| DESCRIPTION | - AL-LAZIKANI et al., J. Mol. Biol., (19970000), vol. 273, pages 927 - 948 |
| DESCRIPTION | - ALWING et al., Eur. Respir. J., (19930000), vol. 6, pages 1368 - 1370 |
| DESCRIPTION | - ANGAL et al., Molecular Immunology, (19930000), vol. 30, page 105 |
| DESCRIPTION | - BJERKE et al., Respir. Med., (19960000), vol. 90, no. 5, pages 271 - 277 |
| DESCRIPTION | - DJUKANOVIC et al., Eur. Respire. J., (20020000), vol. 37, pages 1S - 2S |
| DESCRIPTION | - GOODSON, Medical Applications of Controlled Release, (19840000), vol. 2, pages 115 - 138 |
| DESCRIPTION | - HOPKINS et al., Clin. Otolaryngol., (20090000), vol. 34, pages 447 - 454 |
| DESCRIPTION | - JIA et al., J Allergy Clin Immunol., (20120801), vol. 130, pages 647 - 654 |
| DESCRIPTION | - LANGER, Science, (19900000), vol. 249, pages 1527 - 1533 |
| DESCRIPTION | - LILLY et al., J. Allergy Clin. Immunol., (19990000), vol. 104, pages 786 - 790 |
| DESCRIPTION | - MARECHAL et al., Anticancer Res, (19880000), vol. 8, pages 677 - 680 |
| DESCRIPTION | - MARTIN et al., Proc. Natl. Acad. Sci. USA, (19890000), vol. 86, pages 9268 - 9272 |
| DESCRIPTION | - MOCHIZUKI et al., J. Immunol., (19980000), vol. 160, no. 1, pages 60 - 68 |
| DESCRIPTION | - MORDENTI et al., Pharmaceut. Res., (19910000), vol. 8, page 1351 |
| DESCRIPTION | - POWELL et al., "Compendium of excipients for parenteral formulations", J Pharm Sci Technol, (19980000), vol. 52, pages 238 - 311, XP009119027 |
| DESCRIPTION | - SEFTON, CRC Crit. Ref. Biomed. Eng., (19870000), vol. 14, page 201 |
| DESCRIPTION | - TANG et al., Eur. Respir. J., (20100000), vol. 35, pages 757 - 760 |
| DESCRIPTION | - TAYLOR et al., Nucl. Acids Res., (19920000), vol. 20, pages 6287 - 6295 |
| DESCRIPTION | - VAN DE POL et al., Allergy, (20120000), vol. 67, no. 1, pages 67 - 73 |
| DESCRIPTION | - WU et al., J. Biol. Chem., (19870000), vol. 262, pages 4429 - 4432 |
| EXAMINATION | - WENZEL SALLY ET AL, "Dupilumab in Persistent Asthma with Elevated Eosinophil Levels", THE NEW ENGLAND JOURNAL OF MEDICINE, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 368, no. 26, doi:10.1056/NEJMOA1304048, ISSN 0028-4793, (20130627), pages 2455 - 2466, (20130521), XP008165248 |
| OPPOSITION | - Aerovance Inc, "Phase 2b Clinical Trial Results Show Aerovance's Aerovant™ is Effective in Patients with Eosinophilic Asthma", PR Newswire, (20100608), PR Newswire, URL: https://www.prnewswire.com/news-releases/phase-2b-clinical-trial-results-show-aerovances-aerovant-is-effective-in-patients-with-eosinophilic-asthma-95847899.html, XP093196050 |
| OPPOSITION | - Anonymous, "Efficacy, Safety, and Tolerability of Dupilumab in Patients With Persistent Moderate to Severe Eosinophilic Asthma", ClinicalTrials.gov; NCT01312961, (20120725), ClinicalTrials.gov; NCT01312961, URL: https://clinicaltrials.gov/study/NCT01312961?tab=history&a=30#version-content-panel, XP093195574 |
| OPPOSITION | - Anonymous, "Efficacy, Safety, and Tolerability of SAR231893 (REGN668) in Patients With Persistent Moderate to Severe Eosinophilic Asthma", History of Changes for Study: NCT01312961, (20120820), History of Changes for Study: NCT01312961, URL: https://clinicaltrials.gov/ct2/history/NCT01312961?A=31&B=31&C=merged#, XP093198015 |
| OPPOSITION | - Anonymous, "GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION ", Global Initiative for Asthma, (20120101), Global Initiative for Asthma, XP093196049 |
| OPPOSITION | - Anonymous, "GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION", GLOBAL STRATEGY FOR ASTHMA - GINA reports, (20090101), GLOBAL STRATEGY FOR ASTHMA - GINA reports, URL: https://ginasthma.org/wp-content/uploads/2019/01/2009-GINA.pdf, XP093197881 |
