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Cas Variants For Gene Editing - EP3604511

The patent EP3604511 was granted to President And Fellows OF Harvard College on Feb 28, 2024. The application was originally filed on Dec 12, 2014 under application number EP19181479A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP3604511

PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Application Number
EP19181479A
Filing Date
Dec 12, 2014
Status
Granted And Under Opposition
Jan 26, 2024
Grant Date
Feb 28, 2024
External Links
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JG OPPOSITIONSNov 26, 2024MATHYS & SQUIREADMISSIBLE

Patent Citations (5) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication Number
OPPOSITIONUS2011104787
OPPOSITIONWO2013176772
OPPOSITIONWO2017070632
SEARCHWO2010132092
SEARCHWO2014186686

Non-Patent Literature (NPL) Citations (20) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference Text
EXAMINATION- Prashant Mali ET AL, "CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering", Nature Biotechnology, (20130801), vol. 31, no. 9, doi:10.1038/nbt.2675, ISSN 1087-0156, pages 833 - 838, XP055153963
OPPOSITION- Lei s. Qi, Matthew h. Larson, Luke a. Gilbert, Jennifer a. Doudna, Jonathan s. Weissman, Adam p. Arkin, Wendell a. Lim, "Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression", Cell, Cell Press, (20130201), vol. 152, no. 5, doi:10.1016/j.cell.2013.02.022, ISSN 00928674, pages 1173 - 1183, XP055068548
OPPOSITION- Luke a. Gilbert, Matthew h. Larson, Leonardo Morsut, Zairan Liu, Gloria a. Brar, Sandra e. Torres, Noam Stern-Ginossar, Onn Brandman, Evan h. Whitehead, Jennifer a. Doudna, Wendell a. Lim, Jonathan s. Weissman, Lei s. Qi, "CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes", Cell, Elsevier, Amsterdam NL, Amsterdam NL , (20130718), vol. 154, no. 2, doi:10.1016/j.cell.2013.06.044, ISSN 0092-8674, pages 442 - 451, XP055115843
OPPOSITION- CHENG ALBERT W, ET AL, "Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system", Cell Research, Springer Singapore, Singapore, Singapore , (20131001), vol. 23, no. 10, doi:10.1038/CR.2013.122, ISSN 1001-0602, pages 1163 - 1171, XP002735688
OPPOSITION- Alexis C. Komor, Yongjoo B. Kim, Michael S. Packer, John A. Zuris, David R. Liu, "Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage", Nature, (20160501), vol. 533, no. 7603, doi:10.1038/nature17946, pages 420 - 424, XP055343871
OPPOSITION- Prashant Mali, John Aach, P Benjamin Stranges, Kevin M Esvelt, Mark Moosburner, Sriram Kosuri, Luhan Yang, George M Church, "CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering", Nature Biotechnology, Gale Group Inc., vol. 31, no. 9, doi:10.1038/nbt.2675, ISSN 10870156, pages 833 - 838, XP055149275
OPPOSITION- Jeffry D Sander, J Keith Joung, "CRISPR-Cas systems for editing, regulating and targeting genomes", Nature Biotechnology, Gale Group Inc., vol. 32, no. 4, doi:10.1038/nbt.2842, ISSN 10870156, pages 347 - 355, XP055172520
OPPOSITION- RAMIRO A R,ET AL, "Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand.", Nature Immulogy, Nature Publishing Group US, New York, New York , (20030501), vol. 4, no. 5, doi:10.1038/ni920, ISSN 1529-2908, pages 452 - 456, XP002302401
OPPOSITION- Prashant Mali, Kevin M Esvelt & George M Church, "Cas9 as a versatile tool for engineering biology.", NATURE METHODS, Nature Publishing Group, GB, GB , (20131001), vol. 10, no. 10, doi:10.1038/nmeth.2649, ISSN 1548-7105, pages 957 - 963, XP002718606
OPPOSITION- F Ann Ran, Patrick D Hsu, Jason Wright, Vineeta Agarwala, David A Scott & Feng Zhang, "Genome engineering using the CRISPR-Cas9 system", Nature Protocols, Nature Publishing Group, GB, GB , (20131101), vol. 8, no. 11, doi:10.1038/nprot.2013.143, ISSN 1754-2189, pages 2281 - 2308, XP002744123
OPPOSITION- H. M. Shen, U. Storb, "Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled", Proceedings of the National Academy of Sciences (PNAS), National Academy of Sciences, (20040831), vol. 101, no. 35, doi:10.1073/pnas.0404974101, ISSN 0027-8424, pages 12997 - 13002, XP055491883
OPPOSITION- Chen Zhao-Xia, Riggs Arthur D., "DNA Methylation and Demethylation in Mammals", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20110501), vol. 286, no. 21, doi:10.1074/jbc.R110.205286, ISSN 0021-9258, pages 18347 - 18353, XP093241983
OPPOSITION- D. Bikard, W. Jiang, P. Samai, A. Hochschild, F. Zhang, L. A. Marraffini, "Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system", Nucleic Acids Research, Information Retrieval Ltd., (20130801), vol. 41, no. 15, doi:10.1093/nar/gkt520, ISSN 03051048, pages 7429 - 7437, XP055195374
OPPOSITION- M. Jinek, K. Chylinski, I. Fonfara, M. Hauer, J. A. Doudna, E. Charpentier, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", Science, American Association for the Advancement of Science, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 00368075, pages 816 - 821, XP055067740
OPPOSITION- T. Xu, Y. Li, J. D. Van Nostrand, Z. He, J. Zhou, "Cas9-Based Tools for Targeted Genome Editing and Transcriptional Control", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, American Society for Microbiology, US, US , (20140301), vol. 80, no. 5, doi:10.1128/AEM.03786-13, ISSN 0099-2240, pages 1544 - 1552, XP055290296
OPPOSITION- Jacob Heintze, Luft Christin, Ketteler Robin, "A CRISPR CASe for high-throughput silencing", Frontiers in Genetics, vol. 4, doi:10.3389/fgene.2013.00193, XP055167478
OPPOSITION- Krzysztof Chylinski, Anaïs Le Rhun, Emmanuelle Charpentier, "The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems", RNA Biology, Landes Bioscience, (20130501), vol. 10, no. 5, doi:10.4161/rna.24321, ISSN 15476286, pages 726 - 737, XP055116068
SEARCH- MITCHELL R. O'CONNELL ET AL, "Programmable RNA recognition and cleavage by CRISPR/Cas9", NATURE, (20140928), vol. 516, no. 7530, doi:10.1038/nature13769, ISSN 0028-0836, pages 263 - 266, XP055168138 [PI] 1-17 * the whole document * * in particular Fig. 8d *
SEARCH- PRASHANT MALI ET AL, "Cas9 as a versatile tool for engineering biology", NATURE METHODS, NATURE PUBLISHING GROUP, GB, vol. 10, no. 10, doi:10.1038/NMETH.2649, ISSN 1548-7105, (20131001), pages 957 - 963, (20130927), XP002718606 [A] 1-17 * the whole document * * page 958, col. 1, last full paragraph; Fig. 2(b); page 960, col. 1 paragraphs 2 and 4- col. 2, paragraphs 1 and 3;page 962, col. 1 paragraph 2; *
SEARCH- M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055549487 [A] 1-17 * the whole document * * page 817, column 1, paragraph L; figures 2, 4 *

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