, C. et al., "Multiple Nuclear Localization Sequences Allow Modulation of 5-Lipoxygenase Nuclear Import", TRAFFIC, DK , (20040901), vol. 5, no. 11, doi:10.1111/j.1600-0854.2004.00227.x, ISSN 1398-9219, pages 847 - 854, XP055267733 |
| OPPOSITION | - LUO et al., "Multiple nuclear localization sequences allow modulation of 5-lipoxygenase nuclear import", Traffic, (20040000), vol. 5, no. 11, doi:10.1111/j.1600-0854.2004.00227.x, pages 847 - 854, XP055267791 |
| OPPOSITION | - BRUMMELKAMP et al., "A System for Stable 2002 Expression of Short Interfering RNAs in Mammalian Cells", Science, vol. 296, doi:10.1126/science.1068999, pages 550 - 553, XP055884260 |
| OPPOSITION | - GEURTS ET AL, "Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases", Science, US , (20090724), vol. 325, no. 5939, doi:10.1126/SCIENCE.1172447, ISSN 0036-8075, page 433, XP002580718 |
| OPPOSITION | - JINEK et al., "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, (20120628), vol. 337, no. 6096, doi:10.1126/science.1225829, pages 816 - 821, XP055549487 |
| OPPOSITION | - JINEK et al., "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, (20120817), vol. 337, doi:10.1126/science.1225829, pages 816 - 821, XP055549487 |
| OPPOSITION | - Jinek et al, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, US , (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055549487 |
| OPPOSITION | - JINEK et al., Science, (20120000), vol. 337, pages 816 - 821, XP055549487 |
| OPPOSITION | - JINEK, M. et al., "A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity", Science, (20120000), vol. 337, doi:10.1126/science.1225829, pages 816 - 821, XP055549487 |
| OPPOSITION | - M. Jinek et al, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, American Association for the Advancement of Science, US , (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055549487 |
| OPPOSITION | - BROUNS, "A Swiss Army Knife of Immunity", Science, (20120628), vol. 337, no. 6096, doi:10.1126/science.1227253, pages 808 - 809, XP055113718 |
| OPPOSITION | - BROUNS, "A Swiss Army Knife of Immunity", Science, (20120817), vol. 337, doi:10.1126/science.1227253, pages 808 - 809, XP055113718 |
| OPPOSITION | - BROUNS, S., "A Swiss army knife of immunity", Science, (20120817), vol. 337, doi:10.1126/science.1227253, pages 808 - 809, XP055113718 |
| OPPOSITION | - Brouns S. J. J., "A Swiss Army Knife of Immunity", Science, American Association for the Advancement of Science, (20120817), vol. 337, no. 6096, doi:10.1126/science.1227253, ISSN 00368075, pages 808 - 809, XP055113718 |
| OPPOSITION | - S. J. J. Brouns, "A Swiss Army Knife of Immunity", Science, American Association for the Advancement of Science, (20120817), vol. 337, no. 6096, doi:10.1126/science.1227253, ISSN 00368075, pages 808 - 809, XP055113718 |
| OPPOSITION | - CONG et al., "Multiplex genome engineering using CRISPR/Cas systems", Science, (20130103), vol. 339, doi:10.1126/science.1231143, pages 819 - 823, XP055300065 |
| OPPOSITION | - CONG et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (20130103), vol. 339, doi:10.1126/science.1231143, pages 819 - 823, XP055300065 |
| OPPOSITION | - CONG, L. et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, (20130000), vol. 339, doi:10.1126/science.1231143, pages 819 - 823, XP055458249 |
| OPPOSITION | - CONG, L. et al., "Multiplex genome engineering using CRISPR/Cas systems", Science, (20130103), vol. 339, doi:10.1126/science.1231143, pages 819 - 823, XP055300065 |
| OPPOSITION | - Le Cong et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, US , (20130215), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055458249 |
| OPPOSITION | - Le Cong, F. et al., "Multiplex Genome Engineering Using CRISPR/Cas Systems", Science, US , (20130215), vol. 339, no. 6121, doi:10.1126/science.1231143, ISSN 0036-8075, pages 819 - 823, XP055458249 |
| OPPOSITION | - MALI et al., "RNA-guided human genome engineering via Cas9", Science, (20130103), vol. 339, doi:10.1126/science.1232033, pages 823 - 826, XP055362871 |
| OPPOSITION | - MALI et al., "RNA-Guided Human Genome Engineering via Cas9", Science, (20130103), vol. 339, doi:10.1126/science.1232033, pages 823 - 826, XP055362871 |
| OPPOSITION | - Mali Et Al., "RNA-guided human genome engineering via Cas9", Science, American Association for the Advancement of Science, US , (20130101), vol. 339, doi:10.1126/science.1232033, ISSN 0036-8075, pages 823 - 826, XP055362871 |
| OPPOSITION | - MALI et al., Science, (20130103), vol. 339, pages 823 - 826, XP055469277 |
| OPPOSITION | - MALI, P. et al., "RNA-guided human genome engineering via Cas9", Science, (20130000), vol. 339, doi:10.1126/science.1232033, pages 823 - 826, XP055469277 |
| OPPOSITION | - Mali P et al., "RNA Guided Human Genome Engineering via Cas9", Science, US , (20130215), vol. 339, no. 6121, doi:10.1126/science.1232033, ISSN 0036-8075, pages 823 - 826, XP055469277 |
| OPPOSITION | - BAIKER et al., "The Immediate-Early 63 Protein of 2004 Varicella-Zoster Virus: Analysis of Functional Domains Required for Replication In Vitro and for T- Cell and Skin Tropism in the SCIDhu Model In Vivo", Journal of Virology, vol. 78, no. 3, doi:10.1128/JVI.78.3.1181-1194.2004, pages 1181 - 1194, XP055268139 |
| OPPOSITION | - Miller, et al., "Human Gene Targeting by Adeno-Associated Virus Vectors Is Enhanced by DNA Double-Strand Breaks", MOLECULAR AND CELLULAR BIOLOGY, US , (20030515), vol. 23, no. 10, doi:10.1128/MCB.23.10.3550-3557.2003, ISSN 0270-7306, pages 3550 - 3557, XP055502623 |
| OPPOSITION | - FISCHER-FANTUZZI et al., "Cell -dependent efficiency of reiterated nuclear signals in a mutant simian virus 40 oncoprotein targeted to the nucleus", Mol Cell Biol., (19880000), vol. 8, no. 12, doi:10.1128/MCB.8.12.549, pages 5495 - 5503, XP009140368 |
| OPPOSITION | - FISCHER-FANTUZZI et al., "Cell -Dependent Efficiency of Reiterated Nuclear Signals in a Mutant Simian Virus 40 Oncoprotein Targeted to the Nucleus", Molecular and Cellular Biology, (19881200), vol. 8, no. 12, doi:10.1128/MCB.8.12.549, pages 5495 - 5503, XP009140368 |
| OPPOSITION | - FISCHER-FANTUZZI L; VESCO C, "Cell-dependent efficiency of reiterated nuclear signals in a mutant simian virus 40 oncoprotein targeted to the nucleus", MOLECULAR AND CELLULAR BIOLOGY, US , (19981201), vol. 8, no. 12, doi:10.1128/MCB.8.12.549, ISSN 0270-7306, pages 5495 - 5503, XP009140368 |
| OPPOSITION | - Greenwald, et al., "Engineered Zinc Finger Nuclease-Mediated Homologous Recombination of the Human Rhodopsin Gene", Investigative Opthalmology & Visual Science, US , (20101201), vol. 51, no. 12, doi:10.1167/iovs.10-5781, ISSN 1552-5783, page 6374, XP055557463 |