| OPPOSITION | - Anonymous, "GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION ", GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION, (20110101), GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION , (20220720), XP055944374 |
| OPPOSITION | - Anonymous, "Regeneron Reports Fourth Quarter and Full Year 2011 Financial and Operating Results", Regeneron Pharmaceuticals, Inc. - Press release, (20120213), pages 1 - 7, Regeneron Pharmaceuticals, Inc. - Press release , URL: https://investor.regeneron.com/news-releases/news-release-details/regeneron-reports-fourth-quarter-and-full-year-2011-financial/#:~:text=(NASDAQ%3A%20REGN)%20today%20announced,year%20ended%20December%2031%2C%202011%20., XP093196054 |
| OPPOSITION | - Bousquet Jean, Chanez Pascal, Lacoste Jean Yves, Barneon Gilbert, Ghavanian Nouchine Et Al., "Eosinophilic inflammation in asthma", The New England Journal of Medicine, (19901011), vol. 323, no. 15, pages 1033 - 1039, XP093198751 |
| OPPOSITION | - Firszt, R. ; Kraft, M., "Pharmacotherapy of severe asthma", CURRENT OPINION IN PHARMACOLOGY, ELSEVIER SCIENCE PUBLISHERS,, NL, NL , (20100601), vol. 10, no. 3, ISSN 1471-4892, pages 266 - 271, XP027137700 |
| OPPOSITION | - Gore Robin B, "The utility of antifungal agents for asthma", Current Opinion in Pulmonary Medicine, (20100101), vol. 16, no. 136, page 41, XP093198007 |
| OPPOSITION | - Greulich Timm, Haldar Pranab, Agbetile Josua, Bafadhel Mona, Brightling Christopher E, Wardlaw Andrew J, Pavord Ian D, "E5492: FENO and blood eosinophil count as surrogate barkers of eosinophilic airway inflammation in patients with severe asthma", Eur Respir J, (20100922), vol. 36, no. suppl. 54, page 1005s, XP093198745 |
| OPPOSITION | - Kelly K D, Spooner C H, Rowe B H, "Nedocromil sodium versus sodium cromoglycate in treatment of exercise-induced bronchoconstriction: a systematic review", EUROPEAN RESPIRATORY JOURNAL, European Respiratory Society, GB, GB , (20010101), vol. 17 , no. 12, ISSN 0903-1936, pages 39 - 45, XP093198006 |
| OPPOSITION | - LOMMATZSCH MAREK ET AL, "Severe asthma: definition, diagnosis and treatment.", DEUTSCHES ARZTEBLATT INTERNATIONAL FEB 2013, (20141212), vol. 111, no. 50, ISSN 1866-0452, pages 847 - 855, XP002789189 |
| OPPOSITION | - Morgan J P, "Regeneron science to medicine™", Regeneron Healthcare Conference January 2013, (20130108), pages 1 - 21, Regeneron Healthcare Conference January 2013, URL: https://www.sec.gov/Archives/edgar/data/872589/000119312513006146/d463788dex991.htm, XP093198022 |
| OPPOSITION | - Munakata Mitsuru, "Review Series: Non-Invasive Monitoring of Airway Inflammation in Asthma", Allergology International, (20120101), vol. 61, no. 3, pages 365 - 372, XP093197880 |
| OPPOSITION | - National Library Of Medicine, "Efficacy, Safety, and Tolerability of Dupilumab in Patients With Persistent Moderate to Severe Eosinophilic Asthma", Clinicaltrials gov NCT01312961, (20170608), Clinicaltrials gov NCT01312961 , URL: https://clinicaltrials.gov/study/NCT01312961?tab=history, XP093197882 |
| OPPOSITION | - Pollart Susan M, Elward Kurtis S, "Overview of Changes to Asthma Guidelines: Diagnosis and Screening", American Family Physician, (20090501), vol. 79, no. 9, pages 761 - 767, XP093197889 |
| OPPOSITION | - Pollart Susan M., Kurtis S. Edward, "Overview of Changes to Asthma Guidelines: Diagnosis and Screening ", American Family Physician, (20090501), vol. 79, no. 9, pages 761 - 767, XP055944965 |
| OPPOSITION | - Proudfoot Stuart, Collet John, "Chapter 19 Dosage regimens", Aulton’s Pharmaceutics: The Science of Dosage Form Design. 2nd Ed., Churchill Livingstone , (20010101), pages 275 - 288, XP093198012 |
| OPPOSITION | - Sally Wenzel, P. W. Ind, B. A. Otulana, E. R. Bleecker, P. Kuna, Y. P. Yen, "ERS - Programme", European Respiratory Society, Annual Congress 2010, (20100921), page P3980, European Respiratory Society, Annual Congress 2010, URL: https://www.ersnetsecure.org/public/prg_congres.abstract?ww_i_presentation=48969, (20131121), XP055089619 |
| OPPOSITION | - Sanofi, "Efficacy, Safety, and Tolerability of Dupilumab in Patients With Persistent Moderate to Severe Eosinophilic Asthma", clinicaltrials.gov NCT01312961, (20170608), XP093198755 |
| OPPOSITION | - Ten Brinke Anneke, Aeilko H. Zwinderman, Peter J. Sterk, Klaus F. Rabe, And Elisabeth H. Bel, "Factors Associated with Persistent Airflow Limitation in Severe Asthma", Am J Respir Crit Care Med., (20010101), vol. 164, no. 5, pages 744 - 748, XP093198730 |
| OPPOSITION | - Wenzel et al, "Inhaled pitrakinra, an IL-4/IL-13 antagonist, reduced exacerbations in patients with eosinophilic asthma ", Eur Respir J., (2010), vol. 36, XP093196051 |
| OPPOSITION | - Wenzel Sally E., Philip W. Ind, Babatunde A. Otulana, Eugene R. Bleecker, Piotr Kuna, Yu Ping Yen, "Late Breaking Abstract: Inhaled pitrakinra, an IL-4/IL-13 antagonist, reduced exacerbations in patients with eosinophilic asthma", European Respiratory Journal, (20100921), vol. 36, pages 714S - 718S, XP093196051 |
| OPPOSITION | - WHO Drug Information, "Proposed INN: List 108", WHO Drug Information, (20121209), vol. 26, page 4, XP093196048 |
| OPPOSITION | - Who, " International Nonproprietary Names for Proposed Pharmaceutical Substances (INN).Proposed: List 108", WHO Drug Information, (20120101), vol. 26, no. 4, pages 401 - 472, XP093196048 |
| OPPOSITION | - Kostic Ana, Wen Zhang, Anthony Dore, Blerta Coopey, Douglas Macdonald, Wen Fury, Calvin Lin, Jennifer Hamilton, Brendan Classon, Nicholas J. Papadopoulos, Andrew Murphy, "F.95. A Fully Human IL4Rα Antibody for Inhibition of IL-4/IL-13-driven Th2 Responses in Allergic Disease", Clinical Immunology, (20100101), vol. 135, doi:10.1016/j.clim.2010.03.317, pages S105 - S106, XP093195577 |
| OPPOSITION | - Abdelaty Nancy M., "Patient characteristics that can predict response to omalizumab an (Anti-IgE Antibody) for achieving better control of asthmatic patients", Egyptian Journal of Chest Diseases and Tuberculosis, Wolters Kluwer Medknow Publications, (20120701), vol. 61, no. 3, doi:10.1016/j.ejcdt.2012.10.015, ISSN 0422-7638, pages 15 - 22, XP093197898 |
| OPPOSITION | - Stewart Lora, Katial Rohit K, "Exhaled Nitric Oxide", Immunology and allergy clinics of North America, (20120705), vol. 32, doi:10.1016/j.iac.2012.06.005immunology.theclinics.com, pages 347 - 362, XP093196053 |
| OPPOSITION | - Costantino, H.R. Illum, L. Brandt, G. Johnson, P.H. Quay, S.C., "Intranasal delivery: Physicochemical and therapeutic aspects", International Journal of Pharmaceutics, ELSEVIER, NL, NL , (20070519), vol. 337, no. 1-2, doi:10.1016/j.ijpharm.2007.03.025, ISSN 0378-5173, pages 1 - 24, XP022085247 |
| OPPOSITION | - Szefler et al, "Asthma Outcomes: Biomarkers", J Allergy Clin Immunol., (20120301), vol. 129, doi:10.1016/j.jaci.2011.12.979, XP055944385 |
| OPPOSITION | - Szefler Stanley J., Wenzel Sally, Brown Robert, Erzurum Serpil C., Fahy John V., Hamilton Robert G., Hunt John F., Kita Hirohito, Liu Andrew H., Panettieri Reynold A., Schleimer Robert P., Minnicozzi Michael, "Asthma outcomes: Biomarkers", Journal of Allergy and Clinical Immunology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20120301), vol. 129, no. 3, doi:10.1016/j.jaci.2011.12.979, ISSN 0091-6749, pages S9 - S23, XP055944385 |
| OPPOSITION | - Cara J. Bossley; Louise Fleming; Atul Gupta; Nicolas Regamey; Jennifer Frith; Timothy Oates; Lemonia Tsartsali; Clare M. Lloyd; Andrew Bush; Sejal Saglani;, "Pediatric severe asthma is characterized by eosinophilia and remodeling without T2 cytokines", Journal of Allergy and Clinical Immunology, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20120123), vol. 129, no. 4, doi:10.1016/j.jaci.2012.01.059, ISSN 0091-6749, pages 974 - 982.e13, XP028478864 |
| OPPOSITION | - Jared Darveaux, William W. Busse, "Biologics in Asthma-8212;The Next Step Toward Personalized Treatment", The journal of allergy and clinical immunology : an official journal of AAAAI, American Academy of Allergy Asthma & Immunology, Elsevier BV, NL, NL , (20150301), vol. 3, no. 2, doi:10.1016/j.jaip.2014.09.014, ISSN 2213-2198, pages 152 - 160, XP055535036 |
| OPPOSITION | - Bartoli M.L, Bacci E, Carnevali S, Cianchetti S, Dente F.L, Di Franco A, Giannini D, Taccola M, Vagaggini B, Paggiaro P.L, "Clinical assessment of asthma severity partially corresponds to sputum eosinophilic airway inflammation", Respiratory Medicine, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20040201), vol. 98, no. 2, doi:10.1016/j.rmed.2003.09.012, ISSN 0954-6111, pages 184 - 193, XP093198749 |
| OPPOSITION | - Wenzel, S. Wilbraham, D. Fuller, R. Getz, E.B. Longphre, M., "Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies", The Lancet, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20071018), vol. 370, no. 9596, doi:10.1016/S0140-6736(07)61600-6, ISSN 0140-6736, pages 1422 - 1431, XP022303966 |
| OPPOSITION | - Pavord I D, Korn S, Howarth P, Bleecker E R, Buhl R, Keene O N, Ortega H, Chanez P., "Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial", The Lancet, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20120818), vol. 380, no. 9842, doi:10.1016/S0140-6736(12)60988-X, ISSN 0140-6736, pages 651 - 659, XP002714506 |
| OPPOSITION | - Hashimoto Simone, Bel Elisabeth H, "Targeting IL-5 in severe asthma: a DREAM come true?", The Lancet, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20120818), vol. 380, no. 9842, doi:10.1016/S0140-6736(12)61132-5, ISSN 0140-6736, pages 626 - 627, XP093197896 |
| OPPOSITION | - Wenzel Sally; Castro Mario; Corren Jonathan; Maspero Jorge; Wang Lin; Zhang Bingzhi; Pirozzi Gianluca; Sutherland E Rand; Evans Robert R; Joish Vijay N; Eckert Laurent; Graham Neil M H; Stahl Neil; Yancopoulos George D; Louis-Tisserand Mariana; Teper Ariel, "Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial", The Lancet, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20160427), vol. 388, no. 10039, doi:10.1016/S0140-6736(16)30307-5, pages 31 - 44, XP029627526 |
| OPPOSITION | - Eisenstein M, "Something new under the skin", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20110101), vol. 29, no. 2, doi:10.1038/nbt.1768, ISSN 1087-0156, pages 107 - 109, XP009152843 |
| OPPOSITION | - Wenzel Sally E, "Asthma phenotypes: the evolution from clinical to molecular approaches", Nature Medicine, Nature Publishing Group US, New York, New York, (20120501), vol. 18, no. 5, doi:10.1038/nm.2678, ISSN 1078-8956, pages 716 - 725, XP055944372 |
| OPPOSITION | - Wechsler Michael E, "Inhibiting interleukin-4 and interleukin-13 in difficult-to-control asthma.", New England Journal of Medicine, The - NEJM, Massachusetts Medical Society, US, US , (20130627), vol. 368, no. 26, doi:10.1056/NEJMe1305426, ISSN 1533-4406, pages 2511 - 2513, XP009180486 |
| OPPOSITION | - Pranabashis Haldar, M R C P, Christopher E Brightling, Ph D, F R C P, Beverley Hargadon, R G N, Sumit Gupta, M R C P, William Monteiro, M Sc, Ana Sousa, Ph D, Richard P Marshall, Ph D, M R C P, Peter Bradding, D M, F R C P, Ruth H Green, M D, F R C P, Andrew J Wardlaw, Ph D, F R C P, Ian D Pavord, D M, F R C P, P H, C E B, B H, S G, W M, P B, R H G, A J W, Stevenage A S, "Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma", The New England Journal of Medicine, Mass Med Soc, United States, United States , (20090305), doi:10.1056/NEJMoa0808991, pages 973 - 984, XP055151419 |
| OPPOSITION | - Wenzel Sally; Ford Linda; Pearlman David; Spector Sheldon; Sher Lawrence; Skobieranda Franck; Wang Lin; Kirkesseli Stephane; Rocklin Ross; Bock Brian; Hamilton Jennifer; Ming Jeffrey E; Radin Allen; Stahl Neil; Yancopoulos George D; Graham Neil; Pirozzi Gianluca, "Dupilumab in Persistent Asthma with Elevated Eosinophil Levels", The New England journal of medicine, Massachusetts Medical Society, US, US , (20130627), vol. 368, no. 26, doi:10.1056/NEJMoa1304048, ISSN 0028-4793, pages 2455 - 2466, XP008165248 |
| OPPOSITION | - Wenzel Sally, Ford Linda, Pearlman David, Spector Sheldon, Sher Lawrence, Skobieranda Franck, Wang Lin, Kirkesseli Stephane, Rocklin Ross, Bock Brian, Hamilton Jennifer, Ming Jeffrey E., Radin Allen, Stahl Neil, Yancopoulos George D., Graham Neil, Pirozzi Gianluca, "Protocol for: Dupilumab in persistent asthma with elevated eosinophil levels", The New England journal of medicine, Massachusetts Medical Society, US, US , (20130627), vol. 368, no. 26, doi:10.1056/NEJMoa1304048, ISSN 0028-4793, pages 1 - 288, XP093197891 |
| OPPOSITION | - Wenzel Sally, Ford Linda, Pearlman David, Spector Sheldon, Sher Lawrence, Skobieranda Franck, Wang Lin, Kirkesseli Stephane, Rocklin Ross, Bock Brian, Hamilton Jennifer, Ming Jeffrey E., Radin Allen, Stahl Neil, Yancopoulos George D., Graham Neil, Pirozzi Gianluca, "Supplement to: Wenzel S, Ford L, Pearlman D, et al. Dupilumab in persistent asthma with elevated eosinophil levels.", The New England journal of medicine, Massachusetts Medical Society, US, US , (20130627), vol. 368, no. 26, doi:10.1056/NEJMoa1304048, ISSN 0028-4793, pages 1 - 41, XP093197887 |
| OPPOSITION | - Lagakos Stephen W, "The Challenge of Subgroup Analyses — Reporting without Distorting", The New England journal of medicine, Massachusetts Medical Society, US, US , (20060401), vol. 354, no. 16, doi:10.1056/NEJMp068070, ISSN 0028-4793, pages 1667 - 1669, XP009559958 |
| OPPOSITION | - WANG RUI ET AL, "Statistics in medicine - Reporting of subgroup analyses in clinical trials", The New England journal of medicine, Massachusetts Medical Society, US, US , (20071122), vol. 357, no. 21, doi:10.1056/NEJMsr077003, ISSN 0028-4793, pages 2189 - 2194, XP002567458 |
| OPPOSITION | - John-Paul Silva, Olivia Vetterlein, Joby Jose, Shirley Peters, Hishani Kirby, "The S228P Mutation Prevents in Vivo and in Vitro IgG4 Fab-arm Exchange as Demonstrated using a Combination of Novel Quantitative Immunoassays and Physiological Matrix Preparation", Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, US, US , (20150227), vol. 290, no. 9, doi:10.1074/jbc.M114.600973, ISSN 0021-9258, pages 5462 - 5469, XP055299482 |
| OPPOSITION | - Al-Ramli Wisam, Al Samri Mohamed, Hamid Qutayba, "TH-17 Cell-Related Cytokines' Potential Role in the Pathogenesis of Severe Asthma", JOURNAL OF ASTHMA, ASTHMA PUBLICATIONS SOCIETY, OSSINING, NY., US, US , (20080101), vol. 45, no. sup1, doi:10.1080/02770900802594759, ISSN 0277-0903, pages 41 - 44, XP093198002 |
| OPPOSITION | - Christophe Dumet, Jérémy Pottier, Valérie Gouilleux-Gruart, Hervé Watier, "Insights into the IgG heavy chain engineering patent landscape as applied to IgG4 antibody development", mAbs, Landes Bioscience, US, US , (20191117), vol. 11, no. 8, doi:10.1080/19420862.2019.1664365, ISSN 1942-0862, pages 1341 - 1350, XP055732501 |
| OPPOSITION | - Handlogten et al, "Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region", MABS, (20200707), vol. 12, doi:10.1080/19420862.2020.1779974, page 1, XP055869374 |
| OPPOSITION | - S. Wenzel, "Severe asthma: from characteristics to phenotypes to endotypes", Clinical & Experimental Allergy, Wiley InterScience, UK, UK , (20120118), vol. 42, no. 5, doi:10.1111/j.1365-2222.2011.03929.x, ISSN 0954-7894, pages 650 - 658, XP071887598 |
| OPPOSITION | - S. Hashimoto; E. H. Bel, "Current treatment of severe asthma", Clinical & Experimental Allergy, Wiley InterScience, UK, UK , (20120118), vol. 42, no. 5, doi:10.1111/j.1365-2222.2011.03936.x, ISSN 0954-7894, pages 693 - 705, XP071887619 |
| OPPOSITION | - Fleming Louise, Wilson Nicola, Regamey Nicolas, Bush Andrew, "Use of sputum eosinophil counts to guide management in children with severe asthma", Thorax, BMJ Publishing Group, GB, GB , (20120301), vol. 67, no. 3, doi:10.1136/thx.2010.156836, ISSN 0040-6376, pages 193 - 198, XP093198750 |
| OPPOSITION | - Babatunde A. Otulana, MD 1 , Sally E. Wenzel, MD 2 , Phillip W. Ind, MD Alexandra Bowden, PhD 4 , Silvy Puthukkeril, MS 4 , Adrian Tomkinson, PhD, "A Phase 2b Study Of Inhaled Pitrakinra, An IL-4/IL-13 Antagonist, Successfully Identified Responder Subpopulations Of Patients With Uncontrolled Asthma", (20110501), XP009174512 |
| OPPOSITION | - Babatunde A. Otulana, MD 1 , Sally E. Wenzel, MD 2 , Phillip W. Ind, MD Alexandra Bowden, PhD 4 , Silvy Puthukkeril, MS 4 , Adrian Tomkinson, PhD, "A Phase 2b Study Of Inhaled Pitrakinra, An IL-4/IL-13 Antagonist, Successfully Identified Responder Subpopulations Of Patients With Uncontrolled Asthma", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, (20110518), XP009174512 |
| OPPOSITION | - Babatunde A. Otulana, MD 1 , Sally E. Wenzel, MD 2 , Phillip W. Ind, MD Alexandra Bowden, PhD 4 , Silvy Puthukkeril, MS 4 , Adrian Tomkinson, PhD, "A Phase 2b Study Of Inhaled Pitrakinra, An IL-4/IL-13 Antagonist, Successfully Identified Responder Subpopulations Of Patients With Uncontrolled Asthma", Am J Respir Crit Care Med, (2011058), XP009174512 |
| OPPOSITION | - Otulana et al, "A Phase 2b Study of Inhaled Pitrakinra, an IL-4 / IL-13 antagonist successfully identified responder subpopulations of patients with uncontrolled asthma", American Journal of Respiratory and Critical Care Medicine , (20110518), vol. 183, doi:10.1164/ajrccm-conference.2011.183.1_MeetingAbstracts.A6179, page A6179, XP002716819 |
| OPPOSITION | - Wenzel Sally, "Severe Asthma in Adults", American Thoracic Society 2020 International Conference; May 15-20, 2020, American Thoracic Society, (20050715), vol. 172, no. 2, doi:10.1164/rccm.200409-1181PP, ISSN 1073-449X, pages 149 - 160, XP055944998 |
| OPPOSITION | - Wenzel Sally, "Severe Asthma in Adults", AM J RESPIR CRIT CARE MED, (20050715), vol. 172, no. 2, doi:10.1164/rccm.200409-1181PP, ISSN 1073-449X, pages 149 - 160, XP055944998 |
| OPPOSITION | - P. G. Woodruff, B. Modrek, D. F. Choy, G. Jia, A. R. Abbas, A. Ellwanger, J. R. Arron, L. L. Koth, J. V. Fahy, "T-helper Type 2-driven Inflammation Defines Major Subphenotypes of Asthma", American Journal of Respiratory and Critical Care Medicine, (20090901), vol. 180, no. 5, doi:10.1164/rccm.200903-0392OC, ISSN 1073449X, pages 388 - 395, XP055049862 |
| OPPOSITION | - J. Corren, W. Busse, E. O. Meltzer, L. Mansfield, G. Bensch, J. Fahrenholz, S. E. Wenzel, Y. Chon, M. Dunn, H. H. Weng, S. L. Lin, "A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4R Antagonist, in Patients with Asthma", American Journal of Respiratory and Critical Care Medicine, (20100415), vol. 181, no. 8, doi:10.1164/rccm.200909-1448OC, ISSN 1073449X, pages 788 - 796, XP055013586 |
| OPPOSITION | - Borish Larry, "IL-4 and IL-13 Dual Antagonism : A Promising Approach to the Dilemma of Generating Effective Asthma Biotherapeutics", American Thoracic Society 2020 International Conference; May 15-20, 2020, American Thoracic Society, (20100415), vol. 181, no. 8, doi:10.1164/rccm.201002-0147ED, ISSN 1073-449X, pages 769 - 770, XP055944399 |
| OPPOSITION | - Dweik Raed A., Boggs Peter B., Erzurum Serpil C., Irvin Charles G., Leigh Margaret W., Lundberg Jon O., Olin Anna-Carin, Plummer Alan L., Taylor D. Robin, "An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications", American Thoracic Society 2020 International Conference; May 15-20, 2020, American Thoracic Society, (20110901), vol. 184, no. 5, doi:10.1164/rccm.9120-11ST, ISSN 1073-449X, pages 602 - 615, XP093196052 |
| OPPOSITION | - Djukanovic R., Sterk P.J., Fahy J.V., Hargreave F.E., "Standardised methodology of sputum induction and processing", EUROPEAN RESPIRATORY JOURNAL, European Respiratory Society, GB, GB , (20020701), vol. 20, no. Supplement 37, doi:10.1183/09031936.02.00000102, ISSN 0903-1936, pages 1S - 2s, XP093197905 |
| OPPOSITION | - Bumbacea D., Campbell D., Nguyen L., Carr D., Barnes P.J., Robinson D., Chung K.F., "Parameters associated with persistent airflow obstruction in chronic severe asthma", EUROPEAN RESPIRATORY JOURNAL, European Respiratory Society, GB, GB , (20040701), vol. 24, no. 1, doi:10.1183/09031936.04.00077803, ISSN 0903-1936, pages 122 - 128, XP093198723 |
| OPPOSITION | - Alving K, Weitzberg E, Lundberg Jm, "Increased amount of nitric oxide in exhaled air of asthmatics", EUROPEAN RESPIRATORY JOURNAL, European Respiratory Society, GB, GB , (19931001), vol. 6, no. 9, doi:10.1183/09031936.93.06091368, ISSN 0903-1936, pages 1368 - 1370, XP093197883 |
| OPPOSITION | - Kharitonov S, Alving K, Barnes Pj, "Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force", EUROPEAN RESPIRATORY JOURNAL, European Respiratory Society, GB, GB , (19970701), vol. 10, no. 7, doi:10.1183/09031936.97.10071683, ISSN 0903-1936, pages 1683 - 1693, XP093198760 |
| OPPOSITION | - Steinke John W; Borish Larry, "Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists", Respiratory research, BIOMED CENTRAL LTD., LONDON, GB, GB , (20010219), vol. 2, no. 2, doi:10.1186/rr40, ISSN 1465-9921, pages 66 - 70, XP021013199 |
| OPPOSITION | - A J Wardlaw, C Brightling, R Green, G Woltmann, I Pavord, "Eosinophils in asthma and other allergic diseases", BRITISH MEDICAL BULLETIN., CHURCHILL LIVINGSTONE, LONDON., GB, GB , (20000101), vol. 56, no. 4, doi:10.1258/0007142001903490, ISSN 0007-1420, pages 985 - 1003, XP055756064 |
| OPPOSITION | - Joanne Shannon, Ernst Pierre, Yamauchi Yasuhiro, Olivenstein Ronald, Lemiere Catherine, Foley Susan, Cicora Leo, Ludwig Mara, Hamid Qutayba, Martin James G., "Differences in Airway Cytokine Profile in Severe Asthma Compared to Moderate Asthma", Chest, Elsevier, (20080201), vol. 133, no. 2, doi:10.1378/chest.07-1881, ISSN 0012-3692, pages 420 - 426, XP055535048 |
| OPPOSITION | - Jenkins Henry A., Cherniack Reubin, Szefler Stanley J., Covar Ronina, Gelfand Erwin W., Spahn Joseph D., "A Comparison of the Clinical Characteristics of Children and Adults With Severe Asthma", Chest, Elsevier, (20031001), vol. 124, no. 4, doi:10.1378/chest.124.4.1318, ISSN 0012-3692, pages 1318 - 1324, XP093198727 |
| OPPOSITION | - Brusselle Guy, Bracke Ken, "Targeting Immune Pathways for Therapy in Asthma and Chronic Obstructive Pulmonary Disease", Annals of the American Thoracic Society, (20141201), vol. 11, no. Supplement 5, doi:10.1513/AnnalsATS.201403-118AW, ISSN 2329-6933, pages S322 - S328, XP055932126 |
| OPPOSITION | - Spector Sheldon Laurence, Tan Ricardo Antonio, "Is a Single Blood Eosinophil Count a Reliable Marker for “Eosinophilic Asthma?”", JOURNAL OF ASTHMA, ASTHMA PUBLICATIONS SOCIETY, OSSINING, NY., US, US , (20121001), vol. 49, no. 8, doi:10.3109/02770903.2012.713428, ISSN 0277-0903, pages 807 - 810, XP093197900 |
| OPPOSITION | - Sandeep Thirunavukkarasu, Roopakala Mysoresubrahmanyam, Silvia Chickballapur Rayappawilma Delphine, Chandrashekara Srikantaiah, Rao Mohan, "Evaluation of serum immunoglobulin E levels in bronchial asthma", Lung India, (20100101), vol. 27, no. 3, doi:10.4103/0970-2113.68312, ISSN 0970-2113, pages 138 - 140, XP055945226 |
| OPPOSITION | - Thomson Neil C., Chaudhuri Rekha, "Omalizumab: Clinical Use for the Management of Asthma", Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, (20120612), vol. 6, doi:10.4137/CCRPM.S7793, ISSN 1179-5484, pages 27 - 40, XP093198003 |
| OTHER | - Anonymous, "GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION ", GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION, (20110101), pages 1 - 124, GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION , (20220720), XP055944374 |
| OTHER | - Wenzel Sally E, "Asthma phenotypes: the evolution from clinical to molecular approaches", Nature Medicine, New York, (20120501), vol. 18, no. 5, doi:10.1038/nm.2678, ISSN 1078-8956, pages 716 - 725, XP055944372 |
| OTHER | - S. Wenzel, "Severe asthma: from characteristics to phenotypes to endotypes", Clinical & Experimental Allergy, UK , (20120118), vol. 42, no. 5, doi:10.1111/j.1365-2222.2011.03929.x, ISSN 0954-7894, pages 650 - 658, XP071887598 |
| SEARCH | [ ] - JARED DARVEAUX ET AL, "Biologics in Asthma-The Next Step Toward Personalized Treatment", THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY : AN OFFICIAL JOURNAL OF AAAAI, AMERICAN ACADEMY OF ALLERGY ASTHMA & IMMUNOLOGY, (20150301), vol. 3, no. 2, doi:10.1016/j.jaip.2014.09.014, ISSN 2213-2198, pages 152 - 160, XP055535036 [ ] * page 8, paragraph 3 - paragraph 4 * |
| SEARCH | [ ] - METERAN HOWRAMAN ET AL, "Novel monoclonal treatments in severe asthma", JOURNAL OF ASTHMA : DEVOTED TO ASTHMA AND RELATED CONDITIONS, INFORMA HEALTHCARE, USA, vol. 54, no. 10, doi:10.1080/02770903.2017.1296157, ISSN 1532-4303, (20171130), pages 991 - 1011, (20170316), XP009510079 [ ] * page 1007, column l, paragraph 4 - column r, paragraph 5 * * table 4 * |
| SEARCH | [ ] - DIEGO BAGNASCO ET AL, "A Critical Evaluation of Anti-IL-13 and Anti-IL-4 Strategies in Severe Asthma", INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY., CH, (20160101), vol. 170, no. 2, doi:10.1159/000447692, ISSN 1018-2438, pages 122 - 131, XP055535051 [ ] * page 127, column l, paragraph 2 - column r, paragraph 3 * |
| SEARCH | - J. CORREN ET AL, "A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4R Antagonist, in Patients with Asthma", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, (20100415), vol. 181, no. 8, doi:10.1164/rccm.200909-1448OC, ISSN 1073-449X, pages 788 - 796, XP055013586 [A] 1-15 * abstract * * page 788, column r, paragraph l - page 789, column l, paragraph 3 * * page 792, column l, paragraph 2 * |
