Small Liposomes For Delivery Of Immunogen-Encoding Rna - EP4043040

The patent EP4043040 was granted to Glaxosmithkline on Jan 11, 2023. The application was originally filed on Aug 31, 2011 under application number EP22166818A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP4043040

GLAXOSMITHKLINE
Application Number
EP22166818A
Filing Date
Aug 31, 2011
Status
Granted And Under Opposition
Dec 9, 2022
Grant Date
Jan 11, 2023
External Links
Slate, Register, Google Patents

Patent Summary

Patent Family

Patent Family

Patent Oppositions (4)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentativeOpposition Status

Get instant alerts for new oppositions and patent status changes

JG OPPOSITIONSOct 11, 2023MEWBURN ELLISADMISSIBLE
WEICKMANN & WEICKMANNOct 11, 2023-ADMISSIBLE
HOPFNEROct 10, 2023-ADMISSIBLE
SANOFIOct 9, 2023ELKINGTON AND FIFEADMISSIBLE

Patent Citations (29) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONWO2011057020
OPPOSITIONEP4066856
OPPOSITIONUS2011049873
OPPOSITIONWO02095023
OPPOSITIONWO2005120152
OPPOSITIONWO2005121348
OPPOSITIONWO2006078294
OPPOSITIONWO2007047749
OPPOSITIONWO2010037539
OPPOSITIONWO2011005799
OPPOSITIONWO2011068810
OPPOSITIONWO2012006369
OPPOSITIONWO2012006376
OPPOSITIONWO2012006377
OPPOSITIONWO2012006378
OPPOSITIONWO2012030901
OPPOSITIONWO2014160243
OPPOSITIONWO2017004143
OPPOSITIONWO2017075531
OPPOSITIONWO2022137133
OPPOSITIONWO2022150717
OPPOSITIONWO9011092
SEARCHEP0786522
SEARCHEP1637144
SEARCHJP2007112768
SEARCHUS5750390
SEARCHUS5972704
SEARCHWO2009009054
SEARCHWO9952503

Non-Patent Literature (NPL) Citations (80) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- BOXUS et al., J Virol, (20070000), vol. 81, pages 6879 - 89-
DESCRIPTION- D.M. WEIRC.C. BLACKWELL, Handbook of Experimental Immunology, Blackwell Scientific Publications, (19860000), vol. I-IV-
DESCRIPTION- EL OUAHABI et al., FEBSLetts, (19960000), vol. 380, pages 108 - 12-
DESCRIPTION- "Functional Polymer Colloids and Microparticles", Microspheres, microcapsules & liposomes, Citus Books, (20020000), vol. 4-
DESCRIPTION- GIULIANI et al., Proc Natl Acad Sci USA, (20060000), vol. 1,2,3, no. 29, pages 10834 - 9-
DESCRIPTION- HEYES et al., J Controlled Release, (20050000), vol. 107, pages 276 - 87-
DESCRIPTION- JEFFS et al., Pharmaceutical Research, (20050000), vol. 22, no. 3, pages 362 - 372-
DESCRIPTION- JOHANNING et al., Nucleic Acids Res, (19950000), vol. 23, pages 1495 - 1501-
DESCRIPTION- MAURER et al., Biophysical Journal, (20010000), vol. 80, pages 2310 - 2326-
DESCRIPTION- PERRI et al., J Virol, (20030000), vol. 77, pages 10394 - 10403-
DESCRIPTION- "Pharmaceutical Nanocarriers: Methods and Protocols.", LIPOSOMES, Methods and Protocols, Humana Press, (20090000), vol. 1-
DESCRIPTION- TAYLOR et al., Vaccine, (20050000), vol. 23, pages 1242 - 50-
DESCRIPTION- YONEYAMAFUJITA, Cytokine & Growth Factor Reviews, (20070000), vol. 18, pages 545 - 51-
OPPOSITION- Anonymous, "CureVac Announces Promising Phase 2 Interim Data from Seasonal Influenza Vaccine Development Program in Collaboration with GSK", CUREVAC Press Release, (20240404), CUREVAC Press Release, URL: https://www.curevac.com/en/curevac-announces-promising-phase-2-interim-data-from-seasonal-influenza-vaccine-development-program-in-collaboration-with-gsk/, XP093195769-
OPPOSITION- Anonymous, "Spikevax ( COVID-19 mRNA Vaccine (nucleoside modified) ) An overview of Spikevax, including its adapted vaccine, and why it is authorised in the EU", EUROPEAN MEDICINES AGENCY SCIENCE MEDICINES HEALTH, NL, NL, pages 1 - 5, (20230928), XP093087018-
OPPOSITION- Anonymous, "Zika vaccine (mRNA-1325 and mRNA-1893)", FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 MODERNA, INC., MODERNA, INC., pages 186 - 189, FORM S-1 REGISTRATION STATEMENT Under The Securities Act of 1933 MODERNA, INC., URL: https://www.sec.gov/Archives/edgar/data/1682852/000119312518323562/d577473ds1.htm#toc, (20240304), XP093137428-
OPPOSITION- Arthur Rachel, "Moderna announces mixed results for influenza mRNA vaccine candidate", BioPharma Reporter, William Reed, pages 1 - 2, BioPharma Reporter, URL: https://www.biopharma-reporter.com/Article/2023/02/20/moderna-announces-mixed-results-for-influenza-mrna-vaccine-candidate#, (20240304), XP093137445-
OPPOSITION- D102 - First instance opposition decision concerning EP4066856-
OPPOSITION- Fraenkel-Conrat Heinz, Kimball Paul, "Virology", Virology, PRENTICE-HALL, INC., Englewood Cliffs, N.J., (19820101), pages 35, 124 - 128-130, 285-292, 390, XP093046034-
OPPOSITION- Heinz Fraenkel-Conrat, Paul C. Kimball, "Chapter 10: BIOLOGICAL CONSEQUENCES OF VIRAL INFECTION IN EUKARYOTIC CELLS", Heinz Fraenkel-Conrat, Paul C. Kimball, Heinz Fraenkel-Conrat, Virology, USA, Prentice-Hall, Inc., (19820101), pages 281 - 314, ISBN 0-13-942144-0, XP009553615-
OPPOSITION- Heinz Fraenkel-Conrat, Paul C. Kimball, "Chapter 1.8: Terms used in describing the size, shape, and topography of viruses", Virology, USA, Prentice-Hall, Inc., (19820101), pages 34 - 38, ISBN 0-13-942144-0, XP009553617-
OPPOSITION- Heinz Fraenkel-Conrat, Paul C. Kimball, "Chapter 4: MINUS-STRAND RNA VIRUSES", Virology, USA, Prentice-Hall, Inc., (19820101), pages 117 - 142, ISBN 0-13-942144-0, XP009553614-
OPPOSITION- Heinz Fraenkel-Conrat, Paul C. Kimball, "Glossary of Technical Terms", Virology, USA, Prentice-Hall, Inc., (19820101), pages 379 - 396, ISBN 0-13-942144-0, XP009553616-
OPPOSITION- Ian MACLACHLAN, "CHAPTER 9 Liposomal Formulations for Nucleic Acid Delivery", Ian MACLACHLAN, Stanley T. Crooke, ANTISENSE DRUG TECHNOLOGY - PRINCIPLES, STRATEGIES AND APPLICATIONS (2nd Edition), CRC Press, (20080000), pages 237 - 270, ISBN 978-0-8493-8796-8, XP055915899-
OPPOSITION- Immordino Maria Laura, Dosio Franco, Cattel Luigi, "Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential", INTERNATIONAL JOURNAL OF NANOMEDICINE, DOVE MEDICAL PRESS LTD., AUCKLAND, NZ, AUCKLAND, NZ , (20060101), vol. 1, no. 3, ISSN 1176-9114, pages 297 - 315, XP093134619-
OPPOSITION- Lowe Derek, "CUREVAC COMES AROUND", Science Blog: In the Pipeline, Science.org, Science Blog: In the Pipeline, URL: https://www.science.org/content/blog-post/curevac-comes-around, (20240227), XP093135558-
OPPOSITION- MacLachlan I., "Liposomal formulations for nucleic acid delivery", MacLachlan I., CROOKE STANLEY T, ANTISENSE DRUG TECHNOLOGY: PRINCIPLES, STRATEGIES, AND APPLICATIONS, 2ND ED., US , CRC PRESS , (20070101), pages 237 - 270, ISBN 978-0-8493-8796-8, XP002584305-
OPPOSITION- White, David O., Fenner, Frank , "Chapter 1: Structure and Composition of Viruses", White, David O., Fenner, Frank , David O. White, Frank J. Fenner, Medical Virology, US, Academic Press, (19940101), pages 3 - 15, ISBN 0-12-746642-8, XP009559063-
OPPOSITION- White, David O., Fenner, Frank, "Chapter 26 Flavroiridae", Medical Virology, US, Academic Press, (19940101), pages 433 - 450, ISBN 0-12-746642-8, XP009559067-
OPPOSITION- White, David O., Fenner, Frank, "Chapter 27 Coronaviridae", Medical Virology, US, Academic Press, (19940101), pages 451 - 455, ISBN 0-12-746642-8, XP009559068-
OPPOSITION- White, David O., Fenner, Frank, " Chapter 28 Paramyxoviridae", Medical Virology, US, Academic Press, (19940101), pages 456 - 474, ISBN 0-12-746642-8, XP009559069-
OPPOSITION- White, David O., Fenner, Frank, "Chapter 2: Classification and Nomenclature of Viruses", Medical Virology, US, Academic Press, (19940101), pages 16 - 29, ISBN 0-12-746642-8, XP009559064-
OPPOSITION- White, David O., Fenner, Frank, " Chapter 31 Orthomyxoviridae", Medical Virology, US, Academic Press, (19940101), pages 489 - 499, ISBN 0-12-746642-8, XP009559070-
OPPOSITION- White, David O., Fenner, Frank, " Chapter 35 Retroviridae", Medical Virology, US, Academic Press, (19940101), pages 531 - 562, ISBN 0-12-746642-8, XP009559073-
OPPOSITION- White, David O., Fenner, Frank, "Chapter 4 Viral Genetics and Evolution", Medical Virology, US, Academic Press, (19940101), pages 54 - 73, ISBN 0-12-746642-8, XP009559066-
OPPOSITION- White David O, Fenner Frank J, Diego San, York New, London Boston, Toronto Sydney Tokyo, "Medical Virology Fourth Edition ", Medical Virology, Academic Press, (19940101), pages 3 - 29, 434, ISBN 0-12-746642-8, XP093046091-
OPPOSITION- Wong, J.P. ; Zabielski, M.A. ; Schmaltz, F.L. ; Brownlee, G.G. ; Bussey, L.A. ; Marshall, K. ; Borralho, T. ; Nagata, L.P., "DNA vaccination against respiratory influenza virus infection", Vaccine, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20010321), vol. 19, no. 17-19, ISSN 0264-410X, pages 2461 - 2467, XP027349961-
OPPOSITION- Shayne Cox, Steve Pascolo, "Chapter 7.2. Plasmid DNA and Messenger RNA for Therapy", Handbook of Pharmaceutical Biotechnology, John Wiley & Sons , (20070601), pages 971 - 1011, doi:10.1002/9780470117118.ch07b, ISBN 978-0-471-21386-4, XP055626043
OPPOSITION- MARTINON F., ET AL., "INDUCTION OF VIRUS-SPECIFIC CYTOTOXIC T LYMPHOCYTES IN VIVO BY LIPOSOME-ENTRAPPED MRNA.", European Journal of Immunology, Wiley-VCH, Hoboken, USA, Hoboken, USA, (19930101), vol. 23., doi:10.1002/eji.1830230749, ISSN 0014-2980, pages 1719 - 1722., XP000618955
OPPOSITION- Morrison Trudy G., "Paramyxoviruses, Infection and Immunity", Encyclopedia of immunology, Acad. Press, San Diego [u.a.], San Diego [u.a.] , (19980101), doi:10.1006/rwei.1999.0481, ISBN 978-0-12-226765-9, pages 1909 - 1916, XP093133676
OPPOSITION- Pascolo Steve, "Vaccination with messenger RNA (mRNA)", Toll-like receptors (TLRs) and innate immunity, Berlin [u.a.] : Springer, DE, DE , (20080101), vol. 183, doi:10.1007/978-3-540-72167-3_11, ISBN 978-3-540-72166-6, pages 221 - 235, XP001538300
OPPOSITION- JEFFS et al., "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA", Pharmaceutical Research, (20050000), vol. 22, doi:10.1007/s11095-004-1873-z, pages 362 - 372, XP019370801
OPPOSITION- Jeffs et al., "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA", Pharmaceutical Research, (2005), vol. 22, doi:10.1007/s11095-004-1873-z, page 3, XP019370801
OPPOSITION- Jeffs et al., "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA", Pharmaceutical Research , (2005), vol. 22, doi:10.1007/s11095-004-1873-z, XP019370801
OPPOSITION- Lloyd B. Jeffs ; Lorne R. Palmer ; Ellen G. Ambegia ; Cory Giesbrecht ; Shannon Ewanick ; Ian MacLachlan, "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA", Pharmaceutical Research, Kluwer Academic Publishers-Plenum Publishers, NL, NL , (20050301), vol. 22, no. 3, doi:10.1007/s11095-004-1873-z, ISSN 1573-904X, pages 362 - 372, XP019370801
OPPOSITION- Lloyd B. Jeffs ; Lorne R. Palmer ; Ellen G. Ambegia ; Cory Giesbrecht ; Shannon Ewanick ; Ian MacLachlan, "A Scalable, Extrusion-Free Method for Efficient Liposomal Encapsulation of Plasmid DNA", Pharmaceutical Research, NL , (20050301), vol. 22, no. 3, doi:10.1007/s11095-004-1873-z, ISSN 1573-904X, pages 362 - 372, XP019370801
OPPOSITION- Zhou X, Berglund P, Rhodes G, Parker S.E, Jondal M, Liljeström P, "Self-replicating Semliki Forest virus RNA as recombinant vaccine", Vaccine, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (19941201), vol. 12, no. 16, doi:10.1016/0264-410X(94)90074-4, ISSN 0264-410X, pages 1510 - 1514, XP093134288
OPPOSITION- Minnaert et al., "Strategies for controlling the innate immuneactivity of conventional and self-amplifying mRNA therapeutics: Getting the message across", Advanced Drug Discovery Reviews, (2021), vol. 176, doi:10.1016/j.addr.2021.113900, XP086773295
OPPOSITION- Yamamoto A. et al, "Current prospects for mRNA gene delivery", European journal of pharmaceutics and biopharmaceutics, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM., NL, NL , (20090301), vol. 71, no. 3, doi:10.1016/j.ejpb.2008.09.016, ISSN 0939-6411, pages 484 - 489, XP025992169
OPPOSITION- Schoenmaker Linde, Witzigmann Dominik, Kulkarni Jayesh A., Verbeke Rein, Kersten Gideon, Jiskoot Wim, Crommelin Daan J.A., "mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability", International Journal of Pharmaceutics, ELSEVIER, NL, NL , (20210501), vol. 601, doi:10.1016/j.ijpharm.2021.120586, ISSN 0378-5173, page 120586, XP055828800
OPPOSITION- HEYES et al., "Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids", J. Controlled Release, (20050000), vol. 107, doi:10.1016/j.jconrel.2005.06.014, pages 276 - 287, XP008157522
OPPOSITION- Heyes et al., "Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids", J. Controlled Release , (2005), vol. 107, doi:10.1016/j.jconrel.2005.06.014, XP008157522
OPPOSITION- Heyes, J. Palmer, L. Bremner, K. MacLachlan, I., "Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids", Journal of Controlled Release, Elsevier, AMSTERDAM, NL, AMSTERDAM, NL , (20051003), vol. 107, no. 2, doi:10.1016/j.jconrel.2005.06.014, ISSN 0168-3659, pages 276 - 287, XP005076220
OPPOSITION- James Heyes , Lorne Palmer, Kaz Bremner, Ian MacLachlan, "Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids", Journal of Controlled Release, AMSTERDAM, NL , (20050101), vol. 107, no. 2, doi:10.1016/j.jconrel.2005.06.014, ISSN 0168-3659, pages 276 - 287, XP008157522
OPPOSITION- Wang, D. Christopher, M.E. Nagata, L.P. Zabielski, M.A. Li, H. Wong, J.P. Samuel, J., "Intranasal immunization with liposome-encapsulated plasmid DNA encoding influenza virus hemagglutinin elicits mucosal, cellular and humoral immune responses", Journal of clinical virology, ELSEVIER, AMSTERDAM, NL, NL , (20041201), vol. 31, doi:10.1016/j.jcv.2004.09.013, ISSN 1386-6532, pages 99 - 106, XP004660136
OPPOSITION- Hassett Kimberly J., Benenato Kerry E., Jacquinet Eric, Lee Aisha, Woods Angela, Yuzhakov Olga, Himansu Sunny, Deterling Jessica, Geilich Benjamin M., Ketova Tatiana, Mihai Cosmin, Lynn Andy, Mcfadyen Iain, Moore Melissa J., Senn Joseph J., Stanton Matthew G., Almarsson Örn, Ciaramella Giuseppe, Brito Luis A., "Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines", Molecular Therapy-Nucleic Acids, Cell Press, US, US , (20190415), vol. 15, doi:10.1016/j.omtn.2019.01.013, ISSN 2162-2531, pages 1 - 11, XP055815007
OPPOSITION- Geall Andrew J.; Mandl Christian W.; Ulmer Jeffrey B., "RNA: The new revolution in nucleic acid vaccines", Seminars in immunology, W.B. SAUNDERS COMPANY, PA., US, US , (19000101), vol. 25, no. 2, doi:10.1016/j.smim.2013.05.001, ISSN 1044-5323, pages 152 - 159, XP028694558
OPPOSITION- Ulmer et al., "RNA-based vaccines", Vaccine, (2012), vol. 30, doi:10.1016/j.vaccine.2012.04.060, XP028520925
OPPOSITION- Norbert Maurer, Kim F. Wong, Holger Stark, Lenore Louie, Deirdre Mcintosh, Tabitha Wong, Peter Scherrer, Sean C. Semple, Pieter R. Cullis, "Spontaneous Entrapment of Polynucleotides upon Electrostatic Interaction with Ethanol-Destabilized Cationic Liposomes", Biophysical Journal, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL, (20010501), vol. 80, no. 5, doi:10.1016/S0006-3495(01)76202-9, ISSN 0006-3495, pages 2310 - 2326, XP055550920
OPPOSITION- Nicholson Karl G; Wood John M; Zambon Maria, "Influenza", The Lancet, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (20031122), vol. 362, no. 9397, doi:10.1016/S0140-6736(03)14854-4, ISSN 0140-6736, pages 1733 - 1745, XP085425422
OPPOSITION- LEITNER W.W. YING H, RESTIFO N P, "DNA and RNA-based vaccines: principles, progress and prospects.", Vaccine, ELSEVIER, AMSTERDAM, NL, AMSTERDAM, NL , (19991210), vol. 18, doi:10.1016/S0264-410X(99)00271-6, ISSN 0264-410X, pages 765 - 777, XP002201709
OPPOSITION- Dolgin Elie, "TRIAL SETTLES DEBATE OVER BEST DESIGN FOR MRNA IN COVID VACCINES", Nature, Springer Nature Limited, (20230119), vol. 613, no. 7944, doi:10.1038/d41586-023-00042-z, ISSN 0028-0836, pages 419 - 420, XP093119100
OPPOSITION- KARIKÓ KATALIN ET AL, "Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability.", Molecular Therapy, Nature Publishing Group, GB, GB , (20081101), vol. 16, no. 11, doi:10.1038/mt.2008.200, ISSN 1525-0024, pages 1833 - 1840, XP002614742
OPPOSITION- Zimmermann Tracy S., Lee Amy C. H., Akinc Akin, Bramlage Birgit, Bumcrot David, Fedoruk Matthew N., Harborth Jens, Heyes James A., Jeffs Lloyd B., John Matthias, Judge Adam D., Lam Kieu, Mcclintock Kevin, Nechev Lubomir V., Palmer Lorne R., Racie Timothy, Röhl Ingo, Seiffert Stephan, Shanmugam Sumi, Sood Vandana, Soutschek Jürgen, Toudjarska Ivanka, Wheat Amanda J., Yaworski Ed, Zedalis William, Koteliansky Victor, Manoharan Muthiah, Vornlocher Hans-Peter, Maclachlan Ian, "RNAi-mediated gene silencing in non-human primates", Nature, (20060101), vol. 441, doi:10.1038/nature04688, ISSN 0028-0836, pages 111 - 114, XP093134286
OPPOSITION- David V Morrissey, Jennifer A Lockridge, Lucinda Shaw, Karin Blanchard, Kristi Jensen, Wendy Breen, Kimberly Hartsough, Lynn Machemer, Susan Radka, Vasant Jadhav, Narendra Vaish, Shawn Zinnen, Chandra Vargeese, Keith Bowman, Chris S Shaffer, Lloyd B Jeffs, Adam Judge, Ian MacLachlan & Barry Polisky, "Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs", Nature Biotechnology, Nature Publishing Group US, New York, New York, (20050801), vol. 23, no. 8, doi:10.1038/nbt1122, ISSN 1087-0156, pages 1002 - 1007, XP008157520
OPPOSITION- Petsch et al., "Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection", Nature Biotechnology, (2012), vol. 30, doi:10.1038/nbt.2436, page 12, XP055051005
OPPOSITION- Sahin et al., "mRNA-based therapeutics - developing a new class of drugs ", Nature Reviews Drug Discovery, (2014), vol. 13, doi:10.1038/nrd4278, XP055544673
OPPOSITION- Akinc Akin; Maier Martin A.; Manoharan Muthiah; Fitzgerald Kevin; Jayaraman Muthusamy; Barros Scott; Ansell Steven; Du Xinyao; Hope Michael J.; Madden Thomas D.; Mui Barbara L.; Semple Sean C.; Tam Ying K.; Ciufolini Marco; Witzigmann Dominik; Kulkarni Jayesh A.; van der Meel Roy; Cullis Pieter R., "The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs", arXiv.org, Nature Pub. Group, Inc., London, London , (20191201), vol. 14, no. 12, doi:10.1038/s41565-019-0591-y, ISSN 1748-3387, pages 1084 - 1087, XP036953174
OPPOSITION- Norbert Pardi, Et Al., "Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses", Journal of Experimental Medicine, Rockefeller University Press, US, US , (20180604), vol. 215, no. 6, doi:10.1084/jem.20171450, ISSN 0022-1007, pages 1571 - 1588, XP055545604
OPPOSITION- Fleeton et al., "Self-Replicative RNA Vaccines Elicit Protection against Influenza A Virus, Respiratory Syncytial Virus, and a Tickborne Encephalitis Virus", The Journal of Infectious Diseases, (2001), vol. 183, doi:10.1086/319857, XP002224503
OPPOSITION- Fleeton, Et Al., "Self-replicative vaccines elicit protection against influenza A virus, respiratory syncytial virus and tickborne encephalitis", J. Infectious Diseases, (20010101), vol. 183, doi:10.1086/319857, pages 1395 - 1398, XP055702690
OPPOSITION- W-Z Zhou, D S B Hoon, S K S Huang, et al, "RNA melanoma vaccine: induction of antitumor immunity by human glycoprotein 100 mRNA immunization.", HUMAN GENE THERAPY, Mary Ann Liebert, Inc. Publishers, GB, GB , (19991101), vol. 10, no. 16, doi:10.1089/10430349950016762, ISSN 1043-0342, pages 2719 - 2724, XP002660042
OPPOSITION- STRAUSS, J.H. & STRAUSS, E.G., "The Alphaviruses: gene expression, replication, and evolution", MICROBIOLOGICAL REVIEWS, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, US , (19940901), vol. 58., no. 03., doi:10.1128/mr.58.3.491-562.1994, ISSN 0146-0749, pages 491 - 562, XP002108834
OPPOSITION- Pascolo S, "Vaccination with messenger RNA", METHODS IN MOLECULAR MEDICINE, Humana Press, (20060101), ISSN 1543-1894, pages 23 - 40, XP009117840
OPPOSITION- PASCOLO, "Vaccination with Messenger RNA", Methods in Molecular Medicine, (20060000), vol. 127, pages 23 - 40, XP009117840
OPPOSITION- Pascolo S, "Messenger RNA-based vaccines", EXPERT OPINION ON BIOLOGICAL THERAPY, Informa Healthcare, (20040801), vol. 4, no. 8, doi:10.1517/14712598.4.8.1285, ISSN 1471-2598, pages 1285 - 1294, XP009095328
OPPOSITION- Deering Raquel P; Kommareddy Sushma; Ulmer Jeffrey B, "Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines.", Expert opinion on drug delivery, Informa Healthcare, UK, UK , (20140601), vol. 11, no. 6, doi:10.1517/17425247.2014.901308, ISSN 1744-7593, pages 885 - 899, XP009183535
OPPOSITION- Morais Pedro, Adachi Hironori, Yu Yi-Tao, "The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines", Frontiers in Cell and Developmental Biology, vol. 9, doi:10.3389/fcell.2021.789427, page 789427, XP055885272
OPPOSITION- Karl-Josef Kallen, Regina Heidenreich, Margit Schnee, Benjamin Petsch, Thomas Schlake, Andreas Thess, Patrick Baumhof, Birgit Scheel, Sven D Koch, Mariola Fotin-Mleczek, "A novel, disruptive vaccination technology: Self-adjuvanted RNActive® vaccines", Human vaccines & immunotherapeutics, (20131001), vol. 9, no. 10, doi:10.4161/hv.25181, ISSN 21645515, pages 2263 - 2276, XP055126357
OPPOSITION- Schlake et al., "Developing mRNA-vaccine technologies", RNA Biology, (2012), vol. 9, doi:10.4161/rna.22269, page 11, XP055126360

Download Citation Report

Get a free citation report including examiner, opposition, and international search citations.

Get Citation Report

Dossier Documents

The dossier documents provide a comprehensive record of the patent’s prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent’s legal journey and any challenges it may have faced during examination.

  • Date

    Description

  • Get instant alerts for new documents