| OPPOSITION | - LIU et al., "Sequence space coverage, entropy of genomes and the potential to detect non-human DNA in human samples", BMC Genomics, (20081030), vol. 9, no. 509, pages 1 - 17, XP021048024 |
| OPPOSITION | - RADULOVICH, N. et al., "Modified gateway system for double shRNA expression and Cre/lox based gene expression", BMC Biotech., (20110000), vol. 11, doi:10.1186/1472-6750-11-24, pages 1 - 9, XP021096706 |
| OPPOSITION | - McConnell et al., "Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression", MOLECULAR CANCER, GB , (20110618), vol. 10, no. 1, doi:10.1186/1476-4598-10-75, ISSN 1476-4598, pages 1 - 13, XP021103688 |
| OPPOSITION | - BELHAJ et al., "Plant genome editing made easy: targeted mutagenesis in model and crop plants online ) using the CRISPR/Cas system", Plant Methods, (20131011), vol. 9, no. 39, pages 1 - 10, XP021164954 |
| OPPOSITION | - YANG et al., "Sequence analysis and protein 2020 interactions of Arabidopsis CIA2 and CIL proteins", Botanical Studies, vol. 61, no. 20, doi:10.1186/s40529-020-00297-z, pages 1 - 13, XP021278227 |
| OPPOSITION | - Chang, et al., "Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans", Development, GB , (20110815), vol. 138, no. 16, doi:10.1242/dev.069740, ISSN 0950-1991, pages 3509 - 3518, XP055502632 |
| OPPOSITION | - RAYMOND et al., "High-Efficiency FLP and ) phiC31 Site-Specific Recombination in Mammalian Cells", PLoS ONE, (20070100), vol. 1, no. e162, XP055069998 |
| OPPOSITION | - RAYMOND et al., "High-Efficiency FLP and PHIC31 Site-Specific Recombination in Mammalian Cells", PLoS ONE, (20070117), vol. 2, no. 1, doi:10.1371/journal.pone.0000162, XP055069825 |
| OPPOSITION | - RAYMOND, PLoS One, (20070000), vol. 2, no. 1, page e162, XP055069825 |
| OPPOSITION | - Eric Campeau, Et Al, "A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells. article e6529", PLoS ONE, (20090801), vol. 4, no. 8, doi:10.1371/journal.pone.0006529, pages 1 - 18, XP055251120 |
| OPPOSITION | - CARNEY et al., "Induction of DNA Double- Strand Breaks by Electroporation of Restriction Enzymes into Mammalian Cells", Methods in Mol Biol, (19990000), vol. 113, doi:10.1385/1-59259-675-4:465, pages 465 - 71, XP055340155 |
| OPPOSITION | - James P Carney and William f Morgan, "Induction of DNA Double-Strand Breaks by Electroporation of Restriction Enzymes into Mammalian Cells", James P Carney and William f Morgan, Ducry, Laurent (ed.), Antibody-drug conjugates; IN: Methods in Molecular Biology; ISSN 1064-3745; Vol. 263, US , Humana Press , (19990621), vol. 113, pages 465 - 471, doi:10.1385/1-59259-675-4:465, ISBN 978-1-62703-541-5, XP055340155 |
| OPPOSITION | - Lee et al., "RNA-Guided Genome Editing in Drosophila with the Purified Cas9 Protein", G3 - Genes|Genomes|Genetics, (20140701), vol. 4, no. 7, doi:10.1534/g3.114.012179, pages 1291 - 1295, XP055647268 |
| OPPOSITION | - Christian et al, "Targeting DNA Double-Strand Breaks with TAL Effector Nucleases (plus supporting information)", GENETICS, US , (20101001), vol. 186, no. 2, doi:10.1534/GENETICS.110.120717, ISSN 0016-6731, pages 757 - 761, XP002632806 |
| OPPOSITION | - Michelle Christian et al, "Targeting DNA Double-Strand Breaks with TAL Effector Nucleases (plus supporting information)", GENETICS, GENETICS SOCIETY OF AMERICA, AUSTIN, TX, US, US , (20101001), vol. 186, no. 2, doi:10.1534/GENETICS.110.120717, ISSN 0016-6731, pages 757 - 761, 1SI-8SI, XP002632806 |
| OPPOSITION | - Michelle Christian et al, "Targeting DNA Double-Strand Breaks with TAL Effector Nucleases (plus supporting information)", GENETICS, GENETICS SOCIETY OF AMERICA, AUSTIN, TX, US, US, (20101001), vol. 186, no. 2, doi:10.1534/GENETICS.110.120717, ISSN 0016-6731, pages 757 - 761, 1SI-8SI, XP002632806 |
| OPPOSITION | - Michelle Christian et al, "Targeting DNA Double-Strand Breaks with TAL Effector Nucleases (plus supporting information)", GENETICS, GENETICS SOCIETY OF AMERICA, AUSTIN, TX, US, US , (20101001), vol. 186, no. 2, doi:10.1534/GENETICS.110.120717, ISSN 0016-6731, pages 757 - 761, XP002632806 |
| OPPOSITION | - D. Carroll, "Genome Engineering With Zinc-Finger Nucleases", Genetics, (20110801), vol. 188, no. 4, doi:10.1534/genetics.111.131433, ISSN 00166731, pages 773 - 782, XP055171682 |
| OPPOSITION | - D. Carroll, "Genome Engineering With Zinc-Finger Nucleases", Genetics, Genetics Society of America [etc.], (20110801), vol. 188, no. 4, doi:10.1534/genetics.111.131433, ISSN 00166731, pages 773 - 782, XP055171682 |
| OPPOSITION | - GRATZ et al., "Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease", Genetics, (20130524), vol. 194, page 1029, XP055102690 |
| OPPOSITION | - GRATZ et al., "Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease", Genetics, (20130800), vol. 194, doi:10.1534/genetics.113.152710, pages 1029 - 1035, XP055102690 |
| OPPOSITION | - GRATZ, Genetics, (20130000), vol. 194, pages 1029 - 35, XP055102690 |
| OPPOSITION | - K. G. Golic, "RNA-Guided Nucleases: A New Era for Engineering the Genomes of Model and Nonmodel Organisms", GENETICS, US , (20131001), vol. 195, no. 2, doi:10.1534/genetics.113.155093, ISSN 0016-6731, pages 303 - 308, XP055340188 |
| OPPOSITION | - LYSSENKO et al., "Cognate putative nuclear localization signal effects strong nuclear localization of a GFP reporter and facilitates gene expression studies in Caenorhabditis elegans", Biotechniques, (20071100), vol. 43, doi:10.2144/000112615, pages 596 - 600, XP055268137 |
| OPPOSITION | - Nicholas Lyssenko, Hanna-Rose Wendy, Schlegel Robert, "Cognate putative nuclear localization signal effects strong nuclear localization of a GFP reporter and facilitates gene expression studies in Caenorhabditis elegans", Biotechniques, US , (20071101), vol. 43, no. 5, doi:10.2144/000112615, ISSN 0736-6205, pages 596 - 600, XP055268137 |
| OPPOSITION | - NOGUCHI et al., "PDX-1 containing its own Antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells", Diabetes, (20030000), vol. 52, doi:10.2337/diabetes.52.7.1732, pages 1732 - 1737, XP002549995 |
| OPPOSITION | - NOGUCHI, H. et al., "PDX-1 Protein Containing Its Own 07/2003 Antennapedia-Like Protein Transduction Domain Can Transduce Pancreatic Duct and Islet Cells", Diabetes, (20030000), vol. 52, doi:10.2337/diabetes.52.7.1732, pages 1732 - 1737, XP002549995 |
| OPPOSITION | - NOGUCHI HIROFUMI ET AL, "PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells.", Diabetes, American Diabetes Association, US , (20030701), vol. 52, no. 7, doi:10.2337/diabetes.52.7.1732, ISSN 0012-1797, pages 1732 - 1737, XP002354481 |
| OPPOSITION | - SAUER, "Functional Expression of the cre-lox Site-Specific Recombination System in the Yeast Socchoromyces cerevisiae", Molecular and Cellular Biology, (19870600), vol. 7, no. 6, pages 2087 - 96, XP055393438 |
| OPPOSITION | - KUWAYAMA, "Enhancement of homologous recombination efficiency by homologous oligonucleotides", Tech open science, (20120000), vol. 9, doi:10.5772/47779, pages 233 - 244, XP055394404 |
| OPPOSITION | - JINEK et al., "RNA-programmed genome editing in human cells", eLife, (20130129), vol. 2, no. e00471, doi:10.7554/eLife.00471, pages 1 - 9, XP055245475 |
| OPPOSITION | - Jinek et al., "RNA-programmed genome editing in human cells.", eLife, GB , (20130129), vol. 2, doi:10.7554/eLife.00471, ISSN 2050-084X, pages e00471 - e00471-9, XP002699851 |
| OPPOSITION | - Jinek, et al, "RNA-programmed genome editing in human cells.", eLife, GB , (20130129), vol. 2, doi:10.7554/eLife.00471, ISSN 2050-084X, pages e00471 - e00471-9, XP002699851 |
| OPPOSITION | - JINEK et al., "RNA-programmed genome editing in human cells", eLife, vol. 2, doi:10.7554/eLife.00471, (20130129), page e00471, URL: http://elifesciences.org/content/2/e00471, XP002699851 |
| OPPOSITION | - Martin Jinek, Alexandra East, Aaron Cheng, Steven Lin, Enbo Ma, Jennifer Doudna, "RNA-programmed genome editing in human cells.", eLife Sciences Publications Ltd, GB , (20130129), vol. 2, doi:10.7554/eLife.00471, ISSN 2050-084X, pages e00471 - e00471-9, XP002699851 |
| OPPOSITION | - LANGE et al., "Classical nuclear localization signals: definition, function, and interaction with importin alpha", J. Biol. Chem., (20070000), vol. 282, no. 8, doi:10.1074/JBC.R600026200, pages 5101 - 5105, XP002674492 |
| OPPOSITION | - Lange et al., "Classical nuclear localization signals: Definition, function, and interaction with importin [alpha]", Journal of Biological Chemistry, US , (20070223), vol. 282, no. 8, doi:10.1074/JBC.R600026200, ISSN 0021-9258, pages 5101 - 5105, XP002674492 |
| SEARCH | - LEI S. QI ET AL, "Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression", CELL, US, (20130201), vol. 152, no. 5, doi:10.1016/j.cell.2013.02.022, ISSN 0092-8674, pages 1173 - 1183, XP055299671 [AP] 1-26 * the whole document * |
| SEARCH | - DANA CARROLL, "A CRISPR Approach to Gene Targeting", MOLECULAR THERAPY, (20120901), vol. 20, no. 9, doi:10.1038/mt.2012.171, ISSN 1525-0016, pages 1658 - 1660, XP055106489 [A] 1-26 * the whole document * |
| SEARCH | - G. GASIUNAS ET AL, "PNAS Plus: Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20120925), vol. 109, no. 39, doi:10.1073/pnas.1208507109, ISSN 0027-8424, pages E2579 - E2586, XP055068588 [A] 1-26 |
| SEARCH | - R. SAPRANAUSKAS ET AL, "The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli", NUCLEIC ACIDS RESEARCH, GB, (20110803), vol. 39, no. 21, doi:10.1093/nar/gkr606, ISSN 0305-1048, pages 9275 - 9282, XP055265024 [A] 1-26 * the whole document * |
| SEARCH | - M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, US, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055229606 [A] 1-26 |
| SEARCH | [ ] - M. JINEK ET AL, "Supplementary Materials for A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, US, (20120628), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 1 - 37, XP055067747 |
| SEARCH | - MARTIN JINEK ET AL, "RNA-programmed genome editing in human cells", ELIFE, GB, (20130129), vol. 2, doi:10.7554/eLife.00471, ISSN 2050-084X, pages e00471 - 1, XP055245475 [AP] 1-26 |
