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Small Liposomes For Delivery Of Immunogen-Encoding Rna - EP4008357

The patent EP4008357 was granted to Glaxosmithkline on Dec 28, 2022. The application was originally filed on Aug 31, 2011 under application number EP21208092A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP4008357

GLAXOSMITHKLINE
Application Number
EP21208092A
Filing Date
Aug 31, 2011
Status
Granted And Under Opposition
Nov 25, 2022
Grant Date
Dec 28, 2022
External Links
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Patent Summary

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Patent Family

Patent Oppositions (4)

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HOPFNERSep 28, 2023-ADMISSIBLE
JG OPPOSITIONSSep 28, 2023MEWBURN ELLISADMISSIBLE
WEICKMANN & WEICKMANNSep 27, 2023-ADMISSIBLE
SANOFISep 22, 2023ELKINGTON AND FIFEADMISSIBLE

Patent Citations (25) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONWO2011057020
OPPOSITIONEP4008357
OPPOSITIONEP4066856
OPPOSITIONWO02095023
OPPOSITIONWO2005120152
OPPOSITIONWO2005121348
OPPOSITIONWO2006078294
OPPOSITIONWO2007047749
OPPOSITIONWO2011005799
OPPOSITIONWO2011068810
OPPOSITIONWO2012006369
OPPOSITIONWO2012006376
OPPOSITIONWO2012006377
OPPOSITIONWO2012006378
OPPOSITIONWO2012030901
OPPOSITIONWO2014160243
OPPOSITIONWO2017075531
OPPOSITIONWO2022137133
OPPOSITIONWO9011092
SEARCHEP0786522
SEARCHEP1637144
SEARCHJP2007112768
SEARCHUS5750390
SEARCHUS5972704
SEARCHWO9952503

Non-Patent Literature (NPL) Citations (60) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BOXUS et al., J Virol, (20070000), vol. 81, pages 6879 - 89-
DESCRIPTION- EL OUAHABI et al., FEBSLetts, (19960000), vol. 380, pages 108 - 12-
DESCRIPTION- "Functional Polymer Colloids and Microparticles", Microspheres, microcapsules & liposomes, Citus Books, (20020000), vol. 4-
DESCRIPTION- GIULIANI et al., Proc Natl Acad Sci USA, (20060000), vol. I, II & III, no. 29, pages 10834 - 9-
DESCRIPTION- Handbook of Experimental Immunology, Blackwell Scientific Publications, (19860000), vol. I-IV-
DESCRIPTION- HEYES et al., J Controlled Release, (20050000), vol. 107, pages 276 - 87-
DESCRIPTION- JEFFS et al., Pharmaceutical Research, (20050000), vol. 22, no. 3, pages 362 - 372-
DESCRIPTION- JOHANNING et al., Nucleic Acids Res, (19950000), vol. 23, pages 1495 - 1501-
DESCRIPTION- MAURER et al., Biophysical Journal, (20010000), vol. 80, pages 2310 - 2326-
DESCRIPTION- PERRI et al., J Virol, (20030000), vol. 77, pages 10394 - 10403-
DESCRIPTION- TAYLOR et al., Vaccine, (20050000), vol. 23, pages 1242 - 50-
DESCRIPTION- YONEYAMAFUJITA, Cytokine & Growth Factor Reviews, (20070000), vol. 18, pages 545 - 51-
OPPOSITION- D96 - first instance opposition decision concerning EP4066856-
OPPOSITION- EMA, "Spikevax (COVID-19 mRNA Vaccine (nucleoside modified)) - An overview of Spikevax, including its adapted vaccine, and why it is authorised in the EU", EMEA Leaflet, (202210), pages 1 - 5, XP093087018-
OPPOSITION- Heyes, J. ; Palmer, L. ; Bremner, K. ; MacLachlan, I., "Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids", Journal of Controlled Release, AMSTERDAM, NL , (20051003), vol. 107, no. 2, ISSN 0168-3659, pages 276 - 287, XP027664137-
OPPOSITION- Immordino Maria Laura, Dosio Franco, Cattel Luigi, "Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential", INTERNATIONAL JOURNAL OF NANOMEDICINE, DOVE MEDICAL PRESS LTD., AUCKLAND, NZ, AUCKLAND, NZ , (20060101), vol. 1, no. 3, ISSN 1176-9114, pages 297 - 315, XP093119081-
OPPOSITION- Jiang Shibo, Yuxian He And Shuwen Liu, "SARS Vaccine Development", Emerging Infectious Diseases, (20050701), vol. 11, no. 7, pages 1016 - 1020, XP093119073-
OPPOSITION- Lowe, Derek, "CureVac Comes Around", Science, (20230126), pages 1 - 3, URL: HTTPS://WWW.SCIENCE.ORG/CONTENT/BLOG-POST/CUREVAC-COMES-AROUND, XP093045422-
OPPOSITION- MacLachlan, Ian, "Chapter 9: Liposomal Formulations for Nucleic Acid Delivery", MacLachlan, Ian, CROOKE STANLEY T, ANTISENSE DRUG TECHNOLOGY: PRINCIPLES, STRATEGIES, AND APPLICATIONS, 2ND ED., US , CRC PRESS , (20070725), pages 237 - 270, ISBN 978-0-8493-8796-8, XP055915899-
OPPOSITION- MacLachlan, "Liposomal Formulations for Nucleic Acid Delivery", MacLachlan, Stanley T. Crooke et al., Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition, (20070725), vol. 11, pages 237 - 270, XP055534618-
OPPOSITION- Morrison Trudy G., "Paramyxoviruses, infection and immunity", Morrison Trudy G., DELVES P . J. , ROITT I. M. (EDITORS), Encyclopedia of immunology, San Diego [u.a.] , Acad. Press , (19980101), pages 1909 - 1916, ISBN 978-0-12-226765-9, XP093119058-
OPPOSITION- White David O., Fenner Frank J., Medical Virology, 4th ed., Academic Press, (19940101), pages 3 - 29, 434 - 435, 450 - 459, 538 - 541, XP093119065-
OPPOSITION- Shayne Cox, Steve Pascolo, "Chapter 7.2. Plasmid DNA and Messenger RNA for Therapy", Handbook of Pharmaceutical Biotechnology, John Wiley & Sons , (20070601), pages 971 - 1011, doi:10.1002/9780470117118.ch07b, ISBN 978-0-471-21386-4, XP055626043
OPPOSITION- MARTINON F, ET AL., "INDUCTION OF VIRUS-SPECIFIC CYTOTOXIC T LYMPHOCYTES IN VIVO BY LIPOSOME-ENTRAPPED MRNA", European Journal of Immunology, Wiley-VCH, Hoboken, USA, Hoboken, USA, (19930101), vol. 23, doi:10.1002/eji.1830230749, ISSN 0014-2980, pages 1719 - 1722, XP002937540
OPPOSITION- Lloyd B. Jeffs et al., "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmind DNA", Pharm Res. , (2005), vol. 22, doi:10.1007/s11095-004-1873-z, page 3, XP019370801
OPPOSITION- Lloyd B. Jeffs ; Lorne R. Palmer ; Ellen G. Ambegia ; Cory Giesbrecht ; Shannon Ewanick ; Ian MacLachlan, "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA", Pharmaceutical Research, Kluwer Academic Publishers-Plenum Publishers, NL, NL , (20050301), vol. 22, no. 3, doi:10.1007/s11095-004-1873-z, ISSN 1573-904X, pages 362 - 372, XP019370801
OPPOSITION- Lloyd B. Jeffs ; Lorne R. Palmer ; Ellen G. Ambegia ; Cory Giesbrecht ; Shannon Ewanick ; Ian MacLachlan, "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA", Pharmaceutical Research, NL , (20050301), vol. 22, no. 3, doi:10.1007/s11095-004-1873-z, ISSN 1573-904X, pages 362 - 372, XP019370801
OPPOSITION- ZHOU X., ET AL., "SELF-REPLICATING SEMLIKI FOREST VIRUS RNA AS RECOMBINANT VACCINE.", Vaccine, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (19940101), vol. 12., no. 16., doi:10.1016/0264-410X(94)90074-4, ISSN 0264-410X, pages 1510 - 1514., XP002021790
OPPOSITION- Minnaert An-Katrien; Vanluchene Helena; Verbeke Rein; Lentacker Ine; De Smedt Stefaan C.; Raemdonck Koen; Sanders Niek N.; Remaut Katrien, "Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across", Advanced Drug Delivery Reviews, Elsevier, Amsterdam , NL, Amsterdam , NL , (20210726), vol. 176, doi:10.1016/j.addr.2021.113900, ISSN 0169-409X, XP086773295
OPPOSITION- Kim, H.K. ; Davaa, E. ; Myung, C.S. ; Park, J.S., "Enhanced siRNA delivery using cationic liposomes with new polyarginine-conjugated PEG-lipid", International Journal of Pharmaceutics, NL , (20100615), vol. 392, no. 1-2, doi:10.1016/j.ijpharm.2010.03.047, ISSN 0378-5173, pages 141 - 147, XP027044515
OPPOSITION- Schoenmaker Linde, Witzigmann Dominik, Kulkarni Jayesh A., Verbeke Rein, Kersten Gideon, Jiskoot Wim, Crommelin Daan J.A., "mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability", International Journal of Pharmaceutics, ELSEVIER, NL, NL , (20210501), vol. 601, doi:10.1016/j.ijpharm.2021.120586, ISSN 0378-5173, page 120586, XP055828800
OPPOSITION- James Heyes et al, "Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids", Journal of Controlled Release, Elsevier, AMSTERDAM, NL, AMSTERDAM, NL , (20050101), vol. 107, no. 2, doi:10.1016/j.jconrel.2005.06.014, ISSN 0168-3659, pages 276 - 287, XP008157522
OPPOSITION- James Heyes , Lorne Palmer, Kaz Bremner, Ian MacLachlan, "Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids", Journal of Controlled Release, AMSTERDAM, NL , (20050101), vol. 107, no. 2, doi:10.1016/j.jconrel.2005.06.014, ISSN 0168-3659, pages 276 - 287, XP008157522
OPPOSITION- Hassett et al., "Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines", Mol Ther Nucleic Acids. , (2019), vol. 15, doi:10.1016/j.omtn.2019.01.013, XP055815007
OPPOSITION- Roux, K.H. Taylor, K.A., "AIDS virus envelope spike structure", Current Opinion in Structural Biology, GB , (20070417), vol. 17, no. 2, doi:10.1016/j.sbi.2007.03.008, ISSN 0959-440X, pages 244 - 252, XP022032067
OPPOSITION- Geall Andrew J.; Mandl Christian W.; Ulmer Jeffrey B., "RNA: The new revolution in nucleic acid vaccines", Seminars in immunology, W.B. SAUNDERS COMPANY, PA., US, US , (19000101), vol. 25, no. 2, doi:10.1016/j.smim.2013.05.001, ISSN 1044-5323, pages 152 - 159, XP028694558
OPPOSITION- Jeffrey B. Ulmer; Peter W. Mason; Andrew Geall; Christian W. Mandl;, "RNA-based vaccines", Vaccine, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20120418), vol. 30, no. 30, doi:10.1016/j.vaccine.2012.04.060, ISSN 0264-410X, pages 4414 - 4418, XP028520925
OPPOSITION- Callendret, B. Lorin, V. Charneau, P. Marianneau, P. Contamin, H. Betton, J.M. van der Werf, S. Escriou, N., "Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS", Virology, AMSTERDAM, NL , (20070522), vol. 363, no. 2, doi:10.1016/j.virol.2007.01.012, ISSN 0042-6822, pages 288 - 302, XP022083920
OPPOSITION- Norbert Maurer, Kim F. Wong, Holger Stark, Lenore Louie, Deirdre Mcintosh, Tabitha Wong, Peter Scherrer, Sean C. Semple, Pieter R. Cullis, "Spontaneous Entrapment of Polynucleotides upon Electrostatic Interaction with Ethanol-Destabilized Cationic Liposomes", Biophysical Journal, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20010501), vol. 80, no. 5, doi:10.1016/S0006-3495(01)76202-9, ISSN 0006-3495, pages 2310 - 2326, XP055550920
OPPOSITION- Dolgin Elie, "TRIAL SETTLES DEBATE OVER BEST DESIGN FOR MRNA IN COVID VACCINES", Nature, (20230119), vol. 613, no. 7944, doi:10.1038/d41586-023-00042-z, pages 419 - 420, XP093119100
OPPOSITION- Jiang Shibo, Lu Lu, Liu Qi, Xu Wei, Du Lanying, "Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines", Emerging Microbes & Infections, (20120801), vol. 1, no. 1, doi:10.1038/emi.2012.1, ISSN 2222-1751, pages 1 - 8, XP093130818
OPPOSITION- KARIKÓ KATALIN ET AL, "Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability.", Molecular Therapy, Nature Publishing Group, GB, GB , (20081101), vol. 16, no. 11, doi:10.1038/mt.2008.200, ISSN 1525-0024, pages 1833 - 1840, XP002598556
OPPOSITION- ZIMMERMANN TRACY S ET AL, "RNAi-mediated gene silencing in non-human primates.", Nature, (20060504), vol. 441, no. 7089, doi:10.1038/NATURE04688, pages 111 - 114, XP002577898
OPPOSITION- David V Morrissey, Jennifer A Lockridge, Lucinda Shaw, Karin Blanchard, Kristi Jensen, Wendy Breen, Kimberly Hartsough, Lynn Machemer, Susan Radka, Vasant Jadhav, Narendra Vaish, Shawn Zinnen, Chandra Vargeese, Keith Bowman, Chris S Shaffer, Lloyd B Jeffs, Adam Judge, Ian MacLachlan & Barry Polisky, "Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20050801), vol. 23, no. 8, doi:10.1038/nbt1122, ISSN 1087-0156, pages 1002 - 1007, XP008157520
OPPOSITION- Benjamin Petsch, Margit Schnee, Annette B Vogel, Elke Lange, Bernd Hoffmann, Daniel Voss, Thomas Schlake, Andreas Thess, Karl-Josef Kallen, Lothar Stitz, Thomas Kramps, "Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection", Nature Biotechnology, Gale Group Inc., (20120101), vol. 30, no. 12, doi:10.1038/nbt.2436, ISSN 10870156, pages 1210 - 1216, XP055051005
OPPOSITION- Ugur Sahin, Katalin Karikó, Özlem Türeci, "mRNA-based therapeutics — developing a new class of drugs", Nature Reviews Drug Discovery, Nature Publishing Group, GB, GB , (20141001), vol. 13, no. 10, doi:10.1038/nrd4278, ISSN 1474-1776, pages 759 - 780, XP055544673
OPPOSITION- Lanying Du, Yuxian He, Yusen Zhou, Shuwen Liu, Bo-Jian Zheng, Shibo Jiang, "The spike protein of SARS-CoV — a target for vaccine and therapeutic development", Nature Reviews Microbiology, NATURE PUBLISHING GROUP, GB, GB , (20090301), vol. 7, no. 3, doi:10.1038/nrmicro2090, ISSN 1740-1526, pages 226 - 236, XP055302112
OPPOSITION- Akinc Akin; Maier Martin A.; Manoharan Muthiah; Fitzgerald Kevin; Jayaraman Muthusamy; Barros Scott; Ansell Steven; Du Xinyao; Hope Michael J.; Madden Thomas D.; Mui Barbara L.; Semple Sean C.; Tam Ying K.; Ciufolini Marco; Witzigmann Dominik; Kulkarni Jayesh A.; van der Meel Roy; Cullis Pieter R., "The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs", Nature Nanotechnology, Nature Pub. Group, Inc., London, London , (20191201), vol. 14, no. 12, doi:10.1038/s41565-019-0591-y, ISSN 1748-3387, pages 1084 - 1087, XP036953174
OPPOSITION- Norbert Pardi, Et Al., "Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses", Journal of Experimental Medicine, Rockefeller University Press, US, US , (20180604), vol. 215, no. 6, doi:10.1084/jem.20171450, ISSN 0022-1007, pages 1571 - 1588, XP055545604
OPPOSITION- Fleeton, Et Al., "Self-replicative vaccines elicit protection against influenza A virus, respiratory syncytial virus and tickborne encephalitis", J. Infectious Diseases, (20010101), vol. 183, doi:10.1086/319857, pages 1395 - 1398, XP055702690
OPPOSITION- FLEETON M N,ET AL, "Self-replicative RNA vaccines elicit protection against influenza A virus, respiratory syncytial virus, and a tickborne encephalitis virus.", Journal of Infectious Diseases, University of Chicago Press, US, US , (20010501), vol. 183, no. 9, doi:10.1086/319857, ISSN 0022-1899, pages 1395 - 1398, XP002224503
OPPOSITION- W-Z Zhou, D S B Hoon, S K S Huang, et al, "RNA melanoma vaccine: induction of antitumor immunity by human glycoprotein 100 mRNA immunization.", HUMAN GENE THERAPY, Mary Ann Liebert, Inc. Publishers, GB, GB , (19991101), vol. 10, no. 16, ISSN 1043-0342, pages 2719 - 2724, XP002660042
OPPOSITION- SZOKA F, PAPAHADJOPOULOS D, "COMPARATIVE PROPERTIES AND METHODS OF PREPARATION OF LIPID VESICLES (LIPOSOMES)", ANNUAL REVIEW OF BIOPHYSICS AND BIOENGINEERING., ANNUAL REVIEWS INC., PALO ALTO, CA., US, US , (19800101), vol. 09, doi:10.1146/annurev.bb.09.060180.002343, ISSN 0883-9182, pages 467 - 506, XP008006676
OPPOSITION- Ian MacLachlan, "CHAPTER 9. Liposomal Formulations for Nucleic Acid Delivery", Ian MacLachlan, Stanley T Crooke, Antisense Drug Technology, Second Edition, CRC Press, (20070101), pages 237 - 270, XP093133162
OPPOSITION- Pascolo Steve, "Vaccination with messenger RNA", Pascolo Steve, W M Saltzman , H Shen , J L Brandsma, DNA Vaccines: Methods and protocols : second edition, Humana Press Inc, (20060801), vol. 127, pages 23 - 40, ISSN 1543-1894, XP009117840
OPPOSITION- Pascolo S, "Messenger RNA-based vaccines", EXPERT OPINION ON BIOLOGICAL THERAPY, Informa Healthcare, (20040801), vol. 4, no. 8, doi:10.1517/14712598.4.8.1285, ISSN 1471-2598, pages 1285 - 1294, XP009095328
OPPOSITION- Deering Raquel P; Kommareddy Sushma; Ulmer Jeffrey B, "Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines.", Expert opinion on drug delivery, Informa Healthcare, UK, UK , (20140601), vol. 11, no. 6, doi:10.1517/17425247.2014.901308, ISSN 1744-7593, pages 885 - 899, XP009183535
OPPOSITION- Morais Pedro, Adachi Hironori, Yu Yi-Tao, "The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines", Frontiers in Cell and Developmental Biology, (2021), vol. 9, doi:10.3389/fcell.2021.789427, XP055885272
OPPOSITION- Karl-Josef Kallen, Regina Heidenreich, Margit Schnee, Benjamin Petsch, Thomas Schlake, Andreas Thess, Patrick Baumhof, Birgit Scheel, Sven D Koch, Mariola Fotin-Mleczek, "A novel, disruptive vaccination technology: Self-adjuvanted RNActive® vaccines", Human vaccines & immunotherapeutics, (20131001), vol. 9, no. 10, doi:10.4161/hv.25181, ISSN 21645515, pages 2263 - 2276, XP055126357
OPPOSITION- Thomas Schlake, Andreas Thess, Mariola Fotin-Mleczek, Karl-Josef Kallen, "Developing mRNA-vaccine technologies", RNA Biology, Landes Bioscience, (20121101), vol. 9, no. 11, doi:10.4161/rna.22269, ISSN 15476286, XP055126360

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