IP Verse

Methods And Means For Enhancing Rna Production - EP3521456

The patent EP3521456 was granted to Curevac on Jan 4, 2023. The application was originally filed on Jun 10, 2015 under application number EP18001012A. The patent is currently recorded with a legal status of "Revoked".

EP3521456

CUREVAC
Application Number
EP18001012A
Filing Date
Jun 10, 2015
Status
Revoked
May 17, 2024
Grant Date
Jan 4, 2023
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (3)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

AWA SWEDENOct 4, 2023AWA SWEDENADMISSIBLE
BIONTECHOct 4, 2023THOMANNADMISSIBLE
STRAWMANOct 4, 2023GREAVES BREWSTERADMISSIBLE

Patent Citations (26) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS5256555
DESCRIPTIONUS6586218
DESCRIPTIONUS7074596
DESCRIPTIONWO2006004648
DESCRIPTIONWO2008016473
DESCRIPTIONWO2008077592
DESCRIPTIONWO2008157688
DESCRIPTIONWO2009095226
DESCRIPTIONWO2009149253
DESCRIPTIONWO2011015347
DESCRIPTIONWO2013052523
DESCRIPTIONWO2013059475
DESCRIPTIONWO9508626
OPPOSITIONEP3521456
OPPOSITIONWO2006004648
OPPOSITIONWO2007024708
OPPOSITIONWO2010037408
OPPOSITIONWO2012122413
OPPOSITIONWO2012170930
OPPOSITIONWO2015188933
OPPOSITIONWO9418341
OPPOSITIONWO9508626
SEARCHUS6586218
SEARCHWO2004022574
SEARCHWO2006004648
SEARCHWO9508626

Non-Patent Literature (NPL) Citations (49) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ARNDT-JOVIN et al., Eur. J. Biochem., (19750000), vol. 54, no. 2, pages 411 - 8-
DESCRIPTION- BRUNELLE et al., Methods Enzymol., (20130000), vol. 530, pages 101 - 14-
DESCRIPTION- CUNNINGHAM; OFENGAND, Biotechniques, (19900000), vol. 9, no. 6, pages 713 - 4-
DESCRIPTION- ESTELLER, Nat. Rev. Genet., (20110000), vol. 12, no. 12, pages 861 - 74-
DESCRIPTION- FOTIN-MLECZEK et al., J. Gene Med., (20120000), vol. 14, no. 6, pages 428 - 439-
DESCRIPTION- GALLAGHER, Current Protocols in Molecular Biology, (20110000), vol. 93-
DESCRIPTION- GEALL et al., Semin. Immunol., (20130000), vol. 25, no. 2, pages 152 - 159-
DESCRIPTION- "GenBank", Database accession no. U26404-
DESCRIPTION- "GenBank", Database accession no. X65300-
DESCRIPTION- "GenBank", Database accession no. X65327-
DESCRIPTION- GUREVICH et al., Anal. Biochem., (19910000), vol. 195, no. 2, pages 207 - 13-
DESCRIPTION- KARIKO et al., Mol. Ther., (20120000), vol. 20, no. 5, pages 948 - 953-
DESCRIPTION- KARIKO et al., Nucleic Acids Res., (20110000), vol. 39, no. 21, page e142-
DESCRIPTION- KARIKO et al., Nucleic Acids Res., (20110000), vol. 39, no. 21, page el42-
DESCRIPTION- KERN; DAVIS, Biotechnol. Prog., (19970000), vol. 13, pages 747 - 756-
DESCRIPTION- KERN et al., Biotechnol. Prog., (19970000), vol. 13, pages 747 - 756-
DESCRIPTION- KERN et al., Biotechnol. Prog., (19990000), vol. 15, pages 174 - 184-
DESCRIPTION- KERRIGAN et al., Current Protocols in Molecular Biology, (20010000), vol. 24-
DESCRIPTION- KOLITZ et al., Methods Enzymol., (20130000), vol. 530, pages 331 - 6-
DESCRIPTION- KORE et al., Bioorg. Med. Chem., (20130000), vol. 21, no. 15, pages 4570 - 4-
DESCRIPTION- KORMANN et al., Nat. Biotechnol., (20120000), vol. 29, no. 2, pages 154 - 157-
DESCRIPTION- LAI et al., Development, (19950000), vol. 121, pages 2349 - 2360-
DESCRIPTION- MEYLAN; TSCHOPP, Mol. Cell, (20060000), vol. 22, pages 561 - 569-
DESCRIPTION- MILLIGAN et al., Nucleic Acid Res., (19870000), vol. 15, no. 21, pages 8783 - 8798-
DESCRIPTION- SAMPSON; UHLENBECK, Proc. Natl. Acad. Sci. USA, (19880000), vol. 85, no. 4, pages 1033 - 7-
DESCRIPTION- STEPINSKI et al., RNA, (20010000), vol. 7, no. 10, pages 1486 - 95-
DESCRIPTION- TCHEREPANOVA et al., BMC Mol. Biol., (20080000), vol. 9, page 90-
DESCRIPTION- TRIANA-ALONSO et al., JBC, (19950000), vol. 270, no. 11, pages 6298 - 6307-
DESCRIPTION- VAN DE MERBEL, J. Chromatogr. A, (19990000), vol. 856, no. 1-2, pages 55 - 82-
DESCRIPTION- WEITZMANN et al., Nucleic Acids Res., (19900000), vol. 18, no. 12, pages 3515 - 20-
DESCRIPTION- VANDER VEEN et al., "Alphavirus replicon vaccines", Animal Health Research Reviews, (20120000), doi:doi:10.1017/S1466252312000011, pages 1 - 9, XP009166113
OPPOSITION- Anonymous, "Ambion’s MEGAscript® Kit", Life - User Guide Catalog Numbers AM1330, AM1333, AM1334, AM1338, (20120914), pages 1 - 36, Life - User Guide Catalog Numbers AM1330, AM1333, AM1334, AM1338, (20240305), XP093137819-
OPPOSITION- Anonymous, "Masterflex® L/S “Unified ” drives", Operator’ s Manual, Edition 9992, (19990227), pages 2 - 14, XP093136767-
OPPOSITION- Anonymous, "mMESSAGE mMACHINE® Kit High Yield Capped RNA Transcription Kit", Life - User Guide Catalog Numbers AM1340, AM1344, AM1348, (20121010), pages 1 - 36, Life - User Guide Catalog Numbers AM1340, AM1344, AM1348, (20240305), XP093137821-
OPPOSITION- Gruegelsiepe Heike, Astrid Schon, Leif A. Kirsebom And Roland K. Hartmann, "Enzymatic RNA Synthesis, Ligation and Modification", Gruegelsiepe Heike, Astrid Schon, Leif A. Kirsebom And Roland K. Hartmann, Roland Karl Hartmann, Albrecht Bindereif, Astrid Schon, Eric Westhof, Handbook of RNA Biochemistry Vol 1, WILEY-VCH Verlag GmbH & Co. KGaA, (20050101), pages 3 - 21, XP093140348-
OPPOSITION- Hartmann R K, Bindereif A, Scho ̈n A, Westhof Copyright E, Verlag Wiley-Vch, Co Gmbh, Kgaa Weinheim, "Chapter I: Enzymatic RNA Synthesis, Ligation and Modification", Handbook of RNA Biochemistry, WILEY-VCH Verlag, (20050101), pages 3 - 21, ISBN 978-3-527-30826-2, XP093137822-
OPPOSITION- Williams N T, "Continuous Production of RNA using a Stir-cell Bioreactor", Thesis, (19950322), pages 1 - 132, XP093136738-
OPPOSITION- Naiomi C. Breckenridge, "Optimization of Repeated-Batch Transcription for RNA Production", Biotechnology and Bioengineering, (2000), vol. 69, doi:10.1002/1097-0290(20000920)69:6<679::AID-BIT12>3.0.CO;2-6, XP002742271
OPPOSITION- Markus Gcflringer, Dominik Helmecke, Karen Kohler, Astrid Schon, Le f A. Kirsebom, Albrecht Bindere f, Roland K. Hartmann, "Enzymatic RNA Synthesis Using Bacteriophage T7 RNA Polymerase", Markus Gcflringer, Dominik Helmecke, Karen Kohler, Astrid Schon, Le f A. Kirsebom, Albrecht Bindere f, Roland K. Hartmann, R.K. Hartmann, A. Bindereif, A. Schon, E. Westhof, Handbook of RNA Biochemistry, Second Edition, Wiley-VCH Verlag GmbH, (20140101), pages 3 - 27, doi:10.1002/9783527647064.ch1, XP093136759
OPPOSITION- Beckert Bertrand; Masquida Benoit, "Synthesis of RNA by in vitro transcription.", Methods in Molecular Biology, Humana Pr., US, US , (20110101), vol. 703, doi:10.1007/978-1-59745-248-9_3, ISBN 978-1-61779-291-5, pages 29 - 41, XP009186069
OPPOSITION- Norbert Pardi, "In Vitro Transcription of Long RNA Containing Modified Nucleosides", Synthetic Messenger RNA and Cell Metabolism Modulation, Methods and Protocols, Chapter II, (2013), vol. 969, doi:10.1007/978-1-62703-260-5_2, XP009509413
OPPOSITION- N.C. van der Merbel, "Membrane-based sample preparation coupled on-line to chromatography or electrophoresis", J. Chromatogr. A, (1999), vol. 856, doi:10.1016/S0021-9673(99)00581-6, XP004180075
OPPOSITION- J.A. Kern, R.H. Davis, "Application of a Fed-Batch System To Produce RNA by In Vitro Transcription", Biotechnology Progress, Hoboken, USA, (19990405), vol. 15, no. 2, doi:10.1021/bp990008g, ISSN 8756-7938, pages 174 - 184, XP055739122
OPPOSITION- Jeffrey Kern, "Application of a Fed-Batch System To Produce RNA by In Vitro Transcription", Biotechnol. Prog. , (1999), vol. 15, doi:10.1021/bp990008g, XP055739122
OPPOSITION- Schneider David A., Gaal Tamas, Gourse Richard L., "NTP-sensing by rRNA promoters in Escherichia coli is direct", Proceedings of the National Academy of Sciences, (20020625), vol. 99, no. 13, doi:10.1073/pnas.132285199, ISSN 0027-8424, pages 8602 - 8607, XP093140354
OPPOSITION- Francisco Trianna-Alonso, "Self-coded 3' -Extension of Run-off Transcripts Produces Aberrant Products during in Vitro Transcription with T7 RNA Polymerase", Journal of Biological Chemistry , (19950317), vol. 270, doi:10.1074/jbc.270.30.17680, XP002426628
OPPOSITION- Yin Y., Carter C. W., "Incomplete Factorial and Response Surface Methods in Experimental Design: Yield Optimization of tRNATrp from In vitro T7 RNA Polymerase Transcription", Nucleic Acids Research, GB , (19960401), vol. 24, no. 7, doi:10.1093/nar/24.7.1279, ISSN 0305-1048, pages 1279 - 1286, XP055914624
OPPOSITION- Ohno Hirohisa, Akamine Sae, Mochizuki Megumi, Hayashi Karin, Akichika Shinichiro, Suzuki Tsutomu, Saito Hirohide, "Versatile strategy using vaccinia virus-capping enzyme to synthesize functional 5′ cap-modified mRNAs", Nucleic Acids Research, GB , (20230411), vol. 51, no. 6, doi:10.1093/nar/gkad019, ISSN 0305-1048, pages 1 - 16, XP093136770
SEARCH- J.A. KERN ET AL, "Application of Solution Equilibrium Analysis to in Vitro RNA Transcription", BIOTECHNOLOGY PROGRESS, (19971202), vol. 13, no. 6, doi:10.1021/bp970094p, ISSN 8756-7938, pages 747 - 756, XP055162001 [AD] 1-23 * the whole document *

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents