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Substantially Animal Protein-Free Recombinat Furin And Methods For Producing Same - EP3521422

The patent EP3521422 was granted to Baxalta on Oct 6, 2021. The application was originally filed on Dec 19, 2008 under application number EP19163119A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3521422

BAXALTA
Application Number
EP19163119A
Filing Date
Dec 19, 2008
Status
Granted And Under Opposition
Sep 3, 2021
Grant Date
Oct 6, 2021
External Links
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Patent Family

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KONIG SZYNKA TILMANN VON RENESSEJul 6, 2022KONIG SZYNKA TILMANN VON RENESSE PATENTANWALTE PARTNERSCHAFT MBB DUSSELDORFADMISSIBLE
KONIG SZYNKA TILMANN VON RENESSEJul 6, 2022WALLINGER RICKER SCHLOTTER TOSTMANNADMISSIBLE

Patent Citations (15) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
DESCRIPTIONUS20070018152
DESCRIPTIONWO1997US18255
DESCRIPTIONEP0775750
DESCRIPTIONUS6210929
DESCRIPTIONWO0049047
DESCRIPTIONWO9106314
DESCRIPTIONWO9209698
DESCRIPTIONWO9815614
OPPOSITIONEP2240578
OPPOSITIONUS6210929
OPPOSITIONWO2008141824
OPPOSITIONWO2009088713
OPPOSITIONWO9209698
SEARCHWO0194383
SEARCHWO2008141824

Non-Patent Literature (NPL) Citations (78) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
DESCRIPTION- BARR, Cell, (19910000), vol. 66, pages 1 - 3
DESCRIPTION- BARR et al., DNA Cell Biol., (19910000), vol. 10, pages 319 - 328
DESCRIPTION- BRESNAHAN et al., J. Cell Biol., (19900000), vol. 111, pages 2851 - 2859
DESCRIPTION- BRESNAHAN et al., J. Cell. Biol., (19900000), vol. 111, pages 2851 - 2859
DESCRIPTION- BRISTOL et al., Biochemistry, (19940000), vol. 33, pages 14136 - 14143
DESCRIPTION- CREEMERS et al., J. Biol. Chem., (19930000), vol. 268, pages 21826 - 21834
DESCRIPTION- DECROLY et al., J. Biol. Chem., (19940000), vol. 269, pages 12240 - 12247
DESCRIPTION- "GenBank", Database accession no. EAX02111
DESCRIPTION- HATSUZAWA et al., J. Biochem., (19920000), vol. 101, pages 296 - 301
DESCRIPTION- HATSUZAWA et al., J. Biol. Chem., (19900000), vol. 265, pages 22075 - 22078
DESCRIPTION- HATSUZAWA et al., J. Biol. Chem., (19920000), vol. 267, pages 16094 - 16099
DESCRIPTION- HOSAKA et al., J. Biol. Chem., (19910000), vol. 266, pages 12127 - 12130
DESCRIPTION- KIEFER et al., DNA Cell Biol., (19910000), vol. 10, page 757
DESCRIPTION- KLIMPEL et al., Proc. Natl. Acad. Sci. USA, (19920000), vol. 89, pages 10277 - 10281
DESCRIPTION- LEDUC et al., J. Biol. Chem., (19920000), vol. 267, pages 14304 - 14308
DESCRIPTION- MOLLOY et al., J. Biol. Chem., (19920000), vol. 267, pages 16396 - 16402
DESCRIPTION- NAKAYAMA et al., J. Biol. Chem., (19920000), vol. 267, pages 5897 - 5900
DESCRIPTION- ODA et al., Biochem. Biophys. Res. Commun., (19920000), vol. 189, pages 1353 - 1361
DESCRIPTION- PREININGER et al., Cytotechnology, (19990000), vol. 30, pages 1 - 15
DESCRIPTION- REHEMTULLA et al., Blood, (19920000), vol. 79, pages 2349 - 2355
DESCRIPTION- REHEMTULLA et al., Proc. Natl. Acad. Sci. USA, (19920000), vol. 89, pages 8235 - 8239
DESCRIPTION- ROEBROEK et al., EMBOJ., (19860000), vol. 5, pages 2197 - 2202
DESCRIPTION- ROEBROEK et al., Mol. Biol. Rep., (19860000), vol. 11, pages 117 - 125
DESCRIPTION- SCHLOKAT et al., Biotechnol. Appl. Biochem., (19960000), vol. 24, pages 257 - 267
DESCRIPTION- SMEEKENS et al., J. Biol. Chem., (19900000), vol. 265, pages 2997 - 3000
DESCRIPTION- SMEEKENS et al., Proc. Natl. Acad. Sci. USA., (19910000), vol. 88, pages 340 - 344
DESCRIPTION- STIENEKE-GROBER et al., EMBO J., (19920000), vol. 11, pages 2407 - 2414
DESCRIPTION- STIENEKE-GROBER et al., EMBOJ., (19920000), vol. 11, pages 2407 - 2414
DESCRIPTION- TSUNEOKA et al., J. Biol. Chem., (19930000), vol. 268, pages 26461 - 26465
DESCRIPTION- VAN DEN OUWELAND et al., Nucleic Acids Res., (19890000), vol. 17, pages 7101 - 7102
DESCRIPTION- VAN DEN OUWELAND et al., Nucleic Acids Res., (19900000), vol. 18, page 664
DESCRIPTION- VAN DE VEN et al., Crit. Rev. Oncogen., (19930000), vol. 4, pages 115 - 136
DESCRIPTION- VAN DE VEN et al., Mol. Biol. Rep., (19900000), vol. 14, pages 265 - 275
DESCRIPTION- VAN DE VEN et al., Mol. Bio. Rep., (19900000), vol. 14, pages 265 - 275
DESCRIPTION- VERWEIJ et al., EMBO J., (19860000), vol. 5, pages 1839 - 1847
DESCRIPTION- VEY et al., J. Cell Biol., (19940000), vol. 127, pages 1829 - 1842
DESCRIPTION- VEY et al., J. Cell. Biol., (19940000), vol. 127, pages 1829 - 1842
DESCRIPTION- VIDRICAIRE et al., Biochem. Biophys. Res. Comm., (19930000), vol. 195, pages 1011 - 1018
DESCRIPTION- WASLEY et al., J. Biol. Chem., (19930000), vol. 268, pages 8458 - 8465
DESCRIPTION- WASLEYETAL., J. Biol. Chem., (19930000), vol. 268, pages 8458 - 8465
DESCRIPTION- WASLEY et al., J. Biol. Chem., (19930000), vol. 268, pages 8458 - 8468
DESCRIPTION- WISE et al., Proc. Natl. Acad. Sci. USA, (19900000), vol. 87, pages 9378 - 9382
OPPOSITION- Anonymous, "CPMP Position Statement on DNA and Host Cell Proteins (HCP) Impurities, Routine Testing versus Validation Studies ", EMA The European Agency for the Evaluation of Medicinal Products Human Medicines Evaluation Unit, (19970610), pages 1 - 2, XP093134718
OPPOSITION- BRAVO, D. A. et al., "Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic parameters using the purified, secreted soluble protease expressed by a recombinant baculovirus", Journal of Biological Chemistry, (19940000), vol. 269, no. 41, pages 25830 - 25837, XP002115941
OPPOSITION- Chiron Marielle F., Charlott Em. Fryling, David J. Fitzgerald, "Cleavage of pseudomonas exotoxin and diphtheria toxin by a furin-like D24 enzyme prepared from beef liver", Journal of Biological Chemistry, (19940708), vol. 269, no. 27, pages 18167 - 18176, XP055943439
OPPOSITION- Denault J. B., Richard Leduc, "Furin/PACE/SPC1: a convertase involved in exocytic and endocytic", FEBS Lett., (19960129), vol. 379, no. 2, pages 113 - 116, XP055943433
OPPOSITION- Fricker L. D., "Furin and Mammalian KEX2 Homologues", Peptide Biosynthesis and Processing, CRC Press, (19910101), page 150, XP055943467
OPPOSITION- HATSUZAWA, K. et al., "Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites", The Journal of Biochemistry, (19920000), vol. 111, no. 3, pages 296 - 301, XP008096137
OPPOSITION- HATSUZAWA, K. et al., "Purification and characterization of furin, a Kex2-like processing endoprotease, produced in Chinese hamster ovary cells", Journal of Biological Chemistry, (19920000), vol. 267, no. 23, pages 16094 - 16099, XP002350311
OPPOSITION- Max Steven I., Denis Drapeau, Martin S. Sinacore, Timothy S. Chralebois, James Agacollo, Fraderik J. Carleton, "Cell Culture Process Validation", Validation of pharmaceutical processes. 3rd Ed., Informa Healthcare, (20070101), pages 481 - 490, XP055943443
OPPOSITION- MOLLOY S S ET AL, "Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-XX-Arg and efficiently cleaves anthrax toxin protective antigen", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (19920815), vol. 267, no. 23, ISSN 0021-9258, pages 16396 - 16402, XP002494532
OPPOSITION- NAKAYAMA, K., "Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins", Biochemical Journal, (19970000), vol. 327, no. 3, pages 625 - 635, XP002116727
OPPOSITION- SCHLOKAT, U. et al., "Production of highly homogeneous and structurally intact recombinant von Willebrand factor multimers by furin-mediated propeptide removal in vitro", Biotechnology and applied biochemistry, (19960000), vol. 24, no. 3, pages 257 - 267, XP001097385
OPPOSITION- Takahashi Senye, Kiyotaka Hatsuzawa, Toshio Watanabe, Kazuo Murakami, Kazuhisa Nakayama, "Sequence requirements for endoproteolytic processing of precursor proteins by furin: transfection and in vitro experiments", J Biochem, (19940701), vol. 116, no. 1, pages 47 - 52, XP055943436
OPPOSITION- LAPRISE, M. H. et al., "Enhanced TGF{31 maturation in high five cells coinfected with recombinant baculovirus encoding the convertase furin/pace: improved technology for the production of recombinant proproteins in insect cells", Biotechnology and bioengineering, (19980000), vol. 58, no. 1, doi:10.1002/(SICI)1097-0290(19980405)58:1<85::AID-BIT9>3.0.CO;2-Q, pages 85 - 91, XP071151214
OPPOSITION- VIDRICAIRE, G. et al., "Characterization of a secreted form of human furin endoprotease", Biochemical and biophysical research communications, (19930000), vol. 195, no. 2, doi:10.1006/bbrc.1993.2145, pages 1011 - 1018, XP024766953
OPPOSITION- Himmelspach M., Plaimauer B., Dorner F., Schlokat U., "Furin as a Tool for the Endoproteolytic Maturation of Susceptible Recombinant Biopharmaceuticals", Novel Frontiers in the Production of Compounds for Biomedical Use, Dordrecht, Springer Netherlands, (20010101), vol. 1, pages 219 - 248, doi:10.1007/0-306-46885-9_14, ISSN 1569-268X, ISBN 978-0-306-46885-8, XP055943429
OPPOSITION- Himmelspach M., Schlokat U., Plaimauer B., Falkner F. G., Dorner F., "High Yield Expression of Recombinant Proteins Requiring Proteolytic Maturation: Use of the Endoprotease Furin", Cell Engineering, Dordrecht, Springer Netherlands, (19990101), vol. 1, pages 85 - 107, doi:10.1007/978-0-585-37971-5_3, ISBN 978-0-7923-5790-2, XP055943431
OPPOSITION- Drapeau Denis, Luan Yen-Tung, Popoloski Joanne A., Richards D. Troy, Cohen David C., Sinacore Martin S., Adamson S. Robert, "Extracellular insulin degrading activity creates instability in a CHO-based batch-refeed continuous process : Improvements of Human Health", Cell Culture Engineering IV : Improvements of Human Health, Dordrecht, Springer Netherlands, (19940101), vol. 1, pages 103 - 109, doi:10.1007/978-94-011-0257-5_12, ISSN 1386-2928, ISBN 978-94-011-0257-5, XP055943445
OPPOSITION- AYOUBI, T. A. et al., "Production of recombinant proteins in Chinese hamster ovary cells overexpressing the subtilisin-like proprotein converting enzyme furin", Molecular Biology Reports, (19960000), vol. 23, no. 2, doi:10.1007/BF00424434, pages 87 - 95, XP009096562
OPPOSITION- ODA, K. et al., "Proteolytic cleavages of proalbumin and complement Pro-C3 in vitro by a truncated soluble form of furin, a mammalian homologue of the yeast", Biochem Biophys Res Commun, (19920000), vol. 189, no. 3, doi:10.1016/0006-291X(92)90223-8, pages 1353 - 1361, XP024775693
OPPOSITION- NAKAYAMA, K. et al., "12] Purification of recombinant soluble forms of furin produced in chinese hamster ovary cells", Methods in Enzymology, (19940000), vol. 244, doi:10.1016/0076-6879(94)44014-X, pages 167 - 175, XP008096047
OPPOSITION- Mizuno Kensaku, Nakamura Tomoko, Takada Katsumi, Sakakibara Shumpei, Matsuo Hisayuki, "A membrane-bound, calcium-dependent protease in yeast α-cell cleaving on the carboxyl side of paired basic residues", Biochemical and Biophysical Research Communications, Elsevier, Amsterdam NL, Amsterdam NL , (19870401), vol. 144, no. 2, doi:10.1016/S0006-291X(87)80036-0, ISSN 0006-291X, pages 807 - 814, XP055943416
OPPOSITION- Alexandra Preininger ; Uwe Schlokat ; Gabriele Mohr ; Michèle Himmelspach ; Veronika Stichler ; Astrid Kyd-Rebenburg ; Barbara Plaimauer ; Peter L. Turecek ; Hans-Peter Schwarz ; Waltraud Wernhart ; Bernhard E. Fischer ; Friedrich Dorner, "Strategies for recombinant Furin employment in a biotechnological process: complete target protein precursor cleavage", Cytotechnology, Kluwer Academic Publishers, Do, Do , (19990501), vol. 30, no. 1-3, doi:10.1023/A:1008030407679, ISSN 1573-0778, pages 1 - 15, XP019236610
OPPOSITION- Sucic Joseph F., Moehring Joan M., Inocencio Noel M., Luchini Jason W., Moehring Thomas J., "Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain", Biochemical Journal, Published by Portland Press on behalf of the Biochemical Society., GB, GB , (19990501), vol. 339, no. 3, doi:10.1042/bj3390639, ISSN 0264-6021, pages 639 - 647, XP055943440
OPPOSITION- BRENNER, C. et al., "Structural and enzymatic characterization of a purified prohormone- processing enzyme: secreted, soluble Kex2 protease", Proceedings of the National Academy of Sciences, (19920000), vol. 89, no. 3, doi:10.1073/pnas.89.3.922, pages 922 - 926, XP002062734
OPPOSITION- CHIRON, M. F. et al., "Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins", Journal of Biological Chemistry, (19970000), vol. 272, no. 50, doi:10.1074/jbc.272.50.31707, pages 31707 - 31711, XP008102903
OPPOSITION- APLETALINA, E. et al., "Identification of inhibitors of prohormone convertases 1 and 2 using a peptide combinatorial library", Journal of Biological Chemistry, (19980000), vol. 273, no. 41, doi:10.1074/jbc.273.41.26589, pages 26589 - 26595, XP002355258
OPPOSITION- CAMERON, A. et al., "Polyarginines Are Potent Furin Inhibitors", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20001124), vol. 275, no. 47, doi:10.1074/jbc.M003848200, ISSN 0021-9258, pages 36741 - 36749, XP002251991
OPPOSITION- DOERING et al., "High level expression of recombinant porcine coagulation factor VIII", The Journal of Biological Chemistry, (20020000), vol. 277, no. 41, doi:10.1074/jbc.M206959200, pages 38345 - 38349, XP002379313
OPPOSITION- LIND, P. et al., "Novel forms of B-domain -deleted recombinant factor VIII molecules: construction and biochemical characterization", European Journal of Biochemistry, (19950000), vol. 232, no. 1, doi:10.1111/j.1432-1033.1995.tb20776.x, pages 19 - 27, XP002111900
SEARCH- HATSUZAWA K ET AL, "PURIFICATION AND CHARACTERIZATION OF FURIN A KEX2-LIKE PROCESSING ENDOPROTEASE PRODUCED IN CHINESE HAMSTER OVARY CELLS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM, US, (19920815), vol. 267, no. 23, ISSN 0021-9258, pages 16094 - 16099, XP002350311 [A] 1-11 * the whole document *
SEARCH- TURECEK PETER L ET AL, "Biochemical and functional characterization of a serum-free rVWF drug candidate.", BLOOD, & 48TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; ORLANDO, FL, USA; DECEMBER 09 -12, 2006, (200611), vol. 108, no. 11, Part 1, ISSN 0006-4971, page 303A, XP002524489 [A] 1-11 * the whole document *
SEARCH- AYOUBI TORIK A Y ET AL, "Production of recombinant proteins in Chinese hamster ovary cells overexpressing the subtilisin-like proprotein converting enzyme furin", MOLECULAR BIOLOGY REPORTS, REIDEL, DORDRECHT, NL, (19960101), vol. 23, no. 2, ISSN 0301-4851, pages 87 - 95, XP009096562 [A] 1-11 * the whole document *
SEARCH- NAKAYAMA K, "Purification of recombinant soluble forms of furin produced in Chinese hamster ovary cells", METHODS IN ENZYMO, ACADEMIC PRESS, US, (19940101), vol. 244, doi:10.1016/0076-6879(94)44014-X, ISSN 0076-6879, pages 167 - 175, XP008096047 [A] 1-11 * the whole document *
SEARCH- NISHIGORI T ET AL, "Proinsulin cleaved by furin is processed to chromatographically mature insulin by carboxypeptidases in nonneuroendocrine cells.", PEPTIDES 1996, (1996), vol. 17, no. 5, ISSN 0196-9781, pages 789 - 796, XP002524490 [A] 1,9-11 * the whole document *
SEARCH- ALEXANDRA PREININGER ET AL, "Strategies for recombinant Furin employment in a biotechnological process: complete target protein precursor cleavage", CYTOTECHNOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, (19990501), vol. 30, no. 1-3, doi:10.1023/A:1008030407679, ISSN 1573-0778, pages 1 - 15, XP019236610 [A] 1-11 * the whole document *
SEARCH- CHIRON M F ET AL, "Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM, US, (19971212), vol. 272, no. 50, ISSN 0021-9258, pages 31707 - 31711, XP008102903 [A] 1-11 * the whole document *

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