Methods For Treating Or Preventing Asthma By Administering An Il-4R Antagonist - EP3470432

The patent EP3470432 was granted to Regeneron Pharmaceuticals on Oct 6, 2021. The application was originally filed on Aug 20, 2013 under application number EP18194745A. The patent is currently recorded with a legal status of "Revoked".

EP3470432

REGENERON PHARMACEUTICALS
Application Number
EP18194745A
Filing Date
Aug 20, 2013
Status
Revoked
May 19, 2023
Publication Date
Oct 6, 2021
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (5)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

D YOUNGJul 6, 2022D YOUNGADMISSIBLE
NEUEFEINDJul 6, 2022MAIWALDADMISSIBLE
DR H ULRICH DORRIESJul 5, 2022DORRIESADMISSIBLE
DR H ULRICH DORRIESJul 5, 2022DORRIES, HANS ULRICH , DF-MP DORRIES FRANK-MOLNIA & POHLMANADMISSIBLE
SECERNAJul 5, 2022-ADMISSIBLE

Patent Citations (10) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS2012097565
DESCRIPTIONUS6596541
DESCRIPTIONUS6927044
DESCRIPTIONUS7582298
DESCRIPTIONUS7608693
DESCRIPTIONUS8178098
OPPOSITIONUS8075887
OPPOSITIONWO2010053751
OPPOSITIONWO2014031610
SEARCHWO2010053751

Non-Patent Literature (NPL) Citations (70) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- AL-LAZIKANI et al., J. Mol. Biol., (19970000), vol. 273, pages 927 - 948
DESCRIPTION- ALWING et al., Eur. Respir. J., (19930000), vol. 6, pages 1368 - 1370
DESCRIPTION- BJERKE et al., Respir. Med.,, (19960000), vol. 90, no. 5, pages 271 - 277
DESCRIPTION- GOODSON, Medical Applications of Controlled Release, (19840000), vol. 2, pages 115 - 138
DESCRIPTION- HOPKINS et al., Clin. Otolaryngol., (20090000), vol. 34, pages 447 - 454
DESCRIPTION- JIA et al., J Allergy Clin Immunol, (20120000), vol. 130, pages 647 - 654
DESCRIPTION- LANGER, Science, (19900000), vol. 249, pages 1527 - 1533
DESCRIPTION- LILLY et al., J. Allergy Clin. Immunol., (19990000), vol. 104, pages 786 - 790
DESCRIPTION- MARECHAL et al., Anticancer Res, (19880000), vol. 8, pages 677 - 680
DESCRIPTION- MARTIN et al., Proc. Natl. Acad. Sci. USA, (19890000), vol. 86, pages 9268 - 9272
DESCRIPTION- MOCHIZUKI et al., J. Immunol., (19980000), vol. 160, no. 1, pages 60 - 68
DESCRIPTION- MORDENTI et al., Pharmaceut. Res., (19910000), vol. 8, page 1351
DESCRIPTION- POWELL et al., "Compendium of excipients for parenteral formulations", J Pharm Sci Technol, (19980000), vol. 52, pages 238 - 311, XP009119027
DESCRIPTION- Remington's Pharmaceutical Sciences, Mack Publishing Company
DESCRIPTION- SEFTON, CRC Crit. Ref. Biomed. Eng., (19870000), vol. 14, page 201
DESCRIPTION- TANG et al., Eur. Respir. J., (20100000), vol. 35, pages 757 - 760
DESCRIPTION- TAYLOR et al., Nucl. Acids Res., (19920000), vol. 20, pages 6287 - 6295
DESCRIPTION- VAN DE POL et al., Allergy, (20120000), vol. 67, no. 1, pages 67 - 73
DESCRIPTION- WU et al., J. Biol. Chem., (19870000), vol. 262, pages 4429 - 4432
OPPOSITION- Al-Ramli Wisam, Mohamed Al Samri, Qutayba Hamid, "TH-17 Cell-Related Cytokines' Potential Role in the Pathogenesis of Severe Asthma", Journal of Asthma, (20080101), vol. 45, no. S1, pages 41 - 44, XP055945001
OPPOSITION- Anonymous, "GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION", GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION, (20090101), GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION, (20220720), XP055944397
