IP Verse

Microorganisms And Methods For Producing Sialylated And N-Acetylglucosamine-Containing Oligosaccharides - EP3467100

The patent EP3467100 was granted to Glycosyn on Sep 21, 2022. The application was originally filed on Mar 14, 2014 under application number EP18192520A. The patent is currently recorded with a legal status of "Revoked".

EP3467100

GLYCOSYN
Application Number
EP18192520A
Filing Date
Mar 14, 2014
Status
Revoked
Apr 18, 2025
Grant Date
Sep 21, 2022
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (2)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

CHR HANSENJun 20, 2023HOFFMANN EITLEADMISSIBLE
GRUNECKER PATENT UND RECHTSANWALTE PARTG MBBJun 20, 2023GRUNECKER PATENTADMISSIBLE

Patent Citations (7) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
EXAMINATIONFR2796082
OPPOSITIONUS2011014661
OPPOSITIONUS2012208181
OPPOSITIONWO2008097366
SEARCHFR2796082
SEARCHUS2012208181
SEARCHWO2007101862

Non-Patent Literature (NPL) Citations (93) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- ALBERMANN, C.; PIEPERSBERG, W.; WEHMEIER, U. F., Carbohydr Res, (20010000), vol. 334, pages 97 - 103
DESCRIPTION- ALTSCHUL et al., J Mol Biol, (19900000), vol. 215, no. 3, pages 403 - 410
DESCRIPTION- ALTSCHUL et al., Nucleic Acids Res, (19970000), vol. 25, no. 17, pages 3389 - 402
DESCRIPTION- AMONSEN, M.; SMITH, D. F.; CUMMINGS, R. D.; AIR, G. M., J Virol, (20070000), vol. 81, pages 8341 - 8345
DESCRIPTION- BAO, Y.; NEWBURG, D. S., Electrophoresis, (20080000), vol. 29, pages 2508 - 2515
DESCRIPTION- BELFORT, M.; MALEY, G. F.; MALEY, F., Proceedings of the National Academy of Sciences, (19830000), vol. 80, page 1858
DESCRIPTION- BETTLER, E.; SAMAIN, E.; CHAZALET, V.; BOSSO, C. et al., Glycoconj J, (19990000), vol. 16, pages 205 - 212
DESCRIPTION- CHARLWOOD J. et al., Anal Biochem, (19990000), vol. 273, pages 261 - 277
DESCRIPTION- CHATURVEDI P et al., Glycobiology, (20010000), vol. 11, pages 365 - 372
DESCRIPTION- CHATURVEDI, P.; WARREN, C. D.; BUESCHER, C. R.; PICKERING, L. K.; NEWBURG, D. S., Adv Exp Med Biol, (20010000), vol. 501, pages 315 - 323
DESCRIPTION- COUCEIRO, J. N.; PAULSON, J. C.; BAUM, L. G., Virus Res, (19930000), vol. 29, pages 155 - 165
DESCRIPTION- COURT, D. L.; SAWITZKE. J. A.; THOMASON, L. C., Annu Rev Genet, (20020000), vol. 36, pages 361 - 388
DESCRIPTION- CROUT, D. H.; VIC, G., Curr Opin Chem Biol, (19980000), vol. 2, pages 98 - 111
DESCRIPTION- DANCHIN, A., Bioessays, (20090000), vol. 31, pages 769 - 773
DESCRIPTION- ENDO, T.; KOIZUMI, S., Curr Opin Struct Biol, (20000000), vol. 10, pages 536 - 541
DESCRIPTION- ENDO, T.; KOIZUMI, S.; TABATA, K.; KAKITA, S.; OZAKI, A., Carbohydr Res, (19990000), vol. 316, pages 179 - 183
DESCRIPTION- ENDO, T.; KOIZUMI, S.; TABATA, K.; KAKITA, S.; OZAKI, A., Carbohydr Res, (20010000), vol. 330, pages 439 - 443
DESCRIPTION- ENDO, T.; KOIZUMI, S.; TABATA, K.; OZAKI, A., Appl Microbiol Biotechnol, (20000000), vol. 53, pages 257 - 261
DESCRIPTION- ERNEY, R.; HILTY, M.; PICKERING, L.; RUIZ-PALACIOS, G.; PRIETO, P., Adv Exp Med Biol, (20010000), vol. 501, pages 285 - 297
DESCRIPTION- FLOWERS, H. M., Methods Enzymol, (19780000), vol. 50, pages 93 - 121
DESCRIPTION- "Genbank", Database accession no. AAF42257.1
DESCRIPTION- "Genbank", Database accession no. AAF42258.1
DESCRIPTION- "Genbank", Database accession no. ACF31229.1
DESCRIPTION- "GenBank", Database accession no. BAE77265.1
DESCRIPTION- "Genbank", Database accession no. BAF92026.1
DESCRIPTION- "GenBank", Database accession no. D00067.1
DESCRIPTION- "GenBank", Database accession no. M84410.1
DESCRIPTION- "Genbank", Database accession no. NP_207619.1
DESCRIPTION- "Genbank", Database accession no. NP273962.1
DESCRIPTION- "GenBank", Database accession no. V00295.1
DESCRIPTION- "GenBank", Database accession no. V00296.1
DESCRIPTION- HAMOSH M., Pediatr Clin North Am, (20010000), vol. 48, pages 69 - 86
DESCRIPTION- JOHNSON, K. F., Glycoconj J, (19990000), vol. 16, pages 141 - 146
DESCRIPTION- KOELLER, K. M.; WONG, C. H., Chem Rev, (20000000), vol. 100, pages 4465 - 4494
DESCRIPTION- KOELLER, K. M; WONG, C. H., Chem Rev, (20000000), vol. 100, pages 4465 - 4494
DESCRIPTION- KOIZUMI, S.; ENDO, T.; TABATA, K.; OZAKI, A., Nat Biotechnol, (19980000), vol. 16, pages 847 - 850
DESCRIPTION- KUHLENSCHMIDT, T. B.; HANAFIN, W. P.; GELBERG, H. B.; KUHLENSCHMIDT, M. S., Adv Exp Med Biol, (19990000), vol. 473, pages 309 - 317
DESCRIPTION- MAHDAVI, J.; SONDEN, B.; HURTIG, M.; OLFAT, F. 0. et al., Science, (20020000), vol. 297, pages 573 - 578
DESCRIPTION- MARTIN-SOSA et al., J Dairy Sci, (20030000), vol. 86, pages 52 - 59
DESCRIPTION- M. BELFORT; G. F. MALEY; F. MALEY, Proceedings of the National Academy of Sciences, (19830000), vol. 80, page 1858
DESCRIPTION- MIESCHENDAHL, M.; PETRI, T.; HANGGI, U., Nature Biotechnology, (19860000), vol. 4, pages 802 - 808
DESCRIPTION- MORROW A.L. et al., J Pediatr, (20040000), vol. 145, pages 297 - 303
DESCRIPTION- NEWBURG D.S., Adv Exp Med Biol, (20010000), vol. 501, pages 3 - 10
DESCRIPTION- NEWBURG D.S., Curr_Med Chem, (19990000), vol. 6, pages 117 - 127
DESCRIPTION- NEWBURG D.S. et al., Glycobiology, (20040000), vol. 14, pages 253 - 263
DESCRIPTION- NEWBURG D.S. et al., Lancet, (19980000), vol. 351, pages 1160 - 1164
DESCRIPTION- NINONUEVO M., J Agric Food Chem, (20060000), vol. 54, pages 7471 - 74801
DESCRIPTION- PALCIC, M. M., Curr Opin Biotechnol, (19990000), vol. 10, pages 616 - 624
DESCRIPTION- PARKKINEN J.; FINNE J., Methods Enzymol, (19870000), vol. 138, pages 289 - 300
DESCRIPTION- R. E. BIRD, 1 Bacteriol, (19810000), vol. 145, pages 1305 - 9
DESCRIPTION- REICHENBACH, Nucleic Acids Res, (20080000), vol. 36, pages 2570 - 80
DESCRIPTION- ROBERFROID, M.; GIBSON, G. R.; HOYLES, L.; MCCARTNEY, A. L.; RASTALL, R.; ROWLAND, I.; WOLVERS, D.; WATZL, B.; SZAJEWSKA, H.; STAH, Br J Nutr, (20100000), vol. 104, no. 2, page Sl-63
DESCRIPTION- RUIZ-PALACIOS, G. M.; CERVANTES, L. E.; RAMOS, P.; CHAVEZ-MUNGUIA, B.; NEWBURG, D. S., JBiol Chem, (20030000), vol. 278, pages 14112 - 14120
DESCRIPTION- RYDELL, G. E.; NILSSON, J.; RODRIGUEZ-DIAZ, J.; RUVOEN-CLOUET, N. et al., Glycobiology, (20090000), vol. 19, pages 309 - 320
DESCRIPTION- SANGER, F.; COULSON, A. R.; HONG, G. F.; HILL, D. F.; PETERSEN, G. B., J Mol Biol, (19820000), vol. 162, pages 729 - 773
DESCRIPTION- S. A. WOLFE; J. M. SMITH, J BioZ Chem, (19880000), vol. 263, pages 19147 - 53
DESCRIPTION- SCHARFMAN, A.; DELMOTTE, P.; BEAU, J.; LAMBLIN, G. et al., Glycoconj J, (20000000), vol. 17, pages 735 - 740
DESCRIPTION- SEEBERGER, P. H., Chem Commun (Camb, (20030000), pages 1115 - 1121
DESCRIPTION- SHEN Z. et al., J Chromatogr A, (20010000), vol. 921, pages 315 - 321
DESCRIPTION- SLEIGHT et al., Nucleic Acids Res., (20100500), vol. 38, no. 8, pages 2624 - 2636
DESCRIPTION- WARD, R. E.; NINONUEVO, M.; MILLS, D. A.; LEBRILLA, C. B.; GERMAN, J. B., Mol Nutr Food Res, (20070000), vol. 51, pages 1398 - 1405
DESCRIPTION- WYMER, N.; TOONE, E. J., Curr Opin Chem Biol, (20000000), vol. 4, pages 110 - 119
OPPOSITION- Drouillard, S. ; Mine, T. ; Kajiwara, H. ; Yamamoto, T. ; Samain, E., "Efficient synthesis of 6'-sialyllactose, 6,6'-disialyllactose, and 6'-KDO-lactose by metabolically engineered E. coli expressing a multifunctional sialyltransferase from the Photobacterium sp. JT-ISH-224", Carbohydrate Research, PERGAMON, GB, GB , (20100702), vol. 345, no. 10, ISSN 0008-6215, pages 1394 - 1399, XP027118796
OPPOSITION- Loewe Laurence, "Genetic Mutation", Scitable by nature EDUCATION, (20080101), Scitable by nature EDUCATION, URL: https://www.nature.com/scitable/topicpage/genetic-mutation-1127/, (20240206), XP093128164
OPPOSITION- "N-acetylmannosamine-6-phosphate 2-epimerase [Escherichia coli str. K-12 substr. MG1655]", Protein, (20141215), Database accession no. AIZ89769.1, XP093174760
OPPOSITION- "TPA: N-acetylmannosamine-6-phosphate 2-epimerase [Escherichia coli]", Protein, (20220930), Database accession no. HCK2139692.1, XP093174763
OPPOSITION- Voet Donald, Voet Judith G, "A. The Michaelis-Menten Equation", Biochemistry. 3rd Edition, New York, J. Wiley & Sons, (20040101), pages 478 - 479, XP093128168
OPPOSITION- WAKARCHUK W W, ET AL., "MUTATIONAL AND CRYSTALLOGRAPHIC ANALYSES OF THE ACTIVE SITE RESIDUES OF THE BACILLUS CIRCULANS XYLANASE", Protein Science, Wiley, US, US , (19940301), vol. 03, no. 03, ISSN 0961-8368, pages 467 - 475, XP009002627
OPPOSITION- Yanhong Li; Xi Chen, "Sialic acid metabolism and sialyltransferases: natural functions and applications", Applied Microbiology and Biotechnology, Springer, Berlin, DE, Berlin, DE , (20120413), vol. 94, no. 4, doi:10.1007/s00253-012-4040-1, ISSN 1432-0614, pages 887 - 905, XP035048979
OPPOSITION- Mahesh Madyagol; Hend Al-Alami; Zdeno Levarski; Hana Drahovská; Ján Turňa; Stanislav Stuchlík, "Gene replacement techniques forgenome modification", Folia Microbiologica ; Official Journal of the Institute of Microbiology, Academy of Sciences of the Czech Republic and Czechoslavak Society for Microbiology, Springer Netherlands, Dordrecht, Dordrecht , (20110526), vol. 56, no. 3, doi:10.1007/s12223-011-0035-z, ISSN 1874-9356, pages 253 - 263, XP019921989
OPPOSITION- Durand, P. ; Golinelli-Pimpaneau, B. ; Mouilleron, S. ; Badet, B. ; Badet-Denisot, M.A., "Highlights of glucosamine-6P synthase catalysis", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Academic Press, US, US , (20080615), vol. 474, no. 2, doi:10.1016/j.abb.2008.01.026, ISSN 0003-9861, pages 302 - 317, XP022701464
OPPOSITION- Liu, X.w. ; Xia, C. ; Li, L. ; Guan, W.y. ; Pettit, N. ; Zhang, H.c. ; Chen, M. ; Wang, P.G., "Characterization and synthetic application of a novel b1,3-galactosyltransferase from Escherichia coli O55:H7", Bioorganic & Medicinal Chemistry, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20090715), vol. 17, no. 14, doi:10.1016/j.bmc.2009.06.005, ISSN 0968-0896, pages 4910 - 4915, XP026302954
OPPOSITION- Bar-Even Arren, Salah Tawfik Dan, "Engineering specialized metabolic pathways—is there a room for enzyme improvements?", Current Opinion in Biotechnology, LONDON, GB, GB , (20130401), vol. 24, no. 2, doi:10.1016/j.copbio.2012.10.006, ISSN 0958-1669, pages 310 - 319, XP093128169
OPPOSITION- Wolfgang Wohlleben; Yvonne Mast; Gnther Muth; Marlene Rttgen; Evi Stegmann; Tilmann Weber;, "Synthetic Biology of secondary metabolite biosynthesis in actinomycetes: Engineering precursor supply as a way to optimize antibiotic production", FEBS Letters, ELSEVIER, AMSTERDAM., NL, NL , (20120413), vol. 586, no. 15, doi:10.1016/j.febslet.2012.04.025, ISSN 0014-5793, pages 2171 - 2176, XP028400695
OPPOSITION- Fierfort, N. ; Samain, E., "Genetic engineering of Escherichia coli for the economical production of sialylated oligosaccharides", Journal of Biotechnology, Elsevier, Amsterdam NL, Amsterdam NL , (20080430), vol. 134, no. 3-4, doi:10.1016/j.jbiotec.2008.02.010, ISSN 0168-1656, pages 261 - 265, XP022588000
OPPOSITION- Olano, C. ; Lombo, F. ; Mendez, C. ; Salas, J.A., "Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering", Metabolic Engineering, Academic Press, AMSTERDAM, NL, AMSTERDAM, NL, (20080901), vol. 10, no. 5, doi:10.1016/j.ymben.2008.07.001, ISSN 1096-7176, pages 281 - 292, XP024525632
OPPOSITION- Milewski, S., "Glucosamine-6-phosphate synthase-the multi-facets enzyme", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM; NL, AMSTERDAM; NL , (20020603), vol. 1597, no. 2, doi:10.1016/S0167-4838(02)00318-7, ISSN 0167-4838, pages 173 - 192, XP004361024
OPPOSITION- CHARTRAIN M, ET AL., "METABOLIC ENGINEERING AND DIRECTED EVOLUTION FOR THE PRODUCTION OF PHARMACEUTICALS", Current Opinion in Biotechnology, LONDON, GB, GB , (20000401), vol. 11, no. 02, doi:10.1016/S0958-1669(00)00081-1, ISSN 0958-1669, pages 209 - 214, XP001148060
OPPOSITION- R Whistler, Et Al, "Chromatographic separation of sugars on charcoal", Journal of the American Chemical Society, American Chemical Society, (19500201), vol. 72, no. 2, doi:10.1021/ja01158a009, ISSN 00027863, pages 677 - 679, XP055060186
OPPOSITION- WAKARCHUK W ET AL, "Functional relationships of the genetic locus encoding the glycosyltransferase enzymes involved in expression of the lacto-N-neotetraose terminal lipopolysaccharide structure in Neisseria meningitidis.", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (19960809), vol. 271., no. 32., doi:10.1074/jbc.271.32.19166, ISSN 0021-9258, pages 19166 - 19173., XP002084666
OPPOSITION- PRIEM BERNARD ET AL, "A new fermentation process allows large-scale production of human milk oligosaccharides by metabolically engineered bacteria", GLYCOBIOLOGY, Oxford University Press, US, US , (20020401), vol. 12, no. 4, doi:10.1093/glycob/12.4.235, ISSN 0959-6658, pages 235 - 240, XP002380632
OPPOSITION- Chang A C, Cohen S N, "Construction and characterization of amplifiable multicopy DNA cloning vehicles derived from the P15A cryptic miniplasmid", Journal of Bacteriology, American Society for Microbiology, US, US , (19780601), vol. 134, no. 3, doi:10.1128/jb.134.3.1141-1156.1978, ISSN 0021-9193, pages 1141 - 1156, XP093128159
OPPOSITION- Kalivoda Kathryn A., Steenbergen Susan M., Vimr Eric R., Plumbridge Jacqueline, "Regulation of Sialic Acid Catabolism by the DNA Binding Protein NanR in Escherichia coli", Journal of Bacteriology, American Society for Microbiology, US, US , (20030815), vol. 185, no. 16, doi:10.1128/JB.185.16.4806-4815.2003, ISSN 0021-9193, pages 4806 - 4815, XP093128154
OPPOSITION- Lauren B. Pickens, Yi Tang, Yit-Heng Chooi, "Metabolic Engineering for the Production of Natural Products", Annual Review of Chemical and Biomolecular Engineering, Annual Reviews, (20110715), vol. 2, no. 1, doi:10.1146/annurev-chembioeng-061010-114209, ISSN 19475438, pages 211 - 236, XP055159710
OPPOSITION- Ruffing Anne; Chen Rachel Ruizhen, "Metabolic engineering of microbes for oligosaccharide and polysaccharide synthesis", Microbial cell factories, Springer, (20060721), vol. 5, no. 1, doi:10.1186/1475-2859-5-25, ISSN 1475-2859, page 25, XP021017786
OPPOSITION- Jolanta Lis-Kuberka, Magdalena Orczyk-Pawiłowicz, "Sialylated Oligosaccharides and Glycoconjugates of Human Milk. The Impact on Infant and Newborn Protection, Development and Well-Being", Nutrients, M D P I AG, CH, CH , (20190201), vol. 11, no. 2, doi:10.3390/nu11020306, ISSN 2072-6643, page 306, XP055752269
SEARCH- DROUILLARD S ET AL, "Efficient synthesis of 6'-sialyllactose, 6,6'-disialyllactose, and 6'-KDO-lactose by metabolically engineered E. coli expressing a multifunctional sialyltransferase from the Photobacterium sp. JT-ISH-224", CARBOHYDRATE RESEARCH, PERGAMON, GB, vol. 345, no. 10, ISSN 0008-6215, (20100702), pages 1394 - 1399, (20100224), XP027118796 [Y] 1 * figure 1; page 1398 *
SEARCH- ANTOINE TATIANA ET AL, "Highly efficient biosynthesis of the oligosaccharide moiety of the GD3 ganglioside by using metabolically engineered Escherichia coli", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, DE, (20050218), vol. 44, no. 9, doi:10.1002/ANIE.200461507, ISSN 1433-7851, pages 1350 - 1352, XP002441501 [X] 1 * figure 1 *
SEARCH- ANTOINE T ET AL, "Large-scale in vivo synthesis of the carbohydrate moieties of gangliosides GM1 and GM2 by metabolically engineered Escherichia coli", CHEMBIOCHEM - A EUROPEAN JOURNAL OF CHEMICAL BIOLOGY, WILEY VCH, WEINHEIM, DE, (20030509), vol. 4, no. 5, doi:10.1002/CBIC.200200540, ISSN 1439-4227, pages 406 - 412, XP002416953 [X] 1 * figure 1, page 408 *
SEARCH- NAM SOO HAN ET AL, "Biotechnological production of human milk oligosaccharides", BIOTECHNOLOGY ADVANCES, (20121101), vol. 30, no. 6, doi:10.1016/j.biotechadv.2011.11.003, ISSN 0734-9750, pages 1268 - 1278, XP055074947 [Y] 1-22 * page 1271, figure 2; page 1274 item 4.1 and 4.2 *
SEARCH- FIERFORT N ET AL, "Genetic engineering of Escherichia coli for the economical production of sialylated oligosaccharides", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 134, no. 3-4, doi:10.1016/J.JBIOTEC.2008.02.010, ISSN 0168-1656, (20080430), pages 261 - 265, (20080310), XP022588000 [X] 1-10,15-16,18-19,21-22 * figure 1B; page 263 *
SEARCH- ENDO T ET AL, "Large-scale production of oligosaccharides using engineered bacteria", CURRENT OPINION IN STRUCTURAL BIOLOGY, ELSEVIER LTD, GB, (20001001), vol. 10, no. 5, doi:10.1016/S0959-440X(00)00127-5, ISSN 0959-440X, pages 536 - 541, XP002318519 [Y] 1-22 * page 537, table 1 and corresponding references *
SEARCH- PRIEM BERNARD ET AL, "A new fermentation process allows large-scale production of human milk oligosaccharides by metabolically engineered bacteria", GLYCOBIOLOGY, OXFORD UNIVERSITY PRESS, US, (20020401), vol. 12, no. 4, doi:10.1093/GLYCOB/12.4.235, ISSN 0959-6658, pages 235 - 240, XP002380632 [X] 11-14,17,20 * figures 1, 5; page 238 *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents