Novel Lipids And Compositions For The Delivery Of Therapeutics - EP4241767

The patent EP4241767 was granted to Arbutus Biopharma on Oct 23, 2024. The application was originally filed on Nov 10, 2009 under application number EP23175192A. The patent is currently recorded with a legal status of "Granted And Under Opposition".

EP4241767

ARBUTUS BIOPHARMA
Application Number
EP23175192A
Filing Date
Nov 10, 2009
Status
Granted And Under Opposition
Sep 20, 2024
Grant Date
Oct 23, 2024
External Links
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Patent Summary

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Patent Family

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ARROWHOUSEJul 23, 2025VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBBADMISSIBLE
KELTIEJul 23, 2025-ADMISSIBLE
MERCK SHARP & DOHME UKJul 23, 2025COHAUSZ & FLORACKADMISSIBLE
MODERNAApr 29, 2025HOFFMANN EITLEADMISSIBLE

Patent Citations (236) New

Patent citations refer to prior patents cited during different phases such as opposition or international search.

Citation PhasePublication NumberPublication Link
DESCRIPTIONUS19340108339-
DESCRIPTIONUS19380611854-
DESCRIPTIONUS19390611714-
DESCRIPTIONUS19500611543-
DESCRIPTIONUS19730109468-
DESCRIPTIONUS19790611131-
DESCRIPTIONUS19850109161-
DESCRIPTIONUS19950486214-
DESCRIPTIONUS19980612258-
DESCRIPTIONUS19980612340-
DESCRIPTIONUS20050115989-
DESCRIPTIONUS20070657341-
DESCRIPTIONUS20070944227-
DESCRIPTIONUS20090502158-
DESCRIPTIONWO1992US04294-
DESCRIPTIONWO1992US04305-
DESCRIPTIONWO2004US07070-
DESCRIPTIONEP0360257
DESCRIPTIONUS105
DESCRIPTIONUS3687808
DESCRIPTIONUS3993754
DESCRIPTIONUS4145410
DESCRIPTIONUS4224179
DESCRIPTIONUS4235871
DESCRIPTIONUS4469863
DESCRIPTIONUS4522803
DESCRIPTIONUS4587044
DESCRIPTIONUS4588578
DESCRIPTIONUS4603044
DESCRIPTIONUS4605735
DESCRIPTIONUS4667025
DESCRIPTIONUS4737323
DESCRIPTIONUS4762779
DESCRIPTIONUS4789737
DESCRIPTIONUS4824941
DESCRIPTIONUS4828979
DESCRIPTIONUS4835263
DESCRIPTIONUS4876335
DESCRIPTIONUS4904582
DESCRIPTIONUS4948882
DESCRIPTIONUS4957773
DESCRIPTIONUS4958013
DESCRIPTIONUS4987071
DESCRIPTIONUS5013556
DESCRIPTIONUS5023243
DESCRIPTIONUS5059528
DESCRIPTIONUS5082830
DESCRIPTIONUS5109124
DESCRIPTIONUS5112963
DESCRIPTIONUS5116739
DESCRIPTIONUS5118802
DESCRIPTIONUS5130302
DESCRIPTIONUS5138045
DESCRIPTIONUS5142047
DESCRIPTIONUS5149782
DESCRIPTIONUS5168045
DESCRIPTIONUS5177189
DESCRIPTIONUS5177198
DESCRIPTIONUS5182364
DESCRIPTIONUS5214136
DESCRIPTIONUS5218
DESCRIPTIONUS5223618
DESCRIPTIONUS5235033
DESCRIPTIONUS5245022
DESCRIPTIONUS5254469
DESCRIPTIONUS5256775
DESCRIPTIONUS5258506
DESCRIPTIONUS5262536
DESCRIPTIONUS5264562
DESCRIPTIONUS5264564
DESCRIPTIONUS5272250
DESCRIPTIONUS5286634
DESCRIPTIONUS5292873
DESCRIPTIONUS5317098
DESCRIPTIONUS5334711
DESCRIPTIONUS5359044
DESCRIPTIONUS5366878
DESCRIPTIONUS5371241
DESCRIPTIONUS5378825
DESCRIPTIONUS5386023
DESCRIPTIONUS5391723
DESCRIPTIONUS5414077
DESCRIPTIONUS5416203
DESCRIPTIONUS5451463
DESCRIPTIONUS5457191
DESCRIPTIONUS5459255
DESCRIPTIONUS5473039
DESCRIPTIONUS5476925
DESCRIPTIONUS5484908
DESCRIPTIONUS5486603
DESCRIPTIONUS5489677
DESCRIPTIONUS5508270
DESCRIPTIONUS5510475
DESCRIPTIONUS5512439
DESCRIPTIONUS5512667
DESCRIPTIONUS5514785
DESCRIPTIONUS5519134
DESCRIPTIONUS5525465
DESCRIPTIONUS5525472
DESCRIPTIONUS5532130
DESCRIPTIONUS5534499
DESCRIPTIONUS5539083
DESCRIPTIONUS5541313
DESCRIPTIONUS5545730
DESCRIPTIONUS5552538
DESCRIPTIONUS5565552
DESCRIPTIONUS5567810
DESCRIPTIONUS5574142
DESCRIPTIONUS5578717
DESCRIPTIONUS5578718
DESCRIPTIONUS5580731
DESCRIPTIONUS5585481
DESCRIPTIONUS5587371
DESCRIPTIONUS5591317
DESCRIPTIONUS5591584
DESCRIPTIONUS5595726
DESCRIPTIONUS5597696
DESCRIPTIONUS5599923
DESCRIPTIONUS5599928
DESCRIPTIONUS5608046
DESCRIPTIONUS5610288
DESCRIPTIONUS5614617
DESCRIPTIONUS5631359
DESCRIPTIONUS5672662
DESCRIPTIONUS5672685
DESCRIPTIONUS5688941
DESCRIPTIONUS5714166
DESCRIPTIONUS5718709
DESCRIPTIONUS5721114
DESCRIPTIONUS5739119
DESCRIPTIONUS5747470
DESCRIPTIONUS5759829
DESCRIPTIONUS5783683
DESCRIPTIONUS5789573
DESCRIPTIONUS5801154
DESCRIPTIONUS5820873
DESCRIPTIONUS5834596
DESCRIPTIONUS5840688
DESCRIPTIONUS5876968
DESCRIPTIONUS5885613
DESCRIPTIONUS5976567
DESCRIPTIONUS6004925
DESCRIPTIONUS6027726
DESCRIPTIONUS6037323
DESCRIPTIONUS6046166
DESCRIPTIONUS6153737
DESCRIPTIONUS6172208
DESCRIPTIONUS6287591
DESCRIPTIONUS6300319
DESCRIPTIONUS6320017
DESCRIPTIONUS6335434
DESCRIPTIONUS6335437
DESCRIPTIONUS6372886
DESCRIPTIONUS6395437
DESCRIPTIONUS6444806
DESCRIPTIONUS6486308
DESCRIPTIONUS6525031
DESCRIPTIONUS6528631
DESCRIPTIONUS6559279
DESCRIPTIONUS6858225
DESCRIPTIONWO0044895
DESCRIPTIONWO0175164
DESCRIPTIONWO0244321
DESCRIPTIONWO2007095387
DESCRIPTIONWO2008036825
DESCRIPTIONWO8604920
DESCRIPTIONWO8702062
DESCRIPTIONWO9103162
DESCRIPTIONWO9207065
DESCRIPTIONWO9220822
DESCRIPTIONWO9220823
DESCRIPTIONWO9315187
DESCRIPTIONWO9323569
DESCRIPTIONWO9402595
DESCRIPTIONWO9413688
DESCRIPTIONWO9611266
OPPOSITIONCA2271582
OPPOSITIONUS2004009943
OPPOSITIONUS2004032037
OPPOSITIONUS2005064595
OPPOSITIONUS2005255153
OPPOSITIONUS2006008910
OPPOSITIONUS2006240554
OPPOSITIONUS2007042031
OPPOSITIONUS2007260055
OPPOSITIONUS2008020058
OPPOSITIONUS2009175930
OPPOSITIONUS5965434
OPPOSITIONUS6287591
OPPOSITIONUS6320017
OPPOSITIONUS6835395
OPPOSITIONWO0062813
OPPOSITIONWO0105374
OPPOSITIONWO0115726
OPPOSITIONWO03070735
OPPOSITIONWO2004002453
OPPOSITIONWO2004002468
OPPOSITIONWO2005035764
OPPOSITIONWO2005063305
OPPOSITIONWO2005063306
OPPOSITIONWO2005120152
OPPOSITIONWO2006002538
OPPOSITIONWO2006007712
OPPOSITIONWO2006053430
OPPOSITIONWO2006138380
OPPOSITIONWO2007012191
OPPOSITIONWO2007022152
OPPOSITIONWO2007051303
OPPOSITIONWO2007056861
OPPOSITIONWO2007086881
OPPOSITIONWO2007112107
OPPOSITIONWO2008043575
OPPOSITIONWO2008103276
OPPOSITIONWO2009082817
OPPOSITIONWO2009086558
OPPOSITIONWO2009088891
OPPOSITIONWO2009097332
OPPOSITIONWO2009127060
OPPOSITIONWO2009129319
OPPOSITIONWO2009132131
OPPOSITIONWO2010037539
OPPOSITIONWO2010042877
OPPOSITIONWO2010048228
OPPOSITIONWO2010088927
OPPOSITIONWO2010105209
OPPOSITIONWO2010129687
OPPOSITIONWO2010144740
OPPOSITIONWO2011000106
OPPOSITIONWO2011000107
OPPOSITIONWO2011000108
OPPOSITIONWO2011003834
OPPOSITIONWO9527478
OPPOSITIONWO9851278
OPPOSITIONWO9939740
SEARCHDE3402146
SEARCHUS6320017

Non-Patent Literature (NPL) Citations (148) New

NPL citations refer to non-patent references such as research papers, articles, or other publications cited during examination or opposition phases.

Citation PhaseReference TextLink
DESCRIPTION- ABRA, RM et al., J. Liposome Res., (20020000), vol. 12, pages 1 - 3-
DESCRIPTION- AGRAWAL, Trends in Biotech., (19960000), vol. 14, pages 376 - 387-
DESCRIPTION- ALLEN et al., Biochimica et Biophysica Acta, (19950000), vol. 1237, pages 99 - 108-
DESCRIPTION- ALTSCHUL et al., Nucleic Acids Res., (19970000), vol. 25, no. 17, pages 3389 - 402-
DESCRIPTION- AN, H et al., J. Org. Chem., (20010000), vol. 66, pages 2789 - 2801-
DESCRIPTION- AOKI et al., Cancer Gene Therapy, (20010000), vol. 8, pages 783 - 787-
DESCRIPTION- AVIRAM et al., Arterioscler. Thromb. Vasc. Biol., (19980000), vol. 18, no. 10, pages 1617 - 24-
DESCRIPTION- AVIRAM et al., Arterioscler. Thromb. Vase. Biol., (19980000), vol. 18, no. 10, pages 1617 - 24-
DESCRIPTION- AVIRAM et al., J. Clin. Invest., (19980000), vol. 101, no. 8, pages 1581 - 90-
DESCRIPTION- BEAUCAGE, S. L.IYER, R. P., Tetrahedron, (19920000), vol. 48, pages 2223 - 2311-
DESCRIPTION- BEAUCAGE, S. L.IYER, R. P., Tetrahedron, (19930000), vol. 49, pages 6123 - 6194-
DESCRIPTION- BEHR, Acc. Chem. Res., (19930000), vol. 26, pages 274 - 278-
DESCRIPTION- BENNETT, Pharm., (19920000), vol. 41, pages 1023 - 1033-
DESCRIPTION- BIELICKIODA, Biochemistry, (20020000), vol. 41, pages 2089 - 96-
DESCRIPTION- BILLECKE et al., Drug Metab. Dispos., (20000000), vol. 28, no. 11, pages 1335 - 42-
DESCRIPTION- BLUME et al., Biochimica et Biophysica Acta, (19930000), vol. 1149, pages 180 - 184-
DESCRIPTION- BODANSZKY et al., Peptide Synthesis, John Wiley & Sons, (19760000), vol. II, pages 105 - 237-
DESCRIPTION- BRIGHAM et al., Am. J. Med. Sci., (19890000), vol. 298, pages 278 - 281-
DESCRIPTION- BRIGHAM et al., Am. J. Sci., (19890000), vol. 298, no. 4, pages 278 - 281-
DESCRIPTION- BROWNSIMPSON, Annu Rev Plant Physiol Plant Mol Biol, (19980000), vol. 49, pages 77 - 95-
DESCRIPTION- CECH et al., Cell, (19811200), vol. 27, no. 3, pages 487 - 96-
DESCRIPTION- CHEUNG et al., J. Lipid Res., (19870000), vol. 28, no. 8, pages 913 - 29-
DESCRIPTION- CHUNG et al., J. Lipid Res., (19800000), vol. 21, no. 3, pages 284 - 91-
DESCRIPTION- COLLINSOLIVE, Biochemistry, (19930323), vol. 32, no. 11, pages 2795 - 9-
DESCRIPTION- Concise Encyclopedia Of Polymer Science And Engineering, John Wiley & Sons, (19900000), pages 858 - 859-
DESCRIPTION- CORMIER,J.F., Nucleic Acids Res., (19880000), vol. 16, page 4583-
DESCRIPTION- "Covalent Attachment of Proteins to Liposomes", HEATH, Methods in Enzymology, Academic Press, Inc., (19870000), vol. 149, pages 111 - 119-
DESCRIPTION- CROSSTICK et al., Tetrahedron Lett., (19890000), vol. 30, page 4693-
DESCRIPTION- CULLIS et al., Chem Phys Lipids, (19860000), vol. 40, pages 127 - 144-
DESCRIPTION- CULVER, Human Gene Therapy, MaryAnn Liebert, Inc., Publishers, (19940000), pages 70 - 71-
DESCRIPTION- DAUM et al., J. Mol. Med., (19990000), vol. 77, pages 614 - 22-
DESCRIPTION- DE FOUGCROLLES, A. et al., Nature Reviews, (20070000), vol. 6, pages 443 - 453-
DESCRIPTION- DEFREES et al., Journal of the American Chemistry Society, (19960000), vol. 118, pages 6101 - 6104-
DESCRIPTION- DRAGANOV et al., J. Biol. Chem., (20000000), vol. 275, no. 43, pages 33435 - 42-
DESCRIPTION- DUVERGER et al., Arterioscler. Thromb. Vasc. Biol., (19960000), vol. 16, no. 12, pages 1424 - 29-
DESCRIPTION- DUVERGER et al., Euro. J. Biochem., (19910000), vol. 201, no. 2, pages 373 - 83-
DESCRIPTION- DYER et al., J. Lipid Res., (19950000), vol. 36, no. 1, pages 80 - 8-
DESCRIPTION- EASTMAN et al., Biochemistry, (19920000), vol. 31, pages 4262 - 4268-
DESCRIPTION- EATON, Curr. Opin. Chem. Biol., (19970000), vol. 1, pages 10 - 16-
DESCRIPTION- EDGE, M.D. et al., J. Chem. Soc. Perkin Trans. 1, (19720000), page 1991-
DESCRIPTION- ELLINGTONSZOSTAK, Nature, (19900000), vol. 346, page 818-
DESCRIPTION- ENGLISCH et al., Angewandte Chemie, International Edition, (19910000), vol. 30, page 613-
DESCRIPTION- FAMULOK, Curr. Opin. Struct. Biol., (19990000), vol. 9, pages 324 - 9-
DESCRIPTION- FELGNER, Scientific-
DESCRIPTION- FORSTERSYMONS, Cell, (19870424), vol. 49, no. 2, pages 211 - 20-
DESCRIPTION- FRANCESCHINI et al., J. Biol. Chem., (19850000), vol. 260, no. 14, pages 2258 - 64-
DESCRIPTION- GALBRAITH et al., Antisense Nucl. Acid Drug Des., (19940000), vol. 4, pages 201 - 206-
DESCRIPTION- "GenBank", Database accession no. K00396-
DESCRIPTION- GOODFELLOW, Nature, (19890000), vol. 341, pages 102 - 103-
DESCRIPTION- GORACZNIAK et al., Nature Biotechnology, (20080000), vol. 27, no. 3, pages 257 - 263-
DESCRIPTION- GRIFFITHS-JONES SGROCOCK RJVAN DONGEN SBATEMAN AENRIGHT AJ, "miRBase: microRNA sequences, targets and gene nomenclature", NAR, (20060000), vol. 34, pages D140 - D144-
DESCRIPTION- GUERRIER-TAKADA et al., Cell, (19831200), vol. 35, no. 3, pages 849 - 57-
DESCRIPTION- HAMPEL et al., Nucleic Acids Res., (19900125), vol. 18, no. 2, pages 299 - 304-
DESCRIPTION- HAMPELTRIT, Biochemistry, (19890613), vol. 28, no. 12, pages 4929 - 33-
DESCRIPTION- HAUBNER et al., Jour. Nucl. Med., (20010000), vol. 42, pages 326 - 336-
DESCRIPTION- HERMANNPATEL, Science, (20000000), vol. 287, pages 820 - 5-
DESCRIPTION- HILL, J. Biol. Chem., (19980000), vol. 273, no. 47, pages 30979 - 84-
DESCRIPTION- HIXSONPOWERS, J. Lipid Res., (19910000), vol. 32, no. 9, pages 1529 - 35-
DESCRIPTION- HOEG et al., J. Biol. Chem., (19860000), vol. 261, no. 9, pages 3911 - 4-
DESCRIPTION- HYDE et al., Nature, (19930000), vol. 362, pages 250 - 256-
DESCRIPTION- JASKULSKI et al., Science, (19880610), vol. 240, no. 4858, pages 1544 - 6-
DESCRIPTION- JIA et al., Biochem. Biophys. Res. Comm., (20020000), vol. 297, pages 206 - 13-
DESCRIPTION- KAWASAKI, J. Med. Chem., (19930000), vol. 36, pages 831 - 841-
DESCRIPTION- KIMCECH, Proc Natl Acad Sci USA, (19871200), vol. 84, no. 24, pages 8788 - 92-
DESCRIPTION- KIRPOTIN et al., FEBS Letters, (19960000), vol. 388, pages 115 - 118-
DESCRIPTION- KLIBANOV et al., Journal of Liposome Research, (19920000), vol. 2, pages 321 - 334-
DESCRIPTION- KLON et al., Biophys. J., (20000000), vol. 79, no. 3, pages 1679 - 87-
DESCRIPTION- KRUTZFELDT et al., Nature, (20050000), vol. 438, pages 685 - 689-
DESCRIPTION- KUNKEL et al., Brit. Med. Bull., (19890000), vol. 45, no. 3, pages 630 - 643-
DESCRIPTION- LACKNER et al., J. Biol., (19850000), vol. 260, no. 2, pages 703 - 6-
DESCRIPTION- LAMBERTON, J.S.CHRISTIAN, A.T., Molecular Biotechnology, (20030000), vol. 24, pages 111 - 119-
DESCRIPTION- LAM et al., Nature, (19910000), vol. 354, pages 82 - 84-
DESCRIPTION- LEONETTI et al., Proc. Natl. Acad. Sci. (USA), (19900000), vol. 87, pages 2448 - 2451-
DESCRIPTION- MANN et al., J. Clin. Invest., (20000000), vol. 106, pages 1071 - 1075-
DESCRIPTION- MANNINO et al., Biotechniques, (19880000), vol. 6, pages 682 - 690-
DESCRIPTION- MANOHARAN, M. et al., Antisense and Nucleic Acid Drug Development, (20020000), vol. 12, pages 103 - 128-
DESCRIPTION- MARTIN, P., Helv. Chim. Acta, (19950000), vol. 78, pages 486 - 504-
DESCRIPTION- MARTIN, P., Helv. Chim. Acta, (19960000), vol. 79, pages 1930 - 1938-
DESCRIPTION- MCLEAN et al., J. Biol. Chem., (19830000), vol. 258, no. 14, pages 8993 - 9000-
DESCRIPTION- MERRIFIELD, J. Am. Chem. Soc., (19630000), vol. 85, pages 2149 - 2154-
DESCRIPTION- MICHELWESTHOF, J Mol Biol., (19901205), vol. 216, no. 3, pages 585 - 610-
DESCRIPTION- MULUGETA et al., J. Chromatogr., (19980000), vol. 711, no. 1-2, pages 97 - 109-
DESCRIPTION- NICOLAU et al., Crit. Rev. Ther. Drug Carrier Syst., (19890000), vol. 6, pages 239 - 271-
DESCRIPTION- OBERHAUSER, N.PLANK, C. et al., "Enhancing endosomal exit of nucleic acids using pH-sensitive viral fusion peptides", Deliv. Strategies Antisense Oligonucleotide Ther., (19950000), pages 247 - 66-
DESCRIPTION- PALGUNACHARI, Arterioscler. Throb. Vasc. Biol., (19960000), vol. 16, no. 2, pages 328 - 38-
DESCRIPTION- Peptide Nucleic Acids (PNA): Synthesis, Properties and Potential Applications, Bioorganic & Medicinal Chemistry, (19960000), vol. 4, pages 5 - 23-
DESCRIPTION- PERIS et al., Brain Res Mol Brain Res., (19980615), vol. 57, no. 2, pages 310 - 20-
DESCRIPTION- PERROTTABEEN, Biochemistry, (19921201), vol. 31, no. 47, pages 11843 - 52-
DESCRIPTION- PLANK, C.OBERHAUSER, B.MECHTLER, K.KOCH, C.WAGNER, E., "The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems", J. Biol. Chem., (19940000), vol. 269, pages 12918 - 12924, XP000615488-
DESCRIPTION- POWELL et al., Cell, (19870000), vol. 50, no. 6, pages 831 - 40-
DESCRIPTION- RAIL et al., "Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects", Proc. Nat. Acad. Sci., (19820000), vol. 79, pages 4696 - 4700-
DESCRIPTION- RANEY et al., Journal of Pharmacology and Experimental Therapeutics, (20010000), vol. 298, pages 1185 - 1192-
DESCRIPTION- REINHOLD-HUREKSHUB, Nature, (19920514), vol. 357, no. 6374, pages 173 - 6-
DESCRIPTION- RENNEISEN et al., J. Bio. Chem., (19900000), vol. 265, pages 16337 - 16342-
DESCRIPTION- ROSSI et al., Nucleic Acids Res., (19920911), vol. 20, no. 17, pages 4559 - 65-
DESCRIPTION- SACRE et al., FEBS Lett., (20030000), vol. 540, no. 1-3, pages 181 - 7-
DESCRIPTION- SAPRA, P.ALLEN, TM, Prog. Lipid Res., (20030000), vol. 42, no. 5, pages 439 - 62-
DESCRIPTION- SAVILLECOLLINS, Cell, (19900518), vol. 61, no. 4, pages 685 - 96-
DESCRIPTION- SAVILLECOLLINS, Proc Natl Acad Sci USA., (19911001), vol. 88, no. 19, pages 8826 - 30-
DESCRIPTION- SHELNESS et al., J. Biol. Chem., (19840000), vol. 259, no. 23, pages 14888 - 93-
DESCRIPTION- SIMEONI et al., Nucl. Acids Res., (20030000), vol. 31, pages 2717 - 2724-
DESCRIPTION- SORENSON et al., Arterioscler. Thromb. Vasc. Biol., (19990000), vol. 19, no. 9, pages 2214 - 25-
DESCRIPTION- SPROAT et al., Nucleosides Nucleotides, (19880000), vol. 7, page 651-
DESCRIPTION- STIRCHAK, E.P., Nucleic Acids Res., (19890000), vol. 17, page 6129-
DESCRIPTION- STRAUBRINGER et al., METHODS IN ENZYMOLOGY, Academic Press, (19830000), vol. 101, pages 512 - 527-
DESCRIPTION- SUBBARAO et al., Biochemistry, (19870000), vol. 26, pages 2964 - 2972-
DESCRIPTION- THURBERG et al., J. Biol. Chem., (19910000), vol. 266, no. 23, pages 150009 - 15-
DESCRIPTION- TITTENSOR, J.R., J. Chem. Soc. C, (19710000), page 1933-
DESCRIPTION- TUERKGOLD, Science, (19900000), vol. 249, page 505-
DESCRIPTION- TURK et al., Biochem. Biophys. Acta, (20020000), vol. 1559, pages 56 - 68-
DESCRIPTION- VASANTHAKAMARAHMED, Cancer Commun., (19890000), vol. 1, no. 4, pages 225 - 32-
DESCRIPTION- VERMA, S. et al., Annu. Rev. Biochem., (19980000), vol. 67, pages 99 - 134-
DESCRIPTION- VLASSOV et al., Biochim. Biophys. Acta, (19940000), vol. 1197, pages 95 - 1082-
DESCRIPTION- VOGEL et al., J. Am. Chem. Soc., (19960000), vol. 118, pages 1581 - 1586-
DESCRIPTION- WEERS et al., Biophys. Chem., (20030000), vol. 100, no. 1-3, pages 481 - 92-
DESCRIPTION- WEISGRABER et al., "Human E apoprotein heterogeneity: cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms", J. Biol. Chem., (19810000), vol. 256, pages 9077 - 9083, XP055343671-
DESCRIPTION- WEISGRABER, J. Lipid Res., (19900000), vol. 31, no. 8, pages 1503 - 11-
DESCRIPTION- WENGEL, J., "LNA", Acc. Chem. Res., (19990000), vol. 32, pages 301 - 310-
DESCRIPTION- WIDLER et al., J. Biol. Chem., (19800000), vol. 255, no. 21, pages 10464 - 71-
DESCRIPTION- YAMAMOTO S. et al., J. Immunol., (19920000), vol. 148, pages 4072 - 4076-
DESCRIPTION- ZALIPSKY, Bioconjugate Chemistry, (19930000), vol. 4, pages 296 - 299-
DESCRIPTION- ZALIPSKY, FEBS Letters, (19940000), vol. 353, pages 71 - 74-
DESCRIPTION- ZELPHATI, O. et al., Antisense. Res. Dev., (19930000), vol. 3, pages 323 - 338-
DESCRIPTION- ZELPHATI, OSZOKA, F.C., J. Contr. Rel., (19960000), vol. 41, pages 99 - 119-
DESCRIPTION- ZHU et al., Science, (19930000), vol. 261, pages 209 - 211-
DESCRIPTION- ZIMMERMANN et al., Nature, (20060000), vol. 441, pages 111 - 114-
DESCRIPTION- ZITZMANN et al., Cancer Res., (20020000), vol. 62, pages 5139 - 43-
DESCRIPTION- TURK, M. J.REDDY, J. A. et al., "Characterization of a novel pH-sensitive peptide that enhances drug release from folate-targeted liposomes at endosomal pHs", Biochim. Biophys. Acta, (20020000), vol. 1559, doi:10.1016/S0005-2736(01)00441-2, pages 56 - 68, XP004334733
DESCRIPTION- MASTROBATTISTA, E.KONING, G. A et al., "Functional characterization of an endosome-disruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins", J. Biol. Chem., (20020000), vol. 277, no. 33, doi:10.1074/jbc.M200429200, pages 27135 - 43, XP001187533
DESCRIPTION- GRIFFITHS-JONES S., "The microRNA Registry", NAR, vol. 32, doi:10.1093/nar/gkh023, (20040000), pages D109 - D111, URL: http://microma.sanger.ac.uk/sequences, XP002392427
DESCRIPTION- VERMEULEN et al., "Double-Stranded Regions Are Essential Design Components Of Potent Inhibitors of RISC Function", RNA, (20070000), vol. 13, doi:10.1261/RNA.448107, pages 723 - 730, XP002659375
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OPPOSITION- D60 - Response to EESR - European Patent Application No. 23175192.6-
OPPOSITION- D62 - Declaration of Prof. Dr. Michael D. Pungente-
OPPOSITION- D63 - CRC Handbook o f Chemistry and Physics.-
OPPOSITION- D65 - Table of basis for claims of new DIV-
OPPOSITION- Barrán-Berdón Ana L, Emilio Aicart, Elena Junquera, "Anionic/Zwitterionic Lipid-Based Gene Vectors of pDNA", Barrán-Berdón Ana L, Emilio Aicart, Elena Junquera, Candiani Gabriele, Non-Viral Gene Delivery Vectors - Methods and Protocols, Humana Press, (20160101), pages 45 - 46, doi:10.1007/978-1-4939-3718-9, ISBN 978-1-4939-3716-5, XP093303303
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OPPOSITION- Mendonça Monique C.P., Kont Ayse, Kowalski Piotr S., O'driscoll Caitriona M., "Design of lipid-based nanoparticles for delivery of therapeutic nucleic acids", Drug Discovery Today, AMSTERDAM, NL , (20230301), vol. 28, no. 3, doi:10.1016/j.drudis.2023.103505, ISSN 1359-6446, pages 103505 - 103505-17, XP009554550
OPPOSITION- Hassett Kimberly J., Benenato Kerry E., Jacquinet Eric, Lee Aisha, Woods Angela, Yuzhakov Olga, Himansu Sunny, Deterling Jessica, Geilich Benjamin M., Ketova Tatiana, Mihai Cosmin, Lynn Andy, Mcfadyen Iain, Moore Melissa J., Senn Joseph J., Stanton Matthew G., Almarsson Örn, Ciaramella Giuseppe, Brito Luis A., "Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines", Molecular Therapy-Nucleic Acids, US , (20190415), vol. 15, doi:10.1016/j.omtn.2019.01.013, ISSN 2162-2531, pages 1 - 11, XP055815007
OPPOSITION- Semple Sean C.; Klimuk Sandra K.; Harasym Troy O.; Dos Santos Nancy; Ansell Steven M.; Wong Kim F.; Maurer Norbert; Stark Holger; Cullis Pieter R.; Hope Michael J.; Scherrer Peter, "Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures", Biochimica et Biophysica Acta, AMSTERDAM, NL , (20160613), vol. 1510, no. 1, doi:10.1016/S0005-2736(00)00343-6, ISSN 0005-2736, pages 152 - 166, XP085070789
OPPOSITION- Norbert Maurer, Kim F. Wong, Holger Stark, Lenore Louie, Deirdre Mcintosh, Tabitha Wong, Peter Scherrer, Sean C. Semple, Pieter R. Cullis, "Spontaneous Entrapment of Polynucleotides upon Electrostatic Interaction with Ethanol-Destabilized Cationic Liposomes", Biophysical Journal, AMSTERDAM, NL, (20010501), vol. 80, no. 5, doi:10.1016/S0006-3495(01)76202-9, ISSN 0006-3495, pages 2310 - 2326, XP055550920
OPPOSITION- Bailey Austin L, Cullis Pieter R, "Modulation of Membrane Fusion by Asymmetric Transbilayer Distributions of Amino Lipids", Biochemistry, (19941001), vol. 33, no. 42, doi:10.1021/bi00208a007, pages 12573 - 12580, XP093303276
OPPOSITION- Akin Akinc, Andreas Zumbuehl, Michael Goldberg, Elizaveta S Leshchiner, Valentina Busini, Naushad Hossain, Sergio A Bacallado, David N Nguyen, Jason Fuller, Rene Alvarez, Anna Borodovsky, Todd Borland, Rainer Constien, Antonin De Fougerolles, J Robert Dorkin, K Narayanannair Jayaprakash, Muthusamy Jayaraman, Matthias John, Victor Koteliansky, Muthiah Manoharan, Lubomir Nechev, June Qin, Timothy Racie, Denitza Raitcheva, Kallanthottathil G Rajeev, Dinah W Y Sah, Jürgen Soutschek, Ivanka Toudjarska, Hans-Peter Vornlocher, Tracy S Zimmermann, Robert Langer, Daniel G Anderson, "A combinatorial library of lipid-like materials for delivery of RNAi therapeutics", Nature Biotechnology, New York, (20080501), vol. 26, no. 5, doi:10.1038/nbt1402, ISSN 1087-0156, pages 561 - 569, XP055533621
OPPOSITION- T. M. ALLEN, P. R. CULLIS, "Drug Delivery Systems: Entering the Mainstream", Science - Author Manuscript, US , (20040319), vol. 303, doi:10.1126/science.1095833, ISSN 0036-8075, pages 1818 - 1822, XP002427419
OPPOSITION- D. B. Fenske, A. Chonn, P. R. Cullis, "Liposomal Nanomedicines: An Emerging Field", Toxicologic Pathology, (20080101), vol. 36, no. 1, doi:10.1177/0192623307310960, ISSN 0192-6233, pages 21 - 29, XP055179556
OPPOSITION- Ian MacLachlan, "CHAPTER 9. Liposomal Formulations for Nucleic Acid Delivery", Ian MacLachlan, Stanley T Crooke, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition, CRC Press, (20070725), pages 237 - 270, doi:10.1201/9780849387951, ISBN 0-8493-8796-5, XP093133162
OPPOSITION- Martin B, M Sainlos, A Aissaoui, N Oudrhiri, M Hauchecorne, J-P Vigneron, J-M Lehn, P Lehn, "The design of cationic lipids for gene delivery.", Current Pharmaceutical Design, NL , (20050101), vol. 11, no. 3, doi:10.2174/1381612053382133, ISSN 1381-6128, pages 375 - 394, XP002493549

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