OPPOSITION- Anonymous, "History of Changes for Study: NCT01312961 Efficacy, Safety, and Tolerability of SAR231893 (REGN668) in Patients With Persistent Moderate to Severe Eosinophilic Asthma", clinicaltrials.gov, (20120820), clinicaltrials.gov, URL: https://clinicaltrials.gov/ct2/history/NCT01312961?A=31&B=31&C=merged#StudyPageTop , (20220720), XP055944378
OPPOSITION- Anonymous, "International Nonpropietary Names for Pharmaceutical Substance (INN)", WHO Drug Information, (20120101), vol. 26, no. 4, pages 401 - 471, XP055945232
OPPOSITION- Anonymous, "International Nonproprietary Names for Pharmaceutical Substances (INN) / Dénominations communes internationales des Substances pharmaceutiques (DCI) - List 108", WHO Drug Information, (20120101), vol. 26, no. 4, pages 401 - 471, XP055945085
OPPOSITION- Anonymous, "International Nonproprietary Names for Pharmaceutical Substances (INN), List 108", WHO Drug Information, (20120101), vol. 26, no. 4, pages 401 - 471, XP055932074
OPPOSITION- Anonymous, "REGENERON REPORTS FOURTH QUARTER AND FULL YEAR 2011 FINANCIAL AND OPERATING RESULTS", R, egeneron, (20120213), R, (20220720), XP055944380
OPPOSITION- Anonymous, "Regeneron Science to MedicineTM", J.P. Morgan Healthcare Conference, San Francisco, San Francisco, (20130101), J.P. Morgan Healthcare Conference, (20220722), XP055945238
OPPOSITION- Anonymous, "Targeting IL-5 in severe asthma: a DREAM come true?", the lancet, (20120818), vol. 380, pages 626 - 127, XP055944382
OPPOSITION- BIRKETT D. J., "Pharmacokinetics made easy 11 Designing dose regimens", Aust Prescr, vol. 19, no. 3, (19960701), pages 76 - 78, URL: https://www.nps.org.au/australian-prescriber/articles/pharmacokinetics-made-easy-11-designing-dose-regimens, XP055136785
OPPOSITION- FIRSZT et al., "Pharmacotherapy of Severe Asthma", Curr Opin Pharmacol, (20100600), vol. 10, no. 3, pages 266 - 271, XP027137700
OPPOSITION- Gibaldi, Milo, Biopharmaceutics and Clinical Pharmacokinetics, 4th ed., (19910101), pages 12 - 13, XP055945117
OPPOSITION- "Global Strategy for Asthma Management and Prevention", GINA Report 2011, (20111200), URL: www.qinasthma.org, XP055944374
OPPOSITION- "Global Strategy for Asthma Management and Prevention", GINA Report 2012, (20121200), URL: www.qinasthma.org, XP055944377
OPPOSITION- LOMMATZSCH MAREK ET AL, "Severe asthma: definition, diagnosis and treatment.", DEUTSCHES ARZTEBLATT INTERNATIONAL FEB 2013, (20141212), vol. 111, no. 50, ISSN 1866-0452, pages 847 - 855, XP002789189
OPPOSITION- M.E. Aulton, "Chapter 19: Dosage regimes", Pharmaceutics: The Science of Dosage Form Design, Churchill Livingstone , (20011001), pages 275 - 278, XP055404622
OPPOSITION- Mould Diane R; Sweeney Kevin R D, "The pharmacokinetics and pharmacodynamics of monoclonal antibodies--mechanistic modeling applied to drug development", CURRENT OPINION IN DRUG DISCOVERY AND DEVELOPMENT, CURRENT DRUGS, LONDON, GB, GB , (20070101), vol. 10, no. 1, ISSN 1367-6733, pages 84 - 96, XP009097022
OPPOSITION- Pollart Susan M., Kurtis S. Edward, "Overview of Changes to Asthma Guidelines: Diagnosis and Screening ", American Family Physician, (20090501), vol. 79, no. 9, pages 761 - 767, XP055944965
OPPOSITION- SPECTOR et al., "Is a single blood eosinophil count a reliable marker for ''eosinophilic asthma?", Journal of Asthma, (20120820), vol. 49, no. 8, pages 1 - 4, XP055944391
OPPOSITION- SZEFLER et al., "Asthma Outcomes: Biomarkers", J Allergy Clin Immunol, (20120301), vol. 129, pages S 9 - 23, XP055944385
OPPOSITION- Cara J. Bossley; Louise Fleming; Atul Gupta; Nicolas Regamey; Jennifer Frith; Timothy Oates; Lemonia Tsartsali; Clare M. Lloyd; Andrew Bush; Sejal Saglani;, "Pediatric severe asthma is characterized by eosinophilia and remodeling without T2 cytokines", Journal of Allergy and Clinical Immunology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20120123), vol. 129, no. 4, doi:10.1016/j.jaci.2012.01.059, ISSN 0091-6749, pages 974 - 982.e13, XP028478864
OPPOSITION- De Boever Erika H., Ashman Claire, Cahn Anthony P., Locantore Nicholas W., Overend Phil, Pouliquen Isabelle J., Serone Adrian P., Wright Tracey J., Jenkins Mair M., Panesar Inderpal S., Thiagarajah Sivayogan S., Wenzel Sally E., "Efficacy and safety of an anti-IL-13 mAb in patients with severe asthma: A randomized trial", Journal of Allergy and Clinical Immunology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20140401), vol. 133, no. 4, doi:10.1016/j.jaci.2014.01.002, ISSN 0091-6749, pages 989 - 996.e4, XP055945227
OPPOSITION- DARVEAX et al., "Biologics in asthma - the next step to personalised treatment", J Allergy Clin Immunol Pract, (20150300), vol. 3, no. 2, doi:10.1016/j.jaip.2014.09.014, pages 152 - 161, XP055535036
OPPOSITION- PAVORD et al., "Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial", Lancet, (20120818), vol. 380, doi:10.1016/S0140-6736(12)60988-X, pages 651 - 59, XP002714506
OPPOSITION- EISENSTEIN, "Something new under the skin", Nature Biotechnology, (20110207), vol. 29, no. 2, doi:10.1038/nbt.1768, pages 107 - 109, XP009152843
OPPOSITION- WENZEL, "Asthma phenotypes: the evolution from clinical to molecular approaches (review)", Nature Medicine, (20120504), vol. 18, no. 5, pages 716 - 725, XP055944372
OPPOSITION- WESCHLER, "Inhibiting interleukin-4 and interleukin-13 in difficult-to-control asthma", N Engl J Med, (20130521), vol. 368, doi:10.1056/NEJMe1305426, pages 2511 - 2513, XP009180486
OPPOSITION- Wenzel et al., "Dupilumab in persistent asthma with elevated eosinophil levels", N Engl J Med, (20130521), vol. 368, doi:10.1056/NEJMoa1304048, pages 2455 - 66, XP008165248
OPPOSITION- WENZEL et al., "Dupilumab in persistent asthma with elevated eosinophil levels", N Engl J Med, (20130521), vol. 368, no. 26, doi:10.1056/NEJMoa1304048, pages 2455 - 66, XP008165248
OPPOSITION- Wenzel et al., "Dupilumab in Persistent Asthma with Elevated Eosinophil Levels", The New England Journal of Medicine, US , (20130627), vol. 368, no. 26, doi:10.1056/NEJMoa1304048, ISSN 0028-4793, pages 2455 - 2466, XP008165248
OPPOSITION- Wenzel Sally; Ford Linda; Pearlman David; Spector Sheldon; Sher Lawrence; Skobieranda Franck; Wang Lin; Kirkesseli Stephane; Rocklin Ross; Bock Brian; Hamilton Jennifer; Ming Jeffrey E; Radin Allen; Stahl Neil; Yancopoulos George D; Graham Neil; Pirozzi Gianluca, "Dupilumab in Persistent Asthma with Elevated Eosinophil Levels", The New England journal of medicine, Massachusetts Medical Society, US, US , (20130627), vol. 368, no. 26, doi:10.1056/NEJMoa1304048, ISSN 0028-4793, pages 2455 - 2466, XP008165248
OPPOSITION- WENZEL, "Severe Asthma: from characteristics to phenotypes to endotypes (review)", Clinical & Experimental Allergy, (20120118), vol. 42, pages 650 - 658, XP055944371
OPPOSITION- O'Byrne et al., "Severe asthma: future treatments", Clinical & Experimental Allergy, UK , (20120501), vol. 42, no. 5, doi:10.1111/j.1365-2222.2012.03965.x, ISSN 0954-7894, pages 706 - 711, XP055945097
OPPOSITION- OTULANA et al., "A Phase 2b Study of Inhaled Pitrakinra, an IL -4 / IL -13 antagonist, successfully identified responder subpopulations of patients with uncontrolled asthma", American Journal of Respiratory and Critical Care Medicine, (20110518), vol. 183, doi:10.1164/ajrccm-conference.2011.183.1_MeetingAbstracts.A6179, page A6179, XP002716819
OPPOSITION- Wenzel Sally, "Severe Asthma in Adults", American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, US, US , (20050715), vol. 172, no. 2, doi:10.1164/rccm.200409-1181PP, ISSN 1073-449X, pages 149 - 160, XP055944998
OPPOSITION- P. G. Woodruff, B. Modrek, D. F. Choy, G. Jia, A. R. Abbas, A. Ellwanger, J. R. Arron, L. L. Koth, J. V. Fahy, "T-helper Type 2-driven Inflammation Defines Major Subphenotypes of Asthma", American Journal of Respiratory and Critical Care Medicine, (20090901), vol. 180, no. 5, doi:10.1164/rccm.200903-0392OC, ISSN 1073449X, pages 388 - 395, XP055049862
OPPOSITION- CORREN et al., "A randomized, controlled, Phase 2 study of AMG 317, an IL -4Ra antagonist, in patients with asthma", Am J Respir Crit Care Med, (20100107), vol. 181, no. 8, doi:10.1164/rccm.200909-1448OC, pages 788 - 96, XP055013586
OPPOSITION- Corren et al., "A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4R  Antagonist, in Patients with Asthma", American Journal of Respiratory and Critical Care Medicine, (20100415), vol. 181, no. 8, doi:10.1164/rccm.200909-1448OC, ISSN 1073449X, pages 788 - 796, XP055013586
OPPOSITION- J. Corren, W. Busse, E. O. Meltzer, L. Mansfield, G. Bensch, J. Fahrenholz, S. E. Wenzel, Y. Chon, M. Dunn, H. H. Weng, S. L. Lin, "A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4R  Antagonist, in Patients with Asthma", American Journal of Respiratory and Critical Care Medicine, (20100415), vol. 181, no. 8, doi:10.1164/rccm.200909-1448OC, ISSN 1073449X, pages 788 - 796, XP055013586
OPPOSITION- Borish Larry, "IL-4 and IL-13 Dual Antagonism : A Promising Approach to the Dilemma of Generating Effective Asthma Biotherapeutics", American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, US, US , (20100415), vol. 181, no. 8, doi:10.1164/rccm.201002-0147ED, ISSN 1073-449X, pages 769 - 770, XP055944399
OPPOSITION- Panaccione Remo, Ghosh Subrata, "Review: Optimal use of biologics in the management of Crohn’s disease", Therapeutic Advances in Gastroenterology, (20100501), vol. 3, no. 3, doi:10.1177/1756283X09357579, ISSN 1756-2848, pages 179 - 189, XP055928707
OPPOSITION- Joanne Shannon, Ernst Pierre, Yamauchi Yasuhiro, Olivenstein Ronald, Lemiere Catherine, Foley Susan, Cicora Leo, Ludwig Mara, Hamid Qutayba, Martin James G., "Differences in Airway Cytokine Profile in Severe Asthma Compared to Moderate Asthma", CHEST, American College of Chest Physicians, US, US , (20080201), vol. 133, no. 2, doi:10.1378/chest.07-1881, ISSN 0012-3692, pages 420 - 426, XP055535048
OPPOSITION- Brusselle Guy, Bracke Ken, "Targeting Immune Pathways for Therapy in Asthma and Chronic Obstructive Pulmonary Disease", Annals of the American Thoracic Society, (20141201), vol. 11, no. Supplement 5, doi:10.1513/AnnalsATS.201403-118AW, ISSN 2329-6933, pages S322 - S328, XP055932126
OPPOSITION- Gibson Pg, "Corticosteroids - clinical applications: exacerbations of asthma in adults", AUSTRALIAN PRESCRIBER, AUSTRALIAN GOVERNMENT - PUBLISHING SERVICE, CANBERRA, AU, AU , (19960401), vol. 16, no. 2, doi:10.18773/austprescr.1996.049, ISSN 0312-8008, pages 44 - 47, XP055944949
OPPOSITION- Liang Zhenyu, Zhao Haijin, Lv Yanhua, Li Rui, Dong Hangming, Liu Laiyu, Xia Yang, Hou Changchun, Cai Shaoxi, Zou Fei, "Moderate Accuracy of Peripheral Eosinophil Count for Predicting Eosinophilic Phenotype in Steroid-Naïve Non-Atopic Adult Asthmatics", INTERNAL MEDICINE., JAPANESE SOCIETY OF INTERNAL MEDICINE, TOKYO., JP, JP , (20120101), vol. 51, no. 7, doi:10.2169/internalmedicine.51.6834, ISSN 0918-2918, pages 717 - 722, XP055932140
OPPOSITION- Sandeep Thirunavukkarasu, Roopakala Mysoresubrahmanyam, Silvia Chickballapur Rayappawilma Delphine, Chandrashekara Srikantaiah, Rao Mohan, "Evaluation of serum immunoglobulin E levels in bronchial asthma", Lung India, (20100101), vol. 27, no. 3, doi:10.4103/0970-2113.68312, ISSN 0970-2113, pages 138 - 140, XP055945226
SEARCH- JARED DARVEAUX ET AL, "Biologics in Asthma-The Next Step Toward Personalized Treatment", THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY : AN OFFICIAL JOURNAL OF AAAAI, AMERICAN ACADEMY OF ALLERGY ASTHMA & IMMUNOLOGY, (20150301), vol. 3, no. 2, doi:10.1016/j.jaip.2014.09.014, ISSN 2213-2198, pages 152 - 160, XP055535036 [T] 1-14 * page 8, paragraph 3 - paragraph 4 *
SEARCH- METERAN HOWRAMAN ET AL, "Novel monoclonal treatments in severe asthma", JOURNAL OF ASTHMA : DEVOTED TO ASTHMA AND RELATED CONDITIONS, INFORMA HEALTHCARE, USA, vol. 54, no. 10, doi:10.1080/02770903.2017.1296157, ISSN 1532-4303, (20171130), pages 991 - 1011, (20170316), XP009510079 [T] 1-14 * page 1007, column l, paragraph 4 - column r, paragraph 5 * * table 4 *
SEARCH- DIEGO BAGNASCO ET AL, "A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY., CH, (20160101), vol. 170, no. 2, doi:10.1159/000447692, ISSN 1018-2438, pages 122 - 131, XP055535051 [T] 1-14 * page 127, column l, paragraph 2 - column r, paragraph 3 *
SEARCH- J. CORREN ET AL, "A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4R Antagonist, in Patients with Asthma", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, (20100415), vol. 181, no. 8, doi:10.1164/rccm.200909-1448OC, ISSN 1073-449X, pages 788 - 796, XP055013586 [A] 1-14 * abstract * * page 788, column r, paragraph l - page 789, column l, paragraph 3 * * page 792, column l, paragraph 2 *
SEARCH- JOANNE SHANNON ET AL, "Differences in Airway Cytokine Profile in Severe Asthma Compared to Moderate Asthma", CHEST, US, (20080201), vol. 133, no. 2, doi:10.1378/chest.07-1881, ISSN 0012-3692, pages 420 - 426, XP055535048 [I] 1-14 * abstract *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents